Treatment modelling: The influence of micro-environmental conditions

References

• Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res 1989; 49: 6449–65
   PubMed Web of Science ®Google Scholar
• Denekamp J, Daşu A, Waites A. Vasculature and microenvironmental gradients: The missing links in novel approaches to cancer therapy?. Adv Enzyme Regul 1998; 38: 281–99
   PubMedGoogle Scholar
• Gerweck LE, Dahlberg WK, Epstein LF, Shimm DS. Influence of nutrient and energy deprivation on cellular response to single and fractionated heat treatments. Radiat Res 1984; 99: 573–81
   PubMed Web of Science ®Google Scholar
• Gerweck LE, Seneviratne T, Gerweck KK. Energy status and radiobiological hypoxia at specified oxygen concentrations. Radiat Res 1993; 135: 69–74
   PubMed Web of Science ®Google Scholar
• Skøyum R, Eide K, Berg K, Rofstad EK. Energy metabolism in human melanoma cells under hypoxic and acidic conditions in vitro. Br J Cancer 1997; 76: 421–8
   PubMed Web of Science ®Google Scholar
• Ward JF. Mechanisms of DNA repair and their potential modification for radiotherapy. Int J Radiat Oncol Biol Phys 1986; 12: 1027–32
   PubMed Web of Science ®Google Scholar
• Nagle WA, Moss AJ, Jr, Roberts HG, Jr, Baker ML. Effects of 5-thio-D-glucose on cellular adenosine triphosphate levels and deoxyribonucleic acid rejoining in hypoxic and aerobic Chinese hamster cells. Radiology 1980; 137: 203–11
   PubMed Web of Science ®Google Scholar
• Spiro IJ, Kennedy KA, Stickler R, Ling CC. Cellular and molecular repair of X-ray-induced damage: Dependence on oxygen tension and nutritional status. Radiat Res 1985; 101: 144–55
   PubMed Web of Science ®Google Scholar
• Hall EJ, Bedford JS, Oliver R. Extreme hypoxia; its effect on the survival of mammalian cells irradiated at high and low dose-rates. Br J Radiol 1966; 39: 302–7
   PubMed Web of Science ®Google Scholar
• Berry RJ, Hall EJ, Cavanagh J. Radiosensitivity and the oxygen effect for mammalian cells cultured in vitro in stationary phase. Br J Radiol 1970; 43: 81–90
   PubMedGoogle Scholar
• Franko AJ, Sutherland RM. Radiation survival of cells from spheroids grown in different oxygen concentrations. Radiat Res 1979; 79: 454–67
   PubMed Web of Science ®Google Scholar
• Shrieve DC, Harris JW. The in vitro sensitivity of chronically hypoxic EMT6/SF cells to X-radiation and hypoxic cell radiosensitizers. Int J Radiat Biol 1985; 48: 127–38
   Web of Science ®Google Scholar
• Ling CC, Robinson E, Shrieve DC. Repair of radiation induced damage–dependence on oxygen and energy status. Int J Radiat Oncol Biol Phys 1988; 15: 1179–86
   PubMed Web of Science ®Google Scholar
• Pettersen EO, Wang H. Radiation-modifying effect of oxygen in synchronized cells pre-treated with acute or prolonged hypoxia. Int J Radiat Biol 1996; 70: 319–26
   PubMed Web of Science ®Google Scholar
• Zölzer F, Streffer C. Increased radiosensitivity with chronic hypoxia in four human tumor cell lines. Int J Radiat Oncol Biol Phys 2002; 54: 910–20
   PubMed Web of Science ®Google Scholar
• Denekamp J, Daşu A. Inducible repair and the two forms of tumour hypoxia--time for a paradigm shift. Acta Oncol 1999; 38: 903–18
   PubMed Web of Science ®Google Scholar
• Daşu A, Denekamp J. The impact of tissue microenvironment on treatment simulation. Adv Exp Med Biol 2003; 510: 63–7
   PubMedGoogle Scholar
