Clinical and laboratory findings following transplantation of allogeneic adipose-derived mesenchymal stromal cells in knee osteoarthritis, a brief report

References

• Testa G, Giardina SMC, Culmone A, Vescio A, Turchetta M, Cannavò S Pavone V. Intra-Articular injections in knee osteoarthritis: a review of literature. J Funct Morphol Kinesiol. 2021;6(1): 15. doi:10.3390/jfmk6010015.
   PubMedGoogle Scholar
• Shah K, Zhao AG Sumer H. New approaches to treat osteoarthritis with mesenchymal stem cells. Stem Cells Int. 2018;2018: 1–9. doi:10.1155/2018/5373294.
   Web of Science ®Google Scholar
• Deshpande BR, Katz JN, Solomon DH, Yelin EH, Hunter DJ, Messier SP, Suter LG Losina E. Number of persons with symptomatic knee osteoarthritis in the US: impact of race and ethnicity, age, sex, and obesity. Arthritis Care Res. 2016;68(12): 1743–1750. doi:10.1002/acr.22897.
   PubMed Web of Science ®Google Scholar
• Sasaki E, Ota S, Chiba D, Kimura Y, Sasaki S, Yamamoto Y, Tsuda E, Nakaji S Ishibashi Y. Early knee osteoarthritis prevalence is highest among middle-aged adult females with obesity based on new set of diagnostic criteria from a large sample cohort study in the Japanese general population. Knee Surg Sports Traumatol Arthrosc. 2020;28(3): 984–994. doi:10.1007/s00167-019-05614-z.
   PubMed Web of Science ®Google Scholar
• Driban JB, Harkey MS, Barbe MF, Ward RJ, MacKay JW, Davis JE, Lu B, Price LL, Eaton CB Lo GH, McAlindon TE. Risk factors and the natural history of accelerated knee osteoarthritis: a narrative review. BMC Musculoskelet Disord. 2020;21(1): 1–11. doi:10.1186/s12891-020-03367-2.
   Web of Science ®Google Scholar
• Lu Y, Zhang W, Wang J, Yang G, Yin S, Tang T, Yu C Jiang X. Recent advances in cell sheet technology for bone and cartilage regeneration: from preparation to application. Int J Oral Sci. 2019;11(2): 1–13. doi:10.1038/s41368-019-0050-5.
   PubMed Web of Science ®Google Scholar
• Zhou Z, Wu W, Fang J Yin J. Polymer-Based porous microcarriers as cell delivery systems for applications in bone and cartilage tissue engineering. Int Mater Rev. 2021;66(2): 77–113. doi:10.1080/09506608.2020.1724705.
   Web of Science ®Google Scholar
• Rahmani Del Bakhshayesh A, Babaie S, Tayefi Nasrabadi H, Asadi N, Akbarzadeh A Abedelahi A. An overview of various treatment strategies, especially tissue engineering for damaged articular cartilage. Artif Cells Nanomed Biotechnol. 2020;48(1): 1089–1104. doi:10.1080/21691401.2020.1809439.
   PubMed Web of Science ®Google Scholar
• Urlić I Ivković A. Cell sources for cartilage repair—biological and clinical perspective. Cells. 2021;10(9): 2496. doi:10.3390/cells10092496.
   PubMed Web of Science ®Google Scholar
• Musiał-Wysocka A, Kot M Majka M. The pros and cons of mesenchymal stem cell-based therapies. Cell Transplant. 2019;28(7): 801–812. doi:10.1177/0963689719837897.
   PubMed Web of Science ®Google Scholar
• Macrin D, Joseph JP, Pillai AA Devi A. Eminent sources of adult mesenchymal stem cells and their therapeutic imminence. Stem Cell Rev Rep. 2017;13(6): 741–756. doi:10.1007/s12015-017-9759-8.
   PubMed Web of Science ®Google Scholar
• Dabrowska S, Andrzejewska A, Janowski M Lukomska B. Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases. Front Immunol. 2021;11: 3809. doi:10.3389/fimmu.2020.591065.
