1,107
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Dual-tracer PET of viable tumor volume and hypoxia for identification of necrosis-containing radio-resistant Sub-volumes

, , ORCID Icon &
Pages 1476-1482 | Received 02 Apr 2019, Accepted 26 Jun 2019, Published online: 21 Aug 2019

References

  • Horsman MR, Mortensen LS, Petersen JB, et al. Imaging hypoxia to improve radiotherapy outcome. Nat Rev Clin Oncol. 2012;9:674–687.
  • Toustrup K, Sørensen BS, Lassen P, et al. Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck. Radiother Oncol. 2012;102:122–129.
  • Toustrup K, Sørensen BS, Metwally MA, et al. Validation of a 15-gene hypoxia classifier in head and neck cancer for prospective use in clinical trials. Acta Oncol. 2016;55:1091–1098.
  • Grégoire V, Thorwarth D, Lee JA. Molecular imaging-guided radiotherapy for the treatment of head-and-neck squamous cell carcinoma: does it fulfill the promises? Semin Radiat Oncol. 2018;28:35–45.
  • Busk M, Horsman MR, Overgaard J. Resolution in PET hypoxia imaging: voxel size matters. Acta Oncol. 2008;47:1201–1210.
  • Busk M, Jakobsen S, Horsman MR, et al. PET imaging of tumor hypoxia using 18F-labeled pimonidazole. Acta Oncol. 2013;52:1300–1307.
  • Wack LJ, Mönnich D, van Elmpt W, et al. Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia-a simulation study. Acta Oncol. 2015;54:1370–1377.
  • Peeters SG, Zegers CM, Lieuwes NG, et al. A comparative study of the hypoxia PET tracers [18F]HX4, [18F]FAZA, and [18F]FMISO in a preclinical tumor model. Int J Radiat Oncol Biol Phys. 2015;91:351–359.
  • Chen L, Zhang Z, Kolb HC, et al. 18F-HX4 hypoxia imaging with PET/CT in head and neck cancer: a comparison with 18F-FMISO. Nucl Med Commun. 2012;33:1096–1102.
  • Busk M, Munk OL, Jakobsen SS, et al. Hypoxia positron emission tomography imaging: combining information on perfusion and tracer retention to improve hypoxia specificity. Acta Oncol. 2017;56:1583–1590.
  • Thorwarth D, Eschmann SM, Paulsen F, et al. A kinetic model for dynamic [18F]-Fmiso PET data to analyse tumour hypoxia. Phys Med Biol. 2005;50:2209–2224.
  • Busk M, Horsman MR, Kristjansen PE, et al. Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia. Int J Cancer. 2008;122:2726–2734.
  • Mönnich D, Thorwarth D, Leibfarth S, et al. Overlap of highly FDG-avid and FMISO hypoxic tumor subvolumes in patients with head and neck cancer. Acta Oncol. 2017;56:1577–1582.
  • Di Perri D, Lee JA, Bol A, et al. Correlation analysis of [18F]fluorodeoxyglucose and [18F]fluoroazomycin arabinoside uptake distributions in lung tumours during radiation therapy. Acta Oncol. 2017;56:1181–1188.
  • Zegers CM, van Elmpt W, Hoebers FJ, et al. Imaging of tumour hypoxia and metabolism in patients with head and neck squamous cell carcinoma. Acta Oncol. 2015;54:1378–1384.
  • Busk M, Horsman MR, Jakobsen S, et al. Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage. Eur J Nucl Med Mol Imaging. 2008;35:2294–2303.
  • Gao X, Lin SH, Ren F, et al. Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016;7:11960.
  • Sørensen BS, Busk M, Overgaard J, et al. Simultaneous hypoxia and low extracellular pH suppress overall metabolic rate and protein synthesis in vitro. PLoS One. 2015;10:e0134955.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.