Association between fatigue and depressive symptoms in persons with post-COVID-19 condition: a post hoc analysis

References

• COVID-19 cases [Internet]. datadot. [cited 2024 Jan 24]. Available from: https://data.who.int/dashboards/covid19/cases?n=c.
   Google Scholar
• O'Mahoney LL, Routen A, Gillies C, et al. The prevalence and long-term health effects of long covid among hospitalised and non-hospitalised populations: a systematic review and meta-analysis. EClinicalMedicine. 2023;55:101762. doi:10.1016/j.eclinm.2022.101762.
   PubMedGoogle Scholar
• Davis HE, McCorkell L, Vogel JM, et al. Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol. 2023;21(3):133–146. doi:10.1038/s41579-022-00846-2.
   PubMed Web of Science ®Google Scholar
• Perlis RH, Santillana M, Ognyanova K, et al. Prevalence and correlates of long COVID symptoms among US adults. JAMA Netw Open. 2022;5(10):e2238804. doi:10.1001/jamanetworkopen.2022.38804.
   PubMed Web of Science ®Google Scholar
• Soriano JB, Murthy S, Marshall JC, et al. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect Dis. 2022;22(4):e102–e107. doi:10.1016/S1473-3099(21)00703-9.
   PubMed Web of Science ®Google Scholar
• Post COVID-19 condition (Long COVID). [Internet]. [cited 2023 Apr 6]. Available from: https://www.who.int/europe/news-room/fact-sheets/item/post-covid-19-condition.
   Google Scholar
• Ceban F, Ling S, Lui LMW, et al. Fatigue and cognitive impairment in post-COVID-19 syndrome: a systematic review and meta-analysis. Brain Behav Immun. 2022;101:93–135. doi:10.1016/j.bbi.2021.12.020.
   PubMed Web of Science ®Google Scholar
• Salari N, Khodayari Y, Hosseinian-Far A, et al. Global prevalence of chronic fatigue syndrome among long COVID-19 patients: a systematic review and meta-analysis. BioPsychoSocial Med. 2022;16(1):21. doi:10.1186/s13030-022-00250-5.
   PubMed Web of Science ®Google Scholar
• Fernández-de-Las-Peñas C, Notarte KI, Peligro PJ, et al. Long-COVID symptoms in individuals infected with different SARS-CoV-2 variants of concern: a systematic review of the literature. Viruses. 2022;14(12):2629. doi:10.3390/v14122629.
   PubMed Web of Science ®Google Scholar
• Poole-Wright K, Guennouni I, Sterry O, et al. Fatigue outcomes following COVID-19: a systematic review and meta-analysis. BMJ Open. 2023;13(4):e063969. doi:10.1136/bmjopen-2022-063969.
   PubMed Web of Science ®Google Scholar
• Sherif ZA, Gomez CR, Connors TJ, et al. Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC). Elife. 2023;12:e86002. doi:10.7554/eLife.86002.
   PubMed Web of Science ®Google Scholar
• Astin R, Banerjee A, Baker MR, et al. Long COVID: mechanisms, risk factors and recovery. Exp Physiol. 2023;108(1):12–27. doi:10.1113/EP090802.
   PubMed Web of Science ®Google Scholar
• Gross M, Lansang NM, Gopaul U, et al. What do I need to know about Long-Covid-related fatigue, brain fog, and mental health changes? Arch Phys Med Rehabil. 2023;104(6):996–1002. doi:10.1016/j.apmr.2022.11.021.
   PubMed Web of Science ®Google Scholar
• Chaves-Filho AM, Braniff O, Angelova A, et al. Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome. Brain Res Bull. 2023;201:110702. doi:10.1016/j.brainresbull.2023.110702.
   PubMed Web of Science ®Google Scholar
• Abbott Z, Summers W, Niehaus W. Fatigue in post-acute sequelae of coronavirus disease 2019. Phys Med Rehabil Clin N Am. 2023;34(3):607–621. doi:10.1016/j.pmr.2023.04.006.
   PubMed Web of Science ®Google Scholar
• Premraj L, Kannapadi NV, Briggs J, et al. Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: a meta-analysis. J Neurol Sci. 2022;434:120162. doi:10.1016/j.jns.2022.120162.
