HLA transgenic mice: application in reproducing idiosyncratic drug toxicity

References

• Abraham RS, Kudva YC, Wilson SB, Strominger JL, David CS. 2000. Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice. Diabetes. 49(4):548–554.
   PubMed Web of Science ®Google Scholar
• Adamus G, Brown L, Andrew S, Meza-Romero R, Burrows GG, Vandenbark AA. 2012. Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice. Invest Ophthalmol Vis SciInvest. Ophthalmol Vis Sci. 53(1):406–412.
   PubMed Web of Science ®Google Scholar
• Andersson EC, Hansen BE, Jacobsen H, Madsen LS, Andersen CB, Engberg J, Rothbard JB, McDevitt GS, Malmstrom V, Holmdahl R, et al. 1998. Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice. Proc Natl Acad Sci USA. 95(13):7574–7579.
   PubMed Web of Science ®Google Scholar
• Antal Z, Baker JC, Smith C, Jarchum I, Babad J, Mukherjee G, Yang Y, Sidney J, Sette A, Santamaria P, et al. 2012. Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes. J Immunol. 188(11):5766–5775.
   PubMed Web of Science ®Google Scholar
• Ariyoshi N, Iga Y, Hirata K, Sato Y, Miura G, Ishii I, Nagamori S, Kitada M. 2010. Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese. Drug Metab Pharmacokinet. 25(3):298–306.
   PubMed Web of Science ®Google Scholar
• Atif SM, Mack DG, McKee AS, Rangel-Moreno J, Martin AK, Getahun A, Maier LA, Cambier JC, Tuder R, Fontenot AP. 2019. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 5(12):e125494.
   PubMed Web of Science ®Google Scholar
• Babad J, Ali R, Schloss J, DiLorenzo TP. 2016. An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients. J Diabetes Res. 2016:7959060.
   PubMed Web of Science ®Google Scholar
• Babad J, Mukherjee G, Follenzi A, Ali R, Roep BO, Shultz LD, Santamaria P, Yang OO, Goldstein H, Greiner DL, et al. 2015. Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic micebeta cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. Clin Exp Immunol. 179(3):398–413.
   PubMed Web of Science ®Google Scholar
• Bachmaier K, Neu N, Yeung RS, Mak TW, Liu P, Penninger JM. 1999. Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Circulation. 99(14):1885–1891.
   PubMed Web of Science ®Google Scholar
• Bardos T, Zhang J, Mikecz K, David CS, Glant TT. 2002. Mice lacking endogenous major histocompatibility complex class II develop arthritis resembling psoriatic arthritis at an advanced age. Arthritis Rheum. 46(9):2465–2475.
   PubMed Web of Science ®Google Scholar
• Batsalova T, Dzhambazov B, Merky P, Backlund A, Backlund J. 2010. Breaking T cell tolerance against self type II collagen in HLA-DR4-transgenic mice and development of autoimmune arthritis. Arthritis Rheum. 62(7):1911–1920.
   PubMed Web of Science ®Google Scholar
• Behrens M, Luckey D, Luthra H, David C, Taneja V. 2017. B cells influence sex specificity of arthritis via myeloid suppressors and chemokines in humanized mice. Clin Immunol. 178:10–19.
   PubMed Web of Science ®Google Scholar
• Behrens M, Papadopoulos GK, Moustakas A, Smart M, Luthra H, David CS, Taneja V. 2011. Trans heterodimer between two non-arthritis-associated HLA alleles can predispose to arthritis in humanized mice. Arthritis Rheum. 63(6):1552–1561.
   PubMed Web of Science ®Google Scholar
• Behrens M, Trejo T, Luthra H, Griffiths M, David CS, Taneja V. 2010. Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice. J Autoimmun. 35(1):1–9.
   PubMed Web of Science ®Google Scholar
• Bell CC, Faulkner L, Martinsson K, Farrell J, Alfirevic A, Tugwood J, Pirmohamed M, Naisbitt DJ, Park BK. 2013. T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms. Chem Res Toxicol. 26(5):759–766.
   PubMed Web of Science ®Google Scholar
• Bergamo P, Gogliettino M, Palmieri G, Cocca E, Maurano F, Stefanile R, Balestrieri M, Mazzarella G, David C, Rossi M. 2011. Conjugated linoleic acid protects against gliadin-induced depletion of intestinal defenses. Mol Nutr Food Res. 55(Suppl 2):S248–S256.
   PubMed Web of Science ®Google Scholar
• Black KE, Murray JA, David CS. 2002. HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice. J Immunol. 169(10):5595–5600.
   PubMed Web of Science ®Google Scholar
• Blum JS, Wearsch PA, Cresswell P. 2013. Pathways of antigen processing. Annu Rev Immunol. 31:443–473.
   PubMed Web of Science ®Google Scholar
• Boldizsar F, Tarjanyi O, Olasz K, Hegyi A, Mikecz K, Glant TT, Rauch TA. 2016. FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice. Cardiovasc Pathol. 25(5):353–361.
   PubMed Web of Science ®Google Scholar
• Bonavita R, Isticato R, Maurano F, Ricca E, Rossi M. 2015. Mucosal immunity induced by gliadin-presenting spores of Bacillus subtilis in HLA-DQ8-transgenic mice. Immunol Lett. 165(2):84–89.
   PubMed Web of Science ®Google Scholar
• Bradley DS, Das P, Griffiths MM, Luthra HS, David CS. 1998. HLA-DQ6/8 double transgenic mice develop auricular chondritis following type II collagen immunization: a model for human relapsing polychondritis. J Immunol. 161(9):5046–5053.
   PubMed Web of Science ®Google Scholar
• Bradley DS, Nabozny GH, Cheng S, Zhou P, Griffiths MM, Luthra HS, David CS. 1997. HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis. J Clin Invest. 100(9):2227–2234.
   PubMed Web of Science ®Google Scholar
• Brewerton DA, Hart FD, Nicholls A, Caffrey M, James DC, Sturrock RD. 1973. Ankylosing spondylitis and HL-A 27. Lancet. 1(7809):904–907.
   PubMed Web of Science ®Google Scholar
• Calviño-Sampedro C, Gomez-Tourino I, Cordero OJ, Reche PA, Gómez-Perosanz M, Sánchez-Trincado JL, Rodríguez MÁ, Sueiro AM, Viñuela JE, Calviño RV. 2019. Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetesS100-beta are targets of the autoimmune response in type 1 diabetes. FASEB J. 33(5):6390–6401.
   PubMed Web of Science ®Google Scholar
• Cardone M, Garcia K, Tilahun ME, Boyd LF, Gebreyohannes S, Yano M, Roderiquez G, Akue AD, Juengst L, Mattson E, et al. 2018. A transgenic mouse model for HLA-B*57:01-linked abacavir drug tolerance and reactivity. J Clin Invest. 128(7):2819–2832.
   PubMed Web of Science ®Google Scholar
• Cauli A, Dessole G, Fiorillo MT, Vacca A, Mameli A, Bitti P, Passiu G, Sorrentino R, Mathieu A. 2002. Increased level of HLA-B27 expression in ankylosing spondylitis patients compared with healthy HLA-B27-positive subjects: a possible further susceptibility factor for the development of disease. Rheumatology (Oxford)(Oxford). 41(12):1375–1379.
   PubMed Web of Science ®Google Scholar
• Chapoval SP, David CS. 2003. CD28 costimulation is critical for experimental allergic asthma in HLA-DQ8 transgenic mice. Clin Immunol. 106(2):83–94.
   PubMed Web of Science ®Google Scholar
• Chapoval SP, Iijima K, Marietta EV, Smart MK, Chapoval AI, Andrews AG, David CS. 2002. Allergic inflammatory response to short ragweed allergenic extract in HLA-DQ transgenic mice lacking CD4 gene. J Immunol. 168(2):890–899.
