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ORIGINAL ARTICLES: GYNAECOLOGIC MALIGNANCIES

Radiotherapy for cervical cancer – impact on the vaginal epithelium and sexual function

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Pages 338-345 | Received 24 Mar 2017, Accepted 30 Oct 2017, Published online: 15 Nov 2017

References

  • Jensen PT, Froeding LP. Pelvic radiotherapy and sexual function in women. Transl Androl Urol. 2015;4:186–205.
  • Bergmark K, Avall-Lundqvist E, Dickman PW, et al. Vaginal changes and sexuality in women with a history of cervical cancer. N Engl J Med. 1999;340:1383–1389.
  • Grigsby PW, Russell A, Bruner D, et al. Late injury of cancer therapy on the female reproductive tract. Int J Radiat Oncol Biol Phys. 1995;31:1281–1299.
  • Huffman LB, Hartenbach EM, Carter J, et al. Maintaining sexual health throughout gynecologic cancer survivorship: a comprehensive review and clinical guide. Gynecol Oncol. 2016;140:359–368.
  • Vale CTJ, Stewart LA. Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials. J Clin Oncol. 2008;26:5802–5812.
  • Andreyev HJ, Wotherspoon A, Denham JW, et al. “Pelvic radiation disease”: new understanding and new solutions for a new disease in the era of cancer survivorship. Scand J Gastroenterol. 2011;46:389–397.
  • Hofsjo A, Bohm-Starke N, Blomgren B, et al. Radiotherapy-induced vaginal fibrosis in cervical cancer survivors. Acta Oncol. 2017;1–9.
  • Trotti A, Colevas AD, Setser A, et al. CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 2003;13:176–181.
  • Blomgren B, Johannesson U, Bohm-Starke N, et al. A computerised, unbiased method for epithelial measurement. Micron. 2004;35:319–329.
  • Turesson I. Individual variation and dose dependency in the progression rate of skin telangiectasia. Int J Radiat Oncol Biol Phys. 1990;19:1569–1574.
  • Blomgren B, Bohm-Starke N, Falconer C, et al. A computerised stereological method for quantitative estimation of surface area of blood vessels. Image Anal Stereol. 2001;20:129–132.
  • Baddeley AJ, Gundersen HJ, Cruz-Orive LM. Estimation of surface area from vertical sections. J Microsc. 1986;142:259–276.
  • Campbell LK, Thomas JR, Lamps LW, et al. Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms. Modern Pathol. 2003;16:963–969.
  • Gundersen HJG, Boysen M, Reith A. Comparison of semiautomatic digitizer-tablet and simple point counting performance in morphometry. Virchows Archiv B Cell Pathol. 1981;37:317–325.
  • Kirchheiner K, Fidarova E, Nout RA, et al. Radiation-induced morphological changes in the vagina. Strahlenther Onkol. 2012;188:1010–1017.
  • Bentzen SM. Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer. 2006;6:702–713.
  • Pitkin RM, Bradbury JT. The effect of topical estogen on irradiated vaginal epithelium. Am J Obstet Gynecol. 1965;92:175–182.
  • Abitbol MM, Davenport JH. The irradiated vagina. Obstet Gynecol. 1974;44:249–256.
  • Toillon RA, Magne N, Laios I, et al. Interaction between estrogen receptor alpha, ionizing radiation and (anti-) estrogens in breast cancer cells. Breast Cancer Res Treat. 2005;93:207–215.
  • Laan E, Everaerd W, Evers A. Assessment of female sexual arousal: response specificity and construct validity. Psychophysiology. 1995;32:476–485.
  • Lammerink EA, de Bock GH, Pras E, et al. Sexual functioning of cervical cancer survivors: a review with a female perspective. Maturitas. 2012;72:296–304.
  • Jensen PT, Groenvold M, Klee MC, et al. Longitudinal study of sexual function and vaginal changes after radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys. 2003;56:937–949.
  • Nkiwane KS, Potter R, Tanderup K, et al. Single line source with and without vaginal loading and the impact on target coverage and organ at risk doses for cervix cancer Stages IB, II, and IIIB: treatment planning simulation in patients treated with MRI-guided adaptive brachytherapy in a multicentre study (EMBRACE). Brachytherapy. 2013;12:317–323.
  • Kirchheiner K, Nout RA, Tanderup K, et al. Manifestation pattern of early-late vaginal morbidity after definitive radiation (chemo)therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: an analysis from the EMRACE study. Int J Radiat Oncol Biol Phys. 2014;89:88–95.
  • Gondi V, Bentzen SM, Sklenar KL, et al. Severe late toxicities following concomitant chemoradiotherapy compared to radiotherapy alone in cervical cancer: an inter-era analysis. Int J Radiat Oncol Biol Phys. 2012;84:973–982.

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