The majority of Danish breast cancer survivors on adjuvant endocrine therapy have clinically relevant sexual dysfunction: a cross-sectional study

References

• Ganz PA, Desmond KA, Leedham B, et al. Quality of life in long-term, disease-free survivors of breast cancer: a follow-up study. J Natl Cancer Inst. 2002;94(1):39–49.
   PubMed Web of Science ®Google Scholar
• Malinovszky KM, Gould A, Foster E, Anglo Celtic Co-operative Oncology Group, et al. Quality of life and sexual function after high-dose or conventional chemotherapy for high-risk breast cancer. Br J Cancer. 2006;95(12):1626–1631.
   PubMed Web of Science ®Google Scholar
• Bloom JR, Stewart SL, Chang S, et al. Then and now: quality of life of young breast cancer survivors. Psychooncology. 2004;13(3):147–160.
   PubMed Web of Science ®Google Scholar
• Morales L, Neven P, Timmerman D, et al. Acute effects of tamoxifen and third-generation aromatase inhibitors on menopausal symptoms of breast cancer patients. Anti-Cancer Drugs. 2004;15(8):753–760.
   PubMed Web of Science ®Google Scholar
• Fan HGM, Houédé-Tchen N, Yi Q-L, et al. Fatigue, menopausal symptoms, and cognitive function in women after adjuvant chemotherapy for breast cancer: 1- and 2-year follow-up of a prospective controlled study. J Clin Oncol. 2005;23(31):8025–8032.
   PubMed Web of Science ®Google Scholar
• Fallowfield LJ, Leaity SK, Howell A, et al. Assessment of quality of life in women undergoing hormonal therapy for breast cancer: validation of an endocrine symptom subscale for the FACT-B. Breast Cancer Res Treat. 1999;55(2):187–199.
   Web of Science ®Google Scholar
• Fallowfield L, Cella D, Cuzick J, et al. Quality of life of postmenopausal women in the arimidex, tamoxifen, alone or in combination (ATAC) adjuvant breast cancer trial. J Clin Oncol. 2004;22(21):4261–4271.
   PubMed Web of Science ®Google Scholar
• Berglund G, Nystedt M, Bolund C, et al. Effect of endocrine treatment on sexuality in premenopausal breast cancer patients: a prospective randomized study. J Clin Oncol. 2001;19(11):2788–2796.
   PubMed Web of Science ®Google Scholar
• Ganz PA, Rowland JH, Desmond K, et al. Life after breast cancer: understanding women's health-related quality of life and sexual functioning. J Clin Oncol. 1998;16(2):501–514.
   PubMed Web of Science ®Google Scholar
• Shapiro CL, Recht A. Side effects of adjuvant treatment of breast cancer. N Engl J Med. 2001;344(26):1997–2008.
   PubMed Web of Science ®Google Scholar
• Ewertz M, Jensen AB. Late effects of breast cancer treatment and potentials for rehabilitation. Acta Oncol. 2011;50(2):187–193.
   PubMed Web of Science ®Google Scholar
• Condorelli R, Vaz-Luis I. Managing side effects in adjuvant endocrine therapy for breast cancer. Expert Rev Anticancer Ther. 2018;18(11):1101–1112.
   PubMed Web of Science ®Google Scholar
• Burstein HJ, Lacchetti C, Anderson H, et al. Adjuvant endocrine therapy for women with hormone receptor-positive breast cancer: ASCO clinical practice guideline focused update. J Clin Oncol. 2019;37(5):423–438.
   PubMed Web of Science ®Google Scholar
• Speer JJ, Hillenberg B, Sugrue DP, et al. Study of sexual functioning determinants in breast cancer survivors. Breast J. 2005;11(6):440–447.
   PubMed Web of Science ®Google Scholar
• Raggio GA, Butryn ML, Arigo D, et al. Prevalence and correlates of sexual morbidity in long-term breast cancer survivors. Psychol Health. 2014;29(6):632–650.
   PubMed Web of Science ®Google Scholar
• Pumo V, Milone G, Iacono M, et al. Psychological and sexual disorders in long-term breast cancer survivors. Cancer Management Res. 2012;4:61–65.
   PubMedGoogle Scholar
• Schover LR, Baum GP, Fuson LA, et al. Sexual problems during the first 2 years of adjuvant treatment with aromatase inhibitors. J Sex Med. 2014;11(12):3102–3111.
   PubMed Web of Science ®Google Scholar
• Boquiren VM, Esplen MJ, Wong J, et al. Sexual functioning in breast cancer survivors experiencing body image disturbance. Psychooncology. 2016;25(1):66–76.