   PubMed Web of Science ®Google Scholar
• Renaud-Charest O, Lui LMW, Eskander S, et al. Onset and frequency of depression in post-COVID-19 syndrome: a systematic review. J Psychiatr Res. 2021;144:129–137. doi:10.1016/j.jpsychires.2021.09.054.
   PubMed Web of Science ®Google Scholar
• Schou TM, Joca S, Wegener G, et al. Psychiatric and neuropsychiatric sequelae of COVID-19 – a systematic review. Brain Behav Immun. 2021;97:328–348. https://www.sciencedirect.com/science/article/pii/S0889159121002816.
   PubMed Web of Science ®Google Scholar
• Goodman ML, Molldrem S, Elliott A, et al. Long COVID and mental health correlates: a new chronic condition fits existing patterns. Health Psychol Behav Med. 2023;11(1):2164498. doi:10.1080/21642850.2022.2164498.
   PubMed Web of Science ®Google Scholar
• Vai B, Mazza MG, Delli Colli C, et al. Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis. Lancet Psychiatry. 2021;8(9):797–812. doi:10.1016/S2215-0366(21)00232-7.
   PubMed Web of Science ®Google Scholar
• Ceban F, Nogo D, Carvalho IP, et al. Association between mood disorders and risk of COVID-19 infection, hospitalization, and death: a systematic review and meta-analysis. JAMA Psychiatry. 2021;78(10):1079–1091. doi:10.1001/jamapsychiatry.2021.1818.
   PubMed Web of Science ®Google Scholar
• Mazza MG, Palladini M, Poletti S, et al. Post-COVID-19 depressive symptoms: epidemiology, pathophysiology, and pharmacological treatment. CNS Drugs. 2022;36(7):681–702. doi:10.1007/s40263-022-00931-3.
   PubMed Web of Science ®Google Scholar
• Proal AD, VanElzakker MB. Long COVID or post-acute sequelae of COVID-19 (PASC): an overview of biological factors that may contribute to persistent symptoms. Front Microbiol. 2021;12:698169. doi:10.3389/fmicb.2021.698169.
   PubMed Web of Science ®Google Scholar
• Klein J, Wood J, Jaycox J, et al. Distinguishing features of Long COVID identified through immune profiling (preprint). 2022; Available from: https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/ppzbmed-10.1101.2022.08.09.22278592.
   Google Scholar
• Glynne P, Tahmasebi N, Gant V, et al. Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines. J Investig Med. 2022;70(1):61–67. doi:10.1136/jim-2021-002051.
   PubMed Web of Science ®Google Scholar
• Phetsouphanh C, Darley DR, Wilson DB, et al. Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection. Nat Immunol. 2022;23(2):210–216. doi:10.1038/s41590-021-01113-x.
   PubMed Web of Science ®Google Scholar
• Lyra E Silva NM, Barros-Aragão FGQ, De Felice FG, et al. Inflammation at the crossroads of COVID-19, cognitive deficits and depression. Neuropharmacology. 2022;209:109023. doi:10.1016/j.neuropharm.2022.109023.
   PubMed Web of Science ®Google Scholar
• Ceban F, Leber A, Jawad MY, et al. Registered clinical trials investigating treatment of long COVID: a scoping review and recommendations for research. Infect Dis (Lond). 2022;54(7):467–477. doi:10.1080/23744235.2022.2043560.
   PubMed Web of Science ®Google Scholar
• McIntyre RS, Phan L, Kwan ATH, et al. Vortioxetine for the treatment of post-COVID-19 condition: a randomized controlled trial. Brain. 2023;147(3):849–857. doi:10.1093/brain/awad377.
   Google Scholar
• Vortioxetine for Post-COVID-19 Condition [Internet]. [cited 2024 Jan 24]. Available from: https://clinicaltrials.gov/ct2/show/NCT05047952.
   Google Scholar
• WMA declaration of Helsinki – ethical principles for medical research involving human subjects [Internet]. [cited 2023 Aug 11]. Available from: https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/.
   Google Scholar
• ICH Official web site: ICH [Internet]. [cited 2023 Aug 11]. Available from: https://www.ich.org/page/efficacy-guidelines.
   Google Scholar
• Valko PO, Bassetti CL, Bloch KE, et al. Validation of the fatigue severity scale in a swiss cohort. Sleep. 2008;31(11):1601–1607. doi:10.1093/sleep/31.11.1601.