   Web of Science ®Google Scholar
• Vasiliadis AV Galanis N. Effectiveness of ad-MSCs injections for the treatment of knee osteoarthritis: analysis of the current literature. J Stem Cells Regen Med. 2020;16(1): 3.
   PubMed Web of Science ®Google Scholar
• Lam AT, Reuveny S Oh SK. Human mesenchymal stem cell therapy for cartilage repair: review on isolation, expansion, and constructs. Stem Cell Res. 2020;44(101738): 101738. doi:10.1016/j.scr.2020.101738.
   PubMed Web of Science ®Google Scholar
• McIntyre JA, Jones IA, Han B Vangsness CT. Intra-Articular mesenchymal stem cell therapy for the human joint: a systematic review. Am J Sports Med. 2018;46(14): 3550–3563. doi:10.1177/0363546517735844.
   PubMed Web of Science ®Google Scholar
• Burrow KL, Hoyland JA Richardson SM. Human adipose-derived stem cells exhibit enhanced proliferative capacity and retain multipotency longer than donor-matched bone marrow mesenchymal stem cells during expansion in vitro. Stem Cells Int. 2017;2017: 1–15. doi:10.1155/2017/2541275.
   Web of Science ®Google Scholar
• Han X, Yang B, Zou F Sun J. Clinical therapeutic efficacy of mesenchymal stem cells derived from adipose or bone marrow for knee osteoarthritis: a meta-analysis of randomized controlled trials. J Comp Eff Res. 2020;9(5): 361–374. doi:10.2217/cer-2019-0187.
   PubMed Web of Science ®Google Scholar
• Pers Y-M, Quentin J, Feirreira R, Espinoza F, Abdellaoui N, Erkilic N, Cren M, Dufourcq-Lopez E, Pullig O, Nöth U, Jorgensen C Louis-Plence P. Injection of adipose-derived stromal cells in the knee of patients with severe osteoarthritis has a systemic effect and promotes an anti-inflammatory phenotype of circulating immune cells. Theranostics. 2018;8(20): 5519. doi:10.7150/thno.27674.
   PubMed Web of Science ®Google Scholar
• Wang Y, Shimmin A, Ghosh P, Marks P, Linklater J, Connell D, Hall S, Skerrett D, Itescu S Cicuttini FM. Safety, tolerability, clinical, and joint structural outcomes of a single intra-articular injection of allogeneic mesenchymal precursor cells in patients following anterior cruciate ligament reconstruction: a controlled double-blind randomised trial. Arthritis Res Ther. 2017;19(1): 180. doi:10.1186/s13075-017-1391-0.
   PubMed Web of Science ®Google Scholar
• Park YB, Ha CW, Lee CH, Yoon YC Park YG. Cartilage regeneration in osteoarthritic patients by a composite of allogeneic umbilical cord blood‐derived mesenchymal stem cells and hyaluronate hydrogel: results from a clinical trial for safety and proof‐of‐concept with 7 years of extended follow‐up. Stem Cells Trans Med. 2017;6(2): 613–621. doi:10.5966/sctm.2016-0157.
   PubMed Web of Science ®Google Scholar
• Soltani SK, Forogh B, Ahmadbeigi N, Kharazi HH, Fallahzadeh K, Kashani L, Karami M, Kheyrollah Y Vasei M. Safety and efficacy of allogenic placental mesenchymal stem cells for treating knee osteoarthritis: a pilot study. Cytotherapy. 2019;21(1): 54–63. doi:10.1016/j.jcyt.2018.11.003.
   PubMed Web of Science ®Google Scholar
• Zhao X, Ruan J, Tang H, Li J, Shi Y, Li M, Li S, Xu C, Lu Q Dai C. Multi-Compositional MRI evaluation of repair cartilage in knee osteoarthritis with treatment of allogeneic human adipose-derived mesenchymal progenitor cells. Stem Cell Res Ther. 2019;10(1): 308. doi:10.1186/s13287-019-1406-7.
