Post-injury tendon mechanics are not affected by tamoxifen treatment

References

• Lantto I, Heikkinen J, Flinkkilä T, Ohtonen P, Leppilahti J. Epidemiology of Achilles tendon ruptures: increasing incidence over a 33-year period. Scand J Med Sci Sports. 2015;25(1):e133–e138 [accessed 2020 Nov 10]. doi:10.1111/sms.12253.
   PubMed Web of Science ®Google Scholar
• Lakso M, Sauer B, Mosinger B, Lee EJ, Manning RW, Yu SH, Mulder KL, Westphal H. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci USA. 1992;89(14):6232–6236 [accessed 2020 Nov 10]. doi:10.1073/pnas.89.14.6232.
   PubMed Web of Science ®Google Scholar
• Lobe CG, Nagy A. Conditional genome alteration in mice. BioEssays. 1998;20(3):200–208 [accessed 2020 Nov 10]. doi:10.1002/(SICI)1521-1878(199803)20:3<200:AID-BIES3>3.0.CO;2-V.
   PubMed Web of Science ®Google Scholar
• Metzger D, Clifford J, Chiba H, Chambon P. Conditional site-specific recombination in mammalian cells using a ligand- dependent chimeric Cre recombinase. Proc Natl Acad Sci USA. 1995;92(15):6991–6995. [accessed 2020 Nov 10]. doi:10.1073/pnas.92.15.6991.
   PubMed Web of Science ®Google Scholar
• Schwenk F, Kühn R, Angrand PO, Rajewsky K, Stewart AF. Temporally and spatially regulated somatic mutagenesis in mice. Nucleic Acids Res. 1998;26(6):1427–1432. [accessed 2020 Nov 10]. doi:10.1093/nar/26.6.1427.
   PubMed Web of Science ®Google Scholar
• Barbieri RL. 2009. The Breast. In: Yen & Jaffe’s Reproductive Endocrinology. Elsevier. p. 235–248.
   Google Scholar
• Nakai M, Uchida K, Teuscher C. The development of male reproductive organ abnormalities after neonatal exposure to tamoxifen is genetically determined. J Androl. 1999;20(5):626–634 [accessed 2020 Nov 10].
   PubMedGoogle Scholar
• Tucker HLM, Holdridge J, Parsons CLM, Akers RM. Excess deposition of collagen in mammary glands of tamoxifen-treated Holstein heifers is associated with impaired mammary growth. Domest Anim Endocrinol. 2018;65:49–55 [accessed 2020 Nov 10]. doi:10.1016/j.domaniend.2018.05.006.
   PubMed Web of Science ®Google Scholar
• Mao D, Mi J, Pan X, Li F, Rui Y. Tamoxifen inhibits the progression of trauma-induced heterotopic ossification in mice. Med Sci Monit. 2019;25:7872–7881 [[accessed 2020 Nov 10]. doi:10.12659/MSM.916733.
   Web of Science ®Google Scholar
• Zahreddine R, Davezac M, Smirnova NF, Buscato M, Lhuillier E, Lupieri A, Solinhac R, Vinel A, Vessieres E, Henrion D, Renault M-A, Gadeau A-P, Flouriot G, Lenfant F, Laffargue M, Métivier R, Arnal J-F, Fontaine C. Tamoxifen accelerates endothelial healing by targeting ERα in smooth muscle cells. Circ Res. 2020;127(12):1473–1487 [accessed 2020 Nov 10]. doi:10.1161/circresaha.120.317062.
   PubMed Web of Science ®Google Scholar
• Abot A, Fontaine C, Raymond-Letron I, Flouriot G, Adlanmerini M, Buscato M, Otto C, Bergès H, Laurell H, Gourdy P, Lenfant F, Arnal J-F. The AF-1 activation function of estrogen receptor α is necessary and sufficient for uterine epithelial cell proliferation in vivo. Endocrinology. 2013;154(6):2222–2233 [accessed 2022 Feb 25]. doi:10.1210/en.2012-2059.