   PubMed Web of Science ®Google Scholar
• Chapoval SP, Marietta EV, Smart MK, David CS. 2001. Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic mice. J Allergy Clin Immunol. 108(5):764–771.
   PubMed Web of Science ®Google Scholar
• Chapoval SP, Nabozny GH, Marietta EV, Raymond EL, Krco CJ, Andrews AG, David CS. 1999. Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice. J Clin Invest. 103(12):1707–1717.
   PubMed Web of Science ®Google Scholar
• Chen KY, Liu J, Ren EC. 2012. Structural and functional distinctiveness of HLA-A2 allelic variants. Immunol Res. 53(1–3):182–190.
   PubMed Web of Science ®Google Scholar
• Chowdhary VR, Dai C, Tilahun AY, Hanson JA, Smart MK, Grande JP, Rajagopalan G, Fu SM, David CS. 2015. A central role for HLA-DR3 in anti-smith antibody responses and glomerulonephritis in a transgenic mouse model of spontaneous lupus. J Immunol. 195(10):4660–4667.
   PubMed Web of Science ®Google Scholar
• Cirulli ET, Nicoletti P, Abramson K, Andrade RJ, Bjornsson ES, Chalasani N, Fontana RJ, Hallberg P, Li YJ, Lucena MI, International DILI consortium (iDILIC), et al. 2019. A missense variant in PTPN22 is a risk factor for drug-induced liver injury. Gastroenterology. 156(6):1707–1716 e1702.
   PubMed Web of Science ®Google Scholar
• Daly AK, Donaldson PT, Bhatnagar P, Shen Y, Pe'er I, Floratos A, Daly MJ, Goldstein DB, John S, Nelson MR, International SAE Consortium, et al. 2009. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat GenetNat. Genet. 41(7):816–819.
   PubMed Web of Science ®Google Scholar
• D'Arienzo R, Maurano F, Lavermicocca P, Ricca E, Rossi M. 2009. Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity. Cytokine. 48(3):254–259.
   PubMed Web of Science ®Google Scholar
• D'Arienzo R, Maurano F, Luongo D, Mazzarella G, Stefanile R, Troncone R, Auricchio S, Ricca E, David C, Rossi M. 2008. Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity. Immunol Lett. 119(1–2):78–83.
   PubMed Web of Science ®Google Scholar
• D'Arienzo R, Stefanile R, Maurano F, Luongo D, Bergamo P, Mazzarella G, Troncone R, Auricchio S, David C, Rossi M. 2009. A deregulated immune response to gliadin causes a decreased villus height in DQ8 transgenic mice. Eur J Immunol. 39(12):3552–3561.
   PubMed Web of Science ®Google Scholar
• D'Arienzo R, Stefanile R, Maurano F, Mazzarella G, Ricca E, Troncone R, Auricchio S, Rossi M. 2011. Immunomodulatory effects of Lactobacillus casei administration in a mouse model of gliadin-sensitive enteropathy. Scand J Immunol. 74(4):335–341.
   PubMed Web of Science ®Google Scholar
• Das P, Drescher KM, Geluk A, Bradley DS, Rodriguez M, David CS. 2000. Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis. Hum Immunol. 61(3):279–289.
   PubMed Web of Science ®Google Scholar
• David L, Gokhale A, Jois S, Johnson A, Behrens M, Luthra H, Taneja V. 2016. CD74/DQA1 dimers predispose to the development of arthritis in humanized mice. Immunology. 147(2):204–211.
   PubMed Web of Science ®Google Scholar
• de Kozak Y, Camelo S, Pla M. 2008. Pathological aspects of spontaneous uveitis and retinopathy in HLA-A29 transgenic mice and in animal models of retinal autoimmunity: relevance to human pathologies. Ophthalmic Res. 40(3–4):175–180.
   PubMed Web of Science ®Google Scholar
• de Wolf C, van der Zee R, den Braber I, Glant T, Maillere B, Favry E, van Lummel M, Koning F, Hoek A, Ludwig I, et al. 2016. An arthritis-suppressive and Treg cell-inducing CD4+ T cell epitope is functional in the context of HLA-restricted T cell responses. Arthritis Rheumatol. 68(3):639–647.
   PubMed Web of Science ®Google Scholar
• Elagin RB, Balijepalli S, Diacovo MJ, Baekkeskov S, Jaume JC. 2009. Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice. J Autoimmun. 33(1):50–57.
   PubMed Web of Science ®Google Scholar
• Elagin RB, Jaume JC. 2010. Glucose intolerance and diabetes following antigen-specific insulitis in diabetes-susceptible “humanized” transgenic mice. Biochem Biophys Res Commun. 395(1):99–103.
   PubMed Web of Science ®Google Scholar
• Elliott JF, Liu J, Yuan ZN, Bautista-Lopez N, Wallbank SL, Suzuki K, Rayner D, Nation P, Robertson MA, Liu G, et al. 2003. Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice. Proc Natl Acad Sci USA. 100(23):13447–13452.
   PubMed Web of Science ®Google Scholar
• Ellmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RH, Smith PA, Amor S, Herlihy AH, et al. 2005. High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. J Immunol. 174(4):1938–1946.
   PubMed Web of Science ®Google Scholar
• Ellmerich S, Takacs K, Mycko M, Waldner H, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, et al. 2004. Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. Eur J Immunol. 34(7):1839–1848.
   PubMed Web of Science ®Google Scholar
• Eulderink F, Ivanyi P, Weinreich S. 1998. Histopathology of murine ankylosing enthesopathy. Pathol Res Pract. 194(11):797–803.
   PubMed Web of Science ®Google Scholar
• Flynn JC, Fuller BE, Giraldo AA, Panos JC, David CS, Kong YC. 2001. Flexibility of TCR repertoire and permissiveness of HLA-DR3 molecules in experimental autoimmune thyroiditis in nonobese diabetic mice. J Autoimmun. 17(1):7–15.
   PubMed Web of Science ®Google Scholar
• Flynn JC, Gardas A, Wan Q, Gora M, Alsharabi G, Wei WZ, Giraldo AA, David CS, Kong YM, Banga JP. 2004. Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA-DRB1*0301 (DR3) transgenic mice. Clin Exp Immunol. 137(3):503–512.
   PubMed Web of Science ®Google Scholar
• Flynn JC, Gilbert JA, Meroueh C, Snower DP, David CS, Kong YC, Banga JP. 2007. Chronic exposure in vivo to thyrotropin receptor stimulating monoclonal antibodies sustains high thyroxine levels and thyroid hyperplasia in thyroid autoimmunity-prone HLA-DRB1*0301 transgenic mice. Immunology. 122(2):261–267.
   PubMed Web of Science ®Google Scholar
• Flynn JC, Meroueh C, Snower DP, David CS, Kong YM. 2007. Depletion of CD4 + CD25+ regulatory T cells exacerbates sodium iodide-induced experimental autoimmune thyroiditis in human leucocyte antigen DR3 (DRB1*0301) transgenic class II-knock-out non-obese diabetic mice. Clin Exp Immunol. 147(3):547–554.
   PubMed Web of Science ®Google Scholar
• Flynn JC, Rao PV, Gora M, Alsharabi G, Wei W, Giraldo AA, David CS, Banga JP, Kong YM. 2004. Graves' hyperthyroidism and thyroiditis in HLA-DRB1*0301 (DR3) transgenic mice after immunization with thyrotropin receptor DNA. Clin Exp Immunol. 135(1):35–40.
   PubMed Web of Science ®Google Scholar
• Flynn JC, Wan Q, Panos JC, McCormick DJ, Giraldo AA, David CS, Kong YC. 2002. Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. J Autoimmun. 18(3):213–220.
   PubMed Web of Science ®Google Scholar
• Forsthuber TG, Shive CL, Wienhold W, de Graaf K, Spack EG, Sublett R, Melms A, Kort J, Racke MK, Weissert R. 2001. T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1*0401) transgenic mice are encephalitogenic and are presented by human B cells. J Immunol. 167(12):7119–7125.
