Neuropathic pain: a narrative review of etiology, assessment, diagnosis, and treatment for primary care providers

References

• International Association for the Study of Pain Taxonomy: Nociceptive Pain. IASP. Available at: http://www.iasp-pain.org/Taxonomy#Nociceptivepain [Last accessed 16 November 2015]
   Google Scholar
• International Association for the Study of Pain Taxonomy: Neuropathic Pain. IASP. Available at: http://www.iasp-pain.org/Taxonomy#Neuropathicpain [Last accessed 16 November 2015]
   Google Scholar
• Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain 2011;152(3 Suppl):S2-S15
   PubMed Web of Science ®Google Scholar
• International Association for the Study of Pain Taxonomy: Central Sensitization. IASP. Available at: http://www.iasp-pain.org/Taxonomy#Centralsensitization [Last accessed 16 November 2015]
   Google Scholar
• Petersel DL, Dror V, Cheung R. Central amplification and fibromyalgia: disorder of pain processing. J Neurosci Res 2011;89:29-34
   PubMed Web of Science ®Google Scholar
• Clauw DJ, Arnold LM, McCarberg BH. The science of fibromyalgia. Mayo Clin Proc 2011;86:907-11
   PubMed Web of Science ®Google Scholar
• Yanni LM, McKinney-Ketchum JL, Harrington SB, et al. Preparation, confidence, and attitudes about chronic noncancer pain in graduate medical education. J Grad Med Educ 2010;2:260-8
   PubMedGoogle Scholar
• Briggs EV, Battelli D, Gordon D, et al. Current pain education within undergraduate medical studies across Europe: Advancing the Provision of Pain Education and Learning (APPEAL) study. BMJ Open 2015;5:e006984
   PubMed Web of Science ®Google Scholar
• Mezei L, Murinson BB. Pain education in North American medical schools. J Pain 2011;12:1199-208
   PubMed Web of Science ®Google Scholar
• O’Rorke JE, Chen I, Genao I, et al. Physicians’ comfort in caring for patients with chronic nonmalignant pain. Am J Med Sci 2007;333:93-100
   PubMed Web of Science ®Google Scholar
• Vranken JH. Mechanisms and treatment of neuropathic pain. Cent Nerv Syst Agents Med Chem 2009;9:71-8
   PubMedGoogle Scholar
• Gilron I, Baron R, Jensen T. Neuropathic pain: principles of diagnosis and treatment. Mayo Clin Proc 2015;90:532-45
   PubMed Web of Science ®Google Scholar
• Koroschetz J, Rehm SE, Gockel U, et al. Fibromyalgia and neuropathic pain – differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia. BMC Neurol 2011;11:55
   PubMed Web of Science ®Google Scholar
• Wilbarger JL, Cook DB. Multisensory hypersensitivity in women with fibromyalgia: implications for well being and intervention. Arch Phys Med Rehabil 2011;92:653-6
   PubMed Web of Science ®Google Scholar
• Tesfaye S, Vileikyte L, Rayman G, et al. Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management. Diabetes Metab Res Rev 2011;27:629-38
   PubMed Web of Science ®Google Scholar
• Boulton AJM, Vinik AI, Arezzo JC, et al. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care 2005;28:956-62
   PubMed Web of Science ®Google Scholar
• Sadosky A, McDermott AM, Brandenburg NA, Strauss M. A review of the epidemiology of painful diabetic peripheral neuropathy, postherpetic neuralgia, and less commonly studied neuropathic pain conditions. Pain Pract 2008;8:45-56
   PubMedGoogle Scholar
• Young MJ, Boulton AJ, MacLeod AF, et al. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia 1993;36:150-4
   PubMed Web of Science ®Google Scholar
• Partanen J, Niskanen L, Lehtinen J, et al. Natural history of peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 1995;333:89-94
   PubMed Web of Science ®Google Scholar
• Massengill JS, Kittredge JL. Practical considerations in the pharmacological treatment of postherpetic neuralgia for the primary care provider. J Pain Res 2014;7:125-32
   PubMed Web of Science ®Google Scholar
• Montano N, Conforti G, Di Bonaventura R, et al. Advances in diagnosis and treatment of trigeminal neuralgia. Ther Clin Risk Manag 2015;11:289-99
   PubMed Web of Science ®Google Scholar
• Bangash TH. Trigeminal neuralgia: frequency of occurrence in different nerve branches. Anesth Pain Med 2011;1:70-2
