179
Views
6
CrossRef citations to date
0
Altmetric
Short Report

Alcohol use disorder and GABAB receptor gene polymorphisms in an Italian sample: haplotype frequencies, linkage disequilibrium and association studies

, , , , , , & show all
Pages 384-388 | Received 19 Jul 2016, Accepted 10 Nov 2016, Published online: 14 Feb 2017

References

  • Addolorato G, Leggio L, Abenavoli L, Gasbarrini G. 2005. Neurobiochemical and clinical aspects of craving in alcohol addiction: a review. Addict Behav 30:1209–1224.
  • Addolorato G, Leggio L. 2010. Safety and efficacy of baclofen in the treatment of alcohol-dependent patients. Curr Pharm Des 16:2113–2117.
  • Agrawal A, Lynskey MT. 2008. Are there genetic influences on addiction: evidence from family, adoption and twin studies. Addiction 103:1069–1081.
  • American Psychiatric Association (APA). 2000. Diagnostic and Statistical Manual of Mental Disorders 4th ed. Washington (DC): American Psychiatric Press.
  • Anstee QM, Knapp S, Maguire EP, Hosie AM, Thomas P, Mortensen M, Bhome R, et al. 2013. Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition. Nat Commun 4:2816–2838.
  • Blasi P, Palmerio F, Aiello A, Rocchi M, Malaspina P, Novelletto A. 2006. SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions. J Mol Evol 63:54–68.
  • Blednov YA, Benavidez JM, Black M, Leiter CR, Osterndorff-Kahanek E, Johnson D, Borghese CM, et al. 2014. GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice. PLoS One 9:e85525.
  • Colombo G, Addolorato G, Agabio R, Carai MA, Pibiri F, Serra S, Vacca G, Gessa GL. 2004. Role of GABAB receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res 6:403–414.
  • Connor JP, Haber PS, Hall WD. 2015. Alcohol use disorders. Lancet 387:988–998.
  • Cui WY, Seneviratne C, Gu J, Li MD. 2012. Genetics of GABAergic signaling in nicotine and alcohol dependence. Hum Genet 131:843–855.
  • Deeks JJ, Higgins JPT. 2010. Statistical algorithms in Review Manager 5. Available online at: http://ims.cochrane.org/revman/documentation/Statistical-methods-in-RevMan-5.pdf
  • Enoch MA. 2013. Genetic influences on the development of alcoholism. Curr Psychiatry Rep 15:412–427.
  • Fleming RL, Manis PB, Morrow AL. 2009. The effects of acute and chronic ethanol exposure on presynaptic and postsynaptic gamma-aminobutyric acid (GABA) neurotransmission in cultured cortical and hippocampal neurons. Alcohol 43:603–618.
  • Gauderman WJ, Morrison JM. 2006. QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies. Available online at: http://hydra.usc.edu/gxe
  • Li MD, Mangold JE, Seneviratne C, Chen GB, Ma JZ, Lou XY, Payne TJ. 2009. Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations. PLoS One 4:e7055.
  • Loi B, Maccioni P, Lobina C, Carai MA, Gessa GL, Thomas AW, Malherbe P, Colombo G. 2013. Reduction of alcohol intake by the positive allosteric modulator of the GABA(B) receptor, rac-BHFF, in alcohol-preferring rats. Alcohol 47:69–73.
  • Köhnke M, Schick S, Lutz U, Köhnke A, Vonthein R, Kolb W, Batra A. 2006. The polymorphism GABABR1 T1974C[rs29230] of the GABAB receptor gene is not associated with the diagnosis of alcoholism or alcohol withdrawal seizures. Addict Biol 11:152–156.
  • Kumar S, Porcu P, Werner DF, Matthews DB, Diaz-Granados JL, Helfand RS, Morrow AL. 2009. The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology (Berl) 205:529–564.
  • Rehm J, Anderson P, Barry J, Dimitrov P, Elekes Z, Feijão F, Frick U, et al. 2015. Prevalence of and potential influencing factors for alcohol dependence in Europe. Eur Addict Res 21:6–18.
  • Sander T, Samochowiec J, Ladehoff M, Sander T, Smolka M, Peters C, Riess O, et al. 1999. Association analysis of exonic variants of the gene encoding the GABAB receptor and alcohol dependence. Psychiatr Genet 9:69–73.
  • Schmidt LG, Sander T. 2000. Genetics of alcohol withdrawal. Eur Psychiatry 15:135–139.
  • Sole X, Guino E, Valls J, Iniesta R, Moreno V. 2006. SNPStats: a web tool for the analysis of association studies. Bioinformatics 22:1928–1929.
  • Stephens M, Donnelly P. 2003. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162–1169.
  • Terranova C, Tucci M, Sartore D, Cavarzeran F, Di Pietra L, Barzon L, Palù G, Ferrara SD. 2013. GABA receptors, alcohol dependence and criminal behavior. J Forensic Sci 58:1227–1232.
  • Terranova C, Tucci M, Di Pietra L, Ferrara SD. 2014. GABA receptors genes polymorphisms and alcohol dependence: no evidence of an association in an Italian male population. Clin Psychopharmacol Neurosci 12:142–148.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.