605
Views
20
CrossRef citations to date
0
Altmetric
Articles

Fluid shear stress promotes osteoblast proliferation via the Gαq–ERK5 signaling pathway

, , , , , , , , , & show all
Pages 299-306 | Received 06 Dec 2015, Accepted 31 Mar 2016, Published online: 26 May 2016

References

  • Cowin SC. Wolff’s law of trabecular architecture at remodeling equilibrium. J Biomech Eng 1986;108:83–8.
  • Nowlan NC, Bourdon C, Dumas G, Tajbakhsh S, Prendergast PJ, Murphy P. Developing bones are differentially affected by compromised skeletal muscle formation. Bone 2010;46:1275–85.
  • Liedert A, Kaspar D, Augat P, Ignatius A, Claes L. Mechanobiology of Bone Tissue and Bone Cells. In: Kamkin A, Kiseleva I, eds. Mechanosensitivity in Cells and Tissues. Moscow: Academia; 2005.
  • Li P, Ma YC, Sheng XY, Dong HT, Han H, Wang J, Xia YY. Cyclic fluid shear stress promotes osteoblastic cells proliferation through ERK5 signalling pathway. Mol Cell Biochem 2012;364:321–7.
  • Arnsdorf EJ, Tummala P, Kwon RY, Jacobs CR. Mechanically induced osteogenic differentiation–the role of RhoA, ROCKII and cytoskeletal dynamics. J Cell Sci 2009;122:546–53.
  • Tan SD, Kuijpers-Jagtman AM, Semeins CM, Bronckers AL, Maltha JC, Von Den Hoff JW, Everts V, Klein-Nulend J. Fluid shear stress inhibits TNFalpha-induced osteocyte apoptosis. J Dent Res 2006;85:905–9.
  • Delaine-Smith RM, Sittichokechaiwut A, Reilly GC. Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts. Faseb J 2014;28:430–9.
  • Li P, Ma YC, Shen HL, Han H, Wang J, Cheng HJ, Wang CF, Xia YY. Cytoskeletal reorganization mediates fluid shear stress-induced ERK5 activation in osteoblastic cells. Cell Biol Int 2012;36:229–36.
  • Rangaswami H, Schwappacher R, Tran T, Chan GC, Zhuang S, Boss GR, Pilz RB. Protein kinase G and focal adhesion kinase converge on Src/Akt/beta-catenin signalling module in osteoblast mechanotransduction. J Biol Chem 2012;287:21509–19.
  • Yang M, Xiao LW, Liao EY, Wang QJ, Wang BB, Lei JX. The role of integrin-beta/FAK in cyclic mechanical stimulation in MG-63 cells. Int J Clin Exp Pathol 2014;7:7451–59.
  • Hutcheson JD, Chen J, Sewell-Loftin MK, Ryzhova LM, Fisher CI, Su YR, Merryman WD. Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts. Arterioscler Thromb Vasc Biol 2013;33:114–20.
  • Siller-Jackson AJ, Burra S, Gu S, Xia X, Bonewald LF, Sprague E, Jiang JX. Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading. J Biol Chem 2008;283:26374–82.
  • Zhang YL, Frangos JA, Chachisvilis M. Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells. Am J Physiol Cell Physiol 2009;296:C1391–99.
  • Katritch V, Cherezov V, Stevens RC. Structure-function of the G protein-coupled receptor superfamily. Annu Rev Pharmacol Toxicol 2013;53:531–56.
  • Gudi SR, Clark CB, Frangos JA. Fluid flow rapidly activates G proteins in human endothelial cells. Involvement of G proteins in mechanochemical signal transduction. Circ Res 1996;79:834–9.
  • Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol 2004;6:499–506.
  • Pi M, Quarles LD. A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium. J Bone Miner Res 2004;19:862–9.
  • Goupil E, Wisehart V, Khoury E, Zimmerman B, Jaffal S, Hebert TE, Laporte SA. Biasing the prostaglandin F2alpha receptor responses toward EGFR-dependent transactivation of MAPK. Mol Endocrinol 2012;26:1189–202.
  • Rovida E, Stecca B. Mitogen-activated protein kinases and Hedgehog-GLI signalling in cancer: a crosstalk providing therapeutic opportunities? Semin Cancer Biol 2015;35:154–67.