   PubMedGoogle Scholar
• Osterberg A, Boivie J, Thuomas KA. Central pain in multiple sclerosis – prevalence and clinical characteristics. Eur J Pain 2005;9:531-42
   PubMed Web of Science ®Google Scholar
• Svendsen KB, Jensen TS, Overvad K, et al. Pain in patients with multiple sclerosis: a population-based study. Arch Neurol 2003;60:1089-94
   PubMedGoogle Scholar
• Klit H, Finnerup NB, Jensen TS. Central post-stroke pain: clinical characteristics, pathophysiology, and management. Lancet Neurol 2009;8:857-68
   PubMed Web of Science ®Google Scholar
• Kumar B, Kalita J, Kumar G, Misra UK. Central poststroke pain: a review of pathophysiology and treatment. Anesth Analg 2009;108:1645-57
   PubMed Web of Science ®Google Scholar
• Siddall PJ, McClelland JM, Rutkowski SB, Cousins MJ. A longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injury. Pain 2003;103:249-57
   PubMed Web of Science ®Google Scholar
• Siddall PJ, Taylor DA, Cousins MJ. Classification of pain following spinal cord injury. Spinal Cord 1997;35:69-75
   PubMed Web of Science ®Google Scholar
• Finnerup NB, Baastrup C, Jensen TS. Neuropathic pain following spinal cord injury pain: mechanisms and treatment. Scand J Pain 2009;1:S3-S11
   Google Scholar
• Clinical Update PAIN. IASP. Available at: http://www.iasp-pain.org/files/Content/ContentFolders/Publications2/PainClinicalUpdates/Archives/PCU_19-1_for_web_1390260524448_6.pdf [Last accessed 4 February 2016]
   Google Scholar
• Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet 2006;367:1618-25
   PubMed Web of Science ®Google Scholar
• Subedi B, Grossberg GT. Phantom limb pain: mechanisms and treatment approaches. Pain Res Treat 2011;2011:864605
   PubMedGoogle Scholar
• Verma S, Estanislao L, Simpson D. HIV-associated neuropathic pain: epidemiology, pathophysiology and management. CNS Drugs 2005;19:325-34
   PubMed Web of Science ®Google Scholar
• Bennett MI, Rayment C, Hjermstad M, et al. Prevalence and aetiology of neuropathic pain in cancer patients: a systematic review. Pain 2012;153:359-65
   PubMed Web of Science ®Google Scholar
• Caridi JM, Pumberger M, Hughes AP. Cervical radiculopathy: a review. HSS J 2011;7:265-72
   PubMedGoogle Scholar
• Fishbain DA, Cole B, Lewis JE, Gao J. What is the evidence that neuropathic pain is present in chronic low back pain and soft tissue syndromes? An evidence-based structured review. Pain Med 2014;15:4-15
   PubMed Web of Science ®Google Scholar
• Freynhagen R, Baron R, Gockel U, Tölle TR. painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin 2006;22:1911-20
   PubMed Web of Science ®Google Scholar
• Freynhagen R, Baron R. The evaluation of neuropathic components in low back pain. Curr Pain Headache Rep 2009;13:185-90
   PubMed Web of Science ®Google Scholar
• Franklin GM, Friedman AS. Work-related carpal tunnel syndrome: diagnosis and treatment guideline. Phys Med Rehabil Clin N Am 2015;26:523-37
   PubMed Web of Science ®Google Scholar
• Al-Homood IA. Rheumatic conditions in patients with diabetes mellitus. Clin Rheumatol 2013;32:527-33
   PubMed Web of Science ®Google Scholar
• Mistry N, Wass J, Turner MR. When to consider thyroid dysfunction in the neurology clinic. Pract Neurol 2009;9:145-56
   PubMedGoogle Scholar
• Sadosky A, Schaefer C, Mann R, et al. Burden of illness associated with painful diabetic peripheral neuropathy among adults seeking treatment in the US: results from a retrospective chart review and cross-sectional survey. Diabetes Metab Syndr Obes 2013;6:79-92
   PubMedGoogle Scholar
• van Seventer R, Sadosky A, Lucero M, Dukes E. A cross-sectional survey of health state impairment and treatment patterns in patients with postherpetic neuralgia. Age Ageing 2006;35:132-7
   PubMed Web of Science ®Google Scholar
• Mann R, Schaefer C, Sadosky A, et al. Burden of spinal cord injury-related neuropathic pain in the United States: retrospective chart review and cross-sectional survey. Spinal Cord 2013;51:564-70
   PubMed Web of Science ®Google Scholar
