Worse scores but similar patterns of disease activity: interpreting outcomes in women with axial spondyloarthropathy

References

• Robinson PC, van der Linden S, Khan MA, Taylor WJ. Axial spondyloarthritis: concept, construct, classification and implications for therapy. Nat Rev Rheumatol 2021;17:109–18.
   PubMed Web of Science ®Google Scholar
• Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M. Imaging of axial spondyloarthritis. New aspects and differential diagnoses. Clin Exp Rheumatol 2018;36 Suppl 114:35–42.
   PubMed Web of Science ®Google Scholar
• Marzo-Ortega H. Axial spondyloarthritis: coming of age. Rheumatology (Oxford) 2020;59:iv1–iv5.
   PubMed Web of Science ®Google Scholar
• Gran JT, Husby G. Ankylosing spondylitis in women. Semin Arthritis Rheum 1990;19:303–12.
   PubMed Web of Science ®Google Scholar
• Rusman T, van Bentum RE, van der Horst-bruinsma IE. Sex and gender differences in axial spondyloarthritis: myths and truths. Rheumatology (Oxford) 2020;59:iv38–iv46.
   PubMed Web of Science ®Google Scholar
• Rudwaleit M, van der Heijde D, Landewé R, Listing J, Akkoc N, Brandt J, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 2009;68:777–83.
   PubMed Web of Science ®Google Scholar
• Protopopov M, Poddubnyy D. Radiographic progression in non-radiographic axial spondyloarthritis. Expert Rev Clin Immunol 2018;14:525–33.
   PubMed Web of Science ®Google Scholar
• de Jong H, Paramarta JE, de Winter J, Baeten D, van de Sande M. Differences between females and males in axial spondyloarthritis: data from a real-life cross-sectional cohort. Scand J Rheumatol 2020;49:28–32.
   PubMed Web of Science ®Google Scholar
• Rusman T, van Vollenhoven RF, van der Horst-bruinsma IE. Gender differences in axial spondyloarthritis: women are not so lucky. Curr Rheumatol Rep 2018;20:35.
   PubMed Web of Science ®Google Scholar
• Garrido-Cumbrera M, Poddubnyy D, Gossec L, Mahapatra R, Bundy C, Makri S, et al. Gender differences in patient journey to diagnosis and disease outcomes: results from the European Map of Axial Spondyloarthritis (EMAS). Clin Rheumatol 2021;40:2753–61.
   PubMed Web of Science ®Google Scholar
• Ruiz-Cantero MT, Blasco-Blasco M. Perspectiva de género en epidemiología clínica. Aprendiendo con el caso de las espondiloartritis [Gender perspective in clinical epidemiology. Learning from spondyloarthritis]. Gac Sanit 2020;34:83–6.
   PubMed Web of Science ®Google Scholar
• Zochling J. Measures of symptoms and disease status in ankylosing spondylitis: Ankylosing Spondylitis Disease Activity Score (ASDAS), Ankylosing Spondylitis Quality of Life Scale (ASQoL), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Global Score (BAS-G), Bath Ankylosing Spondylitis Metrology Index (BASMI), Dougados Functional Index (DFI), and Health Assessment Questionnaire for the Spondylarthropathies (HAQ-S). Arthritis Care Res (Hoboken) 2011;63 Suppl 11:S47–58.
   PubMed Web of Science ®Google Scholar
• Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 1994;21:2286–91.
   PubMed Web of Science ®Google Scholar
• Calin A, Garrett S, Whitelock H, Kennedy LG, O’Hea J, Mallorie P, et al. A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 1994;21:2281–5.
   PubMed Web of Science ®Google Scholar
• Kwan YH, Fong W, Lui NL, Yong ST, Cheung YB, Malhotra R, et al. Validity and reliability of the Health Assessment Questionnaire among patients with spondyloarthritis in Singapore. Int J Rheum Dis 2018;21:699–704.
   PubMed Web of Science ®Google Scholar
• Doward LC, Spoorenberg A, Cook SA, Whalley D, Helliwell PS, Kay LJ, et al. Development of the ASQoL: a quality of life instrument specific to ankylosing spondylitis. Ann Rheum Dis 2003;62:20–6.
   PubMed Web of Science ®Google Scholar
• Jenkinson TR, Mallorie PA, Whitelock HC, Kennedy LG, Garrett SL, Calin A. Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS Metrology Index. J Rheumatol 1994;21:1694–8.
   PubMed Web of Science ®Google Scholar
• Andreasen RA, Kristensen LE, Egstrup K, Baraliakos X, Strand V, Horn HC, et al. The impact of sex and disease classification on patient-reported outcome measures in axial spondyloarthritis: a descriptive prospective cross-sectional study. Arthritis Res Ther 2019;21:221.