• Daşu A, Toma-Daşu I, Karlsson M. Theoretical simulation of tumour oxygenation and results from acute and chronic hypoxia. Phys Med Biol 2003; 48: 2829–42
   PubMed Web of Science ®Google Scholar
• Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1955; 9: 539–49
   PubMed Web of Science ®Google Scholar
• Tannock IF. The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Br J Cancer 1968; 22: 258–73
   PubMed Web of Science ®Google Scholar
• Brown JM. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br J Radiol 1979; 52: 650–6
   PubMed Web of Science ®Google Scholar
• Alper T, Howard-Flanders P. Role of oxygen in modifying the radiosensitivity of E. Coli B. Nature 1956; 178: 978–9
   PubMed Web of Science ®Google Scholar
• Kellerer AM, Rossi HH. The theory of dual radiation action. Curr Top Radiat Res Q 1972; 8: 85–158
   Google Scholar
• Chadwick KH, Leenhouts HP. A molecular theory of cell survival. Phys Med Biol 1973; 18: 78–87
   PubMed Web of Science ®Google Scholar
• Douglas BG, Fowler JF. Fractionation schedules and a quadratic dose-effect relationship. Br J Radiol 1975; 48: 502–4
   PubMed Web of Science ®Google Scholar
• Barendsen GW. Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys 1982; 8: 1981–97
   PubMed Web of Science ®Google Scholar
• Fowler JF. The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol 1989; 62: 679–94
   PubMed Web of Science ®Google Scholar
• Joiner MC, Denekamp J, Maughan RL. The use of ‘top-up’ experiments to investigate the effect of very small doses per fraction in mouse skin. Int J Radiat Biol 1986; 49: 565–80
   Web of Science ®Google Scholar
• Joiner MC, Johns H. Renal damage in the mouse: The response to very small doses per fraction. Radiat Res 1988; 114: 385–98
   PubMed Web of Science ®Google Scholar
• Hamilton CS, Denham JW, O'Brien M, Ostwald P, Kron T, Wright S, et al. Underprediction of human skin erythema at low doses per fraction by the linear quadratic model. Radiother Oncol 1996; 40: 23–30
   PubMed Web of Science ®Google Scholar
• Turesson I, Johansson K-A, Nyman J, Flogegard M, Wahlgren T. A clinical study on the effect of low dose per fraction. Radiother Oncol 1998; 48(Suppl 1)S4
   Google Scholar
• Beck-Bornholdt H-P, Maurer T, Becker S, Omniczynski M, Vogler H, Würschmidt F. Radiotherapy of the rhabdomyosarcoma R1H of the rat: Hyperfractionation-126 fractions applied within 6 weeks. Int J Radiat Oncol Biol Phys 1989; 16: 701–5
   PubMed Web of Science ®Google Scholar
• Harney J, Short SC, Shah N, Joiner M, Saunders MI. Low dose hyper-radiosensitivity in metastatic tumors. Int J Radiat Oncol Biol Phys 2004; 59: 1190–5
   PubMed Web of Science ®Google Scholar
• Marples B, Joiner MC. The response of Chinese hamster V79 cells to low radiation doses: Evidence of enhanced sensitivity of the whole cell population. Radiat Res 1993; 133: 41–51
   PubMed Web of Science ®Google Scholar
• Lambin P, Marples B, Fertil B, Malaise EP, Joiner MC. Hypersensitivity of a human tumour cell line to very low radiation doses. Int J Radiat Biol 1993; 63: 639–50
   PubMed Web of Science ®Google Scholar
• Wouters BG, Skarsgard LD. The response of a human tumor cell line to low radiation doses: Evidence of enhanced sensitivity. Radiat Res 1994; 138: S76–S80
   PubMed Web of Science ®Google Scholar
• Singh B, Arrand JE, Joiner MC. Hypersensitive response of normal human lung epithelial cells at low radiation doses. Int J Radiat Biol 1994; 65: 457–64
