Simultaneous determination of pesticides, mycotoxins, tropane alkaloids, growth regulators, and pyrrolizidine alkaloids in oats and whole wheat grains after online clean-up via two-dimensional liquid chromatography tandem mass spectrometry

References

• Malik, A.K.; Blasco, C.; Picó, Y. Liquid chromatography-mass spectrometry in food safety. J. Chromatogr. A 2010, 1217, 4018–4040.
   PubMed Web of Science ®Google Scholar
• Kittlaus, S.; Schimanke, J.; Kempe, G.; Speer, K. Development and validation of an efficient automated method for the analysis of 300 pesticides in foods using two-dimensional liquid chromatography – Tandem mass spectrometry. J. Chromatogr. A 2013, 1283, 98–109.
   PubMed Web of Science ®Google Scholar
• Francois, I.; Sandra, K.; Sandra, P. Comprehensive liquid chromatography: Fundamental aspects and practical considerations — A review. Anal. Chim. Acta 2009, 641, 14–31.
   PubMed Web of Science ®Google Scholar
• Montero, L.; Ibáñez, E.; Russo, M.; Rastrelli, L.; Cifuentes, A.; Herrero, M. Focusing and non-focusing modulation strategies for the improvement of on-line two- dimensional hydrophilic interaction chromatography × reversed phase profiling of complex food samples. Anal. Chim. Acta 2017, 985, 202–212. doi: 10.1016/j.aca.2017.07.013.
   PubMed Web of Science ®Google Scholar
• Cacciola, F.; Russo, M.; Beccaria, M. Comprehensive two-dimensional liquid chromatography methods for analysis of polyphenols in food samples. Austin Chromatogr. 2015, 2, 1–6.
   Google Scholar
• Franco, S. An overview of multidimensional liquid phase separations in food analysis. Electrophoresis 2016, 13, 1–16.
   Web of Science ®Google Scholar
• Tranchida, P. Q.; Dugo, P.; Dugo, G.; Mondello, L. Comprehensive two-dimensional chromatography in food analysis. J. Chromatogr. A 2004, 1054, 3–16.
   PubMed Web of Science ®Google Scholar
• Wang, Y.; Lu, X.; Xu, G. Development of a comprehensive two-dimensional hydrophilic interaction chromatography/quadrupole time-of-flight mass spectrometry system and its application in separation and identification of saponins from Quillaja Saponaria. J. Chromatogr. A 2008, 1181, 51–59.
   PubMed Web of Science ®Google Scholar
• EFSA. Scientific opinion on pyrrolizidine alkaloids in food and feed. EFSA J. 2011, 9, 1–134.
   Google Scholar
• Gottschalk, C.; Barthel, J.; Engelhardt, G.; Bauer, J.; Meyer, K. Occurrence of type a trichothecenes in conventionally and organically produced oats and oat products. Mol. Nutr. Food Res. 2007, 51, 1547–1553.
   PubMed Web of Science ®Google Scholar
• Commission Regulation (EU) No 519/2014 of 16 May 2014, 519.
   Google Scholar
• Commission Recommendation (EU) 2015/976 of 19 June 2015 on the monitoring of the presence of tropane alkaloids in food. 2015, 11(10), 97–98.
   Google Scholar
• WHO. Recommended classifcation of pesticides by hazard and guidelines to classifcation. 2009.
   Google Scholar
• Commission Regulation (EC) NO 396/2005 of the European Parliament and of the Council of 23 February 2005.
   Google Scholar
• SANTE. Guidance document on analytical quality control and method validation procedures for pesticides residues analysis in food and feed. 2015.
   Google Scholar
• Robles-Molina, J.; Gilbert-López, B.; García-Reyes, J. F.; Molina-Díaz, A. Simultaneous liquid chromatography/mass spectrometry determination of both polar and “multiresidue” pesticides in food using parallel hydrophilic interaction/reversed-phase liquid chromatography and a hybrid sample preparation approach. J. Chromatogr. A 2017, 1517, 108–116. doi: 10.1016/j.chroma.2017.08.041.
   PubMed Web of Science ®Google Scholar
• van de Schans, M. G. M.; Blokland, M. H.; Zoontjes, P. W.; Mulder, P. P. J.; Nielen, M. W. F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. J. Chromatogr. A 2017, 1503, 38–48. doi: 10.1016/j.chroma.2017.04.059.
   PubMed Web of Science ®Google Scholar
• Breidbach, A.; Ulberth, F. Two-dimensional heart-cut LC-LC improves accuracy of exact-matching double isotope dilution mass spectrometry measurements of aflatoxin B 1 in cereal-based baby food, maize, and maize-based feed. Anal. Bioanal. Chem. 2014, 407(11), 3159–3167. doi: 10.1007/s00216-014-8003-5.
