Publication Cover
Journal of Environmental Science and Health, Part B
Pesticides, Food Contaminants, and Agricultural Wastes
Volume 54, 2019 - Issue 8
205
Views
9
CrossRef citations to date
0
Altmetric
Articles

Depressed prostaglandins and leukotrienes in veterans with Gulf War illness

, , , , , , , , & show all

References

  • Binns, J. H.; Barlow, C.; Bloom, F. E.; Clauw, D. J.; Golomb, B. A.; Graves, J. C.; Hardie, A.; Knox, M. L.; Meggs, W. J.; Nettleman, M. D.; Research Advisory Committee on Gulf War Veterans' Illnesses.; et al. Gulf War Illness and the Health of Gulf War Veterans. Scientific Findings and Recommendations; U.S. Government Printing Office: Washington DC, 2008.
  • Golomb, B. A. Correction for Golomb, "Reply to Blazer et al.: Flawed challenges to 'acetylcholinesterase inhibitors and Gulf War Illnesses'. Proc. Natl. Acad. Sci. USA 2008, 105, E94. DOI: 10.1073/pnas.0809123105.
  • Nisenbaum, R.; Barrett, D. H.; Reyes, M.; Reeves, W. C. Deployment stressors and a chronic multisymptom illness among Gulf War Veterans. J. Nerv. Ment. Dis. 2000, 188, 259–266. DOI: 10.1097/00005053–200005000–00002.
  • Abou–Donia, M. B.; Wilmarth, K. R.; Abdel–Rahman, A. A.; Jensen, K. F.; Oehme, F. W.; Kurt, T. L. Increased Neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos. Toxicol. Sci. 1996, 34, 201–222. DOI: 10.1093/toxsci/34.2.201.
  • Kayihan, G. C.; Wood, M.; Mouzon, B.; Ferguson, S.; Margenthaler, E.; Mathura, V.; Mullan, M.; Crawford, F. Gulf War agents trigger discrete transcriptional changes in human neuronal cells. Toxicol. Environ. Chem. 2010, 92, 1783–1799. DOI: 10.1080/02772241003611946.
  • Nutter, T. J.; Johnson, R. D.; Cooper, B. Y. A delayed chronic pain like condition with decreased Kv channel activity in a rat model of gulf war illness pain syndrome. Neurotoxicology 2015, 51, 67–79. DOI: 10.1016/j.neuro.2015.09.010.
  • Nishimura, K.; Tsumagari, H.; Morioka, A.; Yamauchi, Y.; Miyashita, K.; Lu, S.; Jisaka, M.; Nagaya, T.; Yokota, K. Regulation of apoptosis through arachidonate cascade in mammalian cells. Abab. 2002, 102–103, 239–250. DOI: 10.1385/ABAB:102–103:1–6:239.
  • Poole, M. D.; Pillsbury, H. C. Prostaglandins and other metabolites of arachidonic acid. An overview for the otolaryngologist. Arch. Otolaryngol. 1985, 111, 317–321.
  • Funk, C. D. Prostaglandins and Leukotrienes: advances in eicosanoid biology. Science 2001, 294, 1871–1875. DOI: 10.1126/science.294.5548.1871.
  • Fukuda, K.; Nisenbaum, R.; Stewart, G.; Thompson, W. W.; Robin, L.; Washko, R. M.; Noah, D. L.; Barrett, D. H.; Randall, B.; Herwaldt, B. L.; et al. Chronic multisymptom illness affecting air force veterans of the Gulf War. Jama 1998, 280, 981–988. DOI: 10.1001/jama.280.11.981.
  • Steele, L. Prevalence and patterns of gulf war illness in Kansas veterans: association of symptoms with characteristics of person, place, and time of military service. Am. J. Epidemiol. 2000, 152, 992–1002. DOI: 10.1093/aje/152.10.992.
  • Fernandez–Bustamante, A.; Klawitter, J.; Wilson, P.; Elkins, N. D.; Agazio, A.; Shibata, T.; Uchida, K.; Christians, U.; Repine, J. E. and Early increase in alveolar macrophage prostaglandin 15d–PGJ2 precedes neutrophil recruitment into lungs of cytokine–insufflated rats. Inflammation 2013, 36, 1030–1040. DOI: 10.1007/s10753–013–9635–x.
  • Repine, J. E.; Wilson, P.; Elkins, N.; Klawitter, J.; Christians, U.; Peters, B.; Smith, D. M. Inhalation of Two Putative Gulf War Toxins by Mice. J Environ Sci Health B .. 2016, 51, 366–373. DOI: 10.1080/03601234.2016.1142318.
