232
Views
7
CrossRef citations to date
0
Altmetric
Biology and Biomechanics

Adipokines induce catabolism of newly synthesized matrix in cartilage and meniscus tissues

&
Pages 246-258 | Received 17 Sep 2016, Accepted 04 Jan 2017, Published online: 22 Feb 2017

References

  • Stürmer T, Günther K-P, Brenner H. Obesity, overweight and patterns of osteoarthritis. J Clin Epidemiol 2000;53:307–313.
  • Sharma L, Lou C, Cahue S, Dunlop DD. The mechanism of the effect of obesity in knee osteoarthritis: the mediating role of malalignment. Arthritis Rheum 2000;43:568.
  • Grotle M, Hagen KB, Natvig B, Dahl FA, Kvien TK. Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BMC Musculoskeletal Disord 2008;9:132.
  • Visser AW, de Mutsert R, le Cessie S, den Heijer M, Rosendaal FR, Kloppenburg M. The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study. Ann Rheum Dis 2015;74:1842–1847.
  • Waki H, Tontonoz P. Endocrine functions of adipose tissue. Annu Rev Pathol Mech Dis 2007;2:31–56.
  • Lyon CJ, Law RE, Hsueh WA. Minireview: adiposity, inflammation, and atherogenesis. Endocrinology 2003;144:2195–2200.
  • Hutley L, Prins JB. Fat as an endocrine organ: relationship to the metabolic syndrome. Am J Med Sci 2005;330:280–289.
  • Neumann E, Frommer KW, Vasile M, Müller-Ladner U. Adipocytokines as driving forces in rheumatoid arthritis and related inflammatory diseases? Arthritis Rheum 2011;63:1159–1169.
  • Abella V, Scotece M, Conde J, López V, Lazzaro V, Pino J, Gómez-Reino JJ, Gualillo O. Adipokines, metabolic syndrome and rheumatic diseases. J Immunol Res 2014;2014:1–14.
  • Conde J, Scotece M, Gómez R, Lopez V, Gómez-Reino JJ, Gualillo O. Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis 2011;2011:1–8.
  • Berenbaum F, Eymard F, Houard X. Osteoarthritis, inflammation and obesity. Curr Opin Rheumatol 2013;25:114–118.
  • Dumond Hln, Presle N, Terlain B, Mainard D, Loeuille D, Netter P, Pottie P. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum 2003;48:3118–3129.
  • Ku JH, Lee CK, Joo BS, An BM, Choi SH, Wang TH, et al. Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis. Clin Rheumatol 2009;28:1431–1435.
  • Duan Y, Hao D, Li M, Wu Z, Li D, Yang X, Qiu G. Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis. Rheumatol Int 2012;32:985–990.
  • Chen W-P, Bao J-P, Feng J, Hu P-F, Shi Z-L, Wu L-D. Increased serum concentrations of visfatin and its production by different joint tissues in patients with osteoarthritis. Clin Chem Lab Med 2010;48:1141–1145.
  • Francin P-J, Abot A, Guillaume C, Moulin D, Bianchi A, Gegout-Pottie P, Jouzeau J-Y, Mainard D, Presle N. Association between adiponectin and cartilage degradation in human osteoarthritis. Osteoarthr Cartilage 2014;22:519–526.
  • Filkova M, Liskova M, Hulejova H, Haluzik M, Gatterova J, Pavelkova A, Pavelka K, Gay S, Muller-Ladner U, Senolt L. Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis. Ann Rheum Dis 2009;68:295–296.
  • Lee JH, Ort T, Ma K, Picha K, Carton J, Marsters PA, Lohmander LS, Baribaud F, Song X-YR, Blake S. Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro. Osteoarthr Cartilage 2009;17:613–620.
  • Choe J-Y, Bae J, Jung H-Y, Park S-H, Lee H-J, Kim S-K. Serum resistin level is associated with radiographic changes in hand osteoarthritis: cross-sectional study. Joint Bone Spine 2012;79:160–165.
  • Koskinen A, Vuolteenaho K, Moilanen T, Moilanen E. Resistin as a factor in osteoarthritis: synovial fluid resistin concentrations correlate positively with interleukin 6 and matrix metalloproteinases MMP-1 and MMP-3. Scand J Rheumatol 2014;43:249–253.
  • Simopoulou T, Malizos KN, Iliopoulos D, Stefanou N, Papatheodorou L, Ioannou M, Tsezou A. Differential expression of leptin and leptin’s receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthr Cartilage 2007;15:872–883.
  • Koskinen A, Vuolteenaho K, Nieminen R, Moilanen T, Moilanen E. Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients. Clin Exp Rheumatol 2011;29:57–64.
  • Vuolteenaho K, Koskinen A, Kukkonen M, Nieminen R, Päivärinta U, Moilanen T, Moilanen E. Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage–mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediat Inflamm 2009;2009:1–10.
