Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy): contribution of body mass index, age and sex

References

• Alves DK, Kummrow F, Cardoso AA, Morales DA, Umbuzeiro GA. 2016. Mutagenicity profile of atmospheric particulate matter in a small urban center subjected to airborne emission from vehicle traffic and sugar cane burning. Environ Mol Mutagen. 57(1):41–50.
   PubMed Web of Science ®Google Scholar
• ARPA (Agenzia Regionale Protezione Ambientale). 2019. Piano Regionale per la qualità dell’aria; [accessed 2019 April 04]. https://www.regione.piemonte.it/web/sites/default/files/media/documenti/2019-04/prqa_allegato1_def.pdf.
   Google Scholar
• Bonassi S, El-Zein R, Bolognesi C, Fenech M. 2011. Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies. Mutagenesis. 26(1):93–100.
   PubMed Web of Science ®Google Scholar
• Bonassi S, Fenech M, Lando C, Lin YP, Ceppi M, Chang WP, Holland N, et al. 2001. HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Environ Mol Mutagen. 37(1):31–45.
   PubMed Web of Science ®Google Scholar
• Brugha R, Grigg J. 2014. Urban air pollution and respiratory infections. Paediatr Respir Rev. 15:194–199.
   PubMed Web of Science ®Google Scholar
• Ceretti E, Feretti D, Viola GC, Zerbini I, Limina RM, Zani C, Capelli M, et al. 2014. DNA damage in buccal mucosa cells of pre-school children exposed to high levels of urban air pollutants. PLoS One. 9(5):e96524.
   PubMed Web of Science ®Google Scholar
• Cho NY, Kim KW, Kim KK. 2017. Genomic health status assessed by a cytokinesis-block micronucleus cytome assay in a healthy middle-aged Korean population. Mutat Res/Genetic Toxicol Environ Mutagen. 814:7–13.
   PubMed Web of Science ®Google Scholar
• Di Giorgio C, De Méo MP, Laget M, Guiraud H, Botta A, Duménil G. 1994. The micronucleus assay in human lymphocytes: screening for inter-individual variability and application to biomonitoring. Carcinogenesis. 15(2):313–317.
   PubMed Web of Science ®Google Scholar
• Domnez-Altuntas H, Sahin F, Bayram F, Bitgen N, Mert M, Guclu K, Hamurcu Z, et al. 2014. Evaluation of chromosomal damage, cytostasis, cytotoxicity, oxidative DNA damage and their association with body-mass index in obese subjects. Mutat Res Genet Toxicol Environ Mutagen. 771:30–36.
   PubMed Web of Science ®Google Scholar
• EAA (European Environment Agency). 2012. Air Quality in Europe 2011. European Environment Agency, Technical report No 4/2012. ISSN 1725-9177.
   Google Scholar
• EC (European Commission). 2008. Air Quality Directive 2008/50/EC; [accessed 2018 Jan 10]. https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32008L0050&from=EN.
   Google Scholar
• Elwakkad A, Hassan NM, Sibaii H, El-Zayat S, Sherif L, Hameed ERA, Shaheed AA. 2011. Relationship between obesity and 8-hydroxy-2-deoxy guanosine as an oxidative marker in obese adolescents of Giza. J Med Sci. 11(5):231–235.
   Google Scholar
• Fenech M, Bonassi S, Turner J, Lando C, Ceppi M, Chang WP, HUman MicroNucleus project, et al. 2003. Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project. Mutat Res. 534(1–2):45–64.
   PubMed Web of Science ®Google Scholar
• Fenech M, Kirsch-Volders M, Natarajan AT, Surralles J, Crott JW, Parry J, Norppa H, et al. 2011. Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. Mutagenesis. 26(1):125–132.
   PubMed Web of Science ®Google Scholar
• Feretti D, Ceretti E, De Donno A, Moretti M, Carducci A, Bonetti S, the MAPEC_LIFE Study Group, et al. 2014. Monitoring air pollution effects on children for supporting public health policy: the protocol of the prospective cohort MAPEC study. BMJ Open. 4(9):e006096–e006096.