   PubMed Web of Science ®Google Scholar
• Wouters BG, Sy AM, Skarsgard LD. Low-dose hypersensitivity and increased radioresistance in a panel of human tumor cell lines with different radiosensitivity. Radiat Res 1996; 146: 399–413
   PubMed Web of Science ®Google Scholar
• Marples B, Adomat H, Koch CJ, Skov KA. Response of V79 cells to low doses of X-rays and negative π-mesons: clonogenic survival and DNA strand breaks. Int J Radiat Biol 1996; 70: 429–36
   PubMed Web of Science ®Google Scholar
• Wouters BG, Skarsgard LD. Low-dose radiation sensitivity and induced radioresistance to cell killing in HT-29 cells is distinct from the “adaptive response” and cannot be explained by a subpopulation of sensitive cells. Radiat Res 1997; 148: 435–42
   PubMed Web of Science ®Google Scholar
• Short S, Mayes C, Woodcock M, Johns H, Joiner MC. Low dose hypersensitivity in the T98G human glioblastoma cell line. Int J Radiat Biol 1999; 75: 847–55
   PubMed Web of Science ®Google Scholar
• Joiner MC, Marples B, Lambin P, Short SC, Turesson I. Low-dose hypersensitivity: Current status and possible mechanisms. Int J Radiat Oncol Biol Phys 2001; 49: 379–89
   PubMed Web of Science ®Google Scholar
• Joiner MC, Lambin P, Malaise EP, Robson T, Arrand JE, Skov KA, et al. Hypersensitivity to very-low single radiation doses: Its relationship to the adaptive response and induced radioresistance. Mutat Res 1996; 358: 171–83
   PubMed Web of Science ®Google Scholar
• Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I, et al. A novel human stress response-related gene with a potential role in induced radioresistance. Radiat Res 1999; 152: 451–61
   PubMed Web of Science ®Google Scholar
• Marples B, Wouters BG, Collis SJ, Chalmers AJ, Joiner MC. Low-dose hyper-radiosensitivity: A consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells. Radiat Res 2004; 161: 247–55
   PubMed Web of Science ®Google Scholar
• Lind BK, Persson LM, Edgren MR, Hedlof I, Brahme A. Repairable-conditionally repairable damage model based on dual Poisson processes. Radiat Res 2003; 160: 366–75
   PubMed Web of Science ®Google Scholar
• Daşu A. Modelling the impact of two forms of hypoxia on novel radiotherapy approaches. 2000. PhD thesis, Umeå University.
   Google Scholar
• Thames HD, Bentzen SM, Turesson I, Overgaard M, Van den Bogaert W. Time-dose factors in radiotherapy: A review of the human data. Radiother Oncol 1990; 19: 219–35
   PubMed Web of Science ®Google Scholar
• Konerding MA, Malkusch W, Klapthor B, van Ackern C, Fait E, Hill SA, et al. Evidence for characteristic vascular patterns in solid tumours: Quantitative studies using corrosion casts. Br J Cancer 1999; 80: 724–32
   PubMed Web of Science ®Google Scholar
• Jain RK. Determinants of tumor blood flow: A review. Cancer Res 1988; 48: 2641–58
   PubMed Web of Science ®Google Scholar
• Vordermark D, Menke DR, Brown JM. Similar radiation sensitivities of acutely and chronically hypoxic cells in HT 1080 fibrosarcoma xenografts. Radiat Res 2003; 159: 94–101
   PubMed Web of Science ®Google Scholar
• Fertil B, Malaise EP. Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: Analysis of 101 published survival curves. Int J Radiat Oncol Biol Phys 1985; 11: 1699–707
   PubMed Web of Science ®Google Scholar
