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Psychiatry

Characterizing the treatment patterns, medication burden, and patient demographics of older adults with major depressive disorder treated with antidepressants with or without selected comorbidities

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Pages 1027-1038 | Received 26 Jan 2024, Accepted 24 Apr 2024, Published online: 16 May 2024

References

  • American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5-TR. Fifth edition, text revision. ed. Washington, DC: American Psychiatric Association Publishing; 2022.
  • Otte C, Gold SM, Penninx BW, et al. Major depressive disorder. Nat Rev Dis Primers. 2016;2(1):16065. doi: 10.1038/nrdp.2016.65.
  • GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the global burden of disease study 2016. Lancet. 2017;390(10100):1211–1259.
  • Friedrich MJ. Depression is the leading cause of disability around the world. JAMA. 2017; 317(15):1517. doi: 10.1001/jama.2017.3826.
  • Substance Abuse and Mental Health Services Administration (SAMHSA). Key substance use and mental health indicators in the United States: results from the 2021 National Survey on Drug Use and Health (HHS Publication No. PEP22-07-01-005, NSDUH Series H-57). Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration; 2022.
  • Yang KH, Han BH, Moore AA, et al. Trends in major depressive episodes and mental health treatment among older adults in the United States, 2010-2019. J Affect Disord. 2022;318:299–303. doi: 10.1016/j.jad.2022.09.007.
  • Rosenblat JD, Lee Y, McIntyre RS. The effect of pharmacogenomic testing on response and remission rates in the acute treatment of major depressive disorder: a meta-analysis. J Affect Disord. 2018;241:484–491. doi: 10.1016/j.jad.2018.08.056.
  • Zhu L, Ferries E, Suthoff E, et al. Economic burden and antidepressant treatment patterns among patients with major depressive disorder in the United States. J Manag Care Spec Pharm. 2022;28(11–a Suppl):S2–S13. doi: 10.18553/jmcp.2022.28.11-a.s1.
  • Rush AJ, Trivedi MH, Wisniewski SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. AJP. 2006;163(11):1905–1917. doi: 10.1176/appi.ajp.163.11.1905.
  • Pocklington C. Depression in older adults. Br J Med Pract. 2017;10(1):a1007.
  • Kok RM, Reynolds CF. 3rd. Management of depression in older adults: a review. JAMA. 2017;317(20):2114–2122. doi: 10.1001/jama.2017.5706.
  • American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. Vol. 5. Washington, DC: American Psychiatric Association; 2013.
  • Serafini G, Adavastro G, Canepa G, et al. Abnormalities in kynurenine pathway metabolism in treatment-resistant depression and suicidality: a systematic review. CNS Neurol Disord Drug Targets. 2017;16(4):440–453.
  • Costanza A, Vasileios C, Ambrosetti J, et al. Demoralization in suicide: a systematic review. J Psychosom Res. 2022;157:110788. doi: 10.1016/j.jpsychores.2022.110788.
  • Conwell Y, Van Orden K, Caine ED. Suicide in older adults. Psychiatr Clin North Am. 2011;34(2):451–468. doi: 10.1016/j.psc.2011.02.002.
  • De Carlo V, Calati R, Serretti A. Socio-demographic and clinical predictors of non-response/non-remission in treatment resistant depressed patients: a systematic review. Psychiatry Res. 2016;240:421–430. doi: 10.1016/j.psychres.2016.04.034.
  • Divo MJ, Martinez CH, Mannino DM. Ageing and the epidemiology of multimorbidity. Eur Respir J. 2014;44(4):1055–1068. doi: 10.1183/09031936.00059814.
  • Greenberg PE, Fournier AA, Sisitsky T, et al. The economic burden of adults with major depressive disorder in the United States (2005 and 2010). J Clin Psychiatry. 2015;76(2):155–162. doi: 10.4088/JCP.14m09298.
  • Bangalore S, Shah R, Pappadopulos E, et al. Cardiovascular hazards of insufficient treatment of depression among patients with known cardiovascular disease: a propensity score adjusted analysis. Eur Heart J Qual Care Clin Outcomes. 2018;4(4):258–266. doi: 10.1093/ehjqcco/qcy023.
  • Nelson RH. Hyperlipidemia as a risk factor for cardiovascular disease. Prim Care. 2013;40(1):195–211. doi: 10.1016/j.pop.2012.11.003.
  • Kannel WB. Hypertension as a risk factor for cardiac events–epidemiologic results of long-term studies. J Cardiovasc Pharmacol. 1993;21 Suppl 2(Suppl 2):S27–S37. doi: 10.1097/00005344-199321002-00006.
  • Arnaud AM, Brister TS, Duckworth K, et al. Impact of major depressive disorder on comorbidities: a systematic literature review. J Clin Psychiatry. 2022;83(6):21r14328. doi: 10.4088/JCP.21r14328.
  • Moore KL, Patel K, Boscardin WJ, et al. Medication burden attributable to chronic co-morbid conditions in the very old and vulnerable. PLoS One. 2018;13(4):e0196109. doi: 10.1371/journal.pone.0196109.
