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Pain Medicine

Potential blood markers as screening tools for subjects with low back pain: an age- and gender-matched cross-sectional analysis

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Pages 77-85 | Received 01 May 2023, Accepted 08 Nov 2023, Published online: 21 Nov 2023

References

  • Disease GBD, Injury I, Prevalence C. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet. 2017;390(10100):1211–1259.
  • Dudli S, Fields AJ, Samartzis D, et al. Pathobiology of Modic changes. Eur Spine J. 2016;25(11):3723–3734. doi:10.1007/s00586-016-4459-7.
  • Costa LdCM, Maher CG, McAuley JH, et al. Prognosis for patients with chronic low back pain: inception cohort study. BMJ. 2009;339(oct06 2):b3829–b3829. doi:10.1136/bmj.b3829.
  • Gjefsen E, Braten LCH, Goll GL, et al. The effect of infliximab in patients with chronic low back pain and modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial. BMC Musculoskelet Disord. 2020;21(1):698. doi:10.1186/s12891-020-03720-5.
  • Pincus T, Kent P, Bronfort G, et al. Twenty-five years with the biopsychosocial model of low back pain-is it time to celebrate? A report from the twelfth international forum for primary care research on low back pain. Spine (Phila Pa 1976). 2013;38(24):2118–2123. doi:10.1097/BRS.0b013e3182a8c5d6.
  • Özcan-Ekşi EE, Ekşi MŞ, Akçal MA. Severe lumbar intervertebral disc degeneration is associated with modic changes and fatty infiltration in the paraspinal muscles at all lumbar levels, except for L1-L2: a Cross-Sectional analysis of 50 symptomatic women and 50 Age-Matched symptomatic men. World Neurosurg. 2019;122:e1069–e77. doi:10.1016/j.wneu.2018.10.229.
  • Ekşi MŞ, Özcan-Ekşi EE, Özmen BB, et al. Lumbar intervertebral disc degeneration, end-plates and paraspinal muscle changes in children and adolescents with low-back pain. J Pediatr Orthop B. 2022;31(1):93–102. doi:10.1097/BPB.0000000000000833.
  • Dudli S, Heggli I, Laux CJ, et al. Role of C-reactive protein in the bone marrow of modic type 1 changes. J Orthop Res. 2023;41(5):1115–1122. doi:10.1002/jor.25437.
  • Brennan PC, Graham MA, Triano JJ, et al. Lymphocyte profiles in patients with chronic low back pain enrolled in a clinical trial. J Manipulative Physiol Ther. 1994;17(4):219–227.
  • Guo Y, Zhao H, Lu J, et al. Preoperative lymphocyte to monocyte ratio as a predictive biomarker for disease severity and spinal fusion failure in lumbar degenerative diseases patients undergoing lumbar fusion. J Pain Res. 2022;15:2879–2891. doi:10.2147/JPR.S379453.
  • Tertemiz OF, Tepe N. Somatosensory temporal discrimination and neutrophil/lymphocyte ratio in patients with chronic low back pain. Balıkesir Health Sciences Journal. 2022;11:377–382.
  • Tian P, Ma XL, Wang T, et al. Correlation between radiculalgia and counts of T lymphocyte subsets in the peripheral blood of patients with lumbar disc herniation. Orthop Surg. 2009;1(4):317–321. doi:10.1111/j.1757-7861.2009.00052.x.
  • Pfirrmann CW, Metzdorf A, Zanetti M, et al. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976). 2001;26(17):1873–1878. doi:10.1097/00007632-200109010-00011.
  • Modic MT, Masaryk TJ, Ross JS, et al. Imaging of degenerative disk disease. Radiology. 1988;168(1):177–186. doi:10.1148/radiology.168.1.3289089.
  • Modic MT, Steinberg PM, Ross JS, et al. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 1988;166(1):193–199. doi:10.1148/radiology.166.1.3336678.
  • Özcan-Ekşi EE, Kara M, Berikol G, et al. A new radiological index for the assessment of higher body fat status and lumbar spine degeneration. Skeletal Radiol. 2022;51(6):1261–1271. doi:10.1007/s00256-021-03957-8.
  • Sharma S, Traeger AC, Reed B, et al. Clinician and patient beliefs about diagnostic imaging for low back pain: a systematic qualitative evidence synthesis. BMJ Open. 2020;10(8):e037820. doi:10.1136/bmjopen-2020-037820.
  • Katsuno R, Hasegawa T, Iwashina T, et al. Age-related effects of cocultured rat nucleus pulposus cells and macrophages on nitric oxide production and cytokine imbalance. Spine (Phila Pa 1976). 2008;33(8):845–849. doi:10.1097/BRS.0b013e31816b4685.
  • Heshmat-Ghahdarijani K, Sarmadi V, Heidari A, et al. The neutrophil-to-lymphocyte ratio as a new prognostic factor in cancers: a narrative review. Front Oncol. 2023;13:1228076. doi:10.3389/fonc.2023.1228076.
