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Journal of Environmental Science and Health, Part B
Pesticides, Food Contaminants, and Agricultural Wastes
Volume 56, 2021 - Issue 3
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Research Article

In vitro α-amylase and α-glucosidase enzyme inhibition and antioxidant activity by capsaicin and piperine from Capsicum chinense and Piper nigrum fruits

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References

  • Charokopou, M.; Sabater, F. J.; Townsend, R.; Roudaut, M.; McEwan, P.; Verheggen, B. G. Methods Applied in Cost-Effectiveness Models for Treatment Strategies in Type 2 Diabetes Mellitus and Their Use in Health Technology Assessments: A Systematic Review of the Literature from 2008 to 2013. Curr. Med. Res. Opin. 2016, 32, 207–218. DOI: 10.1185/03007995.2015.1102722.
  • Sami, W.; Ansari, T.; Butt, N. S.; Ab Hamid, M. R. Effect of Diet on Type 2 Diabetes Mellitus: A Review. Int. J. Health Sci. 2017, 11, 65.
  • Akash, M. S. H.; Rehman, K.; Rasool, F.; Sethi, A.; Abrar, M. A.; Irshad, A.; Abid, A.; Murtaza, G. Alternate Therapy of Type 2 Diabetes Mellitus (T2DM) with Nigella (Ranunculaceae). J. Med. Plants Res. 2011, 5, 6885–6889.
  • Asmat, U.; Abad, K.; Ismail, K. Diabetes Mellitus and Oxidative stress-A Concise Review. Saudi Pharm J 2016, 24, 547–553. DOI: 10.1016/j.jsps.2015.03.013.
  • Kajaria, D.; Ranjana, J. T.; Tripathi, Y. B.; Tiwari, S. In-Vitro α Amylase and Glycosidase Inhibitory Effect of Ethanolic Extract of Antiasthmatic drug-Shirishadi. J. Adv. Pharm. Technol. Res 2013, 4, 206.
  • Chakrabarti, R.; Rajagopalan, R. Diabetes and Insulin Resistance Associated Disorders: disease and the Therapy. Curr. Sci. 2002, 83, 1533–1538.
  • Menichini, F.; Tundis, R.; Bonesi, M.; Loizzo, M. R.; Conforti, F.; Statti, G.; De Cindio, B.; Houghton, P. J.; Menichini, F. The Influence of Fruit Ripening on the Phytochemical Content and Biological Activity of Capsicum Chinense. Jacq. cv Habanero. Food Chem. 2009, 114, 553–560. DOI: 10.1016/j.foodchem.2008.09.086.
  • Ahmad, N.; Fazal, H.; Abbasi, B. H.; Farooq, S.; Ali, M.; Khan, M. A. Biological Role of Piper nigrum L. (Black Pepper): A Review. Asian Pac. J. Trop. Biomed. 2012, 2, S1945–S1953. DOI: 10.1016/S2221-1691(12)60524-3.
  • Watcharachaisoponsiri, T.; Sornchan, P.; Charoenkiatkul, S.; Suttisansanee, U. The α-Glucosidase and α-Amylase Inhibitory Activity from Different Chili Pepper Extracts. Int. Food Res. J. 2016, 23,1439–1445.
  • Molina-Torres, J.; Salazar-Cabrera, C. J.; Armenta-Salinas, C.; Ramírez-Chávez, E. Fungistatic and Bacteriostatic Activities of Alkamides from Heliopsis Longipes Roots: Affinin and Reduced Amides. J. Agric Food Chem. 2004, 52, 4700–4704. DOI: 10.1021/jf034374y.
  • Buitimea-Cantúa, G. V.; Buitimea-Cantúa, N. E.; M.; del Refugio, Rocha-Pizaña, Rosas-Burgos, E. C.; Hernández-Morales, A.; Molina-Torres, J. Antifungal and anti-Aflatoxigenic Activity of Heliopsis Longipes Roots and Affinin/Spilanthol against Aspergillus parasiticus by Downregulating the Expression of Alf D and Afl R Genes of the Aflatoxins Biosynthetic Pathway. J. Environ. Sci. Heal. B 2020, 55, 210–219. DOI: 10.1080/03601234.2019.1681818.
