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Research Article

Clinical Outcome and Tumour Microenvironmental Effects of Accelerated Radiotherapy with Carbogen and Nicotinamide

Pages 875-882 | Published online: 08 Jul 2009

References

  • Ang KK, Kaanders JHAM, Peters U. Radiotherapy for head and neck cancers: indications and techniques. Philadelphia, PA: Lea & Febiger, 1994: 82–5.
  • Robertson JM, Ten Haken RK, Hazuka MB, et al. Dose escalation for non-small cell lung cancer using conformal radiation therapy. Int J Radiat Oncol Biol Phys 1997; 37: 1079–85.
  • Hanks GE, Schultheiss TE, Hanlon AL, et al. Optimization of conformal radiation treatment of prostate cancer: a report of a dose escalation study. Int J Radiat Oncol Biol Phys 1997; 37: 543–50.
  • Overgaard J, Sand Hansen H, Overgaard M, et al. Conven-tional radiotherapy as primary treatment of squamous cell carcinoma of the head and neck. A randomized multicenter study of 5 versus 6 fractions per week-report from the DAHANCA 7 trial. Int J Rad Oncol Biol Phys 1997; 39: S188.
  • Fowler JF, Lindstrom MJ. Loss of local control with prolon-gation in radiotherapy. Int J Radiat Oncol Biol Phys 1992; 23: 457–67.
  • Dische S, Saunders MI, Barrett A, et al. A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer. Radiother Oncol 1997; 44: 123–36.
  • Horiot J-C, Bontemps P, Van den Bogaert W, et al. Acceler-ated fractionation (AF) compared to conventional fractiona-tion (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: results of the EORTC 22851 randomized trial. Radiother Oncol 1997; 44: 111–21.
  • Saunders MI, Dische S, Barrett A, et al. Continuous hyper-fractionated accelerated radiotherapy (CHART) versus con-ventional radiotherapy in non-small-cell lung cancer: a randomised multicentre trial. Lancet 1997; 350: 161–5.
  • Overgaard J, Horsman MR. Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Sem Radiat Oncol 1996; 6: 10–21.
  • Henk JM. Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: a rationale for hypoxic cell sensitizers? Int J Radiat Oncol Biol Phys 1986; 12: 1339–41.
  • Watson ER, Hainan KE, Dische S, et al. Hyperbaric oxygen and radiotherapy: a medical research council trial in car-cinoma of the cervix. Br J Radiol 1978; 51: 879–87.
  • Overgaard J, Sand Hansen H, Overgaard M, et al. A random-ized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) protocol 5-85. Radiother Oncol 1998; 46: 135–46.
  • Bussink J, Tofilon PJ, Brock WA. Repair of chromosome and DNA breaks versus cell survival in Chinese hamster cells. Int J Radiat Biol 1996; 70: 23–32.
  • Fertil B, Malaise EP. Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: analysis of 101 published survival curves. Int J Radiat Oncol Biol Phys 1985; 11: 1699–707.
  • Girinsky T, Lubin R, Pignon JP, et al. Predictive value of in vitro radiosensitivity parameters in head and neck cancers and cervical carcinomas-preliminary correlations with local control and overall survival. Int J Radiat Oncol Biol Phys 1993; 25: 3–7.
  • Hoshino T, Nagashima T, Murovic J, et al. Cell kinetic studies of in situ human brain tumors with bromod-eoxyuridine. Cytometry 1985; 6: 627–32.
  • Dolbeare R, Gratzner HG, Pallavicini MG, et al. Flow cyto-metric measurement of total DNA content and incorporated bromodeoxyuridine. Proc Natl Acad Sci USA 1983; 80: 5573–777.
  • Denekamp J, Fowler JF. ARCON-current status: summary of a workshop on pre-clinical and clinical studies. Acta Onco-logica 1997; 36: 517–25.
  • Bennett MH, Wilson GD, Dische S, et al. Tumour prolifera-tion assessed by combined histological and flow cytometric analysis: implications for therapy in squamous cell carcinoma in the head and neck. Br J Cancer 1992; 65: 870–8.
  • Bussink J, Kaanders JHAM, Rijken PFJW, et al. Multi-parameter analysis of vasculature, perfusion and proliferation in human tumour xenografts. Br J Cancer 1998; 77: 57–64.
  • Gray LH, Conger AD, Ebert M, et al. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953; 26: 638–48.
  • Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radio-therapy. Br J Cancer 1955; 9: 539–49.
  • Brown JM. Evidence for acute hypoxic cells in mouse tu-mours and a possible mechanism of reoxygenation. Br J Radiol 1979; 52: 650–6.
  • Rockwell S, Moulder JE. Hypoxic fractions of human tumors xenografted into mice: a review. Int J Radiat Oncol Biol Phys 1990; 19: 197–202.
  • Gatenby RA, Kessler HB, Rosenblum JS, et al. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int .1- Radiat Oncol Biol Phys 1988; 14: 831–8.
  • Hockel M, Schlenger K, Mitze M, et al. Hypoxia and radia-tion response in human tumors. Sem Radiat Oncol 1996; 6: 3–9.