   PubMed Web of Science ®Google Scholar
• Tournadre A, Pereira B, Lhoste A, Dubost JJ, Ristori JM, Claudepierre P, et al. Differences between women and men with recent-onset axial spondyloarthritis: results from a prospective multicenter French cohort. Arthritis Care Res (Hoboken) 2013;65:1482–9.
   PubMed Web of Science ®Google Scholar
• Mease PJ, McLean RR, Dube B, Liu M, Rebello S, Glynn M, et al. Comparison of men and women with axial spondyloarthritis in the US-based corrona psoriatic arthritis/spondyloarthritis registry. J Rheumatol 2021;48:1528–36.
   PubMed Web of Science ®Google Scholar
• Wallman JK, Kapetanovic MC, Petersson IF, Geborek P, Kristensen LE. Comparison of non-radiographic axial spondyloarthritis and ankylosing spondylitis patients–baseline characteristics, treatment adherence, and development of clinical variables during three years of anti-TNF therapy in clinical practice. Arthritis Res Ther 2015;17:378.
   PubMed Web of Science ®Google Scholar
• Swinnen TW, Westhovens R, Dankaerts W, de Vlam K. Widespread pain in axial spondyloarthritis: clinical importance and gender differences. Arthritis Res Ther 2018;20:156.
   PubMed Web of Science ®Google Scholar
• Webers C, Essers I, Ramiro S, Stolwijk C, Landewé R, van der Heijde D, et al. Gender-attributable differences in outcome of ankylosing spondylitis: long-term results from the Outcome in Ankylosing Spondylitis International Study. Rheumatology (Oxford) 2016;55:419–28.
   PubMed Web of Science ®Google Scholar
• Biallas RL, Dean LE, Davidson L, Hollick R, Pathan E, Robertson L, et al. The role of metrology in axSpA: does it provide unique information in assessing patients and predicting outcome? Results from the BSRBR-AS registry. Arthritis Care Res (Hoboken) 2020.
   PubMed Web of Science ®Google Scholar
• Huang JX, Chung HY, Chui ETF, Lee KH, Chan SCW, Tsang HHL, et al. Intensity of spinal inflammation is associated with radiological structural damage in patients with active axial spondyloarthritis. Rheumatol Adv Pract 2020;4:rkz049.
   PubMedGoogle Scholar
• Baraliakos X, Braun J. Non-radiographic axial spondyloarthritis and ankylosing spondylitis: what are the similarities and differences? RMD Open 2015;1:e000053.
   PubMed Web of Science ®Google Scholar
• Gardiner PV, Small D, Muñoz-Esquivel K, Condell J, Cuesta-Vargas A, Williams J, et al. Validity and reliability of a sensor-based electronic spinal mobility index for axial spondyloarthritis. Rheumatology (Oxford) 2020;59:3415–23.
   PubMed Web of Science ®Google Scholar
• Rencber N, Saglam G, Huner B, Kuru O. Presence of fibromyalgia syndrome and its relationship with clinical parameters in patients with axial spondyloarthritis. Pain Physician 2019;22:E579–e85.
   PubMed Web of Science ®Google Scholar
• Lubrano E, Perrotta FM, Manara M, D’Angelo S, Addimanda O, Ramonda R, et al. The sex influence on response to tumor necrosis factor-α inhibitors and remission in axial spondyloarthritis. J Rheumatol 2018;45:195–201.
   PubMed Web of Science ®Google Scholar
• Lorenzin M, Ortolan A, Frallonardo P, Oliviero F, Punzi L, Ramonda R. Predictors of response and drug survival in ankylosing spondylitis patients treated with infliximab. BMC Musculoskelet Disord 2015;16:166.
   PubMed Web of Science ®Google Scholar
• Marques AP, Santo A, Berssaneti AA, Matsutani LA, Yuan SLK. Prevalence of fibromyalgia: literature review update. Rev Bras Reumatol Engl Ed 2017;57:356–63.
   PubMedGoogle Scholar
• Smith MT Jr., Remeniuk B, Finan PH, Speed TJ, Tompkins DA, Robinson M, et al. Sex differences in measures of central sensitization and pain sensitivity to experimental sleep disruption: implications for sex differences in chronic pain. Sleep 2019;42:1–15.
   Web of Science ®Google Scholar
• Ablin JN, Eshed I, Berman M, Aloush V, Wigler I, Caspi D, et al. Prevalence of axial spondyloarthritis among patients with fibromyalgia: a magnetic resonance imaging study with application of the assessment of spondyloarthritis international society classification criteria. Arthritis Care Res (Hoboken) 2017;69:724–9.