   Web of Science ®Google Scholar
• Nestola, M.; Friedrich, R.; Bluhme, P.; Schmidt, T. C. Universal route to polycyclic aromatic hydrocarbon analysis in foodstuff: Two-dimensional heart-cut liquid chromatography − Gas Chromatography − Mass spectrometry. Anal. Chem. 2015, 87(12), 6195–6203. doi: 10.1021/acs.analchem.5b00825.
   PubMed Web of Science ®Google Scholar
• Tanaka, Y.; Yanagida, A.; Komeya, S.; Kawana, M.; Honma, D.; Tagashira, M.; Kanda, T.; Shibusawa, Y. Comprehensive separation and structural analyses of polyphenols and related compounds from bracts of hops (Humulus lupulus L.). J. Agric. Food Chem. 2014, 62, 2198–2206.
   PubMed Web of Science ®Google Scholar
• Anastassiades, M.; Lehotay, S. J.; Stajnbaher, D.; Schenck, F. J. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and “dispersive solid-phase extraction” for the determination of pesticide residues in produce. J. AOAC Int. 2003, 86, 412–431.
   PubMed Web of Science ®Google Scholar
• Sapozhnikova, Y.; Lehotay, S. J. Multi-class, multi-residue analysis of pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and novel flame retardants in fish using fast, low-pressure gas chromatography-tandem mass spectrometry. Anal. Chim. Acta 2013, 758, 80–92.
   PubMed Web of Science ®Google Scholar
• Kittlaus, S.; Schimanke, J.; Kempe, G.; Speer, K. Assessment of sample cleanup and matrix effects in the pesticide residue analysis of foods using postcolumn infusion in liquid chromatography – Tandem mass spectrometry. J. Chromatogr. A 2011, 1218, 8399–8410.
   PubMed Web of Science ®Google Scholar
• Grande-Martínez, Á.; Arrebola, F. J.; Moreno, L. D.; Vidal, J. L. M.; Frenich, A. G. Development and validation of a multiresidue method for the determination of pesticides in dry samples (rice and wheat flour) using liquid chromatography/triple quadrupole tandem mass spectrometry. J. AOAC Int. 2015, 98, 1186–1198.
   PubMed Web of Science ®Google Scholar
• Feng, M.; Li, W.; Hao, X.; Han, L. Determination of halosulfuron-methyl residues and dissipation in wheat by QuEChERS and LC-MS/MS. Food Addit. Contam. Part A Chem. Anal. Control Expo Risk Assess 2014, 31, 1879–1885.
   PubMed Web of Science ®Google Scholar
• He, Z.; Wang, L.; Peng, Y.; Luo, M.; Wang, W.; Liu, X. Multiresidue analysis of over 200 pesticides in cereals using a QuEChERS and gas chromatography – Tandem mass spectrometry-based method. Food Chem. 2015, 169, 372–380.
   PubMed Web of Science ®Google Scholar
• Chen, H.; Marín-Sáez, J.; Romero-González, R. Simultaneous determination of atropine and scopolamine in buckwheat and related products using modified QuEChERS and liquid chromatography tandem mass spectrometry. Food Chem. 2016, 218, 173–180. doi: 10.1016/j.foodchem.2016.09.075.
   Web of Science ®Google Scholar
• Bolechova, M.; Caslavsky, J.; Pospichalova, M. K. P. UPLC – MS/MS method for determination of selected pyrrolizidine alkaloids in feed. Food Chem. 2015, 170, 265–270.
   PubMed Web of Science ®Google Scholar
• Huang, H.; Zhang, J.; Xu, D.; Zhou, Y.; Luo, J.; Li, M.; Chen, S.; Wang, L. Determination of 21 plant growth regulator residues in fruits by QuEChERS-high performance liquid chromatography-tandem mass spectrometry. Se Pu 01 2014, 32, 707–716.
   PubMedGoogle Scholar
• Hu, W.; Xu, L.; Yang, J.; Ling R. QuEChERS-based extraction procedure and rapid resolution liquid chromatography coupled to triple quadrupole mass spectrometry for the determination of nine mycotoxins in cereal-based complementary foods for infants and young children. Se Pu 2014, 32, 133–138.
   PubMedGoogle Scholar
• Li, P.; Zhang, Z.; Hu, X.; Zhang, Q. Advanced hyphenated chromatographic-mass spectrometry in mycotoxin determination: Current status and prospects. Mass. Spectrom. Rev. 2013, 32(6), 420–452.
   PubMed Web of Science ®Google Scholar
• Porto-Figueira, P.; Camacho, I.; Câmara, J. S. Exploring the potentialities of an improved ultrasound-assisted quick, easy, cheap, effective, rugged, and safebased extraction technique combined with ultrahigh pressure liquid chromatography fluorescence detection for 4 determination of zearalenone in c. J. Chromatogr. A 2015, 1408, 187–196. doi: 10.1016/j.chroma.2015.07.031.
   Web of Science ®Google Scholar
• Commission Regulation (EC) No 1881/2006 of 19 December 2006, 1881, 5–24.