• Parsons B, Schaefer C, Mann R, et al. Economic and humanistic burden of post-trauma and post-surgical neuropathic pain among adults in the United States. J Pain Res 2013;6:459-69
   PubMed Web of Science ®Google Scholar
• Mann R, Sadosky A, Schaefer C, et al. Burden of HIV-related neuropathic pain in the United States. J Int Assoc Provid AIDS Care 2015;15:114-25
   PubMedGoogle Scholar
• Sadosky A, Schaefer C, Mann R, et al. Burden of chronic low back pain with a neuropathic pain component: retrospective chart review and cross-sectional survey among adults seeking treatment in the United States. J Pain Relief 2014;3:163
   Google Scholar
• Schaefer C, Mann R, Sadosky A, et al. Burden of illness associated with peripheral and central neuropathic pain among adults seeking treatment in the United States: a patient-centered evaluation. Pain Med 2014;15:2105-19
   PubMed Web of Science ®Google Scholar
• Schaefer C, Sadosky A, Mann R, et al. Pain severity and the economic burden of neuropathic pain in the United States: BEAT Neuropathic Pain Observational Study. Clinicoecon Outcomes Res 2014;6:483-96
   PubMedGoogle Scholar
• Schaefer C, Mann R, Sadosky A, et al. Health status, function, productivity, and costs among individuals with idiopathic painful peripheral neuropathy with small fiber involvement in the United States: results from a retrospective chart review and cross-sectional survey. J Med Econ 2014;17:394-407
   PubMedGoogle Scholar
• daCosta DiBonaventura M, Cappelleri JC, Joshi AV. A longitudinal assessment of painful diabetic peripheral neuropathy on health status, productivity, and health care utilization and cost. Pain Med 2011;12:118-26
   PubMed Web of Science ®Google Scholar
• Langley PC, Van Litsenburg C, Cappelleri JC, Carroll D. The burden associated with neuropathic pain in Western Europe. J Med Econ 2013;16:85-95
   PubMedGoogle Scholar
• Snedecor SJ, Sudharshan L, Cappelleri JC, et al. Systematic review and comparison of pharmacologic therapies for neuropathic pain associated with spinal cord injury. J Pain Res 2013;6:539-47
   PubMed Web of Science ®Google Scholar
• Margolis JM, Juneau P, Sadosky A, et al. Health care utilization and expenditures among Medicaid beneficiaries with neuropathic pain following spinal cord injury. J Pain Res 2014;7:379-87
   PubMed Web of Science ®Google Scholar
• Margolis J, Juneau P, Sadosky A, et al. Healthcare resource utilization and costs of spinal cord injury with neuropathic pain in a Medicare population. J Pain Relief 2014;S3:S3-S007
   Google Scholar
• Margolis JM, Juneau P, Sadosky A, et al. Health care resource utilization and medical costs of spinal cord injury with neuropathic pain in a commercially insured population in the United States. Arch Phys Med Rehabil 2014;95:2279-87
   PubMed Web of Science ®Google Scholar
• Stewart WF, Ricci JA, Chee E, et al. Lost productive time and costs due to diabetes and diabetic neuropathic pain in the US workforce. J Occup Environ Med 2007;49:672-9
   PubMed Web of Science ®Google Scholar
• Pérez C, Saldaña MT, Navarro A, et al. Trigeminal neuralgia treated with pregabalin in family medicine settings: its effect on pain alleviation and cost reduction. J Clin Pharmacol 2009;49:582-90
   PubMed Web of Science ®Google Scholar
• Athanasakis K, Petrakis I, Karampli E, et al. Pregabalin versus gabapentin in the management of peripheral neuropathic pain associated with post-herpetic neuralgia and diabetic neuropathy: a cost effectiveness analysis for the Greek healthcare setting. BMC Neurol 2013;13:56
   PubMed Web of Science ®Google Scholar
• Beard SM, McCrink L, Le TK, et al. Cost effectiveness of duloxetine in the treatment of diabetic peripheral neuropathic pain in the UK. Curr Med Res Opin 2008;24:385-99
   PubMed Web of Science ®Google Scholar
• Stanos S, Brodsky M, Argoff C, et al. Rethinking chronic pain in a primary care setting. Postgrad Med 2016;128:502-15
   PubMed Web of Science ®Google Scholar
