Publication Cover
Journal of Environmental Science and Health, Part B
Pesticides, Food Contaminants, and Agricultural Wastes
Volume 57, 2022 - Issue 1
380
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Antibiotics in urine of the general population: Exposure, health risk assessment, and food factors

, , , , &

References

  • Di Poi, C.; Costil, K.; Bouchart, V.; Halm-Lemeille, M. P. Toxicity Assessment of Five Emerging Pollutants, Alone and in Binary or Ternary Mixtures, towards Three Aquatic Organisms. Environ. Sci. Pollut. Res. 2018, 25, 6122–6134. DOI: https://doi.org/10.1007/s11356-017-9306-9.
  • Chen, J.; Sun, R.; Pan, C.; Sun, Y.; Mai, B.; Li, Q. X. Antibiotics and Food Safety in Aquaculture. J. Agric. Food Chem. 2020, 68, 11908–11919.
  • Sun, J.; Zeng, Q.; Tsang, D. C. W.; Zhu, L. Z.; Li, X. D. Antibiotics in the Agricultural Soils from the Yangtze River Delta, China. Chemosphere 2017, 189, 301–308.
  • Topp, E.; Larsson, D. G. J.; Miller, D. N.; Van den Eede, C.; Virta, M. P. J. Antimicrobial Resistance and the Environment: assessment of Advances, Gaps and Recommendations for Agriculture, Aquaculture and Pharmaceutical Manufacturing. FEMS Microbiol. Ecol. 2018, 94, fix 185.
  • Van Boeckel, T. P.; Brower, C.; Gilbert, M.; Grenfell, B. T.; Levin, S. A.; Robinson, T. P.; Teillant, A.; Laxminarayan, R. Global Trends in Antimicrobial Use in Food Animals. Proc. Natl. Acad. Sci. U S A. 2015, 112, 5649–5654.
  • Zhang, Q. Q.; Ying, G. G.; Pan, C. G.; Liu, Y. S.; Zhao, J. L. Comprehensive Evaluation of Antibiotics Emission and Fate in the River Basins of China: source Analysis, Multimedia Modeling, and Linkage to Bacterial Resistance. Environ. Sci. Technol. 2015, 49, 6772–6782.
  • Khan, N. A.; Ahmed, S.; Farooqi, I. H.; Ali, I.; Vambol, V.; Changani, F.; Yousefi, M.; Vambol, S.; Khan, S. U.; Khan, A. H. Occurrence, Sources and Conventional Treatment Techniques for Various Antibiotics Present in Hospital Wastewaters: A Critical Review. TrAC- Trends Analyt. Chem 2020, 129, 115921. DOI: https://doi.org/10.1016/j.trac.2020.115921.
  • Elizalde, V. A.; Gomez, O. L. M.; Islas, F. H.; Reyes, N. S. J.; Martınez, M. G.; Medina, S. G.; Garcıa, O. D.; Navarro, M. D. H. Ecotoxicological Studies of Pharmaceuticals in Aquatic Organisms. In Ecopharmacovigilance: The Handbook of Environmental Chemistry, Gómez-Oliván, L. M., Eds.; Springer: Cham, 2017; pp 75–93.
  • Kivits, T.; Broers, H. P.; Beeltje, H.; van Vliet, M.; Griffioen, J. Presence and Fate of Veterinary Antibiotics in Age-Dated Groundwater in Areas with Intensive Livestock Farming. Environ. Pollut. 2018, 241, 988–998.
  • Bacanli, M.; Basaran, N. Importance of Antibiotic Residues in Animal Food. Food Chem. Toxicol. 2019, 125, 462–466.
  • Chen, J.; Ying, G. G.; Deng, W. J. Antibiotic Residues in Food: extraction, Analysis, and Human Health Concerns. J. Agric. Food Chem. 2019, 67, 7569–7586. DOI: https://doi.org/10.1021/acs.jafc.9b01334.
  • Wang, H.; Ren, L.; Yu, X.; Hu, J.; Chen, Y.; He, G.; Jiang, Q. Antibiotic Residues in Meat, Milk and Aquatic Products in Shanghai and Human Exposure Assessment. Food Control 2017, 80, 217–225. DOI: https://doi.org/10.1016/j.foodcont.2017.04.034.
  • Zheng, N.; Wang, J.; Han, R.; Xu, X.; Zhen, Y.; Qu, X.; Sun, P.; Li, S.; Yu, Z. Occurrence of Several Main Antibiotic Residues in Raw Milk in 10 Provinces of China. Food Addit. Contam. Part B Surveill. 2013, 6, 84–89.
  • Li, N.; Ho, K. W. K.; Ying, G. G.; Deng, W. J. Veterinary Antibiotics in Food, Drinking Water, and the Urine of Preschool Children in Hong Kong. Environ. Int. 2017, 108, 246–252. DOI: https://doi.org/10.1016/j.envint.2017.08.014.
