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Scandinavian Journal of Rheumatology Volume 51, 2022 - Issue 3
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Articles/Brief Reports

Serum levels of n-3 and n-6 polyunsaturated fatty acids in patients with systemic lupus erythematosus and their association with disease activity: a pilot study

D Gorczyca1 Third Department and Clinic of Pediatrics, Immunology and Rheumatology of Developmental Age, Wroclaw Medical University, Wroclaw, PolandCorrespondence[email protected]
,
B Szponar2 Laboratory of Medical Microbiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
,
M Paściak2 Laboratory of Medical Microbiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
,
A Czajkowska2 Laboratory of Medical Microbiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
&
M Szmyrka3 Department of Rheumatology and Internal Diseases, Wroclaw Medical University, Wroclaw, Poland
Pages 230-236 | Accepted 26 Apr 2021, Published online: 25 Jun 2021

  • Hinojosa-Azaola A, Sánchez-Guerrero J. Overview and clinical presentation. In: Wallace DJ, Hahn BH, editors. Dubois’ lupus erythematosus and related syndromes, 8th edn. Philadelphia, PA: Saunders, 2013:304–9.
  • Davis LS, Hutcheson J, Mohan C. The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosus. J Interferon Cytokine Res 2011;31:781–9.
  • Leiba A, Amital H, Gershwin ME, Shoenfeld Y. Diet and lupus. Lupus 2001;10:246–8.
  • Crowe W, Allsopp PJ, Nyland JF, Magee PJ, Strain JJ, Doherty LC, et al. Inflammatory response following in vitro exposure to methylmercury with and without n-3 long chain polyunsaturated fatty acids in peripheral blood mononuclear cells from systemic lupus erythematosus patients compared to healthy controls. Toxicol In Vitro 2018;52:272–8.
  • de Medeiros MCS, Medeiros JCA, de Medeiros HJ, Leitão JCGC, Knackfuss MI. Dietary intervention and health in patients with systemic lupus erythematosus: a systematic review of the evidence. Crit Rev Food Sci Nutr 2019;59:2666–73.
  • Klack K, Bonfa E, Borba Neto EF. Diet and nutritional aspects in systemic lupus erythematosus. Rev Bras Reumatol 2012;52:384–408.
  • Aparicio-Soto M, Sánchez-Hidalgo M, Alarcón-de-la-lastra C. An update on diet and nutritional factors in systemic lupus erythematosus management. Nutr Res Rev 2017;30:118–37.
  • Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? Br J Clin Pharmacol 2013;75:645–62.
  • Fritsche KL. The science of fatty acids and inflammation. Adv Nutr 2015;6:293S–301S.
  • Calder PC. Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance. Biochim Biophys Acta 2015;1851:469–84.
  • Crupi R, Cambiaghi M, Deckelbaum R, Hansen I, Mindes J, Spina E, et al. n-3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-cell activating factor (BAFF) transgenic mice. Prev Med 2012;54:S103–8.
  • Calder PC. The 2008 ESPEN Sir David Cuthbertson lecture: fatty acids and inflammation–from the membrane to the nucleus and from the laboratory bench to the clinic. Clin Nutr 2010;29:5–12.
  • Halade GV, Rahman MM, Bhattacharya A, Barnes JL, Chandrasekar B, Fernandes G. Docosahexaenoic acid-enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus-prone mice. J Immunol 2010;184:5280–6.
  • Pestka JJ, Vines LL, Bates MA, He K, Langohr I. Comparative effects of n-3, n-6 and n-9 unsaturated fatty acid-rich diet consumption on lupus nephritis, autoantibody production and CD4+ T cell-related gene responses in the autoimmune NZBWF1 mouse. PLoS One 2014;9:e100255.
  • Bates MA, Brandenberger C, Langohr II, Kumagai K, Lock AL, Harkema JR, et al. Silica-triggered autoimmunity in lupus-prone mice blocked by docosahexaenoic acid consumption. PLoS One 2016;11:e0160622.