   PubMed Web of Science ®Google Scholar
• Fukui Y, Nishimura Y, Iwanga T, Kimura A, Inamitsu T, Hanaoka Y, Kitigawa T, Sasazuki T. 1989. Glycosuria and insulitis in NOD mice expressing the HLA-DQw6 molecule. J Immunogenet. 16(6):445–453.
   PubMedGoogle Scholar
• Galipeau HJ, Rulli NE, Jury J, Huang X, Araya R, Murray JA, David CS, Chirdo FG, McCoy KD, Verdu EF. 2011. Sensitization to gliadin induces moderate enteropathy and insulitis in nonobese diabetic-DQ8 mice. J Immunol. 187(8):4338–4346.
   PubMed Web of Science ®Google Scholar
• Gebe JA, Falk B, Unrath K, Nepom GT. 2007. Autoreactive T cells in a partially humanized murine model of T1D. Ann N Y Acad Sci. 1103:69–76.
   PubMed Web of Science ®Google Scholar
• Gebe JA, Unrath KA, Falk BA, Ito K, Wen L, Daniels TL, Lernmark A, Nepom GT. 2006. Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice. Clin Immunol. 121(3):294–304.
   PubMed Web of Science ®Google Scholar
• Gebe JA, Unrath KA, Yue BB, Miyake T, Falk BA, Nepom GT. 2008. Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice. J Autoimmun. 30(4):197–206.
   PubMed Web of Science ®Google Scholar
• Geng J, Altman JD, Krishnakumar S, Raghavan M. 2018. Empty conformers of HLA-B preferentially bind CD8 and regulate CD8(+) T cell function. Elife. 7:e36341.
   Web of Science ®Google Scholar
• Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, Cardon LR, Bell JI, Fugger L. 2006. Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Nature. 443(7111):574–577.
   PubMed Web of Science ®Google Scholar
• Guery JC, Galbiati F, Smiroldo S, Adorini L. 1997. Non-MHC-linked Th2 cell development induced by soluble protein administration predicts susceptibility to Leishmania major infection. J. Immunol. 159(5):2147–2153.
   PubMed Web of Science ®Google Scholar
• Haag S, Uysal H, Backlund J, Tuncel J, Holmdahl R. 2012. Human alpha-enolase is immunogenic, but not arthritogenic, in HLA-DR4-transgenic mice: comment on the article by Kinloch. Arthritis Rheum. 64(5):1689–1691; author reply 1691-1682.
   PubMed Web of Science ®Google Scholar
• Harada N, Fukaya S, Wada H, Goto R, Osada T, Gomori A, Ikizawa K, Sakuragi M, Oda N. 2017. Generation of a novel HLA class I transgenic mouse model carrying a knock-in mutation at the beta2-microglobulin locus. J Immunol. 198(1):516–527.
   PubMed Web of Science ®Google Scholar
• Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. 2009. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci. 110(1):235–243.
   PubMed Web of Science ®Google Scholar
• Havari E, Lennon-Dumenil AM, Klein L, Neely D, Taylor JA, McInerney MF, Wucherpfennig KW, Lipes MA. 2004. Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes. J Immunol. 173(2):787–796.
   PubMed Web of Science ®Google Scholar
• Hill JA, Bell DA, Brintnell W, Yue D, Wehrli B, Jevnikar AM, Lee DM, Hueber W, Robinson WH, Cairns E. 2008. Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med. 205(4):967–979.
   PubMed Web of Science ®Google Scholar
• Illing PT, Mifsud NA, Purcell AW. 2016. Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions. Curr Opin Immunol. 42:31–40.
   PubMed Web of Science ®Google Scholar
• Irie A, Imamura T, Michibata Y, Kubo T, Takeda N, Shibuya I, Sogo S, Araki K, Nishimura Y. 2017. Accumulation of HLA-DR4 in colonic epithelial cells causes severe colitis in homozygous HLA-DR4 transgenic mice. Inflamm Bowel Dis. 23(12):2121–2133.
   PubMed Web of Science ®Google Scholar
• Ito K, Bian HJ, Molina M, Han J, Magram J, Saar E, Belunis C, Bolin DR, Arceo R, Campbell R, et al. 1996. HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J Exp Med. 183(6):2635–2644.
   PubMed Web of Science ®Google Scholar
• Jacob JB, Kong YC, Meroueh C, Snower DP, David CS, Ho YS, Wei WZ. 2007. Control of Her-2 tumor immunity and thyroid autoimmunity by MHC and regulatory T cells. Cancer Res. 67(14):7020–7027.
   PubMed Web of Science ®Google Scholar
• Jarchum I, Baker JC, Yamada T, Takaki T, Marron MP, Serreze DV, DiLorenzo TP. 2007. In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice. Diabetes. 56(10):2551–2560.
   PubMed Web of Science ®Google Scholar
• Jarchum I, DiLorenzo TP. 2010. Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin. J Immunol. 184(2):658–665.
   PubMed Web of Science ®Google Scholar
• Ji N, Somanaboeina A, Dixit A, Kawamura K, Hayward NJ, Self C, Olson GL, Forsthuber TG. 2013. Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis. J Immunol. 191(10):5074–5084.
   PubMed Web of Science ®Google Scholar
• Kalinke U, Arnold B, Hammerling GJ. 1990. Strong xenogeneic HLA response in transgenic mice after introducing an alpha 3 domain into HLA B27. Nature. 348(6302):642–644.
   PubMed Web of Science ®Google Scholar
• Karras E, Yang H, Lymberi P, Christadoss P. 2005. Human thyroglobulin peptide p2340 induces autoimmune thyroiditis in HLA-DR3 transgenic mice. J Autoimmun. 24(4):291–296.
   PubMed Web of Science ®Google Scholar
• Kaushansky N, Altmann DM, Ascough S, David CS, Lassmann H, Ben-Nun A. 2009. HLA-DQB1*0602 determines disease susceptibility in a new "humanized" multiple sclerosis model in HLA-DR15 (DRB1*1501;DQB1*0602) transgenic mice. J Immunol. 183(5):3531–3541.
   PubMed Web of Science ®Google Scholar
• Kaushansky N, Altmann DM, David CS, Lassmann H, Ben-Nun A. 2012. DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP). J Neuroinflammation. 9:29.
   PubMed Web of Science ®Google Scholar
• Kaushansky N, Eisenstein M, Boura-Halfon S, Hansen BE, Nielsen CH, Milo R, Zeilig G, Lassmann H, Altmann DM, Ben-Nun A. 2015. Role of a novel human leukocyte antigen-DQA1*01:02;DRB1*15:01 mixed isotype heterodimer in the pathogenesis of “humanized” multiple sclerosis-like disease. J Biol Chem. 290(24):15260–15278.
   PubMed Web of Science ®Google Scholar
• Kawamura K, Yamamura T, Yokoyama K, Chui DH, Fukui Y, Sasazuki T, Inoko H, David CS, Tabira T. 2000. Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. J Clin Invest. 105(7):977–984.
   PubMed Web of Science ®Google Scholar
• Khare M, Mangalam A, Rodriguez M, David CS. 2005. HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice. J Neuroimmunol. 169(1-2):1–12.
   PubMed Web of Science ®Google Scholar
• Khare SD, Hansen J, Luthra HS, David CS. 1996. HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin (beta2m) double transgenic mice with disrupted mouse beta2m. J Clin Invest. 98(12):2746–2755.
   PubMed Web of Science ®Google Scholar
• Khare SD, Lee S, Bull MJ, Hanson J, Luthra HS, Hammerling GJ, David CS. 1999. Peptide binding alpha1alpha2 domain of HLA-B27 contributes to the disease pathogenesis in transgenic mice. Hum Immunol. 60(2):116–126.