• Ljungkvist AS, Bussink J, Kaanders JH, Wiedenmann NE, Vlasman R, van der Kogel AJ. Dynamics of hypoxia, proliferation and apoptosis after irradiation in a murine tumor model. Radiat Res 2006; 165: 326–36
   PubMed Web of Science ®Google Scholar
• Foster CJ, Malone J, Orr JS, Macfarlane DE. The recovery of the survival curve shoulder after protracted hypoxia. Br J Radiol 1971; 44: 540–5
   PubMed Web of Science ®Google Scholar
• Siemann DW, Hill RP, Bush RS. The importance of the pre-irradiation breathing times of oxygen and carbogen (5% CO2: 95% O2) on the in vivo radiation response of a murine sarcoma. Int J Radiat Oncol Biol Phys 1977; 2: 903–11
   PubMed Web of Science ®Google Scholar
• Kaanders JH, Pop LA, Marres HA, Liefers J, van den Hoogen FJ, van Daal WA, et al. Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer. Radiother Oncol 1998; 48: 115–22
   PubMed Web of Science ®Google Scholar
• Overgaard J, Hansen HS, Overgaard M, Bastholt L, Berthelsen A, Specht L, et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5–85. Radiother Oncol 1998; 46: 135–46
   PubMed Web of Science ®Google Scholar
• Stubbs M. Application of magnetic resonance techniques for imaging tumour physiology. Acta Oncol 1999; 38: 845–53
   PubMed Web of Science ®Google Scholar
• Littbrand B. Survival characteristics of mammalian cell lines after single or multiple exposures to roentgen radiation under oxic or anoxic conditions. Acta Radiol Ther Phys Biol 1970; 9: 257–81
   PubMed Web of Science ®Google Scholar
• Littbrand B, Edsmyr F, Révész L. A low dose-fractionation scheme for the radiotherapy of carcinoma of the bladder. Experimental background and preliminary results. Bull Cancer 1975; 62: 241–8
   PubMed Web of Science ®Google Scholar
• Taylor YC, Brown JM. Radiosensitization in multifraction schedules. I. Evidence for an extremely low oxygen enhancement ratio. Radiat Res 1987; 112: 124–33
   PubMedGoogle Scholar
• Palcic B, Brosing JW, Skarsgard LD. Survival measurements at low doses: Oxygen enhancement ratio. Br J Cancer 1982; 46: 980–4
   PubMed Web of Science ®Google Scholar
• Watts ME, Hodgkiss RJ, Jones NR, Fowler JF. Radiosensitization of Chinese hamster cells by oxygen and misonidazole at low X-ray doses. Int J Radiat Biol 1986; 50: 1009–21
   Web of Science ®Google Scholar
• Skarsgard LD, Harrison I. Dose dependence of the oxygen enhancement ratio (OER) in radiation inactivation of Chinese hamster V79–171 cells. Radiat Res 1991; 127: 243–7
   PubMed Web of Science ®Google Scholar
• Freyer JP, Jarrett K, Carpenter S, Raju MR. Oxygen enhancement ratio as a function of dose and cell cycle phase for radiation-resistant and sensitive CHO cells. Radiat Res 1991; 127: 297–307
   PubMed Web of Science ®Google Scholar
• Daşu A, Denekamp J. New insights into factors influencing the clinically relevant oxygen enhancement ratio. Radiother Oncol 1998; 46: 269–77
   PubMed Web of Science ®Google Scholar
• Daşu A, Denekamp J. Superfractionation as a potential hypoxic cell radiosensitizer: Prediction of an optimum dose per fraction. Int J Radiat Oncol Biol Phys 1999; 43: 1083–94
   PubMed Web of Science ®Google Scholar
• Yaromina A, Zips D, Thames HD, Eicheler W, Krause M, Rosner A, et al. Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: The need for a multivariate approach in biomarker studies. Radiother Oncol 2006; 81: 122–9
   PubMed Web of Science ®Google Scholar