  • Zhou G, Bao ZQ, Dixon JE. Components of a new human protein kinase signal transduction pathway. J Biol Chem 1995;270:12665–9.
  • Kato Y, Tapping RI, Huang S, Watson MH, Ulevitch RJ, Lee JD. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature 1998;395:713–6.
  • Takeishi Y, Abe J, Lee JD, Kawakatsu H, Walsh RA, Berk BC. Differential regulation of p90 ribosomal S6 kinase and big mitogen-activated protein kinase 1 by ischemia/reperfusion and oxidative stress in perfused guinea pig hearts. Circ Res 1999;85:1164–72.
  • Yan C, Takahashi M, Okuda M, Lee JD, Berk BC. Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells. Dependence on tyrosine kinases and intracellular calcium. J Biol Chem 1999;274:143–50.
  • Yang Q, Deng X, Lu B, Cameron M, Fearns C, Patricelli MP, Yates JR, 3rd, Gray NS, Lee JD. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell 2010;18:258–67.
  • Zhao LG, Chen SL, Teng YJ, An LP, Wang J, Ma JL, Xia YY. The MEK5/ERK5 pathway mediates fluid shear stress promoted osteoblast differentiation. Connect Tissue Res 2014;55:96–102.
  • Bin G, Cuifang W, Bo Z, Jing W, Jin J, Xiaoyi T, Cong C, Yonggang C, Liping A, Jinglin M, Yayi X. Fluid shear stress inhibits TNF-alpha-induced osteoblast apoptosis via ERK5 signalling pathway. Biochem Biophys Res Commun 2015;466:117–23.
  • Jiang J, Zhao LG, Teng YJ, Chen SL, An LP, Ma JL, Wang J, Xia YY. ERK5 signalling pathway is essential for fluid shear stress-induced COX-2 gene expression in MC3T3-E1 osteoblast. Mol Cell Biochem 2015;406:237–43.
  • Augat P, Simon U, Liedert A, Claes L. Mechanics and mechano-biology of fracture healing in normal and osteoporotic bone. Osteoporos Int 2005;16 Suppl 2:S36–43.
  • Lee MJ, Kim DE, Zakrzewska A, Yoo YD, Kim SH, Kim ST, Seo JW, Lee YS, Dorn GW, 2nd, Oh U, Kim BY, Kwon YT. Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signalling of cardiomyocytes. J Biol Chem 2012;287:24043–52.
  • Liu S, Li Y, Zhang Z, Xie F, Xu Q, Huang X, Huang J, Li C. alpha1-Adrenergic receptors mediate combined signals initiated by mechanical stretch stress and norepinephrine leading to accelerated mouse vein graft atherosclerosis. J Vasc Surg 2013;57:1645–56, 1656.e1–3.
  • Caverzasio J, Palmer G, Suzuki A, Bonjour JP. Evidence for the involvement of two pathways in activation of extracellular signal-regulated kinase (Erk) and cell proliferation by Gi and Gq protein-coupled receptors in osteoblast-like cells. J Bone Miner Res 2000;15:1697–706.
  • Ogata N, Kawaguchi H, Chung UI, Roth SI, Segre GV. Continuous activation of G alpha q in osteoblasts results in osteopenia through impaired osteoblast differentiation. J Biol Chem 2007;282:35757–64.
  • Lee DY, Li YS, Chang SF, Zhou J, Ho HM, Chiu JJ, Chien S. Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway. J Biol Chem 2010;285:30–42.
  • Tassinary JA, Lunardelli A, Basso BS, Stulp S, Pozzobon A, Pedrazza L, Bartrons R, Ventura F, Rosa JL, Melo DA, Nunes FB, Donadio MV, Oliveira JR. Therapeutic ultrasound stimulates MC3T3-E1 cell proliferation through the activation of NF-kappaB1, p38alpha, and mTOR. Lasers Surg Med 2015;47:765–72.
  • Hu JT, Li Y, Yu B, Gao GJ, Zhou T, Li S. Girdin/GIV is upregulated by cyclic tension, propagates mechanical signal transduction, and is required for the cellular proliferation and migration of MG-63 cells. Biochem Biophys Res Commun 2015;464:493–9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.