   PubMed Web of Science ®Google Scholar
• Khare SD, Luthra HS, David CS. 1995. Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies. J Exp Med. 182(4):1153–1158.
   PubMed Web of Science ®Google Scholar
• Kievits F, Ivanyi P, Krimpenfort P, Berns A, Ploegh HL. 1987. HLA-restricted recognition of viral antigens in HLA transgenic mice. Nature. 329(6138):447–449.
   PubMed Web of Science ®Google Scholar
• Kievits F, Wijffels J, Lokhorst W, Ivanyi P. 1989. Recognition of xeno-(HLA, SLA) major histocompatibility complex antigens by mouse cytotoxic T cells is not H-2 restricted: a study with transgenic mice. Proc Natl Acad Sci USA. 86(2):617–620.
   PubMed Web of Science ®Google Scholar
• Kim S, Easterling ER, Price LC, Smith SL, Coligan JE, Park JE, Brand DD, Rosloniec EF, Stuart JM, Kang AH, et al. 2017. The role of leukocyte-associated Ig-like receptor-1 in suppressing collagen-induced arthritis. J Immunol. 199(8):2692–2700.
   PubMed Web of Science ®Google Scholar
• Kim YC, Zhang AH, Yoon J, Culp WE, Lees JR, Wucherpfennig KW, Scott DW. 2018. Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells. J Autoimmun. 92:77–86.
   PubMed Web of Science ®Google Scholar
• Kimata M, Cullins DL, Brown ML, Brand DD, Rosloniec EF, Myers LK, Stuart JM, Kang AH. 2012. Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis. Arthritis Res Ther. 14(3):R107.
   PubMed Web of Science ®Google Scholar
• Kingsbury DJ, Mear JP, Witte DP, Taurog JD, Roopenian DC, Colbert RA. 2000. Development of spontaneous arthritis in beta2-microglobulin-deficient mice without expression of HLA-B27: association with deficiency of endogenous major histocompatibility complex class I expression. Arthritis Rheum. 43(10):2290–2296.
   PubMed Web of Science ®Google Scholar
• Kinloch AJ, Alzabin S, Brintnell W, Wilson E, Barra L, Wegner N, Bell DA, Cairns E, Venables PJ. 2011. Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic micealpha-enolase and arthritis in DR4- IE-transgenic mice. Arthritis Rheum. 63(12):3818–3823.
   PubMed Web of Science ®Google Scholar
• Klehmet J, Shive C, Guardia-Wolff R, Petersen I, Spack EG, Boehm BO, Weissert R, Forsthuber TG. 2004. T cell epitope spreading to myelin oligodendrocyte glycoprotein in HLA-DR4 transgenic mice during experimental autoimmune encephalomyelitis. Clin Immunol. 111(1):53–60.
   PubMed Web of Science ®Google Scholar
• Kong YC, Lomo LC, Motte RW, Giraldo AA, Baisch J, Strauss G, Hammerling GJ, David CS. 1996. HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene. J Exp Med. 184(3):1167–1172.
   PubMed Web of Science ®Google Scholar
• Kudva YC, Rajagopalan G, Raju R, Abraham RS, Smart M, Hanson J, David CS. 2002. Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II. Hum Immunol. 63(11):987–999.
   PubMed Web of Science ®Google Scholar
• Lamoureux JL, Buckner JH, David CS, Bradley DS. 2006. Mice expressing HLA-DQ6alpha8beta transgenes develop polychondritis spontaneously. Arthritis Res Ther. 8(4):R134.
   PubMed Web of Science ®Google Scholar
• Li S, Li H, Chen B, Lu D, Deng W, Jiang Y, Zhou Z, Yang Z. 2013. Identification of novel HLA-A 0201-restricted cytotoxic T lymphocyte epitopes from Zinc Transporter 8. Vaccine. 31(12):1610–1615.
   PubMed Web of Science ®Google Scholar
• Lindh M, Hallberg P, Yue QY, Wadelius M. 2018. Clinical factors predicting drug-induced liver injury due to flucloxacillin. Drug Healthc Patient Saf. 10:95–101.
   PubMed Web of Science ®Google Scholar
• Link JM, Rich CM, Korat M, Burrows GG, Offner H, Vandenbark AA. 2007. Monomeric DR2/MOG-35-55 recombinant TCR ligand treats relapses of experimental encephalomyelitis in DR2 transgenic mice. Clin Immunol. 123(1):95–104.
   PubMed Web of Science ®Google Scholar
• Lowther DE, Chong DL, Ascough S, Ettorre A, Ingram RJ, Boyton RJ, Altmann DM. 2013. Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response. Acta Neuropathol. 126(4):501–515.
   PubMed Web of Science ®Google Scholar
• Luce S, Guinoiseau S, Gadault A, Letourneur F, Blondeau B, Nitschke P, Pasmant E, Vidaud M, Lemonnier F, Boitard C. 2018. Humanized mouse model to study type 1 diabetes. Diabetes. 67(9):1816–1829.
   PubMed Web of Science ®Google Scholar
• Lundgren H, Martinsson K, Cederbrant K, Jirholt J, Mucs D, Madeyski-Bengtson K, Havarinasab S, Hultman P. 2017. HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity. PLoS One. 12(9):e0184744.
   PubMed Web of Science ®Google Scholar
• Luo N, Nixon MJ, Gonzalez-Ericsson PI, Sanchez V, Opalenik SR, Li H, Zahnow CA, Nickels ML, Liu F, Tantawy MN, et al. 2018. DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer. Nat Commun. 9(1):248.
   PubMed Web of Science ®Google Scholar
• Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, et al. 2011. Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humansalpha-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest. 121(4):1561–1573.
   PubMed Web of Science ®Google Scholar
• Mack DG, Falta MT, McKee AS, Martin AK, Simonian PL, Crawford F, Gordon T, Mercer RR, Hoover MD, Marrack P, et al. 2014. Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. Proc Natl Acad Sci USA. 111(23):8553–8558.
   PubMed Web of Science ®Google Scholar
• Madsen LS, Andersson EC, Jansson L, Krogsgaard M, Andersen CB, Engberg J, Strominger JL, Svejgaard A, Hjorth JP, Holmdahl R, et al. 1999. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet. 23(3):343–347.
   PubMed Web of Science ®Google Scholar
• Mak A, Kato R, Weston K, Hayes A, Uetrecht J. 2018. Editor's highlight: an impaired immune tolerance animal model distinguishes the potential of troglitazone/pioglitazone and tolcapone/entacapone to cause IDILI. Toxicol Sci. 161(2):412–420.
   PubMed Web of Science ®Google Scholar
• Mak A, Uetrecht J. 2017. Immune mechanisms of idiosyncratic drug-induced liver injury. J Clin Transl Res. 3(1):145–156.
   PubMedGoogle Scholar
• Mallal S, Phillips E, Carosi G, Molina JM, Workman C, Tomazic J, Jagel-Guedes E, Rugina S, Kozyrev O, Cid JF, et al. 2008. HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med. 358(6):568–579.
   PubMed Web of Science ®Google Scholar
• Mangalam A, Luckey D, Basal E, Behrens M, Rodriguez M, David C. 2008. HLA-DQ6 (DQB1*0601)-restricted T cells protect against experimental autoimmune encephalomyelitis in HLA-DR3.DQ6 double-transgenic mice by generating anti-inflammatory IFN-gamma. J Immunol. 180(11):7747–7756.
   PubMed Web of Science ®Google Scholar
• Mangalam A, Luckey D, Basal E, Jackson M, Smart M, Rodriguez M, David C. 2009. HLA-DQ8 (DQB1*0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice. J Immunol. 182(8):5131–5139.
   PubMed Web of Science ®Google Scholar
• Mangalam A, Rodriguez M, David C. 2006. Role of MHC class II expressing CD4+ T cells in proteolipid protein(91-110)-induced EAE in HLA-DR3 transgenic mice. Eur J Immunol. 36(12):3356–3370.