  • Nordsmark M, Overgaard M, Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 1996; 41: 31–9.
  • Nordsmark M, Keller J, Bayer M, et al. Hypoxia in human soft tissue sarcomas is associated with poor survival. Radio-ther Oncol 1998; 48 Suppl 1: S162.
  • Long A, Parrick J, Hodgkiss RJ. An efficient procedure for the 1-alkylation of 2-nitroimidazoles and the synthesis of a probe for hypoxia in solid tumours. Synthesis 1991; 9: 709–13.
  • Raleigh JA, Miller GG, Franko AJ, et al. Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours. Br J Cancer 1987; 56: 395–400.
  • Hodgkiss RJ, Jones G, Long A, et al. Flow cytometric evaluation of hypoxic cells in solid experimental tumours using fluorescence immunodetection. Br J Cancer 1991; 63: 119–25.
  • Kennedy AS, Raleigh JA, Perez GM, et al. Proliferation and hypoxia in human squamous cell carcinoma of the cervix: first report of combined immunohistochemical assays. Int J Rad Oncol Biol Phys 1997; 37: 897–905.
  • Bussink J, Kaanders JHAM, Rijken PFJW, et al. Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: effects of carbogen and nicotinamide. Radiother Oncol 1999; 50: 173–83.
  • Horiot JC, Le Fur R, N'Guyen T, et al. Hyperfractionation versus conventional fractionation in oropharyngeal car-cinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother Oncol 1992; 25: 231–41.
  • Rojas A, Joiner MC, Denekamp J. Extrapolations from labo-ratory and preclinical studies for the use of carbogen and nicotinamide in radiotherapy. Radiother Oncol 1992; 24: 123–4.
  • Rojas A, Hirst VK, Calvert AS, et al. Carbogen and nicoti-namide as radiosensitizers in a murine mammary carcinoma using conventional and accelerated radiotherapy. Int J Radiat Oncol Biol Phys 1996; 34: 357–65.
  • Martin L, Lartigau E, Weeger P, et al. Changes in the oxygenation of head and neck tumors during carbogen breathing. Radiother Oncol 1993; 27: 123–30.
  • Chaplin DJ, Horsman MR, Trotter MJ. The effect of nicoti-namide on the microregional heterogeneity of oxygen delivery within a murine tumour. J Natl Cancer Inst 1990; 82: 672–6.
  • Horsman MR, Chaplin DJ, Overgaard J. Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumour cells. Cancer Res 1990; 50: 7430–6.
  • Haustermans K, Van der Kogel AJ, Vanacker B, et al. Influence of combined use of nicotinamide and carbogen on rat spinal cord radiation tolerance. Radiother Oncol 1994; 31: 123–8.
  • Kaanders JHAM, Van der Maazen RWM. A convenient and reliable method for carbogen breathing in man. Radiother Oncol 1993; 29: 341–3.
  • Stratford MRL, Dennis MF, Hoskin P, et al. Nicotinamide pharmacokinetics in normal volunteers and patients undergo-ing palliative radiotherapy. Acta Oncol 1996; 35: 213–9.
  • Rijken PFJW, Bernsen HJJA, Van der Kogel AJ. Application of an image analysis system to the quantitation of tumor perfusion and vascularity in human glioma xenografts. Mi-crovasc Res 1995; 50: 141–53.
  • Barton MB, Keane TJ, Gadella T, et al. The effect of treatment time and treatment interruption on tumor control following radical radiotherapy of laryngeal cancer. Radiother Oncol 1992; 23: 137–43.
  • Terhaard CHJ, Karim ABMF, Hoogenraad WJ, et al. Local control in T3 laryngeal cancer treated with radical radiother-apy, time dose relationship: the concept of nominal standard dose and linear quadratic model. Int J Radiat Oncol Biol Phys 1991; 20: 1207–14.
  • Wang CC. Radiation therapy of laryngeal tumors: curative radiation therapy. In: Thawley SE, Panje WR, Batsakis JG. Comprehensive management of head and neck tumors, vol. 1. Philadelphia, PA: WB Saunders, 1987: 906–18.
  • Kaanders JHAM, Van Daal WAJ, Hoogenraad WJ, et al. Accelerated fractionation radiotherapy for laryngeal cancer, acute and late toxicity. Int J Rad Oncol Biol Phys 1992; 24: 497–503.
  • Kaanders JHAM, Pop LAM, Manes HAM, et al. Radiother-apy with carbogen breathing and nicotinamide in head and neck cancer: feasibility and toxicity. Radiother Oncol 1995; 37: 190–8.
  • Kaanders JHAM, Pop LAM, Marres HAM, et al. Acceler-ated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer. Radiother Oncol 1998; 48: 115–22.
  • Powell MEB, Hill SA, Saunders MI, et al. Effect of carbogen breathing on tumour microregional blood flow in humans. Radiother Oncol 1996; 41: 225–31.
  • Chaplin DJ, Hill SA, Bell KM, et al. Modification of tumour blood flow: current status and future directions. Sem Rad Oncol 1998; 8: 151–63.
  • Stubbs M, Robinson SP, Rodrigues LM, et al. The effects of host carbogen (95% oxygen/5% carbon dioxide) breathing on metabolic characteristics of Morris hepatoma 9618a. Br J Cancer 1998; 78: 1449–56.

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