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Original Article

Increased levels of alveolar and airway exhaled nitric oxide in runners

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Pages 85-91 | Received 30 Jan 2017, Accepted 06 Apr 2017, Published online: 08 May 2017

References

  • Ricciardolo FL. Multiple roles of nitric oxide in the airways. Thorax. 2003;58:175–82.
  • Moilanen E, Vapaatalo H. Nitric oxide in inflammation and immune response. Ann Med. 1995;27:359–67.
  • Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun. 1991;181:852–7.
  • Kharitonov SA, Yates DH, Chung KF, Barnes PJ. Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. Eur Respir J. 1996;9:196–201.
  • Hellsten Y, Nyberg M. Cardiovascular adaptations to exercise training. Compr Physiol. 2015;6:1–32.
  • McKenzie DC. Respiratory physiology: adaptations to high-level exercise. Br J Sports Med. 2012;46:381–4.
  • Nosarev AV, Smagliy LV, Anfinogenova Y, Popov SV, Kapilevich LV. Exercise and NO production: relevance and implications in the cardiopulmonary system. Front Cell Dev Biol. 2014;2:73.
  • Tsoukias NM, George SC. A two-compartment model of pulmonary nitric oxide exchange dynamics. J Appl Phsyiol. 1998;85:653–66.
  • Horwath I, Barnes PJ, Loukides S, Sterk PJ, Högman M, Olin AC. An official European Respiratory Society Technical Standard: exhaled biomarkers in lung disease. Eur Respir J. 2017;49:1600965. DOI: 10.1183/13993003.00965-2016.
  • Högman M, Strömberg S, Schedin U, Frostell C, Hedenstierna G, Gustafsson LE. Nitric oxide from the human respiratory tract efficiently quantified by standardized single breath measurements. Acta Physiol Scand. 1997;159:345–6.
  • Silkoff PE, McClean PA, Slutsky AS, Furlott HG, Hoffstein E, Wakita S, et al. Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am J Respir Crit Care Med. 1997;155:260–7.
  • American Thoracic Society; European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005;171:912–30.
  • Högman M, Ludviksdottir D, Anderson SD, George SC, Håkansson L, Chan HK, et al. Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects. Respir Physiol. 2001;124:141–50.
  • Högman M, Drca N, Ehrstedt C, Meriläinen M. Exhaled nitric oxide partitioned into alveolar, lower airways and nasal contributions. Respir Med. 2000;94:985–91.
  • Cordain L, Stager J. Pulmonary structure and function in swimmers. Sports Med. 1988;6:271–8.
  • Duong-Quy S, Hua-Huy T, Tran-Mai-Thi HT, Le-Dong NN, Craig TJ, Dinh-Xuan AT. Study of exhaled nitric oxide in subjects with suspected obstructive sleep apnea: a pilot study in Vietnam. Pulm Med. 2016;2016:3050918.
  • Lehtimäki L, Kankaanranta H, Saarelainen S, Turjanmaa V, Moilanen E. Peripheral inflammation in patients with asthmatic symptoms but normal lung function. J Asthma. 2005;42:605–9.
  • Högman M, Holmkvist T, Wegener T, Emtner M, Andersson M, Hedenström H, et al. Extended NO analysis applied to patients with COPD, allergic asthma and allergic rhinitis. Respir Med. 2002;96:24–30.
  • Dempsey JA, Hanson PG, Henderson KS. Exercise-induced arterial hypoxaemia in healthy human subjects at sea level. J Physiol. 1984;355:161–75.
  • Rice AJ, Thornton AT, Gore CJ, Scroop GC, Greville HW, Wagner H, et al. Pulmonary gas exchange during exercise in highly trained cyclists with arterial hypoxemia. J Appl Physiol. 1999;87:1802–12.
  • Hopkins SR, McKenzie DC. Hypoxic ventilatory response and arterial desaturation during heavy work. J Appl Physiol. 1989;67:1119–24.
  • McKenzie DC, O'Hare TJ, Mayo J. The effect of sustained heavy exercise on the development of pulmonary edema in trained male cyclists. Respir Physiol Neurobiol. 2005;145:209–18.
  • Zavorsky GS, Milne EN, Lavorini F, Rienzi JP, Cutrufello PT, Kumar SS, et al. Small changes in lung function in runners with marathon-induced interstitial lung edema. Physiol Rep. 2014;2:e12056.
  • Duplain H, Sartori C, Lepori M, Egli M, Allemann Y, Nicod P, et al. Exhaled nitric oxide in high-altitude pulmonary edema: role in the regulation of pulmonary vascular tone and evidence for a role against inflammation. Am J Respir Crit Care Med. 2000;162:221–4.
  • Kubes P, Granger DN. Nitric oxide modulates microvascular permeability. Am J Physiol. 1992;262:H611–15.
  • Hickok JR, Vasudevan D, Jablonski K, Thomas DD. Oxygen dependence of nitric oxide-mediated signaling. Redox Biol. 2013;1:203–9.
  • Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med. 1993;328:399–405.
  • Tedjasaputra V, Bouwsema MM, Stickland MK. Effect of aerobic fitness on capillary blood volume and diffusing membrane capacity response to exercise. J Appl Physiol. 2016;594:4359–70.
  • Nieman DC, Johanssen LM, Lee JW, Arabatzis K. Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness. 1990;30:316–28.
  • Margonis K, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Douroudos I, Chatzinikolaou A, et al. Oxidative stress biomarkers responses to physical overtraining: implications for diagnosis. Free Radic Biol Med. 2007;43:901–10.
  • Ricciardolo FL, Di Stefano A, Sabatini F, Folkerts G. Reactive nitrogen species in the respiratory tract. Eur J Pharmacol. 2006;533:240–52.
  • Kippelen P, Fitch KD, Anderson SD, Bougault V, Boulet LP, Rundell KW, et al. Respiratory health of elite athletes – preventing airway injury: a critical review. Br J Sports Med. 2012;46:471–6.
  • Nieman DC. Exercise, upper respiratory tract infection, and the immune system. Med Sci Sports Exerc. 1994;26:128–39.
  • Li D, Shirakami G, Zhan X, Johns RA. Regulation of ciliary beat frequency by the nitric oxide-cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells. Am J Respir Cell Mol Biol. 2000;23:175–81.
  • Muns G, Singer P, Wolf F, Rubinstein I. Impaired nasal mucociliary clearance in long-distance runners. Int J Sports Med. 1995;16:209–13.