   PubMed Web of Science ®Google Scholar
• Mangalam AK, Khare M, Krco C, Rodriguez M, David C. 2004. Identification of T cell epitopes on human proteolipid protein and induction of experimental autoimmune encephalomyelitis in HLA class II-transgenic mice. Eur J Immunol. 34(1):280–290.
   PubMed Web of Science ®Google Scholar
• Mangalam AK, Luckey D, Giri S, Smart M, Pease LR, Rodriguez M, David CS. 2012. Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice. J Autoimmun. 38(4):344–353.
   PubMed Web of Science ®Google Scholar
• Mangalam AK, Luo N, Luckey D, Papke L, Hubbard A, Wussow A, Smart M, Giri S, Rodriguez M, David C. 2014. Absence of IFN-γ increases brain pathology in experimental autoimmune encephalomyelitis-susceptible DRB1*0301.DQ8 HLA transgenic mice through secretion of proinflammatory cytokine IL-17 and induction of pathogenic monocytes/microglia into the central nervous systemIFN-gamma increases brain pathology in experimental autoimmune encephalomyelitis-susceptible DRB1*0301.DQ8 HLA transgenic mice through secretion of proinflammatory cytokine IL-17 and induction of pathogenic monocytes/microglia into the central nervous system. J Immunol. 193(10):4859–4870.
   PubMed Web of Science ®Google Scholar
• Marietta EV, Murray JA, Luckey DH, Jeraldo PR, Lamba A, Patel R, Luthra HS, Mangalam A, Taneja V. 2016. Suppression of inflammatory arthritis by human gut-derived prevotella histicola in humanized mice. Arthritis Rheumatol. 68(12):2878–2888.
   PubMed Web of Science ®Google Scholar
• Marietta E, Black K, Camilleri M, Krause P, Rogers RS, 3rd, David C, Pittelkow MR, Murray JA. 2004. A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice. J Clin Invest. 114(8):1090–1097.
   PubMed Web of Science ®Google Scholar
• Marron MP, Graser RT, Chapman HD, Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice. Proc Natl Acad Sci USA. 99(21):13753–13758.
   PubMed Web of Science ®Google Scholar
• Martin AM, Nolan D, Gaudieri S, Almeida CA, Nolan R, James I, Carvalho F, Phillips E, Christiansen FT, Purcell AW, et al. 2004. Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Proc Natl Acad Sci USA. 101(12):4180–4185.
   PubMed Web of Science ®Google Scholar
• Matsunaga T, Cabilly-Horesh O, Terz D, Lee A, Christian L, Ohno S, Biro AP. 1985. Use of transgenic mice with human MHC class 1 gene (HLA-A2). Adv Exp Med Biol. 186:341–347.
   PubMed Web of Science ®Google Scholar
• Maurano F, Ogita T, Luongo D, Rotondi Aufiero V, Bergamo P, Mazzarella G, Tanabe S, Rossi M. 2020. Innate immunity is a late event in the onset of gliadin-specific enteropathy in the HLA-DQ8 mice. Immunobiology. 225(3):151903.
   PubMed Web of Science ®Google Scholar
• Mazzarella G, Bergamo P, Maurano F, Luongo D, Rotondi Aufiero V, Bozzella G, Palmieri G, Troncone R, Auricchio S, David C, et al. 2014. Gliadin intake alters the small intestinal mucosa in indomethacin-treated HLA-DQ8 transgenic mice. Am J Physiol Gastrointest Liver Physiol. 307(3):G302–G312.
   PubMed Web of Science ®Google Scholar
• Metushi IG, Hayes MA, Uetrecht J. 2015. Treatment of PD-1(-/-) mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients. Hepatology. 61(4):1332–1342.
   PubMed Web of Science ®Google Scholar
• Meza-Romero R, Benedek G, Yu X, Mooney JL, Dahan R, Duvshani N, Bucala R, Offner H, Reiter Y, Burrows GG, et al. 2014. HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitisHLA-DRalpha1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis. J Immunol. 192(9):4164–4173.
   PubMed Web of Science ®Google Scholar
• Miller DC, Whittington KB, Brand DD, Hasty KA, Rosloniec EF. 2016. The CII-specific autoimmune T-cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis. Arthritis Res Ther. 18:8. 8
   PubMed Web of Science ®Google Scholar
• Monshi MM, Faulkner L, Gibson A, Jenkins RE, Farrell J, Earnshaw CJ, Alfirevic A, Cederbrant K, Daly AK, French N, et al. 2013. Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology. 57(2):727–739.
   PubMed Web of Science ®Google Scholar
• Moon SH, Kim J, Kim MY, Park do H, Song TJ, Kim SA, Lee SS, Seo DW, Lee SK, Kim MH. 2016. Sensitization to and challenge with gliadin induce pancreatitis and extrapancreatic inflammation in HLA-DQ8 Mice: an animal model of type 1 autoimmune pancreatitis. Gut Liver. 10(5):842–850.
   PubMed Web of Science ®Google Scholar
• Morgan ME, Witteveen HJ, Sutmuller RP, de Vries RR, Toes RE. 2004. CD25+ regulatory cells from HLA-DQ8 transgenic mice are capable of modulating collagen-induced arthritis. Hum Immunol. 65(11):1319–1327.
   PubMed Web of Science ®Google Scholar
• Myers LK, Pihlajamaa T, Brand DD, Cremer MA, Bodo M, Ala-Kokko L, Kang AH. 2002. Immunogenicity of recombinant type IX collagen in murine collagen-induced arthritis. Arthritis Rheum. 46(4):1086–1093.
   PubMed Web of Science ®Google Scholar
• Myers LK, Sakurai Y, Tang B, He X, Rosloniec EF, Stuart JM, Kang AH. 2002. Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice. Arthritis Rheum. 46(12):3369–3377.
   PubMed Web of Science ®Google Scholar
• Myers LK, Tang B, Brand DD, Rosloniec EF, Stuart JM, Kang AH. 2004. Efficacy of modified recombinant type II collagen in modulating autoimmune arthritis. Arthritis Rheum. 50(9):3004–3011.
   PubMed Web of Science ®Google Scholar
• Nabozny GH, Baisch JM, Cheng S, Cosgrove D, Griffiths MM, Luthra HS, David CS. 1996. HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J Exp Med. 183(1):27–37.
   PubMed Web of Science ®Google Scholar
• Nakayama S, Atsumi R, Takakusa H, Kobayashi Y, Kurihara A, Nagai Y, Nakai D, Okazaki O. 2009. A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding. Drug Metab Dispos. 37(9):1970–1977.
   PubMed Web of Science ®Google Scholar
• Nalawade SA, Ji N, Raphael I, Pratt A, Kraig E, Forsthuber TG. 2018. Aire is not essential for regulating neuroinflammatory disease in mice transgenic for human autoimmune-diseases associated MHC class II genes HLA-DR2b and HLA-DR4. Cell Immunol. 331:38–48.
   PubMed Web of Science ®Google Scholar
• Nattrass R, Faulkner L, Vocanson M, Antoine DJ, Kipar A, Kenna G, Nicolas JF, Park BK, Naisbitt DJ. 2015. Activation of flucloxacillin-specific CD8+ T-cells with the potential to promote hepatocyte cytotoxicity in a mouse model. Toxicol Sci. 146(1):146–156.
   PubMed Web of Science ®Google Scholar
• Nickerson CL, Hanson J, David CS. 1990. Expression of HLA-B27 in transgenic mice is dependent on the mouse H-2D genes. J Exp Med. 172(4):1255–1261.
   PubMed Web of Science ®Google Scholar
• Nickerson-Nutter CL, Hogen KL, David CS. 1992. Expression of HLA-B27 in transgenic mice is controlled by gene(s) mapping between H-2D and H-2L loci. Immunogenetics. 35(3):199–204.