   PubMed Web of Science ®Google Scholar
• Paiva CE, Rezende FF, Paiva BS, et al. Associations of body mass index and physical activity with sexual dysfunction in breast cancer survivors. Arch Sex Behav. 2016;45(8):2057–2068.
   PubMed Web of Science ®Google Scholar
• Lee M, Kim YH, Jeon MJ. Risk factors for negative impacts on sexual activity and function in younger breast cancer survivors. Psychooncology. 2015;24(9):1097–1103.
   PubMed Web of Science ®Google Scholar
• Alder J, Zanetti R, Wight E, et al. Sexual dysfunction after premenopausal stage I and II breast cancer: do androgens play a role? J Sex Med. 2008;5(8):1898–1906.
   PubMed Web of Science ®Google Scholar
• Cobo-Cuenca AI, Martin-Espinosa NM, Sampietro-Crespo A, et al. Sexual dysfunction in Spanish women with breast cancer. PloS One. 2018;13(8):e0203151.
   PubMed Web of Science ®Google Scholar
• Kedde H, van de Wiel HB, Weijmar Schultz WC, et al. Sexual dysfunction in young women with breast cancer. Support Care Cancer. 2013;21(1):271–280.
   PubMed Web of Science ®Google Scholar
• Ljungman L, Ahlgren J, Petersson LM, et al. Sexual dysfunction and reproductive concerns in young women with breast cancer: type, prevalence, and predictors of problems. Psychooncology. 2018;27(12):2770–2777.
   PubMed Web of Science ®Google Scholar
• World Health Organization. International statistical classification of diseases and related health problems. 10th ed. Geneva: World Health Organization;1992.
   Google Scholar
• American Psychiatric Association: Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA. American Psychiatric Association;2013.
   Google Scholar
• American Psychiatric Association: Diagnostic and statistical manual of mental disorders. 4th ed, text revision. Washington, DC: American Psychiatric Press;2000.
   Google Scholar
• McCabe MP, Sharlip ID, Atalla E, et al. Definitions of sexual dysfunctions in women and men: a consensus statement from the Fourth International Consultation on Sexual Medicine 2015. J Sex Med. 2016;13(2):135–143.
   PubMed Web of Science ®Google Scholar
• Rosen R, Brown C, Heiman J, et al. The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000;26(2):191–208.
   PubMed Web of Science ®Google Scholar
• Meston CM, Freihart BK, Handy AB, et al. Scoring and Interpretation of the FSFI: what can be learned from 20 years of use? J Sex Med. 2020;17(1):17–25.
   PubMed Web of Science ®Google Scholar
• Robinson PJ, Bell RJ, Christakis MK, et al. Aromatase inhibitors are associated with low sexual desire causing distress and fecal incontinence in women: an observational study. J Sex Med. 2017;14(12):1566–1574.
   PubMed Web of Science ®Google Scholar
• Gandhi C, Butler E, Pesek S, et al. Sexual dysfunction in breast cancer survivors: is it surgical modality or adjuvant therapy? Am J Clin Oncol. 2019;42(6):500–506.
   PubMed Web of Science ®Google Scholar
• Avis NE, Johnson A, Canzona MR, et al. Sexual functioning among early post-treatment breast cancer survivors. Support Care Cancer. 2018;26(8):2605–2613.
   PubMed Web of Science ®Google Scholar
• Oberguggenberger A, Martini C, Huber N, et al. Self-reported sexual health: breast cancer survivors compared to women from the general population - an observational study. BMC Cancer. 2017;17(1):599.
   PubMed Web of Science ®Google Scholar
• Bredart A, Dolbeault S, Savignoni A, et al. Prevalence and associated factors of sexual problems after early-stage breast cancer treatment: results of a French exploratory survey. Psychooncology. 2011;20(8):841–850.
   PubMed Web of Science ®Google Scholar
• Ganz PA, Desmond KA, Belin TR, et al. Predictors of sexual health in women after a breast cancer diagnosis. J Clin Oncol. 1999;17(8):2371–2380.
   PubMed Web of Science ®Google Scholar
• Ussher JM, Perz J, Gilbert E. Changes to sexual well-being and intimacy after breast cancer. Cancer Nursing. 2012;35(6):456–465.
   PubMed Web of Science ®Google Scholar
• Panjari M, Bell RJ, Davis SR. Sexual function after breast cancer. J Sex Med. 2011;8(1):294–302.
   PubMed Web of Science ®Google Scholar
• Rosenberg SM, Tamimi RM, Gelber S, et al. Treatment-related amenorrhea and sexual functioning in young breast cancer survivors. Cancer. 2014;120(15):2264–2271.
   PubMed Web of Science ®Google Scholar
• Fobair P, Stewart SL, Chang S, et al. Body image and sexual problems in young women with breast cancer. Psychooncology. 2006;15(7):579–594.