   PubMed Web of Science ®Google Scholar
• Rush AJ, Trivedi MH, Ibrahim HM, et al. The 16-item quick inventory of depressive symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry. 2003;54(5):573–583. doi:10.1016/s0006-3223(02)01866-8.
   PubMed Web of Science ®Google Scholar
• Ghanean H, Ceniti AK, Kennedy SH. Fatigue in patients with major depressive disorder: prevalence, burden and pharmacological approaches to management. CNS Drugs. 2018;32(1):65–74. doi:10.1007/s40263-018-0490-z.
   PubMed Web of Science ®Google Scholar
• Xia H, Zhu X, Zhu C. Associations between pro-inflammatory cytokines and fatigue in pregnant women. PeerJ. 2022;10:e13965. doi:10.7717/peerj.13965.
   PubMed Web of Science ®Google Scholar
• Liu Y, Ho RC-M, Mak A. Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. J Affect Disord. 2012;139(3):230–239. doi:10.1016/j.jad.2011.08.003.
   PubMed Web of Science ®Google Scholar
• Finsterer J, Mahjoub SZ. Fatigue in healthy and diseased individuals. Am J Hosp Palliat Care. 2014;31(5):562–575. doi:10.1177/1049909113494748.
   PubMed Web of Science ®Google Scholar
• Azcue N, Gómez-Esteban JC, Acera M, et al. Brain fog of post-COVID-19 condition and chronic fatigue syndrome, same medical disorder? J Transl Med. 2022;20(1):569. doi:10.1186/s12967-022-03764-2.
   PubMed Web of Science ®Google Scholar
• Menza M, Marin H, Opper RS. Residual symptoms in depression: can treatment be symptom-specific? J Clin Psychiatry. 2003;64(5):516–523. doi:10.4088/jcp.v64n0504.
   PubMed Web of Science ®Google Scholar
• Harvey SB, Wessely S, Kuh D, et al. The relationship between fatigue and psychiatric disorders: evidence for the concept of neurasthenia. J Psychosom Res. 2009;66(5): 445–454. doi:10.1016/j.jpsychores.2008.12.007.
   PubMed Web of Science ®Google Scholar
• Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018;391(10128):1357–1366. doi:10.1016/S0140-6736(17)32802-7.
   PubMed Web of Science ®Google Scholar
• Barth J, Munder T, Gerger H, et al. Comparative efficacy of seven psychotherapeutic interventions for patients with depression: a network Meta-Analysis. Focus (Am Psychiatr Publ). 2016;14(2): 229–243. doi:10.1176/appi.focus.140201.
   PubMedGoogle Scholar
• Kim D-Y, Lee J-S, Park S-Y, et al. Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Transl Med. 2020;18(1):7. doi:10.1186/s12967-019-02196-9.
   PubMed Web of Science ®Google Scholar
• Kuut TA, Müller F, Csorba I, et al. Efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19: results of a randomized controlled trial. Clin Infect Dis. 2023;77(5):687–695. doi:10.1093/cid/ciad257.
   PubMed Web of Science ®Google Scholar
• Estévez-López F, Maestre-Cascales C, Russell D, et al. Effectiveness of exercise on fatigue and sleep quality in fibromyalgia: a systematic review and meta-analysis of randomized trials. Arch Phys Med Rehabil. 2021;102(4):752–761. doi:10.1016/j.apmr.2020.06.019.
   PubMed Web of Science ®Google Scholar
• McIntyre RS, Cha DS, Soczynska JK, et al. Cognitive deficits and functional outcomes in major depressive disorder: determinants, substrates, and treatment interventions. Depress Anxiety. 2013;30(6):515–527. doi:10.1002/da.22063.
   PubMed Web of Science ®Google Scholar
• Ekiz T, Kara M, Özçakar L. Measuring grip strength in COVID-19: a simple way to predict overall frailty/impairment [internet]. Heart Lung. 2020;49(6):853–854. doi:10.1016/j.hrtlng.2020.05.011.
   PubMed Web of Science ®Google Scholar
• Kersten J, Wolf A, Hoyo L, et al. Symptom burden correlates to impairment of diffusion capacity and exercise intolerance in long COVID patients. Sci Rep. 2022;12(1):8801. doi:10.1038/s41598-022-12839-5.
   PubMed Web of Science ®Google Scholar
• Craig CL, Marshall AL, Sjöström M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381–1395. doi:10.1249/01.MSS.0000078924.61453.FB.
   PubMed Web of Science ®Google Scholar