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Acta Oncologica Volume 61, 2022 - Issue 12
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Letters to the Editor: Clinical Oncology

High-dose hydroxyurea with differentiating agents for treating ultra-high-risk acute promyelocytic leukemia in resource-challenged settings

Charanpreet Singha Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Sarthak Wadheraa Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Uday Yanamandraa Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Parathan Karunakarana Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Nishant Jindala Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Saloni Rani Kumara Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Neha Sainia Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Aditya Jandiala Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Arihant Jaina Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Chandan Dasa Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Gaurav Prakasha Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Alka Khadwala Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Shano Naseemb Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0003-0580-019X
ORCID Icon,
Reena Dasb Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Neelam Varmab Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Subhash Varmaa Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Pankaj Malhotraa Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
&
Deepesh Lada Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3754-7774
ORCID Icon show all
Pages 1512-1514 | Received 11 Oct 2022, Accepted 18 Dec 2022, Published online: 29 Dec 2022

References

  • Stahl M, Tallman MS. Acute promyelocytic leukemia (APL): remaining challenges towards a cure for all. Leuk Lymphoma. 2019;60(13):3107–3115.
  • Yilmaz M, Kantarjian H, Ravandi F. Acute promyelocytic leukemia current treatment algorithms. Blood Cancer J. 2021;11(6):123.
  • Zhu H-H, Liu Y-R, Jia J-S, et al. Oral arsenic and all-trans retinoic acid for high-risk acute promyelocytic leukemia. Blood. 2018;131(26):2987–2989.
  • Vaid T, Aggarwal M, Dass J, et al. Shifting gears to differentiation agents in acute promyelocytic leukemia with resource constraints-a cohort study. Acta Oncol. 2022;2022:1–6.
  • Kulkarni UP, Selvarajan S, Lionel S, et al. Real world data with concurrent retinoic acid and arsenic trioxide for the treatment of acute promyelocytic leukemia. Blood Cancer J. 2022;12(1):22.
  • Kapoor J, Mirgh SP, Agrawal N, et al. High risk acute promyelocytic Leukemia – an enigma for hematologists: optimizing treatment with APML-4 protocol. Indian J Hematol Blood Transfus. 2022;38(2):394–402.
  • Yedla RP, Bala SC, Pydi VR, et al. Outcomes in adult acute promyelocytic leukemia: a decade experience. Clin Lymphoma Myeloma Leuk. 2020;20(4):e158–e64.
  • Varma S, Yanamandra U, Khadwal A, et al. High risk apml treated successfully with four cycles of ATO and ATRA combination in resource constrained settings. Blood. 2015;126(23):3322–3322.
  • Lou Y, Ma Y, Sun J, et al. Effectivity of a modified Sanz risk model for early death prediction in patients with newly diagnosed acute promyelocytic leukemia. Ann Hematol. 2017;96(11):1793–1800.
  • Rodriguez GI, Kuhn JG, Weiss GR, et al. A bioavailability and pharmacokinetic study of oral and intravenous hydroxyurea. Blood. 1998;91(5):1533–1541.
  • Grund FM, Armitage JO, Burns P. Hydroxyurea in the prevention of the effects of leukostasis in acute leukemia. Arch Intern Med. 1977;137(9):1246–1247.
  • Gandhi V, Plunkett W, Kantarjian H, et al. Cellular pharmacodynamics and plasma pharmacokinetics of parenterally infused hydroxyurea during a phase I clinical trial in chronic myelogenous leukemia. J Clin Oncol. 1998;16(7):2321–2331.
  • Kim K, Konopleva M, DiNardo CD, et al. Urgent cytoreduction for newly diagnosed acute myeloid leukemia patients allows acquisition of pretreatment genomic data and enrollment on investigational clinical trials. Am J Hematol. 2022;97(7):885–894.

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