The involvement of the ERK-MAPK pathway in TGF-β1–mediated connexin43-gap junction formation in chondrocytes

References

• Bhosale AM, Richardson JB. Articular cartilage: structure, injuries and review of management. Br Med Bull. 2008;87(1):77–95. doi:10.1093/bmb/ldn025.
   PubMed Web of Science ®Google Scholar
• Xie J, Fu N, Cai LY, Gong T, Li G, Peng Q, Cai XX. The effects of interleukin-1β in modulating osteoclast-conditioned medium’s influence on gelatinases in chondrocytes through mitogen-activated protein kinases. Int J Oral Sci. 2015;7(4):220–231. doi:10.1038/ijos.2015.39.
   PubMed Web of Science ®Google Scholar
• Nimlamool W, Andrews RM, Falk MM. Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization. Mol Biol C. 2015;26(15):2755–2768.
   PubMed Web of Science ®Google Scholar
• Plotkin LI, Laird DW, Amedee J. Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone. BMC Cell Biol. 2016;17(1):29–38. doi:10.1186/s12860-016-0107-7.
   PubMedGoogle Scholar
• Plotkin LI, Stains JP. Connexins and pannexins in the skeleton: gap junctions, hemichannels and more. Cell Mol Life Sci. 2015;72(15):2853–2867.
   PubMed Web of Science ®Google Scholar
• Mayan MD, Gagofuentes R, Carpinterofernandez P, Fernandez-Puente P, Filgueira-Fernandez P, Goyanes N, Valiunas V, Brink PR, Goldberg GS, Blanco FJ. Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis. Ann Rheum Dis. 2015;74:275–284. doi:10.1136/annrheumdis-2013-204244.
   PubMed Web of Science ®Google Scholar
• Marino AA, Waddell DD, Kolomytkin OV, Meek WD, Wolf R, Sadasivan KK, Albright JA. Increased intercellular communication through gap junctions may contribute to progression of osteoarthritis. Clin Orthop Relat Res. 2004;422:224–232.
   Web of Science ®Google Scholar
• Ohno S, Tanaka N, Ueki M, Honda K, Tanimoto K, Yoneno K, Ohno-Nakahara M, Fujimoto K, Kato Y, Tanne K. Mechanical regulation of terminal chondrocyte differentiation via RGD-CAP/beta ig-h3 induced by TGF-beta. Connect Tissue Res. 2005;46(4–5):227–234.
   PubMed Web of Science ®Google Scholar
• Kuczma M, C Y W, Ignatowicz L, Gourdie R, Kraj P. Altered connexin 43 expression underlies age-dependent decrease of regulatory T cell suppressor function in nonobese diabetic mice. JImmunol. 2015;194(11):5261–5271.
   PubMed Web of Science ®Google Scholar
• Hills C, Price GW, Wall MJ, Kaufmann TJ, Chi-Wai Tang S, Yiu WH, Squires PE. Transforming growth factor beta 1 drives a switch in connexin mediated cell-to-cell communication in tubular cells of the diabetic kidney. Cell Physiol Biochem. 2018;45(6):2369–2388.
   PubMed Web of Science ®Google Scholar
• Mu Y, Gudey SK, Landstrom M. Non-Smad signaling pathways. Cell Tissue Res. 2012;347(1):11–20. doi:10.1007/s00441-011-1201-y.
   PubMed Web of Science ®Google Scholar
• Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 2004;23(16):2838–2849. doi:10.1038/sj.onc.1207556.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Yu L, Qiu F, Fan Y, Fu G. Down-regulation of connexin43 gap junction by serum deprivation in human endothelial cells was improved by (-)-epigallocatechingallate via ERK MAP kinase pathway. Biochem Biophys Res Commun. 2011;404(1):217–222. doi:10.1016/j.bbrc.2010.11.096.
   PubMed Web of Science ®Google Scholar
• Epifantseva I, Shaw RM. Intracellular trafficking pathways of Cx43 gap junction channels. Biochim Biophys Acta Biomemb. 2018;1860(1):40–47.
   PubMed Web of Science ®Google Scholar
• Watanabetakano H, Takano K, Hatano M, Hatano M, Tokuhisa T, Endo T. DA-Raf-mediated suppression of the Ras—ERK pathway is essential for TGF-β1-induced epithelial—mesenchymal transition in alveolar epithelial Type 2 cells. PLoS One. 2015;10(15):e0127888. doi:10.1371/journal.pone.0127888.
   PubMed Web of Science ®Google Scholar
• Babica P, Sovadinová I, Upham BL. Scrape Loading/Dye Transfer Assay. Methods Mol Biol. 2016;1437:133.