  • Kayalar AE, Çakmak Çelik F, Köylü RC, et al. Increased neutrophil lymphocyte ratio could be predictive for higher mortality in preterm infants with intraventricular hemorrhage. World Neurosurg. 2023;175:e1191–e1196. doi:10.1016/j.wneu.2023.04.097.
  • Liu Y, Cheng L, Zhao M, et al. Development and validation of diagnostic and activity-assessing models for relapsing polychondritis based on laboratory parameters. Front Immunol. 2023;14:1274677. doi:10.3389/fimmu.2023.1274677.
  • Tung HT, Liu CM, Huang HS, et al. Increased risk of chronic kidney disease in uric acid stone formers with high neutrophil-to-lymphocyte ratio. Sci Rep. 2023;13(1):17686. doi:10.1038/s41598-023-45034-1.
  • Garcia-Escobar A, Vera-Vera S, Tebar-Marquez D, et al. Neutrophil-to-lymphocyte ratio an inflammatory biomarker, and prognostic marker in heart failure, cardiovascular disease and chronic inflammatory diseases: new insights for a potential predictor of anti-cytokine therapy responsiveness. Microvasc Res. 2023;150:104598. doi:10.1016/j.mvr.2023.104598.
  • Dogan A, Dogan K, Tasolar S. Magnetic resonance imaging evaluation of the effects of cigarette and maras powder (smokeless tobacco) on lumbar disc degeneration. Clin Neurol Neurosurg. 2019;186:105500.
  • Ohtori S, Koshi T, Yamashita M, et al. Existence of pyogenic spondylitis in modic type 1 change without other signs of infection: 2-year follow-up. Eur Spine J. 2010;19(7):1200–1205. doi:10.1007/s00586-010-1358-1.
  • Karppinen J, Koivisto K, Ketola J, et al. Serum biomarkers for modic changes in patients with chronic low back pain. Eur Spine J. 2021;30(4):1018–1027. doi:10.1007/s00586-020-06713-z.
  • Sproston NR, Ashworth JJ. Role of C-Reactive protein at sites of inflammation and infection. Front Immunol. 2018;9:754. doi:10.3389/fimmu.2018.00754.
  • Boras E, Slevin M, Alexander MY, et al. Monomeric C-reactive protein and notch-3 co-operatively increase angiogenesis through PI3K signalling pathway. Cytokine. 2014;69(2):165–179. doi:10.1016/j.cyto.2014.05.027.
  • Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003;107(3):363–369. doi:10.1161/01.cir.0000053730.47739.3c.
  • Ciubotaru I, Potempa LA, Wander RC. Production of modified C-reactive protein in U937-derived macrophages. Exp Biol Med (Maywood). 2005;230(10):762–770. doi:10.1177/153537020523001010.
  • Hage FG, Szalai AJ. C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk. J Am Coll Cardiol. 2007;50(12):1115–1122. doi:10.1016/j.jacc.2007.06.012.
  • Klyne DM, Barbe MF, Hodges PW. Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain. Brain Behav Immun. 2017;60:84–92. doi:10.1016/j.bbi.2016.10.003.
  • Park CH, Lee SH. Investigation of High-Sensitivity C-reactive protein and erythrocyte sedimentation rate in low back pain patients. Korean J Pain. 2010;23(2):147–150. doi:10.3344/kjp.2010.23.2.147.
  • Klyne DM, Barbe MF, Hodges PW. Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain. Spine J. 2022;22(2):214–225. doi:10.1016/j.spinee.2021.09.006.
  • Gebhardt K, Brenner H, Sturmer T, et al. The course of high-sensitive C-reactive protein in correlation with pain and clinical function in patients with acute lumbosciatic pain and chronic low back pain - a 6 months prospective longitudinal study. Eur J Pain. 2006;10(8):711–719. doi:10.1016/j.ejpain.2005.11.005.
  • Wu Y, Potempa LA, El Kebir D, et al. C-reactive protein and inflammation: conformational changes affect function. Biol Chem. 2015;396(11):1181–1197. doi:10.1515/hsz-2015-0149.
  • Khreiss T, Jozsef L, Potempa LA, et al. Opposing effects of C-reactive protein isoforms on shear-induced neutrophil-platelet adhesion and neutrophil aggregation in whole blood. Circulation. 2004;110(17):2713–2720. doi:10.1161/01.CIR.0000146846.00816.DD.
  • Thiele JR, Habersberger J, Braig D, et al. Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy. Circulation. 2014;130(1):35–50. doi:10.1161/CIRCULATIONAHA.113.007124.
  • van den Hoogen HM, Koes BW, van Eijk JT, et al. On the accuracy of history, physical examination, and erythrocyte sedimentation rate in diagnosing low back pain in general practice. A criteria-based review of the literature. Spine (Phila Pa 1976). 1995;20(3):318–327. doi:10.1097/00007632-199502000-00010.

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