   PubMed Web of Science ®Google Scholar
• Niens M, Grier AE, Marron M, Kay TW, Greiner DL, Serreze DV. 2011. Prevention of “Humanized” diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. Diabetes. 60(4):1229–1236.
   PubMed Web of Science ®Google Scholar
• Ogita T, Bergamo P, Maurano F, D’Arienzo R, Mazzarella G, Bozzella G, Luongo D, Sashihara T, Suzuki T, Tanabe S, et al. 2015. Modulatory activity of Lactobacillus rhamnosus OLL2838 in a mouse model of intestinal immunopathology. Immunobiology. 220(6):701–710.
   PubMed Web of Science ®Google Scholar
• Ooi JD, Chang J, O'Sullivan KM, Pedchenko V, Hudson BG, Vandenbark AA, Fugger L, Holdsworth SR, Kitching AR. 2013. The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN. J Am Soc Nephrol. 24(3):419–431.
   PubMed Web of Science ®Google Scholar
• Pan RY, Chu MT, Wang CW, Lee YS, Lemonnier F, Michels AW, Schutte R, Ostrov DA, Chen CB, Phillips EJ, et al. 2019. Identification of drug-specific public TCR driving severe cutaneous adverse reactions. Nat Commun. 10(1):3569.
   PubMed Web of Science ®Google Scholar
• Pan S, Taneja V, Griffiths MM, Luthra H, David CS. 1999. Complementation between HLA-DR4 (DRB1*0401) and specific H2-A molecule in transgenic mice leads to collagen-induced arthritis. Hum Immunol. 60(9):816–825.
   PubMed Web of Science ®Google Scholar
• Papouchado BG, Chapoval SP, Marietta EV, Weiler CR, David CS. 2001. Cockroach allergen-induced eosinophilic airway inflammation in HLA-DQ/human CD4(+) transgenic mice. J Immunol. 167(8):4627–4634.
   PubMed Web of Science ®Google Scholar
• Pavlos R, Deshpande P, Chopra A, Leary S, Strautins K, Nolan D, Thorborn D, Shaefer M, Rauch A, Dunn D, et al. 2020. New genetic predictors for abacavir tolerance in HLA-B*57:01 positive individuals. Hum Immunol. 81:300–304.
   PubMed Web of Science ®Google Scholar
• Pennesi G, Mattapallil MJ, Sun SH, Avichezer D, Silver PB, Karabekian Z, David CS, Hargrave PA, McDowell JH, Smith WC, et al. 2003. A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. J Clin Invest. 111(8):1171–1180.
   PubMed Web of Science ®Google Scholar
• Pichurin P, Chen CR, Pichurina O, David C, Rapoport B, McLachlan SM. 2003. Thyrotropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b. Thyroid. 13(10):911–917.
   PubMed Web of Science ®Google Scholar
• Pow Sang L, Majji S, Casares S, Brumeanu TD. 2014. Long-term silencing of autoimmune diabetes and improved life expectancy by a soluble pHLA-DR4 chimera in a newly-humanized NOD/DR4/B7 mouse. Hum Vaccin Immunother. 10(3):693–699.
   PubMed Web of Science ®Google Scholar
• Pyzik M, Sand KMK, Hubbard JJ, Andersen JT, Sandlie I, Blumberg RS. 2019. The Neonatal Fc Receptor (FcRn): A Misnomer? Front Immunol. 10:1540.
   PubMed Web of Science ®Google Scholar
• Quandt JA, Huh J, Baig M, Yao K, Ito N, Bryant M, Kawamura K, Pinilla C, McFarland HF, Martin R, et al. 2012. Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis. J Immunol. 189(6):2897–2908.
   PubMed Web of Science ®Google Scholar
• Racine JJ, Stewart I, Ratiu J, Christianson G, Lowell E, Helm K, Allocco J, Maser RS, Chen YG, Lutz CM, et al. 2018. Improved murine MHC-deficient HLA transgenic NOD mouse models for type 1 diabetes therapy development. Diabetes. 67(5):923–935.
   PubMed Web of Science ®Google Scholar
• Rajagopalan G, Kudva YC, Chen L, Wen L, David CS. 2003. Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans. Int Immunol. 15(9):1035–1044.
   PubMed Web of Science ®Google Scholar
• Rajagopalan G, Mangalam AK, Sen MM, Cheng S, Kudva YC, David CS. 2007. Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of Langerhans. Autoimmunity. 40(3):169–179.
   PubMed Web of Science ®Google Scholar
• Raju R, Spack EG, David CS. 2001. Acetylcholine receptor peptide recognition in HLA DR3-transgenic mice: in vivo responses correlate with MHC-peptide binding. J Immunol. 167(2):1118–1124.
   PubMed Web of Science ®Google Scholar
• Raju R, Zhan WZ, Karachunski P, Conti-Fine B, Sieck GC, David C. 1998. Polymorphism at the HLA-DQ locus determines susceptibility to experimental autoimmune myasthenia gravis. J Immunol. 160(9):4169–4174.
   PubMed Web of Science ®Google Scholar
• Raju R, Zhan WZ, Karachunski P, Sieck GC, Conti-Fine BM, David CS. 1998. Susceptibility of HLA DR3 transgenic mice to experimental autoimmune myasthenia gravis. Ann N Y Acad Sci. 841:360–364.
   PubMed Web of Science ®Google Scholar
• Raphael I, Gomez-Rivera F, Raphael RA, Robinson RR, Nalawade S, Forsthuber TG. 2019. TNFR2 limits proinflammatory astrocyte functions during EAE induced by pathogenic DR2b-restricted T cells. JCI Insight. 4(24):e132527.
   PubMed Web of Science ®Google Scholar
• Rashtak S, Marietta E, Cheng S, Camilleri M, Pittelkow M, David C, Grande J, Murray J. 2010. Spontaneous lupus-like syndrome in HLA-DQ2 transgenic mice with a mixed genetic background. Lupus. 19(7):815–829.
   PubMed Web of Science ®Google Scholar
• Redwood AJ, Pavlos RK, White KD, Phillips EJ. 2018. HLAs: key regulators of T-cell-mediated drug hypersensitivity. HLA. 91(1):3–16.
   PubMed Web of Science ®Google Scholar
• Rich C, Link JM, Zamora A, Jacobsen H, Meza-Romero R, Offner H, Jones R, Burrows GG, Fugger L, Vandenbark AA. 2004. Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. Eur J Immunol. 34(5):1251–1261.
   PubMed Web of Science ®Google Scholar
• Rosloniec EF, Brand DD, Myers LK, Esaki Y, Whittington KB, Zaller DM, Woods A, Stuart JM, Kang AH. 1998. Induction of autoimmune arthritis in HLA-DR4 (DRB1*0401) transgenic mice by immunization with human and bovine type II collagen. J Immunol. 160(6):2573–2578.
   PubMed Web of Science ®Google Scholar
• Rosloniec EF, Brand DD, Myers LK, Whittington KB, Gumanovskaya M, Zaller DM, Woods A, Altmann DM, Stuart JM, Kang AH. 1997. An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen. J Exp Med. 185(6):1113–1122.
   PubMed Web of Science ®Google Scholar
• Saag M, Balu R, Phillips E, Brachman P, Martorell C, Burman W, Stancil B, Mosteller M, Brothers C, Wannamaker P, et al.; Study of Hypersensitivity to Abacavir and Pharmacogenetic Evaluation Study Team. 2008. High sensitivity of human leukocyte antigen-b*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients. Clin Infect Dis. 46(7):1111–1118.
   PubMed Web of Science ®Google Scholar
• Sakurai Y, Brand DD, Tang B, Rosloniec EF, Stuart JM, Kang AH, Myers LK. 2006. Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice. Arthritis Res Ther. 8(5):R150.