  • Benninghoff AD, Bates MA, Chauhan PS, Wierenga KA, Gilley KN, Holian A, et al. Docosahexaenoic acid consumption impedes early interferon- and chemokine-related gene expression while suppressing silica-triggered flaring of murine lupus. Front Immunol 2019;10:2851.
  • Duffy EM, Meenagh GK, McMillan SA, Strain JJ, Hannigan BM, Bell AL. The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus. J Rheumatol 2004;31:1551–6.
  • Wright SA, O’Prey FM, McHenry MT, Leahey WJ, Devine AB, Duffy EM, et al. A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus. Ann Rheum Dis 2008;67:841–8.
  • Borges MC, Santos Fde M, Telles RW, Correia MI, Lanna CC.Polyunsaturated omega-3 fatty acids and systemic lupus erythematosus: what do we know? [in Portuguese] Rev Bras Reumatol 2014;54:459–66.
  • Arriens C, Hynan LS, Lerman RH, Karp DR, Mohan C. Placebo-controlled randomized clinical trial of fish oil’s impact on fatigue, quality of life, and disease activity in systemic lupus erythematosus. Nutr J 2015;14:82.
  • Westberg G, Tarkowski A. Effect of MaxEPA in patients with SLE. A double-blind, crossover study. Scand J Rheumatol 1990;19:137–43.
  • Bello KJ, Fang H, Fazeli P, Bolad W, Corretti M, Magder LS, et al. Omega-3 in SLE: a double-blind, placebo-controlled randomized clinical trial of endothelial dysfunction and disease activity in systemic lupus erythematosus. Rheumatol Int 2013;33:2789–96.
  • Curado Borges M, de Miranda Moura Dos Santos F, Weiss Telles R, Melo de Andrade MV, Toulson Davisson Correia MI, Lanna CCD. Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study. Rev Bras Reumatol Engl Ed 2017;57:526–34.
  • Clark WF, Parbtani A, Naylor CD, Levinton CM, Muirhead N, Spanner E, et al. Fish oil in lupus nephritis: clinical findings and methodological implications. Kidney Int 1993;44:75–86.
  • Clark WF, Parbtani A, Huff MW, Spanner E, De Salis H, Chin-Yee I, et al. Flaxseed: a potential treatment for lupus nephritis. Kidney Int 1995;48:475–80.
  • Nakamura N, Kumasaka R, Osawa H, Yamabe H, Shirato K, Fujita T, et al. Effects of eicosapentaenoic acids on oxidative stress and plasma fatty acid composition in patients with lupus nephritis. Vivo 2005;19:879–82.
  • Rodríguez-Carrio J, Alperi-López M, López P, Ballina-García FJ, Suárez A. Non-esterified fatty acids profiling in rheumatoid arthritis: associations with clinical features and Th1 response. PLoS One 2016;11:e0159573.
  • Sundström B, Johansson G, Kokkonen H, Cederholm T, Wållberg-Jonsson S. Plasma phospholipid fatty acid content is related to disease activity in ankylosing spondylitis. J Rheumatol 2012;39:327–33.
  • Trebble TM, Arden NK, Wootton SA, Calder PC, Mullee MA, Fine DR, et al. Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease. Am J Clin Nutr 2004;80:1137–44.
  • Aghdassi E, Ma DW, Morrison S, Hillyer LM, Clarke S, Gladman DD, et al. Alterations in circulating fatty acid composition in patients with systemic lupus erythematosus: a pilot study. JPEN J Parenter Enteral Nutr 2011;35:198–208.
  • Wu T, Xie C, Han J, Ye Y, Weiel J, Li Q, et al. Metabolic disturbances associated with systemic lupus erythematosus. PLoS One 2012;7:e37210.
  • Hochberg MC. Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.
  • Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012;64:2677–86.