   PubMed Web of Science ®Google Scholar
• Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), 2016.
   Google Scholar
• Corrigendum to Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation). 2018.
   Google Scholar
• Baser RE, Li Y, Carter J. Psychometric validation of the Female Sexual Function Index (FSFI) in cancer survivors. Cancer. 2012;118(18):4606–4618.
   PubMed Web of Science ®Google Scholar
• Wiegel M, Meston C, Rosen R. The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther. 2005;31(1):1–20.
   PubMed Web of Science ®Google Scholar
• Petersen CD, Giraldi A, Lundvall L, et al. Botulinum toxin type A-a novel treatment for provoked vestibulodynia? Results from a randomized, placebo controlled, double blinded study. J Sex Med. 2009;6(9):2523–2537.
   PubMed Web of Science ®Google Scholar
• Giraldi A, Rellini A, Pfaus JG, et al. Questionnaires for assessment of female sexual dysfunction: a review and proposal for a standardized screener. J Sex Med. 2011;8(10):2681–2706.
   PubMed Web of Science ®Google Scholar
• Burri A, Porst H. Preliminary validation of a german version of the sexual complaints screener for women in a female population sample. Sexual Med. 2018;6(2):123–130.
   PubMed Web of Science ®Google Scholar
• Brookes ST, Donovan JL, Wright M, et al. A scored form of the Bristol Female Lower Urinary Tract Symptoms questionnaire: data from a randomized controlled trial of surgery for women with stress incontinence. Am J Obstet Gynecol. 2004;191(1):73–82.
   PubMed Web of Science ®Google Scholar
• ICIQ-Female Sexual Matters associated with Lower Urinary Tract Symptoms. [cited 2020 Aug 21]. Available from: http://www.iciq.net/ICIQ.FLUTSsex.html.
   Google Scholar
• Warmenhoven F, van Rijswijk E, Engels Y, et al. The Beck Depression Inventory (BDI-II) and a single screening question as screening tools for depressive disorder in Dutch advanced cancer patients. Support Care Cancer. 2012;20(2):319–324.
   PubMed Web of Science ®Google Scholar
• Hopko DR, Bell JL, Armento ME, et al. The phenomenology and screening of clinical depression in cancer patients. J Psychosoc Oncol. 2008;26(1):31–51.
   PubMed Web of Science ®Google Scholar
• Vodermaier A, Linden W, Siu C. Screening for emotional distress in cancer patients: a systematic review of assessment instruments. J Natl Cancer Inst. 2009;101(21):1464–1488.
   PubMed Web of Science ®Google Scholar
• Ganz PA, Schag CA, Lee JJ, et al. The CARES: a generic measure of health-related quality of life for patients with cancer. Qual Life Res. 1992;1(1):19–29.
   PubMedGoogle Scholar
• Schag CA, Heinrich RL, Aadland RL, et al. Assessing problems of cancer patients: psychometric properties of the cancer inventory of problem situations. Health psychology: official journal of the Division of Health Psychology. Am Psychological Assoc. 1990;9(1):83–102.
   Google Scholar
• Mapi Research Institute. Mapi Institute Linguistic Validation. [cited 2020 Aug 21]. Available from: http://mapigroup.com/services/language-services/
   Google Scholar
• Harrell FE. Regression modeling strategies. 2nd ed. New York (NY): Springer Verlag; 2015. p. 72–74.
   Google Scholar
• Peduzzi P, Concato J, Kemper E, et al. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996;49(12):1373–1379.
   PubMed Web of Science ®Google Scholar
• Derogatis L, Clayton A, Lewis-D'Agostino D, et al. Validation of the female sexual distress scale-revised for assessing distress in women with hypoactive sexual desire disorder. J Sex Med. 2008;5(2):357–364.
   PubMed Web of Science ®Google Scholar
• Jing L, Zhang C, Li W, et al. Incidence and severity of sexual dysfunction among women with breast cancer: a meta-analysis based on female sexual function index. Support Care Cancer. 2019;27(4):1171–1180.
   PubMed Web of Science ®Google Scholar
• Frisch M, Moseholm E, Andersson M, et al. Sex in Denmark. Key findings from Project SEXUS 2017-2018. 2019.
   Google Scholar
• Bancroft J, Loftus J, Long JS. Distress about sex: a national survey of women in heterosexual relationships. Arch Sex Behav. 2003;32(3):193–208.
   PubMed Web of Science ®Google Scholar
• Rosen RC, Shifren JL, Monz BU, et al. Correlates of sexually related personal distress in women with low sexual desire. J Sex Med. 2009;6(6):1549–1560.
   PubMed Web of Science ®Google Scholar