   PubMed Web of Science ®Google Scholar
• Schloss J, Ali R, Racine JJ, Chapman HD, Serreze DV, DiLorenzo TP. 2018. HLA-B*39:06 efficiently mediates type 1 diabetes in a mouse model incorporating reduced thymic insulin expression. J Immunol. 200(10):3353–3363.
   PubMed Web of Science ®Google Scholar
• Şelli ME, Thomas AC, Wraith DC, Newby AC. 2017. A humanized HLA-DR4 mouse model for autoimmune myocarditis. J Mol Cell Cardiol. 107:22–26.
   PubMed Web of Science ®Google Scholar
• Senger S, Maurano F, Mazzeo MF, Gaita M, Fierro O, David CS, Troncone R, Auricchio S, Siciliano RA, Rossi M. 2005. Identification of immunodominant epitopes of alpha-gliadin in HLA-DQ8 transgenic mice following oral immunization. J Immunol. 175(12):8087–8095.
   PubMed Web of Science ®Google Scholar
• Serreze DV, Marron MP, Dilorenzo TP. 2007. “Humanized” HLA transgenic NOD mice to identify pancreatic beta cell autoantigens of potential clinical relevance to type 1 diabetes. Ann NY Acad Sci. 1103:103–111.
   PubMed Web of Science ®Google Scholar
• Shirayanagi T, Aoki S, Fujimori S, Watanabe K, Aida T, Hirasawa M, Kumagai K, Hoshino T, Ito K. 2020. Detection of abacavir-induced structural alterations in human leukocyte antigen-B*57 : 01 using phage displayantigen- B*57: 01 using phage display. Biol Pharm Bull. 43(6):1007–1015.
   PubMed Web of Science ®Google Scholar
• Sidhu M, Griffiths MM, Bradley DS. 2009. Vaccination with collagen-pulsed dendritic cells prevents the onset and reduces the disease severity in the mouse model of spontaneous polychondritis. Clin Exp Immunol. 157(3):350–358.
   PubMed Web of Science ®Google Scholar
• Silva MA, Jury J, Sanz Y, Wiepjes M, Huang X, Murray JA, David CS, Fasano A, Verdu EF. 2012. Increased bacterial translocation in gluten-sensitive mice is independent of small intestinal paracellular permeability defect. Dig Dis Sci. 57(1):38–47.
   PubMed Web of Science ®Google Scholar
• Sireci G, Dieli F, Caccamo N, Barera A, Carta P, Di Sano C, Meraviglia S, Bonanno CT, Salerno A. 2003. A human leucocyte antigen-DR1 transgene confers susceptibility to experimental allergic encephalomyelitis elicited by an epitope of myelin basic protein. Scand J Immunol. 58(2):188–194.
   PubMed Web of Science ®Google Scholar
• Song B, Aoki S, Liu C, Susukida T, Ito K. 2018. An animal model of abacavir-induced HLA-mediated liver injury. Toxicol Sci. 162(2):713–723.
   PubMed Web of Science ®Google Scholar
• Susukida T, Aoki S, Kogo K, Fujimori S, Song B, Liu C, Sekine S, Ito K. 2018. Evaluation of immune-mediated idiosyncratic drug toxicity using chimeric HLA transgenic mice. Arch Toxicol. 92(3):1177–1188.
   PubMed Web of Science ®Google Scholar
• Svendsen P, Andersen CB, Willcox N, Coyle AJ, Holmdahl R, Kamradt T, Fugger L. 2004. Tracking of proinflammatory collagen-specific T cells in early and late collagen-induced arthritis in humanized mice. J Immunol. 173(11):7037–7045.
   PubMed Web of Science ®Google Scholar
• Szanto S, Bardos T, Szabo Z, David CS, Buzas EI, Mikecz K, Glant TT. 2004. Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background. Arthritis Rheum. 50(6):1984–1995.
   PubMed Web of Science ®Google Scholar
• Szpak Y, Vieville JC, Tabary T, Naud MC, Chopin M, Edelson C, Cohen JH, Dausset J, de Kozak Y, Pla M. 2001. Spontaneous retinopathy in HLA-A29 transgenic mice. Proc Natl Acad Sci USA. 98(5):2572–2576.
   PubMed Web of Science ®Google Scholar
• Takaki T, Marron MP, Mathews CE, Guttmann ST, Bottino R, Trucco M, DiLorenzo TP, Serreze DV. 2006. HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol. 176(5):3257–3265.
   PubMed Web of Science ®Google Scholar
• Takeno M, Kariyone A, Yamashita N, Takiguchi M, Mizushima Y, Kaneoka H, Sakane T. 1995. Excessive function of peripheral blood neutrophils from patients with Behçet's disease and from HLA-B51 transgenic miceBehcet's disease and from HLA-B51 transgenic mice. Arthritis Rheum. 38(3):426–433.
   PubMed Web of Science ®Google Scholar
• Taneja V, Behrens M, Basal E, Sparks J, Griffiths MM, Luthra H, David CS. 2008. Delineating the role of the HLA-DR4 “shared epitope” in susceptibility versus resistance to develop arthritis. J Immunol. 181(4):2869–2877.
   PubMed Web of Science ®Google Scholar
• Taneja V, Behrens M, Cooper LT, Yamada S, Kita H, Redfield MM, Terzic A, David C. 2007. Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice. J Mol Cell Cardiol. 42(6):1054–1064.
   PubMed Web of Science ®Google Scholar
• Taneja V, Behrens M, Mangalam A, Griffiths MM, Luthra HS, David CS. 2007. New humanized HLA-DR4-transgenic mice that mimic the sex bias of rheumatoid arthritis. Arthritis Rheum. 56(1):69–78.
   PubMed Web of Science ®Google Scholar
• Taneja V, Griffiths MM, Luthra H, David CS. 1998. Modulation of HLA-DQ-restricted collagen-induced arthritis by HLA-DRB1 polymorphism. Int Immunol. 10(10):1449–1457.
   PubMed Web of Science ®Google Scholar
• Taneja V, Hansen J, Smart M, Griffiths M, Luthra H, David CS. 1997. Expression of the H2-E molecule mediates protection to collagen-induced arthritis in HLA-DQ8 transgenic mice: role of cytokines. Int Immunol. 9(8):1213–1219.
   PubMed Web of Science ®Google Scholar
• Taneja V, Krco CJ, Behrens MD, Luthra HS, Griffiths MM, David CS. 2007. B cells are important as antigen presenting cells for induction of MHC-restricted arthritis in transgenic mice. Mol Immunol. 44(11):2988–2996.
   PubMed Web of Science ®Google Scholar
• Taneja V, Taneja N, Behrens M, Griffiths MM, Luthra HS, David CS. 2005. Requirement for CD28 may not be absolute for collagen-induced arthritis: study with HLA-DQ8 transgenic mice. J Immunol. 174(2):1118–1125.
   PubMed Web of Science ®Google Scholar
• Taneja V, Taneja N, Behrens M, Pan S, Trejo T, Griffiths M, Luthra H, David CS. 2003. HLA-DRB1*0402 (DW10) transgene protects collagen-induced arthritis-susceptible H2Aq and DRB1*0401 (DW4) transgenic mice from arthritis. J Immunol. 171(8):4431–4438.
   PubMed Web of Science ®Google Scholar
• Taneja V, Taneja N, Paisansinsup T, Behrens M, Griffiths M, Luthra H, David CS. 2002. CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: implications for rheumatoid arthritis. J Immunol. 168(11):5867–5875.
   PubMed Web of Science ®Google Scholar
• Tang B, Kim S, Hammond S, Cullins DL, Brand DD, Rosloniec EF, Stuart JM, Postlethwaite AE, Kang AH, Myers LK. 2014. Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis. Arthritis Res Ther. 16(1):R7.
   PubMed Web of Science ®Google Scholar
• Tarantino-Hutchison LM, Sorrentino C, Nadas A, Zhu Y, Rubin EM, Tinkle SS, Weston A, Gordon T. 2009. Genetic determinants of sensitivity to beryllium in mice. J Immunotoxicol. 6(2):130–135.