• Bouhassira D, Attal N, Fermanian J, et al. Development and validation of the Neuropathic Pain Symptom Inventory. Pain 2004;108:248-57
   PubMed Web of Science ®Google Scholar
• Portenoy R. Development and testing of a neuropathic pain screening questionnaire: ID Pain. Curr Med Res Opin 2006;22:1555-65
   PubMed Web of Science ®Google Scholar
• Bennett M. The LANSS Pain Scale: the Leeds assessment of neuropathic symptoms and signs. Pain 2001;92:147-57
   PubMed Web of Science ®Google Scholar
• Bouhassira D, Attal N, Alchaar H, et al. Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain 2005;114:29-36
   PubMed Web of Science ®Google Scholar
• Attal N, Cruccu G, Baron R, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol 2010;17:1113-88
   PubMed Web of Science ®Google Scholar
• Dworkin RH, O’Connor AB, Audette J, et al. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc 2010;85(3 Suppl):S3-S14
   PubMed Web of Science ®Google Scholar
• Bril V, England J, Franklin GM, et al. Evidence-based guideline: treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology 2011;76:1758-65
   PubMed Web of Science ®Google Scholar
• Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015;14:162-73
   PubMed Web of Science ®Google Scholar
• Cymbalta US prescribing information. Eli Lilly and Company. Available at: http://pi.lilly.com/us/cymbalta-pi.pdf [Last accessed 16 November 2015]
   Google Scholar
• Effexor XR US prescribing information. Wyeth Pharmaceuticals Inc. Available at: http://labeling.pfizer.com/showlabeling.aspx?ID=100 [Last accessed 16 November 2015]
   Google Scholar
• Knadler MP, Lobo E, Chappell J, Bergstrom R. Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet 2011;50:281-94
   PubMed Web of Science ®Google Scholar
• Lyrica US prescribing information. Parke-Davis Div of Pfizer Inc. Available at: http://labeling.pfizer.com/ShowLabeling.aspx?id=561 [Last accessed 16 November 2015]
   Google Scholar
• Neurontin US prescribing information. Parke-Davis Div of Pfizer Inc. Available at: http://labeling.pfizer.com/ShowLabeling.aspx?id=630 [Last accessed 16 November 2015]
   Google Scholar
• Bockbrader HN, Wesche D, Miller R, et al. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet 2010;49:661-9
   PubMed Web of Science ®Google Scholar
• Fick DM, Cooper JW, Wade WE, et al. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med 2003;163:2716-24
   PubMed Web of Science ®Google Scholar
• Feinberg M. The problems of anticholinergic adverse effects in older patients. Drugs Aging 1993;3:335-48
   PubMed Web of Science ®Google Scholar
• Lidoderm US prescribing information Endo Pharmaceuticals Inc. Available at: http://www.endo.com/File%20Library/Products/Pre-scribing%20Information/LIDODERM_prescribing_information.html [Last accessed 16 November 2015]
   Google Scholar
• Qutenza US prescribing information. Acorda Therapeutics Inc. Available at: http://www.qutenza.com/_docs/qutenza_full_PI_.pdf [Last accessed 16 November 2015]
   Google Scholar
• Raffa RB, Buschmann H, Christoph T, et al. Mechanistic and functional differentiation of tapentadol and tramadol. Expert Opin Pharmacother 2012;13:1437-49
   PubMed Web of Science ®Google Scholar
• Nucynta extended release US prescribing information. Janssen Pharmaceuticals Inc. Available at: http://www.nucynta.com/_assets/pdf/nucyntaer-pi.pdf [Last accessed 27 June 2016]
   Google Scholar
• Dayer P, Desmeules J, Collart L. [Pharmacology of tramadol]. Drugs 1997;53(Suppl 2):18-24
   PubMed Web of Science ®Google Scholar
• Vazzana M, Andreani T, Fangueiro J, et al. Tramadol hydrochloride: Pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug delivery systems. Biomed Pharmacother 2015;70:234-8
   PubMed Web of Science ®Google Scholar
• Dworkin RH, O’Connor AB, Kent J, et al. Interventional management of neuropathic pain: NeuPSIG recommendations. Pain 2013;154:2249-61
   PubMed Web of Science ®Google Scholar
• Dimitrova A, Murchison C, Oken B. Effects of acupuncture on neuropathic pain: a systematic review and meta-analysis. Neurology 2015;84(14 Suppl). Abstract P3.306
   Google Scholar