Myocarditis as a manifestation of Erdheim–Chester Disease: successful use of anti- IL1 and BRAF inhibitor combination therapy

C Campochiaro1 Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy;2 Vita-Salute San Raffaele University, Milan, ItalyCorrespondence[email protected]

A Tomelleri1 Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy;2 Vita-Salute San Raffaele University, Milan, Italy

N Farina1 Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy;2 Vita-Salute San Raffaele University, Milan, Italy

G Cavalli1 Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy;2 Vita-Salute San Raffaele University, Milan, Italy

G De Luca1 Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy;2 Vita-Salute San Raffaele University, Milan, Italy

A Palmisano2 Vita-Salute San Raffaele University, Milan, Italy;3 Department of Radiology, IRCCS San Raffaele Hospital, Milan, Italy

G Peretto4 Department of Arrhythmology, IRCCS San Raffaele Hospital, Milan, Italy

A Esposito2 Vita-Salute San Raffaele University, Milan, Italy;3 Department of Radiology, IRCCS San Raffaele Hospital, Milan, Italy

S Rizzo5 Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy

C Basso5 Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy

M Matucci-Cerinic1 Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy;6 Department of Experimental and Clinical Medicine, University of Florence and Division of Rheumatology Aouc, Florence, Italy

L Dagna1 Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy;2 Vita-Salute San Raffaele University, Milan, Italy

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Campochiaro C, Tomelleri A, Cavalli G, Berti A, Dagna L. Erdheim-Chester disease. Eur J Intern Med 2015;26:223–9.
PubMed Web of Science ®Google Scholar
Cangi MG, Biavasco R, Cavalli G, Grassini G, Dal-Cin E, Campochiaro C, et al. BRAFV600E-mutation is invariably present and associated to oncogene-induced senescence in Erdheim-Chester disease. Ann Rheum Dis 2015;74:1596–602.
PubMed Web of Science ®Google Scholar
Hajek E, Krebs F, Bent R, Haas K, Bast A, Steinmetz I, et al. BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells. Oncotarget 2018;9:28294–308.
PubMedGoogle Scholar
De Luca G, Cavalli G, Campochiaro C, Tresoldi M, Dagna L. Myocarditis: an interleukin-1-mediated disease? Front Immunol 2018;9:1335.
PubMed Web of Science ®Google Scholar
Campochiaro C, Cavalli G, Farina N, Tomelleri A, De Luca G, Dagna L. Efficacy and improved tolerability of combination therapy with interleukin-1 blockade and MAPK pathway inhibitors for the treatment of Erdheim-Chester disease. Ann Rheum Dis 2019:annrheumdis-2019-216610.
Web of Science ®Google Scholar

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Myocarditis as a manifestation of Erdheim–Chester Disease: successful use of anti- IL1 and BRAF inhibitor combination therapy

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