   PubMedGoogle Scholar
• Zhang FF, Morioka N, Nakashimahisaoka K, Nakata Y. Spinal astrocytes stimulated by tumor necrosis factor-α and/or interferon-γ attenuate connexin 43-gap junction via c-jun terminal kinase activity. J Neurosci Res. 2013;91(6):745–756. doi:10.1002/jnr.23213.
   PubMed Web of Science ®Google Scholar
• Jacobsen NL, Pontifex TK, Li H, Solan JL, Lampe PD, Sorgen PL, Burt JM. Regulation of cx37 channel and growth-suppressive properties by phosphorylation. J Cell Sci. 2017;130(19):3308–3321. doi:10.1242/jcs.200857.
   PubMed Web of Science ®Google Scholar
• Su X, Wang X, Zhang K, Yang S, Xue Q, Wang P, Liu Q. ERK inhibitor U0126 enhanced SDT-induced cytotoxicity of human leukemia U937 cells. Gen Physiol Biophys. 2014;33(3):295.
   PubMed Web of Science ®Google Scholar
• Li J, Zhao Z, Liu J, Huang N, Long D, Wang J, Li X, Liu Y. MEK/ERK and p38 MAPK regulate chondrogenesis of rat bone marrow mesenchymal stem cells through delicate interaction with TGF-beta1/Smads pathway. Cell Prolif. 2010;43(4):333–343. doi:10.1111/j.1365-2184.2010.00682.x.
   PubMed Web of Science ®Google Scholar
• Xie J, Zhang D, Lin Y, Yuan Q, Zhou X. Anterior cruciate ligament transection-induced cellular and extracellular events in menisci: implications for osteoarthritis. Am J Sports Med. 2018;46(5):1185–1198. doi:10.1177/0363546518756087.
   PubMed Web of Science ®Google Scholar
• Stains J, Civitelli R. Gap junctions in skeletal development and function. Biochim Biophys Acta. 2005;1719(1):69–81.
   PubMed Web of Science ®Google Scholar
• Ribeirorodrigues TM, Martinsmarques T, Morel S, Kwak BR, Girão H. Role of connexin 43 in different forms of intercellular communication - gap junctions, extracellular vesicles and tunnelling nanotubes. J Cell Sci. 2017;130(21):3619–3630. doi:10.1242/jcs.200667.
   PubMed Web of Science ®Google Scholar
• Sato M, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, Takeya T, Minamisawa S, Lanier SM, Ishikawa Y. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J Biol Chem. 2009;284(45):31431–31440.
   PubMed Web of Science ®Google Scholar
• Wang Q, Zhou C, Li X, Cai X, Cai L, Zou J, Zhang D, Xie J, Lai W. TGF-β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling. Cell Prolif. 2018;e12544. doi:10.1111/cpr.12544.
   PubMed Web of Science ®Google Scholar
• Ikushima H, Miyazono K. TGFβ signalling: a complex web in cancer progression. Nat Rev Cancer. 2010;10(6):415–424. doi:10.1038/nrc2853.
   PubMed Web of Science ®Google Scholar
• Sun Y, W Z L, Liu T, Feng X, Yang N, Zhou HF. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 2015;35(6):600–604. doi:10.3109/10799893.2015.1030412.
   PubMed Web of Science ®Google Scholar
• Shishido SN, Nguyen TA. Induction of apoptosis by PQ1, a gap junction enhancer that upregulates connexin 43 and activates the MAPK signaling pathway in mammary carcinoma cells. IntJ Mol Sci. 2016;17(2):178. doi:10.3390/ijms17020178.
   PubMed Web of Science ®Google Scholar
• Zhang YE. Non-Smad signaling pathways of the TGF-β family. Cold Spring Harb Perspect Biol. 2017;9(2):a022129. doi:10.1101/cshperspect.a022129.
   PubMed Web of Science ®Google Scholar
• Hayashida T, Decaestecker M, Schnaper HW. Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF- beta-dependent responses in human mesangial cells. FASEB J. 2003;17(11):1576–1578. doi:10.1096/fj.03-0037fje.
   PubMed Web of Science ®Google Scholar
• Hebert C, Stains JP. An intact connexin43 is required to enhance signaling and gene expression in osteoblast-like cells. J Cell Biochem. 2013;114(11):2542–2550. doi:10.1002/jcb.24603.
   PubMed Web of Science ®Google Scholar
• Aasen T, Mesnil M, Naus CC, Lampe PD, Laird DW. Gap junctions and cancer: communicating for 50 years. Nat Rev Cancer. 2017;17(1):74. doi:10.1038/nrc.2016.142.
   PubMed Web of Science ®Google Scholar