   PubMed Web of Science ®Google Scholar
• López-Medina C, Moltó A. Comorbid pain in axial spondyloarthritis, including fibromyalgia. Ther Adv Musculoskelet Dis 2020;12:1759720x20966123.
   Web of Science ®Google Scholar
• Dougados M, Perrot S. Fibromyalgia and central sensitization in chronic inflammatory joint diseases. Joint Bone Spine 2017;84:511–3.
   PubMed Web of Science ®Google Scholar
• Slobodin G, Reyhan I, Avshovich N, Balbir-Gurman A, Boulman N, Elias M, et al. Recently diagnosed axial spondyloarthritis: gender differences and factors related to delay in diagnosis. Clin Rheumatol 2011;30:1075–80.
   PubMed Web of Science ®Google Scholar
• Salaffi F, De Angelis R, Carotti M, Gutierrez M, Sarzi-Puttini P, Atzeni F. Fibromyalgia in patients with axial spondyloarthritis: epidemiological profile and effect on measures of disease activity. Rheumatol Int 2014;34:1103–10.
   PubMed Web of Science ®Google Scholar
• van der Horst-bruinsma IE, Zack DJ, Szumski A, Koenig AS. Female patients with ankylosing spondylitis: analysis of the impact of gender across treatment studies. Ann Rheum Dis 2013;72:1221–4.
   PubMed Web of Science ®Google Scholar
• Blasco-Blasco M, Castrejón I, Jovaní V, Pascual E, Ruiz-Cantero MT. Reviewing disease activity indices in spondyloarthritis from the gender perspective: a systematic review and meta-analysis. J Rheumatol 2021;48:1395–404.
   PubMed Web of Science ®Google Scholar
• Marona J, Sepriano A, Rodrigues-Manica S, Pimentel-Santos F, Mourão AF, Gouveia N, et al. Eligibility criteria for biologic disease-modifying antirheumatic drugs in axial spondyloarthritis: going beyond BASDAI. RMD Open 2020;6:e001145.
   PubMed Web of Science ®Google Scholar
• Calin A, Nakache JP, Gueguen A, Zeidler H, Mielants H, Dougados M. Defining disease activity in ankylosing spondylitis: is a combination of variables (Bath Ankylosing Spondylitis Disease Activity Index) an appropriate instrument? Rheumatology (Oxford) 1999;38:878–82.
   PubMed Web of Science ®Google Scholar
• Nieto RE, Plasencia Rodriguez C, Peiteado López D, Villalba Yllán A, Balsa Criado A, Navarro-Compán V. Are we treating women patients with real axial spondyloarthritis? Semin Arthritis Rheum 2020;50:432–5.
   PubMed Web of Science ®Google Scholar
• Wright GC, Kaine J, Deodhar A. Understanding differences between men and women with axial spondyloarthritis. Semin Arthritis Rheum 2020;50:687–94.
   PubMed Web of Science ®Google Scholar
• Fish EN. The X-files in immunity: sex-based differences predispose immune responses. Nat Rev Immunol 2008;8:737–44.
   PubMed Web of Science ®Google Scholar
• Mahendira D, Thavaneswaran A, Carty A, Haroon N, Anton A, Passalent L, et al. Analysis of the effect of the oral contraceptive pill on clinical outcomes in women with ankylosing spondylitis. J Rheumatol 2014;41:1344–8.
   PubMed Web of Science ®Google Scholar
• Shepherd R, Cheung AS, Pang K, Saffery R, Novakovic B. Sexual dimorphism in innate immunity: the role of sex hormones and epigenetics. Front Immunol 2020;11:604000.
   PubMed Web of Science ®Google Scholar
• Maguire S, O’Dwyer T, Mockler D, O’Shea F, Wilson F. Pregnancy in axial spondyloarthropathy: a systematic review & meta-analysis. Semin Arthritis Rheum 2020;50:1269–79.
   PubMed Web of Science ®Google Scholar
• Jimenez-Balderas FJ, Tapia-Serrano R, Madero-Cervera JI, Murrieta S, Mintz G. Ovarian function studies in active ankylosing spondylitis in women. Clinical response to estrogen therapy. J Rheumatol 1990;17:497–502.
   PubMed Web of Science ®Google Scholar
• Central Statistics Office (CSO). Census 2016 published reports [Website]. Cork, Ireland 2016 [ cited 2021]. Available from: https://www.cso.ie/en/census/census2016reports/.
   Google Scholar