  • Gladman DD, Ibañez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol 2002;29:288–91.
  • Böcking C, Nockher WA, Schreiner M, Renz H, Pfefferle PI. Development and validation of a combined method for the biomonitoring of omega-3/-6 fatty acids and conjugated linoleic acids in different matrices from human and nutritional sources. Clin Chem Lab Med 2010;48:1757–63.
  • Brown AC. Lupus erythematosus and nutrition: a review of the literature. J Ren Nutr 2000;10:170–83.
  • Fritsche KL. Too much linoleic acid promotes inflammation-doesn’t it? Prostaglandins Leukot Essent Fatty Acids 2008;79:173–5.
  • Li Q, Zhou J, Zhang D, Zhang X, Xu Z, Wu D. Metabolic profiling reveals an abnormal pattern of serum fatty acids in MRL/lpr mice under treatment with prednisone. Front Pharmacol 2020;11:115.
  • Yan B, Huang J, Zhang C, Hu X, Gao M, Shi A, et al. Serum metabolomic profiling in patients with systemic lupus erythematosus by GC/MS. Mod Rheumatol 2016;26:914–22.
  • Elkan AC, Anania C, Gustafsson T, Jogestrand T, Hafström I, Frostegård J. Diet and fatty acid pattern among patients with SLE: associations with disease activity, blood lipids and atherosclerosis. Lupus 2012;21:1405–11.
  • Mohan IK, Das UN. Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. Prostaglandins Leukot Essent Fatty Acids 1997;56:193–8.
  • Walton AJ, Snaith ML, Locniskar M, Cumberland AG, Morrow WJ, Isenberg DA. Dietary fish oil and the severity of symptoms in patients with systemic lupus erythematosus. Ann Rheum Dis 1991;50:463–6.
  • Rodríguez Huerta MD, Trujillo-Martín MM, Rúa-Figueroa Í, Cuellar-Pompa L, Quirós-López R, Serrano-Aguilar P. Spanish SLE CPG development group. Healthy lifestyle habits for patients with systemic lupus erythematosus: a systemic review. Semin Arthritis Rheum 2016;45:463–70.
  • Castrejón I, Tani C, Jolly M, Huang A, Mosca M. Indices to assess patients with systemic lupus erythematosus in clinical trials, long-term observational studies, and clinical care. Clin Exp Rheumatol 2014;32:S-85-95.
  • Lozovoy MA, Simão AN, Morimoto HK, Scavuzzi BM, Iriyoda TV, Reiche EM, et al. Fish oil N-3 fatty acids increase adiponectin and decrease leptin levels in patients with systemiclupus erythematosus. Mar Drugs 2015;13:1071–83.
  • Vordenbäumen S, Sokolowski A, Kutzner L, Rund KM, Düsing C, Chehab G, et al. membrane polyunsaturated fatty acid profiles are associated with systemic inflammation and fish consumption in systemic lupus erythematosus: a cross-sectional study. Lupus 2020;29:554–9.
  • Reifen R, Blank M, Afek A, Kopilowiz Y, Sklan D, Gershwin ME, et al. Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus. Lupus 1998;7:192–7.
  • Ferreira HB, Pereira AM, Melo T, Paiva A, Domingues MR. Lipidomics in autoimmune diseases with main focus on systemic lupus erythematosus. J Pharm Biomed Anal 2019;174:386–95.
  • Li K, Brennan L, McNulty BA, Bloomfield JF, Duff DJ, Devlin NF, et al. Plasma fatty acid patterns reflect dietary habits and metabolic health: a cross-sectional study. Mol Nutr Food Res 2016;60:2043–52.
  • Diep CS, Lemaitre RN, Chen TA, Baranowski T, Lutsey PL, Manichaikul AW, et al. Acculturation and plasma fatty acid concentrations in hispanic and Chinese-American adults: the multi-ethnic study of atherosclerosis. PLoS One 2016;11:e0149267.

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