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Current Medical Research and Opinion Volume 33, 2017 - Issue 11
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Pain

Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a multiple ascending dose study in opioid-naïve healthy volunteers

Richard L. RauckCarolinas Pain Institute and The Center for Clinical Research, Winston-Salem, NC, USA; Correspondence[email protected]
,
D. Alexander OhINSYS Development Company, Inc., Chandler, AZ, USA;
,
Neil SinglaLotus Clinical Research, LLC, Pasadena, CA, USA;
,
Christian KochLotus Clinical Research, LLC, Pasadena, CA, USA;
,
Neha ParikhINSYS Development Company, Inc., Chandler, AZ, USA;
,
Srinivas NalamachuInternational Clinical Research Institute, Overland Park, KS, USA
,
Daniel WilsonINSYS Development Company, Inc., Chandler, AZ, USA;
,
Jin YuINSYS Development Company, Inc., Chandler, AZ, USA;
&
Santosh VetticadenINSYS Development Company, Inc., Chandler, AZ, USA;
show all
Pages 1921-1933 | Received 07 Jul 2017, Accepted 21 Aug 2017, Published online: 23 Sep 2017

References

  • The Joint Commission. Joint Commission on Accreditation of Healthcare Organizations pain standards for 2001. Oakbrook Terrace (IL): The Joint Commission; 2001. Available at: https://www.jointcommission.org/assets/1/6/2001_Pain_Standards.pdf. [Last accessed 22 June 2017]
  • Ritsema TS, Kelen GD, Pronovost PJ, et al. The national trend in quality of emergency department pain management for long bone fractures. Acad Emerg Med 2007;14:163-9
  • Committee on Advancing Pain Research Care and Education, Institute of Medicine of the National Academies. Relieving pain in America: a blueprint for transforming prevention, care, education, and research. Washington (DC): The National Academies Press; 2011
  • Todd KH, Ducharme J, Choiniere M, et al. Pain in the emergency department: results of the pain and emergency medicine initiative (PEMI) multicenter study. J Pain 2007;8:460-6
  • Stanley TH. The history and development of the fentanyl series. J Pain Symptom Manage 1992;7(3Suppl):S3-S7
  • Nelson L, Schwaner R. Transdermal fentanyl: pharmacology and toxicology. J Med Toxicol 2009;5:230-41
  • SUBLIMAZE® (fentanyl citrate) injection [package insert]. Lake Forest (IL): Akorn, Inc.; 2012
  • Patanwala AE, Keim SM, Erstad BL. Intravenous opioids for severe acute pain in the emergency department. Ann Pharmacother 2010;44:1800-9
  • Soares LG, Martins M, Uchoa R. Intravenous fentanyl for cancer pain: a “fast titration” protocol for the emergency room. J Pain Symptom Manage 2003;26:876-81
  • Simmonds MA, Richenbacher J. Transdermal fentanyl: long-term analgesic studies. J Pain Symptom Manage 1992;7(3Suppl):S36-S39
  • Sandler A. Transdermal fentanyl: acute analgesic clinical studies. J Pain Symptom Manage 1992;7(3Suppl):S27-S35
  • Actiq (fentanyl citrate) oral transmucosal lozenge, CII [package insert]. Frazer (PA): Cephalon, Inc.; 2011
  • Rauck R, Oh DA, Parikh N, et al. Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a single ascending dose study in opioid-naive healthy volunteers [published online ahead of print August 11, 2017]. Curr Med Res Opin 2017;10.1080/03007995.2017.1352496:1-23
  • Chan IS, Zhang Z. Test-based exact confidence intervals for the difference of two binomial proportions. Biometrics 1999;55:1202-9

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