  • Chen, Y.; Zhang, R.; Liu, C.; Zheng, X.; Liu, B. Enhancing Antioxidant Activity and Antiproliferation of Wheat Bran through Steam Flash Explosion. J Food Sci Technol. 2016, 53, 3028–3034. DOI: 10.1007/s13197-016-2274-0.
  • Chen, Y.; Ma, X.; Fu, X.; Yan, R. Phytochemical Content, Cellular Antioxidant Activity and Antiproliferative Activity of Adinandra Nitida Tea (Shiyacha) Infusion Subjected to in Vitro Gastrointestinal Digestion. RSC Adv. 2017, 7, 50430–50440. DOI: 10.1039/C7RA07429H.
  • Aiyegoro, O. A.; Okoh, A. I. Preliminary Phytochemical Screening and in Vitro Antioxidant Activities of the Aqueous Extract of Helichrysum longifolium DC. BMC Complemen. Altern. Med. 2010, 10, 21.
  • Benzie, I. F.; Szeto, Y. T. Total Antioxidant Capacity of Teas by the Ferric Reducing/Antioxidant Power Assay. J Agric Food Chem. 1999, 47, 633–636. DOI: 10.1021/jf9807768.
  • Aguilar-Urbano, M.; Pineda-Priego, M.; Prieto, P. Spectrophotometric Quantitation of Antioxidant Capacity through the Formation of a Phosphomolybdenum Complex: specific Application to the Determination of Vitamin E1. Anal. Biochem. 2013, 269, 337–341.
  • Siow, H. L.; Tye, G. J.; Gan, C. Y. Pre-Clinical Evidence for the Efficacy and Safety of α-Amylase Inhibitory Peptides from Cumin (Cuminum cyminum) Seed. J. Funct. Foods 2017, 35, 216–223. DOI: 10.1016/j.jff.2017.05.046.
  • Jabeen, B.; Riaz, N.; Saleem, M.; Naveed, M. A.; Ashraf, M.; Alam, U.; Rafiq, H. M.; Tareen, R. B.; Jabbar, A. Isolation of Natural Compounds from Phlomis stewartii Showing α-Glucosidase Inhibitory Activity. Phytochemistry 2013, 96, 443–448. DOI: 10.1016/j.phytochem.2013.09.015.
  • Nahoum, V.; Roux, G.; Anton, V.; Rougé, P.; Puigserver, A.; Bischoff, H.; Henrissat, B.; Payan, F. Crystal Structures of Human Pancreatic α-Amylase in Complex with Carbohydrate and Proteinaceous Inhibitors. Biochem. J. 2000, 346, 201–208. DOI: 10.1042/bj3460201.
  • Yamamoto, K.; Miyake, H.; Kusunoki, M.; Osaki, S. Steric Hindrance by 2 Amino Acid Residues Determines the Substrate Specificity of Isomaltase from Saccharomyces cerevisiae. J. Biosci. Bioeng. 2011, 112, 545–550. DOI: 10.1016/j.jbiosc.2011.08.016.
  • Andradea, K. S.; Salvador-Ferreira, R. S. 2013. Antioxidant Activity of Black Pepper (Piper nigrum L.) Oil Obtained by Supercritical CO2. In III Iberoamerican Conference on Supercritical Fluids, Cartagena de Indias (Colombia).
  • Amruthraj, N. J.; Preetam-Raj, J. P.; Antoine-Lebel, L. Impact of Organic Solvents in the Extraction Efficiency of Therapeutic Analogue Capsaicin from Capsicum Chinense Bhut Jolokia Fruits. Int. J. Pharm. Clin. Res. 2014, 6, 159–164.