  • Ben, Y.; Fu, C.; Hu, M.; Liu, L.; Wong, M. H.; Zheng, C. Human Health Risk Assessment of Antibiotic Resistance Associated with Antibiotic Residues in the Environment: A Review. Environ. Res. 2019, 169, 483–493.
  • Australian Pesticides and Veterinary Medicines Authority. Acceptable daily intakes (ADI) for agricultural and veterinary. https://apvma.gov.au/node/26596,2021.
  • Chen, C. Q.; Zheng, L.; Zhou, J. L.; Zhao, H. Persistence and Risk of Antibiotic Residues and Antibiotic Resistance Genes in Major Mariculture Sites in Southeast China. Sci. Total Environ. 2017, 580, 1175–1184.
  • Gullberg, E.; Cao, S.; Berg, O. G.; Ilback, C.; Sandegren, L.; Hughes, D.; Andersson, D. I. Selection of Resistant Bacteria at Very Low Antibiotic Concentrations. PLoS Pathog. 2011, 7, e1002158. DOI: https://doi.org/10.1371/journal.ppat.1002158.
  • Sang, Y.; Zhang, J.; Liu, K.; Wang, Q.; Wang, S.; Sheng, J.; Wang, L.; Zhang, D.; Li, X.; Cao, H. J.; et al. Antibiotics Biomonitored in Urine and Obesogenic Risk in a Community-Dwelling Elderly Population. Ecotoxicol. Environ. Saf. 2021, 210, 111863. DOI: https://doi.org/10.1016/j.ecoenv.2020.111863.
  • Dong, R.; Zhou, T.; Zhao, S.; Zhang, H.; Zhang, M.; Chen, J.; Wang, M.; Wu, M.; Li, S.; Chen, B. Food Consumption Survey of Shanghai Adults in 2012 and Its Associations with Phthalate Metabolites in Urine. Environ. Int. 2017, 101, 80–88. DOI: https://doi.org/10.1016/j.envint.2017.01.008.
  • Huang, W.; Qiu, Q.; Chen, M.; Shi, J.; Huang, X.; Kong, Q.; Long, D.; Chen, Z.; Yan, S. Determination of 18 Antibiotics in Urine Using LC-QqQ-MS/MS. J. Chromatogr. B 2019, 1105, 176–183. DOI: https://doi.org/10.1016/j.jchromb.2018.12.019.
  • Wang, H.; Tang, C.; Yang, J.; Wang, N.; Jiang, F.; Xia, Q.; He, G.; Chen, Y.; Jiang, Q. Predictors of Urinary Antibiotics in Children of Shanghai and Health Risk Assessment. Environ. Int. 2018, 121, 507–514.
  • Zhu, Y.; Liu, K.; Zhang, J.; Liu, X.; Yang, L.; Wei, R.; Wang, S.; Zhang, D.; Xie, S.; Tao, F. Antibiotic Body Burden of Elderly Chinese Population and Health Risk Assessment: A Human Biomonitoring-Based Study. Environ. Pollut. 2020, 256, 113311.
  • Bekoe, S. O.; Orman, E.; Asare-Nkansah, S.; Sørensen, A. M. L.; Björklund, E.; Adosraku, R. K.; Hansen, M.; Styrishave, B. Detection and Quantification of Antibiotic Residues in Urine Samples of Healthy Individuals from Rural and Urban Communities in Ghana Using a Validated SPE-LC-MS/MS Method. SN Appl. Sci. 2020, 2. 1903. DOI: https://doi.org/10.1007/s42452-020-03742-7.
  • Ji, K.; Kho, Y.; Park, Y.; Choi, K. Influence of a Five-Day Vegetarian Diet on Urinary Levels of Antibiotics and Phthalate Metabolites: A Pilot Study with "Temple Stay" Participants. Environ. Res. 2010, 110, 375–382.
  • Wang, K.; Lin, K.; Huang, X.; Chen, M. A Simple and Fast Extraction Method for the Determination of Multiclass Antibiotics in Eggs Using LC-MS/MS. J. Agric. Food Chem. 2017, 65, 5064–5073. DOI: https://doi.org/10.1021/acs.jafc.7b01777.
  • He, J.; Song, L.; Zhou, G.; Zhao, L. The Rapid Analysis of Antibiotics in Animal Meat and Egg Using a Novel SEP Method and UPLC–MS/MS. Chromatographia 2017, 80, 1329–1342. DOI: https://doi.org/10.1007/s10337-017-3366-3.