   PubMed Web of Science ®Google Scholar
• Gajski G, Gerić M, Oreščanin V, Garaj-Vrhovac V. 2018. Cytokinesis-block micronucleus cytome assay parameters in peripheral blood lymphocytes of the general population: contribution of age, sex, seasonal variations and lifestyle factors. Ecotoxicol Environ Saf. 148:561–570.
   PubMed Web of Science ®Google Scholar
• Garcia-Sagredo JM. 2008. Fifty years of cytogenetics: a parallel view of the evolution of cytogenetics and genotoxicology. Biochim Biophys Acta. 1779(6–7):363–375.
   PubMed Web of Science ®Google Scholar
• Gekara NO. 2017. DNA damage-induced immune response: micronuclei provide key platform. J Cell Biol. 216(10):2999–3001.
   PubMed Web of Science ®Google Scholar
• Hankey S, Marshall JD. 2017. Urban form, air pollution, and health. Curr Envir Health Rpt. 4(4):491–503.
   PubMedGoogle Scholar
• Haveric A, Haveric S, Ibrulj S. 2010. Micronuclei frequencies in peripheral blood and buccal exfoliated cells of young smokers and non-smokers. Toxicol Mech Methods. 20(5):260–266.
   PubMed Web of Science ®Google Scholar
• Heng HH. 2019. Genome chaos: rethinking genetics, evolution, and molecular medicine. Cambridge, MA: Academic Press Elsevier. ISBN 978-012-8136-35-5.
   Google Scholar
• Ibrulj S, Haverić S, Haverić A, Durmić-Pasić A, Marjanović D. 2006. Effect of war and postwar genotoxins on micronuclei frequency in Sarajevo study group. Bosn J of Basic Med Sci. 6(4):54–57.
   PubMedGoogle Scholar
• Kopjar N, Kasuba V, Milić M, Rozgaj R, Zeljezić D, Gajski G, Mladinić M, Garaj-Vrhovac V. 2010. Normal and cut-off values of the cytokinesis-block micronucleus assay on peripheral blood lymphocytes in the Croatian general population. Arh Hig Rada Toksikol. 61(2):219–234.
   PubMed Web of Science ®Google Scholar
• Köteles GJ, Bojtor I, Szirmai S, Bérces J, Otos M. 1993. Micronucleus frequency in cultured lymphocytes of an urban population. Mutat Res. 319(4):267–271.
   PubMed Web of Science ®Google Scholar
• Landi S, Iazzolino E, Barale R. 2000. Are baseline frequencies of SCEs, CAs, and MN in human lymphocytes related to hematological values? Mutat Res. 469(1):159–166.
   PubMed Web of Science ®Google Scholar
• Leopardi P, Zijno A, Marcon F, Conti L, Carere A, Verdina A, Galati R, et al. 2003. Analysis of micronuclei in peripheral blood lymphocytes of traffic wardens: effects of exposure, metabolic genotypes, and inhibition of excision repair in vitro by ARA-C. Environ Mol Mutagen. 41(2):126–130.
   PubMed Web of Science ®Google Scholar
• Liu C, Chen R, Sera F, Vicedo-Cabrera AM, Guo Y, Tong S, Coelho M, et al. 2019. Ambient particulate air pollution and daily mortality in 652 cities. N Engl J Med. 381(8):705–715.
   PubMed Web of Science ®Google Scholar
• Look KV, Botsivali M, Zangogianni M, Anderson D, Baumgartner A, Fthenou E, Chatzi L, et al. 2014. The effect of dietary estimates calculated using food freuqency questionnaires on micronuclei formation in EUropean pregnant women: a NewGeneris study. Mutagenesis. 29:393–400.
   PubMed Web of Science ®Google Scholar
• Maffei F, Zolezzi Moraga JM, Angelini S, Zenesini C, Musti M, Festi D, Cantelli-Forti G, Hrelia P. 2014. Micronucleus frequency in human peripheral blood lymphocytes as a biomarker for the early detection of colorectal cancer risk. Mutagenesis. 29(3):221–225.