  • Castro-Concha, L. A.; Tuyub-Che, J.; Moo-Mukul, A.; Vazquez-Flota, F. A.; Miranda-Ham, M. L. Antioxidant Capacity and Total Phenolic Content in Fruit Tissues from Accessions of Capsicum Chinense Jacq. (Habanero pepper) at Different Stages of Ripening. ScientificWorldJournal 2014, 2014, 809073. DOI: 10.1155/2014/809073.
  • Vázquez-Flota, F.; de Lourdes Miranda-Ham, M.; Monforte-González, M.; Gutiérrez-Carbajal, G.; Velázquez-García, C.; Nieto-Pelayo, Y. La Biosíntesis de Capsaicinoides, el Principio Picante Del chile. Rev. Fitotec. Mex. 2007, 30, 353–360.
  • Hu, L.; Xu, Z.; Wang, M.; Fan, R.; Yuan, D.; Wu, B.; Wu, H.; Qin, X.; Yan, L.; Tan, L.; et al. The Chromosome-Scale Reference Genome of Black Pepper Provides Insight into Piperine Biosynthesis. Nat. Commun. 2019, 10, 1–11.
  • Srinivasan, K. Black Pepper and Its Pungent principle-piperine: a review of diverse physiological effects. Crit. Rev. Food Sci. Nutr. 2007, 47, 735–748. DOI: 10.1080/10408390601062054.
  • Sultana, B.; Anwar, F.; Ashraf, M. Effect of Extraction Solvent/Technique on the Antioxidant Activity of Selected Medicinal Plant Extracts. Molecules 2009, 14, 2167–2180. DOI: 10.3390/molecules14062167.
  • VöSgen, B.; Herrmann, K. Flavonoglycoside Von Pfeffer (Piper nigrum L.), GewüRznelken (Syzygium aromaticum L., Merr. Et Perry) Und Piment (Pimenta dioica L., Merr.). Z. Lebensm. Unters Forsch 1980, 170, 204–207.
  • Nakatani, N.; Inatani, R.; Ohta, H.; Nishioka, A. Chemical Constituents of Peppers (Piper Spp.) and Application to Food Preservation: naturally Occurring Antioxidative Compounds. Environ Health Perspect. 1986, 67, 135–142. DOI: 10.1289/ehp.8667135.
  • Yang, B.; Liu, H.; Yang, J.; Gupta, V. K.; Jiang, Y. New Insights on Bioactivities and Biosynthesis of Flavonoid Glycosides. Trends Food Sci. Tech. 2018, 79, 116–124. DOI: 10.1016/j.tifs.2018.07.006.
  • Markus, F.; Daood, H. G.; Kapitany, J.; Biacs, P. A. Change in the Carotenoid and Antioxidant Content of Spice Red Pepper (Paprika) as a Function of Ripening and Some Technological Factors. J. Agric. Food Chem. 1999, 47, 100–107.
  • Loizzo, M. R.; Pugliese, A.; Bonesi, M.; Menichini, F.; Tundis, R. Evaluation of Chemical Profile and Antioxidant Activity of Twenty Cultivars from Capsicum annuum, Capsicum baccatum, Capsicum chacoense and Capsicum chinense: A Comparison between Fresh and Processed Peppers. LWT-Food Sci. Technol. 2015, 64, 623–631. DOI: 10.1016/j.lwt.2015.06.042.
  • Gajbhiye, R. L.; Ganapathy, A.; Jaisankar, P. A Review of α-Glucosidase and α-Amylase Inhibitors for Type 2 Diabetes Isolated from Some Important Indian Medicinal Plants. Ann. Clin. Pharmacol. Ther. 2018, 1, 1–10.
  • Abdelli, I.; Benariba, N.; Adjdir, S.; Fekhikher, Z.; Daoud, I.; Terki, M.; Benramdane, H.; Ghalem, S. In Silico Evaluation of Phenolic Compounds as Inhibitors of α-Amylase and α-Glucosidase. J. Biomol. Struct. Dyn. 2020, 1–7.