   PubMed Web of Science ®Google Scholar
• Lu L, Dai C, Du H, Li S, Ye P, Zhang L, Wang X, Song Y, Togashi R Vangsness CT, Bao C. Intra-Articular injections of allogeneic human adipose-derived mesenchymal progenitor cells in patients with symptomatic bilateral knee osteoarthritis: a phase I pilot study. Regen Med. 2020;15(5): 1625–1636. doi:10.2217/rme-2019-0106.
   PubMed Web of Science ®Google Scholar
• Sadri B, Sh N, Hossein-Khannazer N, Mohammadi J Vosough M. Current and novel theranostic modalities for knee osteoarthritis. Сеченовский Вестник. 2021;12(3): 17–30.
   Google Scholar
• Ha C-W, Park Y-B, Kim SH Lee HJ. Intra-Articular mesenchymal stem cells in osteoarthritis of the knee: a systematic review of clinical outcomes and evidence of cartilage repair. Arthroscopy. 2019;35(1): 277–288. doi:10.1016/j.arthro.2018.07.028.
   PubMed Web of Science ®Google Scholar
• Dai W, Leng X, Wang J, Shi Z, Cheng J, Hu X Ao Y. Intra-Articular mesenchymal stromal cell injections are no different from placebo in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Arthroscopic. 2021;37(1): 340–358. doi:10.1016/j.arthro.2020.10.016.
   PubMed Web of Science ®Google Scholar
• Xiang X-N, Zhu S-Y, H-C H, Yu X, Xu Y He CQ. Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis. Stem Cell Res Ther. 2022;13(1): 1–20. doi:10.1186/s13287-021-02689-9.
   PubMed Web of Science ®Google Scholar
• Alonso-Goulart V, Ferreira LB, Duarte CA, de Lima IL, Ferreira ER, de Oliveira BC, Vargas LN, de Moraes DD, Silva IBB de Oliveira Faria R, Souza AGD, Castro-Filice LDS. Mesenchymal stem cells from human adipose tissue and bone repair: a literature review. Biotechnol Res Innov. 2018;2(1): 74–80. doi:10.1016/j.biori.2017.10.005.
   Google Scholar
• Estrada E, Décima JL, Rodríguez M, Di Tomaso M Roberti J. Patient-Reported outcomes after platelet-rich plasma, bone marrow aspirate, and adipose-derived mesenchymal stem cell injections for symptomatic knee osteoarthritis. Clin Med Insights Arthritis Musculoskelet Disord. 2020;13: 1179544120931086. doi:10.1177/1179544120931086.
   Web of Science ®Google Scholar
• Mautner K, Carr D, Whitley J Bowers R. Allogeneic versus autologous injectable mesenchymal stem cells for knee osteoarthritis: Review and current status. Tech Orthop. 2019;34(4): 244–256. doi:10.1097/BTO.0000000000000357.
   Web of Science ®Google Scholar
• Weiss ARR Dahlke MH Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead mscs. Front immunol. 2019;10: 1191.
   PubMed Web of Science ®Google Scholar
• Vega A, Martín-Ferrero MA, Del Canto F, Alberca M, García V, Munar A, Orozco L, Soler R, Fuertes JJ, Huguet M, Sánchez A García-Sancho J. Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: a randomized controlled trial. Transplantation. 2015;99(8): 1681–1690. doi:10.1097/TP.0000000000000678.
   PubMed Web of Science ®Google Scholar
• Song Y, Du H, Dai C, Zhang L, Li S, Hunter DJ, Lu L Bao C. Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections. Regen Med. 2018;13(3): 295–307. doi:10.2217/rme-2017-0152.
   PubMed Web of Science ®Google Scholar
• Cabon Q, Febre M, Gomez N, Cachon T, Pillard P, Carozzo C, Saulnier N, Robert C, Livet V Rakic R, Plantier N, Saas P, Maddens S, Viguier E. Long-Term safety and efficacy of single or repeated intra-articular injection of allogeneic neonatal mesenchymal stromal cells for managing pain and lameness in moderate to severe canine osteoarthritis without anti-inflammatory pharmacological support: pilot clinical study. Front Vet Sci. 2019;6:10.
