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LETTERS TO THE EDITOR

Hunting for abscopal and bystander effects: clinical exploitation of non-targeted effects induced by partial high-single-dose irradiation of the hypoxic tumour segment in oligometastatic patients

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References

  • Cook AM, Berry RJ. Direct and indirect effects of radiation: their relation to growth. Nature. 1966;210:324–325.
  • Nagasawa H, Little JB. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res. 1992;52:6394–6396.
  • Tubin S, Mansoor MA, Gupta S. Radiation and acute hypoxia-induced abscopal effects in normoxic and hypoxic conditions in human lung cancer cells. ESTRO 35, Turin, Italy, 2016: Abstract Book. Available at https://user-swndwmf.cld.bz/ESTRO-35-Abstract-book3/989.
  • Mole RH. Whole body irradiation; radiobiology or medicine? Br J Radiol. 1953;26:234–241.
  • Cao X. Regulatory T cells and immune tolerance to tumors. Immunol Res. 2010;46:79–93.
  • Golden EB, Chhabra A, Chachoua A, et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial. Lancet Oncol. 2015;16:795–803.
  • Brody JD, Ai WZ, Czerwinski DK, et al. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J Clin Oncol. 2010;28:4324–4332.
  • Wersall PJ, Blomgren H, Pisa P, et al. Regression of non-irradiated metastases after extracranial stereotactic radiotherapy in metastatic renal cell carcinoma. Acta Oncol. 2006;45:493–497.
  • Tubin S, Casamassima F, Menichelli C, et al. A case report on metastatic thyroid carcinoma: radiation-induced bystander or abscopal effect? J Cancer Sci Ther. 2012;4:408–411.
  • Siva S, Callahan J, Mac Manus MP, et al. Abscopal [corrected] effects after conventional and stereotactic lung irradiation of non-small-cell lung cancer. J Thorac Oncol. 2013;8:e71–e72.
  • Kanagavelu S, Gupta S, Wu X, et al. In vivo effects of lattice radiation therapy on local and distant lung cancer: potential role of immunomodulation. Radiat Res. 2014;182:149–162.
  • Gupta S, Zagurovskaya M, Wu X, et al. Spatially Fractionated Grid High-dose radiation-induced tumor regression in A549 lung adenocarcinoma xenografts: cytokines and ceramide regulators balance in abscopal phenomena. Sylvester Comprehensive Cancer Center, 2014:20.
  • Shareef MM, Cui N, Burikhanov R, et al. Role of tumor necrosis factor alpha and TRAIL in high-dose radiation-induced bystander signaling in lung adenocarcinoma. Cancer Res. 2007;67:11811–11820.
  • Tubin S, Valeriani M, Salerno G, et al. Manipulation of radiation-induced bystander effect in prostate adenocarcinoma by dose and tumor differentiation grade: in vitro study. Int J Radiat Biol. 2015;91:166–171.
  • Prise KM, O’sullivan JM. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer. 2009;9:351–360.
  • Baskar R. Emerging role of radiation induced bystander effects: cell communications and carcinogenesis. Genome Integr. 2010;1:13.
  • Kaminski JM, Shinohara E, Summers JB, et al. The controversial abscopal effect. Cancer Treat Rev. 2005;31:159–172.
  • Schaue D, Ratikan JA, Iwamoto KS, et al. Maximizing tumor immunity with fractionated radiation. Int J Radiat Oncol Biol Phys. 2012;83:1306–1310.
  • Ishihara D, Pop L, Takeshima T, et al. Rationale and evidence to combine radiation therapy and immunotherapy for cancer treatment. Cancer Immunol Immunother. 2016;66:281–298.
  • Takebayashi R, Izuichi K, Yamamoto Y, et al. [18F]fluorodeoxyglucose accumulation as a biological marker of hypoxic status but not glucose transport ability in gastric cancer. J Exp Clin Cancer Res. 2013;32:34.
  • Han MW, Lee HJ, Cho KJ, et al. Role of FDG-pet as a biological marker for predictiong the hypoxic status of tongue cancer. Head Neck. 2012;3:1395–1402.
  • Van Baardwijk A, Dooms C, Van Suylen RJ, et al. The maximum uptake of (18)F-deoxyglucose on positron emission tomography scan correlated with survival, hypoxia inducible factor-1alpha and GLUT-1 in non-small cell lung cancer. Eur J Cancer. 2007;43:1392–1398.
  • Kaira K, Okumura T, Ohde Y, et al. Correlation between 18F-FDG uptake on PET and molecular biology in metastatic pulmonary tumors. J Nucl Med. 2011;52:705–711.
  • Yamada T, Uchida M, Kwang-Lee K, et al. Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:464–471.
  • Yeom CJ, Zeng L, Zhu Y, et al. Strategies to assess hypoxic/HIF-1-active cancer cells for the development of innovative radiation therapy. Cancers (Basel). 2011;3:3610–3631.

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