   PubMed Web of Science ®Google Scholar
• Best KT, Studentsova V, Ackerman JE, Nichols AEC, Myers M, Cobb J, Knapp E, Awad HA, Loiselle AE. Effects of tamoxifen on tendon homeostasis and healing: considerations for the use of tamoxifen-inducible mouse models. J Orthop Res. 2020;39(7):jor.24767 [ accessed 2020 Nov 10]. doi:10.1002/jor.24767.
   PubMed Web of Science ®Google Scholar
• Beason DP, Kuntz AF, Hsu JE, Miller KS, Soslowsky LJ. Development and evaluation of multiple tendon injury models in the mouse. J Biomech. 2012;45(8):1550–1553 [accessed 2016 Jul 11]. doi:10.1016/j.jbiomech.2012.02.022.
   PubMed Web of Science ®Google Scholar
• Robinson KA, Sun M, Barnum CE, Weiss SN, Huegel J, Shetye SS, Lin L, Saez D, Adams SM, Iozzo RV, Soslowsky LJ, Birk DE. Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons. Matrix Biol. 2017;64:81–93 [ accessed 2017 Sep 25]. doi:10.1016/j.matbio.2017.08.004.
   PubMed Web of Science ®Google Scholar
• Dunkman AA, Buckley MR, Mienaltowski MJ, Adams SM, Thomas SJ, Kumar A, Beason DP, Iozzo RV, Birk DE, Soslowsky LJ. The injury response of aged tendons in the absence of biglycan and decorin. Matrix Biol. 2014;35:232–238 [accessed 2016 Jul 13]. doi:10.1016/j.matbio.2013.10.008.
   PubMed Web of Science ®Google Scholar
• Dunkman AA, Buckley MR, Mienaltowski MJ, Adams SM, Thomas SJ, Satchell L, Kumar A, Pathmanathan L, Beason DP, Iozzo RV, Birk DE, Soslowsky LJ. The tendon injury response is influenced by decorin and biglycan. Ann Biomed Eng. 2014;42(3):619–630. [accessed 2016 Jul 13]. doi:10.1007/s10439-013-0915-2.
   PubMed Web of Science ®Google Scholar
• Peltz CD, Perry SM, Getz CL, Soslowsky LJ. Mechanical properties of the long-head of the biceps tendon are altered in the presence of rotator cuff tears in a rat model. J. Orthop. Res. 2009;27(3):416–420. doi:10.1002/jor.20770.
   PubMed Web of Science ®Google Scholar
• Lake SP, Miller KS, Elliott DM, Soslowsky LJ. Effect of fiber distribution and realignment on the nonlinear and inhomogeneous mechanical properties of human supraspinatus tendon under longitudinal tensile loading. J Orthop Res. 2009;27(12):1596–1602 [accessed 2016 May 31]. doi:10.1002/jor.20938.
   PubMed Web of Science ®Google Scholar
• Miller KS, Connizzo BK, Feeney E, Soslowsky LJ. Characterizing local collagen fiber re-alignment and crimp behavior throughout mechanical testing in a mature mouse supraspinatus tendon model. J Biomech. 2012;45(12):2061–2065 [accessed 2019 May 30]. doi:10.1016/J.JBIOMECH.2012.06.006
   PubMed Web of Science ®Google Scholar
• Ma X, Liu Y, Wang Q, Chen Y, Liu M, Li X, Xiang R, Wei Y, Duan Y, Han J. Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. Biochimica et Biophysica Acta Mol Basis Dis. 2015:1852(5):1038–1048. doi:10.1016/j.bbadis.2015.02.006.
   Web of Science ®Google Scholar
• Li X, Clappier C, Kleiter I, Heuchel R. Tamoxifen affects chronic pancreatitis-related fibrogenesis in an experimental mouse model: an effect beyond Cre recombination. FEBS Open Bio. 2019;9(10):1756–1768 [accessed 2020 Nov 25]. doi:10.1002/2211-5463.12714.
   PubMed Web of Science ®Google Scholar
• Ashcroft GS, Mills SJ, Lei KJ, Gibbons L, Jeong MJ, Taniguchi M, Burow M, Horan MA, Wahl SM, Nakayama T. Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J Clin Invest. 2003:111(9):1309 [accessed 2022 Mar 2]. doi:10.1172/JCI16288.
   PubMed Web of Science ®Google Scholar