   PubMed Web of Science ®Google Scholar
• Pers Y-M, Rackwitz L, Ferreira R, Pullig O, Delfour C, Barry F, Sensebe L, Casteilla L, Fleury S, Bourin P, Noël D, Canovas F, Cyteval C, Lisignoli G, Schrauth J, Haddad D, Domergue S, Noeth U Jorgensen C. Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase I dose-escalation trial. Stem Cells Trans Med. 2016;5(7): 847–856. doi:10.5966/sctm.2015-0245.
   PubMed Web of Science ®Google Scholar
• Jo CH, Chai JW, Jeong EC, Oh S, Shin JS, Shim H Yoon KS. Intra-Articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a 2-year follow-up study. Am J Sports Med. 2017;45(12): 2774–2783. doi:10.1177/0363546517716641.
   PubMed Web of Science ®Google Scholar
• Sekiya I, Katano H, Mizuno M, Koga H, Masumoto J, Tomita M Ozeki N. Alterations in cartilage quantification before and after injections of mesenchymal stem cells into osteoarthritic knees. Sci Rep. 2021;11(1): 1–14. doi:10.1038/s41598-021-93462-8.
   PubMed Web of Science ®Google Scholar
• Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS Shin IS, Ra JC, Oh S, Yoon KS. Intra‐articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof‐of‐concept clinical trial. Stem Cells. 2014;32(5): 1254–1266. doi:10.1002/stem.1634.
   PubMed Web of Science ®Google Scholar
• Stannus O, Jones G, Cicuttini F, Parameswaran V, Quinn S, Burgess J Ding C. Circulating levels of il-6 and tnf-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Ostenarthr Cartil. 2010;18(11): 1441–1447. doi:10.1016/j.joca.2010.08.016.
   PubMed Web of Science ®Google Scholar
• Li J, Shao Q, Zhu X Sun G. Efficacy of autologous bone marrow mesenchymal stem cells in the treatment of knee osteoarthritis and their effects on the expression of serum tnf-α and il-6. J Musculoskelet Neuronal Interact. 2020;20(1): 128.
   PubMed Web of Science ®Google Scholar
• Potere N, Batticciotto A, Vecchié A, Porreca E, Cappelli A, Abbate A, Dentali F Bonaventura A. The role of il-6 and il-6 blockade in COVID-19. Expert Rev Clin Immunol. 2021;17(6): 601–618. doi:10.1080/1744666X.2021.1919086.
   PubMed Web of Science ®Google Scholar
• Haddad R Saldanha-Araujo F. Mechanisms of t-cell immunosuppression by mesenchymal stromal cells: what do we know so far? Biomed Res Int. 2014;2014: 1–14. doi:10.1155/2014/216806.
   Web of Science ®Google Scholar
• Jiao Q, Wei L, Chen C, Li P, Wang X, Li Y, Guo L, Zhang C Wei X. Cartilage oligomeric matrix protein and hyaluronic acid are sensitive serum biomarkers for early cartilage lesions in the knee joint. Biomarkers. 2016;21(2): 146–151. doi:10.3109/1354750X.2015.1118547.
   PubMed Web of Science ®Google Scholar
• Chahal J, Gómez-Aristizábal A, Shestopaloff K, Bhatt S, Chaboureau A, Fazio A, Chisholm J, Weston A, Chiovitti J Keating A, Kapoor M, Ogilvie-Harris DJ, Syed KA, Gandhi R, Mahomed NN, Marshall KW, Sussman MS, Naraghi AM, Viswanathan S. Bone marrow mesenchymal stromal cell treatment in patients with osteoarthritis results in overall improvement in pain and symptoms and reduces synovial inflammation. Stem Cells Transl Med. 2019;8(8): 746–757. doi:10.1002/sctm.18-0183.
   PubMed Web of Science ®Google Scholar
• Bannuru RR, McAlindon TE, Sullivan MC, Wong JB, Kent DM Schmid CH. Effectiveness and implications of alternative placebo treatments: a systematic review and network meta-analysis of osteoarthritis trials. Ann Intern Med. 2015;163(5): 365–372. doi:10.7326/M15-0623.
   PubMed Web of Science ®Google Scholar