  • Peixoto, F. Comparative effects of the roundup and glyphosate on mitochondrial oxidative phosphorylation. Chemosphere 2005, 61, 1115–1122. DOI: 10.1016/j.chemosphere.2005.03.044.
  • Jansen, K. M.; Pavlath, G. K. Prostaglandin F2alpha promotes muscle cell survival and growth through upregulation of the inhibitor of apoptosis protein BRUCE. Cell Death Differ. 2008, 15, 1619–1628. DOI: 10.1038/cdd.2008.90.
  • Calder, P. C. Polyunsaturated Fatty Acids and Inflammation. Prostaglandins Leukot. Essent. Fatty Acids 2006, 75, 197–202.
  • Aoki, T.; Narumiya, S. Prostaglandins and chronic inflammation. Trends Pharmacol. Sci. 2012, 33, 304–311. DOI: 10.1016/j.tips.2012.02.004.
  • Ricciotti, E.; FitzGerald, G. A. Prostaglandins and inflammation. Arterioscler. Thromb. Vasc. Biol. 2011, 31, 986–1000. DOI: 10.1161/ATVBAHA.110.207449.
  • Johnson, G. J.; Slater, B. C.; Leis, L. A.; Rector, T. S.; Bach, R. R. Blood biomarkers of chronic inflammation in Gulf War illness. PLoS One. 2016, 11, e0157855DOI: 10.1371/journal.pone.0157855.
  • Johnson, G. J.; Leis, L. A.; Slater, B. C.; Bach, R. R. Elevated platelet count, C–Reactive protein and thromboxane analog–induced platelet aggregation in patients with Gulf War Veterans' illnesses: evidence of a chronic inflammatory state? Blood Coagul Fibrinolysis. 2013, 24, 736–741.
  • Golomb, B. A. Acetylcholinesterase inhibitors and Gulf War illnesses. Proc. Natl. Acad. Sci. USA 2008, 105, 4295–4300. DOI: 10.1073/pnas.0711986105.
  • Monleau, M.; De Méo, M.; Paquet, Fois.; Chazel, Valérie.; Duménil, Gérard.;.; Donnadieu–Claraz, Marie.; Genotoxic and inflammatory effects of depleted uranium particles inhaled by rats. Toxicol. Sci. 2006, 89, 287–295. DOI: 10.1093/toxsci/kfj010.
  • Pepi, M.; Heipieper, H. J.; Fischer, J.; Ruta, M.; Volterrani, M.; Focardi, S. E. Membrane fatty acids adaptive profile in the simultaneous presence of arsenic and toluene in Bacillus sp. ORAs2 and pseudomonas sp. ORAs5 strains. Extremophiles 2008, 12, 343–349. DOI: 10.1007/s00792–008–0147–9.
  • Kyrklund, T.; Kjellstrand, P.; Haglid, KGMembrane. Lipid changes in organic solvent tolerant neural cells. Arch. Toxicol. Suppl. 1986, 9, 38–45.
  • Antunes–Madeira, M. C.; Almeida, L. M.; Madeira, V. M. C. Depth–dependent. Effects of DDT and lindane on the fluidity of native membranes and extracted lipids. Implicat. Mech. Toxicity. Bull. Environ. Contam. Toxicol. 1993, 51, 787–794.
  • Antunes–Madeira, M. C.; Madeira, V. M. Interaction of insecticides with lipid membranes. Biochim. Biophys. Acta. 1979, 550, 384–392.
  • Shabarchin, E. I.; Kruglyakova, K. E.; Gendel, L. Y.; Kabanov, V. V. Influence of metaphos on the structuro–functional organization of mitochondrial membranes. Biol. Bull. Acad. Sci. USSR 1979, 6, 788–793.
  • Baureus Koch, C. L.; Sommarin, M.; Persson, B. R.; Salford, L. G.; Eberhardt, J. L. Interaction between weak low frequency magnetic fields and cell membranes. Bioelectromagnetics 2003, 24, 395–402. DOI: 10.1002/bem.10136.
  • Benderitter, M.; Vincent–Genod, L.; Pouget, J. P.; Voisin, P. The cell membrane as a biosensor of oxidative stress induced by radiation exposure: a multiparameter investigation. Radiat. Res. 2003, 159, 471–483.