   Google Scholar
• Eurachem 2014. The Fitness for Purpose of Analytical Methods. 2014.
   Google Scholar
• Malachová, A.; Sulyok, M.; Beltrán, E.; Berthiller, F.; Krska, R. Optimization and validation of a quantitative liquid chromatography – tandem mass spectrometric method covering 295 bacterial and fungal metabolites including all regulated mycotoxins in four model food matrices. J. Chromatogr. A 2014, 1362, 145–156.
   PubMed Web of Science ®Google Scholar
• Chawla, S.; Patel, H. K.; Gor, H. N.; Vaghela, K. M.; Solanki, P. P. Evaluation of matrix effects in multiresidue analysis of pesticide residues in vegetables and spices by LC-MS/MS. J. AOAC Int. 2017, 100, 17–21.
   Web of Science ®Google Scholar
• Malysheva, S. V.; Diana, J.; Mavungu, D.; Goryacheva, I. Y.; Saeger, S. A systematic assessment of the variability of matrix effects in LC-MS/MS analysis of ergot alkaloids in cereals and evaluation of method robustness. Anal. Bioanal. Chem. 2013, 405, 5595–5604.
   PubMed Web of Science ®Google Scholar
• Mol, H. G. J.; Plaza-Bolan, P.; Zomer, P.; de Rijk, T. C.; Stolker, A. A. M.; Mulder, P. P. J. Toward a generic extraction method for simultaneous determination of pesticides, mycotoxins, plant toxins, and veterinary drugs in feed and food matrixes. Anal. Chem. 2008, 80, 9450–9459.
   PubMed Web of Science ®Google Scholar
• Martinello, M.; Borin, A.; Stella, R.; Bovo, D. Development and validation of a QuEChERS method coupled to liquid chromatography and high resolution mass spectrometry to determine pyrrolizidine and tropane alkaloids in honey. Food Chem. 2017, 234, 295–302. doi: 10.1016/j.foodchem.2017.04.186.
   PubMed Web of Science ®Google Scholar
• Mudge, E. M.; Jones, A. M. P.; Brown, P. N.; Mudge, E. M.; Jones, A. M. P.; Brown, P. N. Quantification of pyrrolizidine alkaloids in North American plants and honey by LC-MS: Single laboratory validation. Food Addit. Contam. Part A 2015, 1, 2068–2074. doi: 10.1080/19440049.2015.1099743.
   Google Scholar
• ISO ÖVE/ÖNORM 17025. 2007.
   Google Scholar
• Cirlini, M.; Demuth, T. M.; Biancardi, A.; Rychlik, M.; Dall, C.; Bruni, R. Are tropane alkaloids present in organic foods? Detection of scopolamine and atropine in organic buckwheat (Fagopyron esculentum L) products by UHPLC – MS/MS. Food Chem. 2018, 239, 141–147.
   PubMed Web of Science ®Google Scholar
• Yu, Z.; Jin, F.; Hu, J.; Zhang, X.; Sun, J.; Yang, M. An improved method for analyzing chlormequat and mepiquat in source waters by solid-phase extraction and liquid chromatography – mass spectrometry. Anal. Chim. Acta 2010, 678, 90–95.
   PubMed Web of Science ®Google Scholar
• Xue, J.; Wang, S.; You, X.; Dong, J.; Han, L.; Liu, F. Multi-residue determination of plant growth regulators in apples and tomatoes by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2011, 25, 3289–3297.
   PubMed Web of Science ®Google Scholar
• Esparza, X.; Moyano, E.; Galceran, M. T. Analysis of chlormequat and mepiquat by hydrophilic interaction chromatography coupled to tandem mass spectrometry in food samples. J. Chromatogr. A 2009, 1216, 4402–4406.
   PubMed Web of Science ®Google Scholar
• Commission Regulation (EU) 2015/399 of 25 February 2015 amending. 2015, 6(396).
   Google Scholar
• Kittlaus, S.; Kempe, G. S. Evaluation of matrix effects in different multi-pesticide residue analysis methods using liquid chromatography – tandem mass spectrometry, including an automated two-dimensional clean-up approach. J. Sep. Sci. 2013, 36(13), 2185–2195.
   PubMed Web of Science ®Google Scholar
• Łozowicka, B.; Rutkowska, E.; Jankowska, M. Influence of QuEChERS modifications on recovery and matrix effect during the multi-residue pesticide analysis in soil by GC/MS/MS and GC/ECD/NPD. Environ. Sci. Pollut. Res. 2017, 24(8), 7124–7138. doi: 10.1007/s11356-016-8334-1.
   PubMed Web of Science ®Google Scholar
• Norli, H. R.; Christiansen, A. L.; Stuveseth, K. Analysis of non-cleaned QuEChERS extracts for the determination of pesticide residues in fruit, vegetables and cereals by gas chromatography- tandem mass spectrometry. Food Addit. Contam. Part A 2015, 33(2), 300–312. doi: 10.1080/19440049.2015.1124292.
   Google Scholar