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Review

Current understanding of the mixed pain concept: a brief narrative review

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Pages 1011-1018 | Received 23 Jul 2018, Accepted 20 Nov 2018, Published online: 03 Jan 2019

References

  • Freynhagen R. [“Mixed pain” as new rationale: pie in the sky or pie on the plate.] Psychoneuro. 2005:31:103–105. German.
  • Kosek E, Cohen M, Baron R, et al. Do we need a third mechanistic descriptor for chronic pain states? Pain. 2016;157:1382–1386.
  • Ross E. Moving towards rational pharmacological management of pain with an improved classification system of pain. Expert Opin Pharmacother. 2001;2:1529–1530.
  • Treede RD, Jensen TS, Campbell JN, et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008;70:1630–1635.
  • IASP Terminology [Internet]. Washington DC, USA: International Association for the Study of Pain; c2018 [updated 2017 Dec 14; cited 2018 Jul 9]. Available from: https://www.iasp-pain.org/terminology?navItemNumber=576
  • IASP Council Adopts Task Force Recommendation for Third Mechanistic Descriptor of Pain [Internet]. Washington DC, USA: International Association for the Study of Pain; c2018 [updated 2017 Nov 14; cited 2018 Jul 9]. Available from: https://www.iasp-pain.org/PublicationsNews/NewsDetail.aspx?ItemNumber=6862-&navItemNumber=643
  • Brummett C, Clauw D, Harris R, et al. We agree with the need for a new term but disagree with the proposed terms. Pain. 2016;157:2876.
  • Granan LP. We do not need a third mechanistic descriptor for chronic pain states! Not yet. Pain. 2017;158:179.
  • Argoff CE. New Insights Into Pain Mechanisms and Rationale for Treatment [Internet]. New York, NY, USA: WebMD LLC; c1994–2018 [updated 2011 Sep 16; cited 2018 Jul 9]. Available from: http://www.medscape.org/viewarticle/742578_transcript
  • Takahashi N, Shirado O, Kobayashi K, et al. Classifying patients with lumbar spinal stenosis using painDETECT: a cross-sectional study. BMC Fam Pract. 2016;17:90.
  • Samolsky Dekel BG, Remondini F, et al. Development, validation and psychometric properties of a diagnostic/prognostic tool for breakthrough pain in mixed chronic-pain patients. Clin Neurol Neurosurg. 2016;141:23–29.
  • Portenoy RK, Bennett DS, Rauck R, et al. Prevalence and characteristics of breakthrough pain in opioid-treated patients with chronic noncancer pain. J Pain. 2006;7:583–591.
  • Roosink M, Guerts ACH, Ijzerman MJ. Defining post-stroke pain: diagnostic challenges. Lancet Neurol. 2010;9:344.
  • Wilder-Smith OHG, Tassonyi E, Arendt-Nielsen L. Preoperative back pain is associated with diverse manifestations of central neuroplasticity. Pain. 2002;97:189–194.
  • Andrews N. What’s in a Name for Chronic Pain? [Internet]. Washington DC, USA: Pain Research Forum; c2018 [updated 2018 Feb 5; cited 2018 Jul 9]. Available from: https://www.painresearchforum.org/news/92059-whats-name-chronic-pain
  • Ibor PJ, Sánchez-Magro I, Villoria J, et al. Mixed Pain Can Be Discerned in the Primary Care and Orthopedics Settings in Spain: A Large Cross-Sectional Study. Clin J Pain. 2017;33:1100–1108.
  • Romanò CL, Romanò D, Lacerenza M. Antineuropathic and antinociceptive drugs combination in patients with chronic low back pain: a systematic review. Pain Res Treat. 2012;2012:154781.
  • Grond S, Radbruch L, Meuser T, et al. Assessment and treatment of neuropathic cancer pain following WHO guidelines. Pain. 1999;79:15–20.
  • Junker U, Baron R, Freynhagen R. [Chronic pain: the “mixed pain concept” as a new rationale]. Dtsch Arztebl. 2004;101:1393–1394. German.
  • Baron R, Binder A. [How neuropathic is sciatica? The mixed pain concept]. Orthopäde. 2004;33:568–575. German.
  • Freynhagen R, Busche P. [The mixed pain concept]. Psychoneuro. 2005;31:331–333. German.
  • Freynhagen R, Baron R. The evaluation of neuropathic components in low back pain. Curr Pain Headache Rep. 2009;13:185–190.
  • Fallon MT. Neuropathic pain in cancer. Br J Anaesth. 2013;111:105–111.
  • Mulvey MR, Boland EG, Bouhassira D, et al. Neuropathic pain in cancer: systematic review, performance of screening tools and analysis of symptom profiles. Br J Anaesth. 2017;119:765–774.