  • Chattopadhyay, A.; Paila, Y. D.; Jafurulla, M.; Chaudhuri, A.; Singh, P.; Murty, M. R.; Vairamani, M. Differential effects of cholesterol and 7–Dehydrocholesterol on ligand binding of solubilized hippocampal serotonin1A receptors: implications in SLOS. Biochem. Biophys. Res. Commun. 2007, 363, 800–805. DOI: 10.1016/j.bbrc.2007.09.040.
  • Antonenko, Y. N.; Kinnally, K. W.; Perini, S.; Tedeschi, H. Selective effect of inhibitors on inner mitochondrial membrane channels. FEBS Lett. 1991, 285, 89–93. DOI: 10.1016/0014–5793(91)80731–H.
  • Alves–Ferreira, M.; Scofano, H. M.; Ferreira–Pereira, A. Ca(2+)–ATPase from chicken (Gallus Domesticus) erythrocyte plasma membrane: effects of calmodulin and taurine on the Ca(2+)–dependent ATPase activity and Ca2+ uptake. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 1999, 122, 269–276. DOI: 10.1016/S0305–0491(99)00008–5.
  • Khairallah, R. J.; Kim, J.; O'Shea, K. M.; O'Connell, K. A.; Brown, B. H.; Galvao, T.; Daneault, C.; Des Rosiers, C.; Polster, B. M.; Hoppel, C. L.; Stanley, W. C. Improved mitochondrial function with diet–induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. PLoS One. 2012, 7, e34402DOI: 10.1371/journal.pone.0034402.
  • Haines, T. H. Do sterols reduce proton and sodium leaks through lipid bilayers? Prog. Lipid Res. 2001, 40, 299–324.
  • Mejia, E. M.; Hatch, G. M. Mitochondrial phospholipids: role in mitochondrial function. J. Bioenerg. Biomembr. 2015, 48, 99–112.
  • Bester, R.; Lochner, A. Sarcolemmal phospholipid fatty acid composition and permeability. Biochim. Biophys. Acta 1988, 941, 176–186. DOI: 10.1016/0005–2736(88)90178–2.
  • Chalder, T.; Hotopf, M.; Unwin, C.; Hull, L.; Ismail, K.; David, A.; Wessely, S. Prevalence of Gulf War Veterans who believe they have Gulf War syndrome: questionnaire study. BMJ 2001, 323, 473–476. DOI: 10.1136/bmj.323.7311.473.
  • Cherry, N.; Creed, F.; Silman, A.; Dunn, G.; Baxter, D.; Smedley, J.; Taylor, S.; Macfarlane, G. J. Health and Exposures of United Kingdom Gulf War Veterans. Part II: The Relation of Health to Exposure. Occup. Environ. Med. 2001, 58, 299–306. DOI: 10.1136/oem.58.5.299.
  • Hotopf, M.; David, A.; Hull, L.; Ismail, K.; Unwin, C.; Wessely, S. Role of vaccinations as risk factors for ill health in veterans of the Gulf War: cross sectional study. BMJ 2000, 320, 1363–1367.
  • Hotopf, M.; Hull, L.; Ismail, K.; Unwin, C.; Wessely, S.; David, A. In Vaccinations as a Risk Factor for Ill Health in Gulf War Veterans: Results of the King’s Study [abstract]. Proceedings of the Conference on Federally Sponsored Gulf War Veterans’ Illnesses Research, Pentagon City, 1999; 103.
  • Unwin, C.; Blatchley, N.; Coker, W.; Ferry, S.; Hotopf, M.; Hull, L.; Ismail, K.; Palmer, I.; David, A.; Wessely, S. Health of UK servicemen who served in Persian Gulf War. Lancet 1999, 353, 169–178. DOI: 10.1016/S0140–6736(98)11338–7.
  • Gray, G. C.; Reed, R. J.; Kaiser, K. S.; Smith, T. C.; Gastanaga, V. M. Self–reported symptoms and medical conditions among 11,868 Gulf War–Era Veterans: The Seabee Health Study. Am. J. Epidemiol. 2002, 155, 1033–1044. DOI: 10.1093/aje/155.11.1033.
  • Schumm, W. R.; Reppert, E. J.; Jurich, A. P.; Bollman, S. R.; Webb, F. J.; Castelo, C. S.; Stever, J. C.; Sanders, D.; Bonjour, G. N.; Crow, J. R.; et al. Self–reported changes in subjective health and anthrax vaccination as reported by over 900 Persian Gulf War Era Veterans. Psychol. Rep. 2002, 90, 639–653. DOI: 10.2466/pr0.2002.90.2.639.
