11
Views
0
CrossRef citations to date
0
Altmetric
Article

Effect of active site‐inactivated factor viia on ischaemia/reperfusion injury in a porcine flap model

, , , &
Pages 326-334 | Accepted 28 Jan 2003, Published online: 08 Jul 2009

References

  • Ambrosio G, Flaherty JT, Duilio C et al. Oxygen radicals generated at reflow induce peroxidation of membrane lipids in reperfused hearts. J Clin Invest 1991; 87: 2056–2066.
  • Ambrosio G, Tritto I. Reperfusion injury: experimental evidence and clinical implications. Am Heart J 1999; 138: S69–S75.
  • Arnljots B, Ezban M, Hedner U. Prevention of experi-mental arterial thrombosis by topical administration of active site-inactivated factor VIIa. J Vase Surg 1997; 25: 341–346.
  • Birk-Sorensen L, Fuglsang J, Sorensen JIB et al. Apro-xtinin attenuates platelet accumulation in ischaemia-reperfusion-injured porcine skeletal muscle. Blood Coagul Fibrinolysis 1999; 10: 157–165.
  • Birk-Sorensen L, Tromborg HB, Kerrigan CL, Solymoss S, Hjortdal VE. Sedimentation of formed elements in distally ischaemic flaps. Seand J Plast Reconstr Surg Hand Surg 1997; 31: 203–211.
  • Cunningham MA, Romas P. Hutchinson P. Holdsworth SR, Tipping PG. Tissue factor and factor VIIa receptor/ ligand interactions induce proinflammatory effects in macrophages. Blood 1999; 94: 3413–3420.
  • Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol 1989; 134: 1087–1097.
  • Eppinger MJ, Deeb GM, Bolling SF, Ward PA. Mediators of isehemia-reperfusion injury of rat lung. Am J Pathol 1997; 150: 1773–1784.
  • Erlich JH, Apostolopoulos J, Wun TC, Kretzmer KK, Holdsworth SR, Tipping PG. Renal expression of tissue factor pathway inhibitor and evidence for a role in crescentic glomerulonephritis in rabbits. J Clin Invest 1996; 98: 325–335.
  • Erlich JH, Holdsworth SR, Tipping PG. Tissue factor initiates glomerular fibrin deposition and promotes major histoeompatibility complex class II expression in crescentic glomerulonephritis. Am J Pathol 1997; 150: 873–880.
  • Golino P. Ragni M, Cirillo P et al. Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion. Nat Med 1996; 2: 35–40.
  • Golino P. Ragni M, Cirillo P et al. Antithrombotie effects of recombinant human, active site-blocked factor VIIa in a rabbit model of recurrent arterial thrombosis. Cire Res 1998; 82: 39–46.
  • Golino P. Ragni M, Cirillo P et al. Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits. Am J Physiol Heart Cire Physiol 2000; 278: H1507–H1516.
  • Harker LA, Hanson SR, Kelly AB. Antithrombotie benefits and hemorrhagic risks of direct thrombin antagonists. Thromb Haemost 1995; 74: 464–472.
  • Harker LA, Hanson SR, Kelly AB. Antithrombotie strategies targeting thrombin activities, thrombin recep-tors and thrombin generation. Thromb Haemost 1997; 78: 736–741.
  • Harker LA, Hanson SR, Wilcox JN, Kelly AB. Anti-thrombotic and antilesion benefits without hemorrhagic risks by inhibiting tissue factor pathway. Haemo stasis 1996; 26 (suppl 1): 76–82.
  • Hoist J, Kristensen AT, Kristensen HI, Ezban M, Hedner U. Local application of recombinant active-site inhi-bited human clotting factor VIIa reduces thrombus weight and improves pateney in a rabbit venous throm-bosis model. Eur J Vase Endovase Surg 1998; 15: 515–520.
  • Kirehhofer D, Nemerson Y. Initiation of blood coagula-tion: the tissue factor/factor VIIa complex. Curr Opin Biotechnol 1996; 7: 386–391.
  • Kirschner RE, Xu J, Fyfe B, Chang B, Bueky LP. Salvage of free flaps after secondary venous isehemia by local delivery of heparin. Ann Plast Surg 1999; 42: 521–528.
  • Lee C, Kerrigan CL. Ibuprofen treatment of ischemic musculocutaneous flaps. Ann Plast Surg 1994; 32: 300–304.
  • Lee C, Kerrigan CL. Neutrophil localization following reperfusion of ischemic skin flaps. Plast Reconstr Surg 1992; 89: 910–915.
  • Mann KG, van't Veer C, Cawthem K, Butenas S. The role of the tissue factor pathway in initiation of co-agulation. Blood Coagul Fibrinolysis 1998; 9 (suppl 1): S3–S7.
  • Mann J, Rodriguez-Martinez MA. Nitric oxide, oxygen-derived free radicals and vascular endothelium. J Auton Pharmaeol 1995; 15: 279–307.
  • Muhlfelder TW, Niemetz J, Kreutzer D, Beebe D, Ward PA, Rosenfeld SI. C5 chemotactie fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation. J Clin Invest 1979; 63: 147–150.
  • Söderström T, Hedner U, Arnljots B. Active site-inactivated factor VIIa prevents thrombosis without increased surgical bleeding: topical and intravenous administration in a rat model of deep arterial injury. J Vase Surg 2001; 33: 1072–1079.
  • Sorensen BB, Persson E, Freskgard PO et al. Incorpora-tion of an active site inhibitor in factor VIIa alters the affinity for tissue factor. J Biol Chem 1997; 272: 11863–11868.
  • Stotland MA, Kerrigan CL. E- and L-selectin adhesion molecules in musculocutaneous flap reperfusion injury. Plast Reconstr Surg 1997; 99: 2010–2020.
  • Stotland MA, Kerrigan CL. The role of platelet-activating factor in musculocutaneous flap reperfusion injury. Plast Reconstr Surg 1997; 99: 1989–2001.
  • Taylor FB Jr, Chang A, Ruf W et al. Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody. Circ Shock 1991; 33: 127–134.
  • ten Cate JVV, van der Poll T, Levi M, ten Cate H, van Deventer SJ. Cytokines: triggers of clinical thrombotic disease. Thromb Haemost 1997; 78: 415–419.
  • Thiagarajan RR, Winn RK, Harlan JM. The role of leukocyte and endothelial adhesion molecules in ischemia-reperfusion injury. Thromb Haemost 1997; 78: 310–314.
  • Thim L, Bjoem S, Christensen M et al. Amino acid sequence and posttranslational modifications of human factor Vila from plasma and transfected baby hamster kidney cells. Biochemistry 1988; 27: 7785–7793.
  • Vedder NB, Winn RK, Rice CL, Chi EY, Arfors KE, Harlan JM. Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear. Proc Natl Acad Sci U S A 1990; 87: 2643–2646.
  • Zweier JL, Flaherty JT, Weisfeldt ML. Direct measure-ment of free radical generation following reperfusion of ischemic myocardium. Proc Natl Acad Sci U S A 1987; 84: 1404–1407.
  • Zweier JL, Kuppusamy P, Williams R et al. Measure-ment and characterization of postischemic free radical generation in the isolated perfused heart. J Biol Chem 1989; 264: 18890–18895.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.