  • Bennett MI, Rayment C, Hjermstad M, et al. Prevalence and aetiology of neuropathic pain in cancer patients: a systematic review. Pain. 2012;153:359–365.
  • Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2163–2196.
  • Perrot S. Osteoarthritis pain. Best Pract Res Clin Rheumatol. 2015;29:90–97.
  • Thakur M, Dickenson AH, Baron R. Osteoarthritis pain: nociceptive or neuropathic? Nat Rev Rheumatol. 2014;10:374–80.
  • Hochman JR, French MR, Bermingham SL, Hawker GA. The nerve of osteoarthritis pain. Arthritis Care Res (Hoboken). 2010;62:1019–1023.
  • French HP, Smart KM, Doyle F. Prevalence of neuropathic pain in knee or hip osteoarthritis: a systematic review and meta-analysis. Semin Arthritis Rheum. 2017;47:1–8.
  • Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367:1618–1625.
  • Dualé C, Ouchchane L, Schoeffler P, et al. Neuropathic aspects of persistent postsurgical pain: a French multicenter survey with a 6-month prospective follow-up. J Pain. 2014;15:24.e1–24.e20.
  • Förster M, Mahn F, Gockel U, et al. Axial low back pain: one painful area – many perceptions and mechanisms. PLoS One. 2013;8:e68273.
  • Cedraschi C, Delézay S, Marty M, et al. “Let’s talk about OA pain”: a qualitative analysis of the perceptions of people suffering from OA. Towards the development of a specific pain OA-related questionnaire, the Osteoarthritis Symptom Inventory Scale (OASIS). PLoS One. 2013;8:e79988.
  • Wylde V, Hewlett S, Learmonth ID, et al. Persistent pain after joint replacement: prevalence, sensory qualities, and postoperative determinants. Pain. 2011;152:566–572.
  • Binder A, Baron R. The pharmacological therapy of chronic neuropathic pain. Dtsch Arztebl Int. 2016;113:616–626.
  • Farajidavar A, Gharibzadeh S, Towhidkhah F, et al. A cybernetic view on wind-up. Med Hypotheses. 2006;67:304–306.
  • Freynhagen R, Baron R, Gockel U, et al. painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin. 2006;22:1911–1920.
  • Gálvez R, Marsal C, Vidal J, et al. Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions. Eur J Pain. 2007;11:244–255.
  • Haroun OM, Hietaharju A, Bizuneh E, et al. Investigation of neuropathic pain in treated leprosy patients in Ethiopia: a cross-sectional study. Pain. 2012;153:1620–1624.
  • Müller-Schwefe G, Morlion B, Ahlbeck K, et al. Treatment for chronic low back pain: the focus should change to multimodal management that reflects the underlying pain mechanisms. Curr Med Res Opin. 2017;33:1199–1210.
  • Finnerup NB, Haroutounian S, Kamerman P, et al. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016;157:1599–1606.
  • Attal N, Bouhassira D, Baron R. Diagnosis and assessment of neuropathic pain through questionnaires. Lancet Neurol. 2018;17:456–466.
  • Bennett MI, Smith BH, Torrance N, et al. The S-LANSS score for identifying pain of predominantly neuropathic origin: validation for use in clinical and postal research. J Pain. 2005;6:149–158.
  • Bouhassira D, Attal N, Alchaar H A, et al. Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain. 2005;114:29–36.
  • Haanpää M, Attal N, Backonja M, et al. NeuPSIG guidelines on neuropathic pain assessment. Pain. 2011;152:14–27.
  • Vollert J, Maier C, Attal N, et al. Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations. Pain. 2017;158:1446–1455.
  • Tavakoli M, Quattrini C, Abbott C, et al. Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes Care. 2010;33:1792–1797.
  • Lauria G, Hsieh ST, Johansson O, et al. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur J Neurol. 2010;17:903–912,e44–e49.
  • Koch A, Zacharowski K, Boehm O, et al. Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients. Inflamm Res. 2007;56:32–37.
  • Kosek E, Cohen M, Baron R, et al. Reply. Pain. 2017;158(1):180.
  • National Poll: Chronic Pain and Drug Addiction [Internet]. Arlington, VA, USA: Research!America; c2018 [updated 2013 Apr; cited 2018 Jul 9]. Available from: https://www.researchamerica.org/sites/default/files/uploads/March2013painaddiction.pdf

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