  • Tundis, R.; Loizzo, M. R.; Menichini, F.; Bonesi, M.; Conforti, F.; De Luca, D.; Menichini, F. Air-Dried Capsicum Annuum Var. acuminatum Medium and Big: Determination of Bioactive Constituents, Antioxidant Activity and Carbohydrate-Hydrolyzing Enzymes Inhibition. Food Res. Int. 2012, 45, 170–176. DOI: 10.1016/j.foodres.2011.10.028.
  • Bae, H.; Jayaprakasha, G. K.; Jifon, J.; Patil, B. S. Variation of Antioxidant Activity and the Levels of Bioactive Compounds in Lipophilic and Hydrophilic Extracts from Hot Pepper (Capsicum Spp.) Cultivars. Food Chem. 2012, 134, 1912–1918. DOI: 10.1016/j.foodchem.2012.03.108.
  • Kim, Y. C.; Choi, D.; Lee, J. H.; Lee, S. Alpha-Glucosidase Inhibitory Activity in Different Pepper Cultivars (Capsicum annuum L.). Hortic. Sci. Technol. 2018, 36, 444–450.
  • Thongnum, K.; Chanthai, S. Inhibitory Reactivity of Capsaicin with α-Amylase and α-Glucosidase Related to Antidiabetes Using Molecular Docking and Quantum Calculation Methods. Orient. J. Chem. 2018, 34, 2211–2228. DOI: 10.13005/ojc/340501.
  • Nanok, K.; Sansenya, S. α-Glucosidase, α-Amylase, and Tyrosinase Inhibitory Potential of Capsaicin and Dihydrocapsaicin. J Food Biochem. 2020, 44, e13099. DOI: 10.1111/jfbc.13099.
  • Oboh, G.; Ademosun, A. O.; Odubanjo, O. V.; Akinbola, I. A. Antioxidative Properties and Inhibition of Key Enzymes Relevant to Type-2 Diabetes and Hypertension by Essential Oils from Black pepper. Adv. Pharmacol. Sci. 2013, 2013, 926047 DOI: 10.1155/2013/926047..
  • Thakre, D.; Damodar, K.; Khan, N. D.; Khan, Z. H.; Mular, S. M. In Vitro Assay of Alpha Amylase Inhibitory Activity of Piper Species. Bio. Disc. 2017, 8, 125–128.
  • Patel Amit, G.; Kaur, G.; Meena, C. α-Glucosidase Inhibitory Activity of Curcumin and Its Comparison with Combinatorial Extract Consisting of Curcumin with Piperine and Quercetin. Pharmacologyonline 2011, 3, 796–801.
  • Bajpai, V. K.; Kang, S. C. Tyrosinase and α-Glucosidase Inhibitory Effects of an Abietane Type Diterpenoid Taxodone from Metasequoia Glyptostroboides. Natl. Acad. Sci. Lett. 2015, 38, 399–402. DOI: 10.1007/s40009-015-0383-3.
  • He, Q.; Lv, Y.; Yao, K. Effects of Tea Polyphenols on the Activities of α-Amylase, Pepsin, Trypsin and Lipase. Food Chem. 2007, 101, 1178–1182. DOI: 10.1016/j.foodchem.2006.03.020.
  • Tadera, K.; Minami, Y.; Takamatsu, K.; Matsuoka, T. Inhibition of alpha-glucosidase and alpha-amylase by flavonoids. J. Nutr. Sci. Vitaminol. (Tokyo) 2006, 52, 149–153. DOI: 10.3177/jnsv.52.149.
  • Yan, J.; Zhang, G.; Pan, J.; Wang, Y. α-Glucosidase Inhibition by Luteolin: Kinetics, Interaction and Molecular Docking. Int. J. Biol. Macromol. 2014, 64, 213–223. DOI: 10.1016/j.ijbiomac.2013.12.007.

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