  • Vojdani, A.; Thrasher, J. D. Cellular and humoral immune abnormalities in Gulf War Veterans. Environ. Health. Perspect. 2004, 112, 840–846. DOI: 10.1289/ehp.6881.
  • Abou–Donia, M. B.; Conboy, L. A.; Kokkotou, E.; Jacobson, E.; Elmasry, E. M.; Elkafrawy, P.; Neely, M.; Bass, C. R.; Sullivan, K. Screening for novel central nervous system biomarkers in veterans with Gulf War illness. Neurotoxicol. Teratol. 2017, 61, 36–46.
  • Proksch, E.; Feingold, K. R.; Elias, P. M. Epidermal HMG CoA reductase activity in essential fatty acid deficiency: barrier requirements rather than eicosanoid generation regulate cholesterol synthesis. J. Invest. Dermatol. 1992, 99, 216–220. DOI: 10.1111/1523–1747.ep12650440.
  • Harris, I. R.; Farrell, A. M.; Grunfeld, C.; Holleran, W. M.; Elias, P. M.; Feingold, K. R. Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis. J. Invest. Dermatol. 1997, 109, 783–787. DOI: 10.1111/1523–1747.ep12340962.
  • Sartorelli, P.; Aprea, C.; Bussani, R.; Novelli, M. T.; Orsi, D.; Sciarra, G. In Vitro Percutaneous Penetration of Methyl–Parathion from a Commercial Formulation through the Human Skin. Occup. Environ. Med. 1997, 54, 524–525. DOI: 10.1136/oem.54.7.524.
  • Yin, H.; Gao, L.; Tai, H. H.; Murphey, L. J.; Porter, N. A.; Morrow, J. D. Urinary prostaglandin F2alpha is generated from the isoprostane pathway and not the cyclooxygenase in humans. J. Biol. Chem. 2007, 282, 329–336. DOI: 10.1074/jbc.M608975200.
  • Chen, C. T.; Trepanier, M. O.; Hopperton, K. E.; Domenichiello, A. F.; Masoodi, M.; Bazinet, R. P. Inhibiting mitochondrial beta–oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain. J. Cereb. Blood Flow Metab. 2014, 34, 376–379. DOI: 10.1038/jcbfm.2013.221.
  • Ito, S.; Narumiya, S.; Hayaishi, O. Prostaglandin D2: A biochemical perspective. Prostag. Leukot. Essen. Fatty Acids 1989, 37, 219–234. DOI: 10.1016/0952–3278(89)90033–1.
  • Bach, R. Gulf War Associated Chronic Coagulopathies Update. In Meeting of the Research Advisory Committee on Gulf War Veterans Illnesses, Boston University School of Public Health. 2009. Available at http://www1.va.gov/rac–gwvi/docs/June2009FinalAgenda.doc.
  • Hannan, K. L.; Berg, D. E.; Baumzweiger, W.; Harrison, H. H.; Berg, L. H.; Ramirez, R.; Nichols, D. Activation of the coagulation system in gulf war illness: a potential pathophysiologic link with chronic fatigue syndrome. A laboratory approach to diagnosis. Blood Coagul. Fibrinolysis 2000, 11, 673–678. DOI: 10.1097/00001721–200010000–00013.
  • Bray, M. A.; Ford–Hutchinson, A. W.; Smith, M. J. Leukotriene B4: An Inflammatory Mediator in Vivo. Prostaglandins 1981, 22, 213–222.
  • Barcellos–de–Souza, P.; Canetti, C. u.; Barja–Fidalgo, C.; Arruda, M. A. Leukotriene B4 inhibits neutrophil apoptosis via NADPH oxidase activity: redox control of NF–ΰB pathway and mitochondrial stability. Biochim. Biophys. Acta (BBA) – Mol. Cell Res. 2012, 1823, 1990–1997. DOI: 10.1016/j.bbamcr.2012.07.012.
  • Palmblad, J.; Gyllenhammar, H.; Ringertz, B.; Nilsson, E.; Cottell, B. Leukotriene B4 triggers highly characteristic and specific functional responses in neutrophils: studies of stimulus specific mechanisms. Biochim. Biophys. Acta 1988, 971, 92–102. DOI: 10.1016/0167–4889(88)90165–6.
  • Golomb, B. A. A Review of the Scientific Literature as it Pertains to Gulf War Illnesses, Vol 2: Pyridostigmine Bromide. RAND: Washington, DC, 1999; 385.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.