A novel role for endoplasmic reticulum protein ERp72 in the pathogenesis of autoantibody-induced arthritis

References

• Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet 2016;388:2023–38.
   PubMed Web of Science ®Google Scholar
• Jutley G, Raza K, Buckley CD. New pathogenic insights into rheumatoid arthritis. Curr Opin Rheumatol 2015;27:249–55.
   PubMed Web of Science ®Google Scholar
• de Moel EC, Derksen V, Trouw LA, Bang H, Collée G, Lard LR, et al. In rheumatoid arthritis, changes in autoantibody levels reflect intensity of immunosuppression, not subsequent treatment response. Arthritis Res Ther 2019;21:28.
   PubMed Web of Science ®Google Scholar
• Maibom-Thomsen SL, Trier NH, Holm BE, Hansen KB, Rasmussen MI, Chailyan A, et al. Immunoglobulin G structure and rheumatoid factor epitopes. PLoS One 2019;14:e0217624.
   PubMed Web of Science ®Google Scholar
• Rasmussen EB, Thiele LS, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, et al. Baseline serum levels of IgA anti-cyclic citrullinated protein antibodies in early rheumatoid arthritis predict radiographic progression after 11 years of treatment: a secondary analysis of the CIMESTRA study. Scand J Rheumatol 2023;52:493–7.
   PubMed Web of Science ®Google Scholar
• Kirino Y, Remmers EF. Genetic architectures of seropositive and seronegative rheumatic diseases. Nat Rev Rheumatol 2015;11:401–14.
   PubMed Web of Science ®Google Scholar
• Korganow A-S, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999;10:451–61.
   PubMed Web of Science ®Google Scholar
• Gerlag DM, Norris JM, Tak PP. RA: from risk factors and pathogenesis to prevention: towards prevention of autoantibody-positive rheumatoid arthritis: from lifestyle modification to preventive treatment. Rheumatology 2016;55:607–14.
   PubMed Web of Science ®Google Scholar
• Sahlström P, Hansson M, Steen J, Amara K, Titcombe PJ, Forsström B, et al. Different hierarchies of anti-modified protein autoantibody reactivities in rheumatoid arthritis. Arthritis Rheumatol 2020;72:1643–57.
   PubMed Web of Science ®Google Scholar
• Kissel T, Reijm S, Slot LM, Cavallari M, Wortel CM, Vergroesen RD, et al. Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications. Ann Rheum Dis 2020;79:472–80.
   PubMed Web of Science ®Google Scholar
• Steiner G, Toes REM. Autoantibodies in rheumatoid arthritis - rheumatoid factor, anticitrullinated protein antibodies and beyond. Curr Opin Rheumatol 2024;36:217–24.
   PubMed Web of Science ®Google Scholar
• Edwards JCW, Szczepański L, Szechiński J, Filipowicz-Sosnowska A, Emery P, Close DR, et al. Efficacy of B-cell–targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 2004;350:2572–81.
   PubMed Web of Science ®Google Scholar
• Majka DS, Deane KD, Parrish LA, Lazar AA, Barón AE, Walker CW, et al. Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis. Ann Rheum Dis 2008;67:801–7.
   PubMed Web of Science ®Google Scholar
• Chang X, Cui Y, Zong M, Zhao YAN, Yan X, Chen YU, et al. Identification of proteins with increased expression in rheumatoid arthritis synovial tissues. J Rheumatol 2009;36:872.
   PubMed Web of Science ®Google Scholar
• Wang L, Zheng Y, Xu H, Yan X, Chang X, Phillips W. Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis. PLoS One 2013;8:e53301.
   PubMed Web of Science ®Google Scholar
• Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, et al. The disulfide isomerase ERp72 supports arterial thrombosis in mice. Blood 2017;130:817–28.
   PubMed Web of Science ®Google Scholar
• Yang A, Zhou J, Wang B, Dai J, Colman RW, Song W, et al. A critical role for plasma kallikrein in the pathogenesis of autoantibody-induced arthritis. FASEB J 2017;31:5419–31.
   PubMed Web of Science ®Google Scholar
• Monach P, Hattori K, Huang H, Hyatt E, Morse J, Nguyen L, et al. The K/BxN mouse model of inflammatory arthritis: theory and practice. Methods Mol Med 2007;136:269–82.
   PubMedGoogle Scholar
• Gao L, He C, Yang A, Zhou H, Lu Q, Birge RB, et al. Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis. Cell Commun Signal 2023;21:195.
   PubMed Web of Science ®Google Scholar
• García S, Forteza J, López-Otin C, Gómez-Reino JJ, González A, Conde C. Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model. Arthritis Res Ther 2010;12:R224–R.
   PubMed Web of Science ®Google Scholar
• Mideksa YG, Aschenbrenner I, Fux A, Kaylani D, Weiss CAM, Nguyen TA, et al. A comprehensive set of ER protein disulfide isomerase family members supports the biogenesis of proinflammatory interleukin 12 family cytokines. J Biol Chem 2022;298:102677.
   PubMed Web of Science ®Google Scholar
• Wang L, Wu Y, Zhou J, Ahmad SS, Mutus B, Garbi N, et al. Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the alphaIIbbeta3 integrin. Blood 2013;122:3642–50.
   PubMed Web of Science ®Google Scholar
• Blom AB, van Lent PL, van Vuuren H, Holthuysen AE, Jacobs C, van de Putte LB, et al. Fc gamma R expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA). Arthritis Res 2000;2:489–503.
   PubMedGoogle Scholar
• Solomon S, Rajasekaran N, Jeisy-Walder E, Snapper SB. Illges H: a crucial role for macrophages in the pathology of K/B x N serum-induced arthritis. Eur J Immunol 2005;35:3064–73.
   PubMed Web of Science ®Google Scholar
• Mancardi DA, Jönsson F, Iannascoli B, Khun H, Van Rooijen N, Huerre M, et al. Cutting Edge: the murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis. J Immunol 2011;186:1899–903.
   PubMed Web of Science ®Google Scholar
• Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, Weinblatt ME, et al. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 2010;327:580–3.
   PubMed Web of Science ®Google Scholar
• Li Y, Xu X, Wang HJ, Chen YC, Chen Y, Chiu J, et al. Fang C: endoplasmic reticulum protein 72 regulates integrin Mac-1 activity to influence neutrophil recruitment. Arterioscler Thromb Vasc Biol 2024;44:e82–e98.
   PubMed Web of Science ®Google Scholar
• Weisbart RH. An antibody that binds a neutrophil membrane protein, ERp72, primes human neutrophils for enhanced oxidative metabolism in response to formyl-methionyl-leucyl-phenylalanine. Implications for ERp72 in the signal transduction pathway for neutrophil priming. J Immunol 1992;148:3958–63.
   PubMed Web of Science ®Google Scholar