  • Gosset M, Berenbaum F, Salvat C, Sautet A, Pigenet A, Tahiri K, Jacques C. Crucial role of visfatin/pre–B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. Arthritis Rheum 2008;58:1399–1409.
  • McNulty AL, Miller MR, O’Connor SK, Guilak F. The effects of adipokines on cartilage and meniscus catabolism. Connect Tissue Res 2011;52:523–533.
  • Lago R, Gomez R, Otero M, Lago F, Gallego R, Dieguez C, Gomez-Reino JJ, Gualillo O. A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthr Cartilage 2008;16:1101–1109.
  • Tong K-M, Chen C-P, Huang K-C, Shieh D-C, Cheng H-C, Tzeng C-Y, Chen K-H, Chiu Y-C, Tang C-H. Adiponectin increases MMP-3 expression in human chondrocytes through adipor1 signaling pathway. J Cell Biochem 2011;112:1431–1440.
  • Koskinen A, Juslin S, Nieminen R, Moilanen T, Vuolteenaho K, Moilanen E. Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. Arthritis Res Ther 2011;13:R184.
  • Nishimuta JF, Levenston ME. Meniscus is more susceptible than cartilage to catabolic and anti-anabolic effects of adipokines. Osteoarthr Cartilage 2015;23:1551–1562.
  • Mow VC, Ratcliffe A. Structure and function of articular cartilage and meniscus. Basic orthopaedic biomechanics. Vol. 2. New York (NY): Raven; 1997. p. 113–177.
  • Petersen W, Tillmann B. Collagenous fibril texture of the human knee joint menisci. Anat Embryol 1998;197:317–324.
  • Knudson CB, Knudson W. Cartilage proteoglycans. Semin Cell Dev Biol 2001;12:69–78.
  • Vanderploeg EJ, Wilson CG, Imler SM, Ling CH-Y, Levenston ME. Regional variations in the distribution and colocalization of extracellular matrix proteins in the juvenile bovine meniscus. J Anat 2012;221:174–186.
  • Andrews SHJ, Rattner JB, Abusara Z, Adesida A, Shrive NG, Ronsky JL. Tie-fibre structure and organization in the knee menisci. J Anat 2014;224:531–537.
  • DiMicco MA, Patwari P, Siparsky PN, Kumar S, Pratta Ma, Lark MW, Kim Y-J, Grodzinsky AJ. Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. Arthritis Rheum 2004;50:840–848.
  • Farndale R, Buttle D, Barrett A. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta (BBA) Gener Sub 1986;883:173–177.
  • Kim Y-J, Sah RLY, Doong J-YH, Grodzinsky AJ. Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 1988;174:168–176.
  • Burnham KP. Multimodel inference: understanding AIC and BIC in model selection. Sociol Methods Res 2004;33(2):261–304.
  • Palmer AW, Wilson CG, Baum EJ, Levenston ME. Composition-function relationships during IL-1-induced cartilage degradation and recovery. Osteoarthr Cartilage 2009;17:1029–1039.
  • Wilson CG, Palmer AW, Zuo F, Eugui E, Wilson S, Mackenzie R, Sandy JD, Levenston ME. Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties. Matrix Biol 2007;26:259–268.
  • Manicourt DH, Lefebvre V. An assay for matrix metalloproteinases and other proteases acting on proteoglycans, casein, or gelatin. Anal Biochem 1993;215:171–179.
  • Towle CA, Hung HH, Bonassar LJ, Treadwell BV, Mangham DC. Detection of interleukin-1 in the cartilage of patients with osteoarthritis: a possible autocrine/paracrine role in pathogenesis. Osteoarthr Cartilage 1997;5:293–300.
  • Hopkins SJ, Humphreys M, Jayson MI. Cytokines in synovial fluid. I. The presence of biologically active and immunoreactive IL-1. Clin Exp Immunol 1988;72:422–427.
  • Arner EC, Hughes CE, Decicco CP, Caterson B, Tortorella MD. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase. Osteoarthr Cartilage 1998;6:214–228.
  • Pratta MA, Yao W, Decicco C, Tortorella MD, Liu R-Q, Copeland RA, Magolda R, Newton RC, Trzaskos JM, Arner EC. Aggrecan protects cartilage collagen from proteolytic cleavage. J Biol Chem 2003;278:45539–45545.
  • Patwari P, Gao G, Lee JH, Grodzinsky AJ, Sandy JD. Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Osteoarthr Cartilage 2005;13:269–277.
  • Shin S-J, Fermor B, Weinberg JB, Pisetsky DS, Guilak F. Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. J Appl Physiol 2003;95:308–313.
  • Fuller ES, Smith MM, Little CB, Melrose J. Zonal differences in meniscus matrix turnover and cytokine response. Osteoarthr Cartilage 2012;20:49–59.
  • Wilson CG, Vanderploeg EJ, Zuo F, Sandy JD, Levenston ME. Aggrecanolysis and in vitro matrix degradation in the immature bovine meniscus: mechanisms and functional implications. Arthritis Res Ther 2009;11:R173.
  • Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, Mitchell P, Hambor J, Diekmann O, Tschesche H, Chen J, Van Wart H, Poole AR. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 1997;99:1534–1545.
  • Billinghurst RC, Wu W, Ionescu M, Reiner A, Dahlberg L, Chen J, Van Wart H, Poole AR. Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase. Arthritis Rheum 2000;43:664.
  • Sandy JD, Plaas AH, Koob TJ. Pathways of aggrecan processing in joint tissues. Implications for disease mechanism and monitoring. Acta Orthopaed Scand Suppl 1995;266:26–32.
  • Troeberg L, Nagase H. Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta (BBA) Proteins Proteomics 2012;1824:133–145.
  • Duerr S, Stremme S, Soeder S, Bau B, Aigner T. MMP-2/gelatinase A is a gene product of human adult articular chondrocytes and is increased in osteoarthritic cartilage. Clin Exp Rheumatol 2004;22:603–608.
  • Aigner T, Zien A, Gehrsitz A, Gebhard PM, McKenna L. Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum 2001;44:2777–2789.
  • Hsieh Y-S, Yang S-F, Chu S-C, Chen P-N, Chou M-C, Hsu M-C, Lu K-H. Expression changes of gelatinases in human osteoarthritic knees and arthroscopic debridement. Arthrosc J Arthrosc Relat Surg 2004;20:482–488.
  • Tanaka A, Kawashiri S, Kumagai S, Takatsuka S, Narinobou M, Nakagawa K, Tanaka S. Expression of matrix metalloproteinase-2 in osteoarthritic fibrocartilage from human mandibular condyle. J Oral Pathol Med 2000;29:314–320.
  • Yusuf E, Ioan-Facsinay A, Bijsterbosch J, Klein-Wieringa I, Kwekkeboom J, Slagboom PE, Huizinga TW, Kloppenburg M. Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis. Ann Rheum Dis 2011;70:1282–1284.
  • Kang EH, Lee YJ, Kim TK, Chang CB, Chung J-H, Shin K, Lee EY, Lee EB, Song YW. Adiponectin is a potential catabolic mediator in osteoarthritis cartilage. Arthritis Res Ther 2010;12:R231.
  • Gomez R, Scotece M, Conde J, Gomez-Reino JJ, Lago F, Gualillo O. Adiponectin and leptin increase IL-8 production in human chondrocytes. Ann Rheum Dis 2011;70:2052–2054.
  • Chen T-H, Chen L, Hsieh M-S, Chang C-P, Chou D-T, Tsai S-H. Evidence for a protective role for adiponectin in osteoarthritis. Biochim Biophys Acta (BBA) Mol Basis Dis 2006;1762:711–718.
  • Liu C, Yang H, Gao F, Li X, An Y, Wang J, Jin A. Resistin promotes intervertebral disc degeneration by upregulation of ADAMTS-5 through p38 MAPK signaling pathway. Spine 2016;41:1414–1420.
  • Zhang Z, Xing X, Hensley G, Chang L-W, Liao W, Abu-Amer Y, Sandell LJ. Resistin induces expression of pro-inflammatory cytokines and chemokines in human articular chondrocytes via transcription and mRNA stabilization. Arthritis Rheum 2010;62:1993–2003.
  • Zhang Z, Zhang Z, Kang Y, Hou C, Duan X, Sheng P, Sandell L, Liao W. Resistin stimulates expression of chemokine genes in chondrocytes via combinatorial regulation of C/EBPβ and NF-κB. Int J Mol Sci 2014;15:17242–17255.
  • Vuolteenaho K, Leppänen T, Kekkonen R, Korpela R, Moilanen E. Running a marathon induces changes in adipokine levels and in markers of cartilage degradation – novel role for resistin. PLoS ONE 2014;9:e110481.
  • Song Y-Z, Guan J, Wang H-J, Ma W, Li F, Xu F, Ding L-B, Xie L, Liu B, Liu K, Lv Z. possible involvement of serum and synovial fluid resistin in knee osteoarthritis: cartilage damage, clinical, and radiological links. J Clin Lab Anal 2016;30(5):437–443.
  • Wang K, Xu J, Cai J, Zheng S, Yang X, Ding C. Serum levels of resistin and interleukin-17 are associated with increased cartilage defects and bone marrow lesions in patients with knee osteoarthritis. Mod Rheumatol 2016. doi:10.1080/14397595.2016.1205777 [Epub ahead of print]
  • Karachalios T, Zibis A, Papanagiotou P, Karantanas AH, Malizos KN, Roidis N. MR imaging findings in early osteoarthritis of the knee. Eur J Radiol 2004;50:225–230.
  • Bennett LD. Meniscal and articular cartilage changes in knee osteoarthritis: a cross-sectional double-contrast macroradiographic study. Rheumatology 2002;41:917–923.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.