   PubMed Web of Science ®Google Scholar
• Milosevic-Djordjevic O, Grujicic D, Novakovic T, Arsenijevic S, Marinkovic D. 2002. Micronuclei and ageing in a sample of Yugoslavian population. Genetika. 38(2):264–267.
   PubMedGoogle Scholar
• Nefic H, Handzic I. 2013. The effect of age, sex, and lifestyle factors on micronucleus frequency in peripheral blood lymphocytes of the Bosnian population. Mutat Res. 753:1–11.
   PubMed Web of Science ®Google Scholar
• Raaschou-Nielsen O, Andersen ZJ, Beelen R, Samoli E, Stafoggia M, Winmayr G, Hoffmann B, et al. 2013. Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol. 14(9):813–822.
   PubMed Web of Science ®Google Scholar
• Rossner P, Rossnerova JA, Spatova M, Beskid O, Uhlirova K, Libalova H, Solansky I, et al. 2013. Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II: chromosomal aberrations and oxidative stress. Mutagenesis. 28(1):97–106.
   PubMed Web of Science ®Google Scholar
• Rossnerova A, Honkova K, Pavlikova J, Skalicka ZF, Havrankova R, Solansky I, Rossner P, Jr, et al. 2016. Mapping the factors affecting the frequency and types of micronuclei in an elderly population from Southern Bohemia. Mutat Res. 793–794:32–40.
   PubMed Web of Science ®Google Scholar
• Santovito A, Cervella P, Delpero M. 2012. Chromosomal aberrations in cultured human lymphocytes treated with the fungicide Thiram. Drug Chem Toxicol. 35(3):347–351.
   PubMed Web of Science ®Google Scholar
• Santovito A, Cervella P, Delpero M. 2016. Baseline frequency of chromosomal aberrations and sister chromatid exchanges in peripheral blood lymphocytes of healthy individuals living in Turin (North-Western Italy): assessment of the effects of age, sex and GSTs gene polymorphisms on the levels of genomic damage. Ann Hum Biol. 43(3):269–278.
   PubMed Web of Science ®Google Scholar
• Santovito A, Gendusa C, Cervella P. 2017. Evaluation of baseline frequency of sister chromatid exchanges in an Italian population according to age, sex, smoking habits, and gene polymorphisms. Am J Hum Biol. 29(6):e23034.
   Web of Science ®Google Scholar
• Scarpato R, Verola C, Fabiani B, Bianchi V, Saggese G, Federico G. 2011. Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the γ-H2AX focus assay and micronucleus test. FASEB J. 25(2):685–693.
   PubMed Web of Science ®Google Scholar
• Villarini M, Levorato S, Salvatori T, Ceretti E, Bonetta S, Carducci A, MAPEC LIFE Study Group, et al. 2018. Buccal micronucleus cytome assay in primary school children: a descriptive analysis of the MAPEC_LIFE multicenter cohort study. Int J Hyg Environ Health. 221(6):883–892.
   PubMed Web of Science ®Google Scholar
• WHO (World Health Organization) Europe. 2006. Air quality guidelines. Global Update 2005. Copenhagen, Denmark: WHO. ISBN 92 890 2192 6
   Google Scholar
• WHO (World Health Organization) Europe. 2007. Children’s health and the environment in Europe: a baseline assessment. (Dalbokova D., Krzyzanowski M., Lloyd S., editors), Copenhagen, Denmark: WHO. ISBN: 978 92 890 7297 7.
   Google Scholar
• WHO (World Health Organization) Europe. 2013. Review of evidence on health aspects of air pollution-REVIHAAP Project. Copenhagen, Denmark.
   Google Scholar
• Ye CJ, Sharpe Z, Alemara S, Mackenzie S, Liu G, Abdallah B, Horne S, et al. 2019. Micronuclei and genome chaos: changing the system inheritance. Genes. 10(5):366.
   PubMed Web of Science ®Google Scholar