  • Holt RI, de Groot M, Golden SH. Diabetes and depression. Curr Diab Rep. 2014;14(6):491. doi: 10.1007/s11892-014-0491-3.
  • Grenard JL, Munjas BA, Adams JL, et al. Depression and medication adherence in the treatment of chronic diseases in the United States: a meta-analysis. J Gen Intern Med. 2011;26(10):1175–1182. doi: 10.1007/s11606-011-1704-y.
  • Goldstein CM, Gathright EC, Garcia S. Relationship between depression and medication adherence in cardiovascular disease: the perfect challenge for the integrated care team. Patient Prefer Adherence. 2017;11:547–559. doi: 10.2147/PPA.S127277.
  • Zivin K, Kales HC. Adherence to depression treatment in older adults: a narrative review. Drugs Aging. 2008;25(7):559–571. doi: 10.2165/00002512-200825070-00003.
  • Sabaté E, World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: World Health Organization; 2003.
  • Kardas P, Lewek P, Matyjaszczyk M. Determinants of patient adherence: a review of systematic reviews. Front Pharmacol. 2013;4:91. doi: 10.3389/fphar.2013.00091.
  • Kantor ED, Rehm CD, Haas JS, et al. Trends in prescription drug use among adults in the United States from 1999-2012. JAMA. 2015;314(17):1818–1831. doi: 10.1001/jama.2015.13766.
  • Fried TR, O'Leary J, Towle V, et al. Health outcomes associated with polypharmacy in community-dwelling older adults: a systematic review. J Am Geriatr Soc. 2014;62(12):2261–2272. doi: 10.1111/jgs.13153.
  • Penninx BW, Nolen WA, Lamers F, et al. Two-year course of depressive and anxiety disorders: results from The Netherlands Study of Depression and Anxiety (NESDA). J Affect Disord. 2011;133(1–2):76–85. doi: 10.1016/j.jad.2011.03.027.
  • National Center for Health Statistics. National Health Interview Survey. 2019. https://www.cdc.gov/nchs/nhis/2019nhis.htm
  • Rector TS, Wickstrom SL, Shah M, et al. Specificity and sensitivity of claims-based algorithms for identifying members of medicare + choice health plans that have chronic medical conditions. Health Serv Res. 2004;39(6 Pt 1):1839–1857. doi: 10.1111/j.1475-6773.2004.00321.x.
  • Centers for Disease Control and Prevention (CDC). Hypertension Cascade: Hypertension Prevalence, Treatment and Control Estimates Among US Adults Aged 18 Years and Older Applying the Criteria From the American College of Cardiology and American Heart Association’s 2017 Hypertension Guideline—NHANES; 2017. [cited 20202023]. https://millionhearts.hhs.gov/data-reports/hypertension-prevalence.html.
  • Centers for Disease Control and Prevention (CDC). Table 23. Cholesterol among adults aged 20 and over, by selected characteristics: United States, selected years 1988–1994 through 2015–2018; 2019. https://www.cdc.gov/nchs/data/hus/2019/023-508.pdf.
  • Centers for Disease Control and Prevention (CDC). National Diabetes Statistics Report: Prevalence of Both Diagnosed and Undiagnosed Diabetes; 2022. https://www.cdc.gov/diabetes/data/statistics-report/diagnosed-undiagnosed-diabetes.html.
  • National Center for Health Statistics; U.S. Census Bureau. Household Pulse Survey, 2020–2023. Anxiety and Depression; 2023. Generated interactively from https://www.cdc.gov/nchs/covid19/pulse/mental-health.htm.
  • Centers for Disease Control and Prevention. National Center for Health Statistics; Analysis by American Lung Assocation Research and Program Services Division. National Health Interview Survey, 2019-2020. 2020. https://www.lung.org/research/trends-in-lung-disease/copd-trends-brief/copd-prevalence.
  • Gelenberg AJ, Freeman MP, Markowitz JC, et al. American Psychiatric Association: Practice guideline for the treatment of patients with major depressive disorder. 3rd ed. Am J Psychiatry. 2010;167(suppl):1–152.
  • Gauthier G, Guérin A, Zhdanava M, et al. Treatment patterns, healthcare resource utilization, and costs following first-line antidepressant treatment in major depressive disorder: a retrospective US claims database analysis. BMC Psychiatry. 2017;17(1):222. doi: 10.1186/s12888-017-1385-0.
  • Shih YT, Liu L. Use of claims data for cost and cost-effectiveness research. Semin Radiat Oncol. 2019;29(4):348–353. doi: 10.1016/j.semradonc.2019.05.009.
  • Dalli LL, Kilkenny MF, Arnet I, et al. Towards better reporting of the proportion of days covered method in cardiovascular medication adherence: a scoping review and new tool TEN-SPIDERS. Br J Clin Pharmacol. 2022;88(10):4427–4442. doi: 10.1111/bcp.15391.
  • Forbes CA, Deshpande S, Sorio-Vilela F, et al. A systematic literature review comparing methods for the measurement of patient persistence and adherence. Curr Med Res Opin. 2018;34(9):1613–1625. doi: 10.1080/03007995.2018.1477747.
  • Girgus JS, Yang K, Ferri CV. The gender difference in depression: are elderly women at greater risk for depression than elderly men? Geriatrics (Basel). 2017;2(4):35. doi: 10.3390/geriatrics2040035.