  • Tang, Q.; Yang, T.; Tan, X.; Luo, J. Simultaneous Determination of Fluoroquinolone Antibiotic Residues in Milk Sample by Solid-Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometry. J. Agric. Food Chem. 2009, 57, 4535–4539. DOI: https://doi.org/10.1021/jf900513b.
  • Han, R. W.; Zheng, N.; Yu, Z. N.; Wang, J.; Xu, X. M.; Qu, X. Y.; Li, S. L.; Zhang, Y. D.; Wang, J. Q. Simultaneous Determination of 38 Veterinary Antibiotic Residues in Raw Milk by UPLC-MS/MS. Food Chem. 2015, 181, 119–126.
  • Wei, Y.; Zhang, Y.; Xu, J.; Guo, C.; Li, L.; Fan, W. Simultaneous Quantification of Several Classes of Antibiotics in Water, Sediments, and Fish Muscles by Liquid Chromatography-Tandem Mass Spectrometry. Front. Environ. Sci. Eng. 2014, 8, 357–371. DOI: https://doi.org/10.1007/s11783-013-0580-6.
  • Zhao, J. L.; Liu, Y. S.; Liu, W. R.; Jiang, Y. X.; Su, H. C.; Zhang, Q. Q.; Chen, X. W.; Yang, Y. Y.; Chen, J.; Liu, S. S.; et al. Tissue-Specific Bioaccumulation of Human and Veterinary Antibiotics in Bile, Plasma, Liver and Muscle Tissues of Wild Fish from a Highly Urbanized Region. Environ. Pollut. 2015, 198, 15–24.
  • Liu, X.; Lu, S.; Guo, W.; Xi, B.; Wang, W. Antibiotics in the Aquatic Environments: A Review of Lakes. Sci. Total Environ. 2018, 627, 1195–1208.
  • Hu, X.; Zhou, Q.; Luo, Y. Occurrence and Source Analysis of Typical Veterinary Antibiotics in Manure, Soil, Vegetables and Groundwater from Organic Vegetable Bases, Northern China. Environ. Pollut. 2010, 158, 2992–2998.
  • Pan, M.; Wong, C. K.; Chu, L. M. Distribution of Antibiotics in Wastewater-Irrigated Soils and Their Accumulation in Vegetable Crops in the Pearl River Delta, Southern. J. Agric. Food Chem. 2014, 62, 11062–11069. DOI: https://doi.org/10.1021/jf503850v.
  • Yu, X.; Liu, H.; Pu, C.; Chen, J.; Sun, Y.; Hu, L. Determination of Multiple Antibiotics in Leafy Vegetables Using QuEChERS-UHPLC-MS/MS. J. Sep. Sci. 2018, 41, 713–722.
  • Ji, K.; Kho, Y.; Park, C.; Paek, D.; Ryu, P.; Paek, D.; Kim, M.; Kim, P.; Choi, K. Influence of Water and Food Consumption on Inadvertent Antibiotics Intake among General Population. Environ. Res. 2010, 110, 641–649.
  • Wang, H. X.; Wang, B.; Zhao, Q.; Zhao, Y. P.; Fu, C. W.; Feng, X.; Wang, N.; Su, M. F.; Tang, C. X.; Jiang, F.; et al. Antibiotic Body Burden of Chinese School Children: A Multisite Biomonitoring-Based Study. Environ. Sci. Technol. 2015, 49, 5070–5079.
  • Wang, H. X.; Wang, N.; Qian, J. H.; Hu, L. Y.; Huang, P. X.; Su, M. F.; Yu, X.; Fu, C. W.; Jiang, F.; Zhao, Q.; et al. Urinary Antibiotics of Pregnant Women in Eastern China and Cumulative Health Risk Assessment. Environ. Sci. Technol. 2017, 51, 3518–3525.
  • Wang, H. X.; Wang, N.; Wang, B.; Fang, H.; Fu, C. W.; Tang, C. X.; Jiang, F.; Zhou, Y.; He, G. S.; Zhao, Q.; et al. Antibiotics Detected in Urines and Adipogenesis in School Children. Environ. Int. 2016, 89–90, 204–211.
  • Wei, R.; Ge, F.; Huang, S.; Chen, M.; Wang, R. Occurrence of Veterinary Antibiotics in Animal Wastewater and Surface Water around Farms in Jiangsu Province, China. Chemosphere 2011, 82, 1408–1414.
  • Zhang, J. J.; Liu, X. J.; Zhu, Y. T.; Yang, L. S.; Sun, L.; Wei, R.; Chen, G. M.; Wang, Q. N.; Sheng, J.; Liu, A. N.; et al. Antibiotic Exposure across Three Generations from Chinese Families and Cumulative Health Risk. Ecotoxicol. Environ. Saf. 2020, 191, 110237. DOI: https://doi.org/10.1016/j.ecoenv.2020.110237.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.