   PubMed Web of Science ®Google Scholar
• Taylor JA, Havari E, McInerney MF, Bronson R, Wucherpfennig KW, Lipes MA. 2004. A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J Immunol. 172(4):2651–2658.
   PubMed Web of Science ®Google Scholar
• Thompson RA, Isin EM, Ogese MO, Mettetal JT, Williams DP. 2016. Reactive Metabolites: Current and Emerging Risk and Hazard Assessments. Chem Res Toxicol. 29(4):505–533.
   PubMed Web of Science ®Google Scholar
• Thomson PJ, Illing PT, Farrell J, Alhaidari M, Bell CC, Berry N, O'Neill PM, Purcell AW, Park KB, Naisbitt DJ. 2020. Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation. Allergy. 75(3):636–647.
   PubMed Web of Science ®Google Scholar
• Usui T, Mise M, Hashizume T, Yabuki M, Komuro S. 2009. Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins. Drug Metab Dispos. 37(12):2383–2392.
   PubMed Web of Science ®Google Scholar
• Usui T, Naisbitt DJ. 2017. Human leukocyte antigen and idiosyncratic adverse drug reactions. Metab. Pharmacokinet. 32(1):21–30.
   PubMed Web of Science ®Google Scholar
• Vandenbark AA, Rich C, Mooney J, Zamora A, Wang C, Huan J, Fugger L, Offner H, Jones R, Burrows GG. 2003. Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice. J Immunol. 171(1):127–133.
   PubMed Web of Science ®Google Scholar
• Vassallo R, Luckey D, Behrens M, Madden B, Luthra H, David C, Taneja V. 2014. Cellular and humoral immunity in arthritis are profoundly influenced by the interaction between cigarette smoke effects and host HLA-DR and DQ genes. Clin Immunol. 152(1-2):25–35.
   PubMed Web of Science ®Google Scholar
• Verdu EF, Huang X, Natividad J, Lu J, Blennerhassett PA, David CS, McKay DM, Murray JA. 2008. Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice. Am. J. Physiol. Gastrointest. Liver Physiol. 294(1):G217–G225.
   PubMed Web of Science ®Google Scholar
• Verhagen J, Smith EL, Whettlock EM, Macintyre B, Peakman M. 2018. Proinsulin-mediated induction of type 1 diabetes in HLA-DR4-transgenic mice. Sci RepRep. 8(1):14106.
   PubMed Web of Science ®Google Scholar
• von Delwig A, Altmann DM, Charlton FG, McKie N, Isaacs JD, Holmdahl R, Robinson JH. 2007. T cell responses to a non-glycosylated epitope predominate in type II collagen-immunised HLA-DRB1*0101 transgenic mice. Ann Rheum Dis. 66(5):599–604.
   PubMed Web of Science ®Google Scholar
• Wade MF, Collins MK, Richards D, Mack DG, Martin AK, Dinarello CA, Fontenot AP, McKee AS. 2018. TLR9 and IL-1R1 promote mobilization of pulmonary dendritic cells during beryllium sensitization. J Immunol. 201(8):2232–2243.
   PubMed Web of Science ®Google Scholar
• Walker KM, Rytelewski M, Mazzuca DM, Meilleur SA, Mannik LA, Yue D, Brintnell WC, Welch I, Cairns E, Haeryfar SM. 2012. Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist. Immunol. Cell Biol. 90(6):630–639.
   PubMed Web of Science ®Google Scholar
• Wan Q, Shah R, Panos JC, Giraldo AA, David CS, Kong Y. 2002. HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible. Hum Immunol. 63(4):301–310.
   PubMed Web of Science ®Google Scholar
• Wang D, Hill JA, Jevnikar AM, Cairns E, Bell DA. 2002. Induction of transient arthritis by the adoptive transfer of a collagen II specific Th1 clone to HLA-DR4 (B1*0401) transgenic mice. J Autoimmun. 19(1–2):37–43.
   PubMed Web of Science ®Google Scholar
• Weinreich S, Eulderink F, Capkova J, Pla M, Gaede K, Heesemann J, van Alphen L, Zurcher C, Hoebe-Hewryk B, Kievits F, et al. 1995. HLA-B27 as a relative risk factor in ankylosing enthesopathy in transgenic mice. Hum Immunol. 42(2):103–115.
   PubMed Web of Science ®Google Scholar
• Wen L, Chen NY, Tang J, Sherwin R, Wong FS. 2001. The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model. J Clin Invest. 107(7):871–880.
   PubMed Web of Science ®Google Scholar
• Wen L, Wong FS, Burkly L, Altieri M, Mamalaki C, Kioussis D, Flavell RA, Sherwin RS. 1998. Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. J Clin Invest. 102(5):947–957.
   PubMed Web of Science ®Google Scholar
• Wen L, Wong FS, Tang J, Chen NY, Altieri M, David C, Flavell R, Sherwin R. 2000. In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes. J Exp Med. 191(1):97–104.
   PubMed Web of Science ®Google Scholar
• Wing K, Bhaskaran K, Pealing L, Root A, Smeeth L, van Staa TP, Klungel OH, Reynolds RF, Douglas I. 2017. Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study. J Antimicrob Chemother. 72(9):2636–2646.
   PubMed Web of Science ®Google Scholar
• Woods A, Chen HY, Trumbauer ME, Sirotina A, Cummings R, Zaller DM. 1994. Human major histocompatibility complex class II-restricted T cell responses in transgenic mice. J Exp Med. 180(1):173–181.
   PubMed Web of Science ®Google Scholar
• Wu X, Tuzun E, Li J, Xiao T, Saini SS, Qi H, Allman W, Christadoss P. 2012. Ocular and generalized myasthenia gravis induced by human acetylcholine receptor γ subunit immunizationgamma subunit immunization. Muscle Nerve. 45(2):209–216.
   PubMed Web of Science ®Google Scholar
• Wu X, Tuzun E, Saini SS, Wang J, Li J, Aguilera-Aguirre L, Huda R, Christadoss P. 2015. Ocular myasthenia gravis induced by human acetylcholine receptor ϵ subunit immunization in HLA DR3 transgenic micesubunit immunization in HLA DR3 transgenic mice. Immunol Lett. 168(2):306–312.
   PubMed Web of Science ®Google Scholar
• Yadav SK, Boppana S, Ito N, Mindur JE, Mathay MT, Patel A, Dhib-Jalbut S, Ito K. 2017. Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood. Proc Natl Acad Sci USA. 114(44):E9318–E9327.
   PubMed Web of Science ®Google Scholar
• Yang H, Goluszko E, David C, Okita DK, Conti-Fine B, Chan TS, Poussin MA, Christadoss P. 2002. Mapping myasthenia gravis-associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice. J Clin Invest. 109(8):1111–1120.
   PubMed Web of Science ®Google Scholar
• Yang H, Wu B, Tuzun E, Saini SS, Li J, Allman W, Higgs S, Xiao TL, Christadoss P. 2007. A new mouse model of autoimmune ocular myasthenia gravis. Invest Ophthalmol Vis Sci. 48(11):5101–5111.
   PubMed Web of Science ®Google Scholar
• Yorifuji H, Arase N, Kohyama M, Hirano T, Suenaga T, Kumanogoh A, Arase H. 2019. Transport of cellular misfolded proteins to the cell surface by HLA-B27 free heavy chain. Biochem Biophys Res Commun. 511(4):862–868.
   PubMed Web of Science ®Google Scholar
• You Q, Cheng L, Ju C. 2010. Generation of T cell responses targeting the reactive metabolite of halothane in mice. Toxicol Lett. 194(3):79–85.
   PubMed Web of Science ®Google Scholar
• You Q, Cheng L, Reilly TP, Wegmann D, Ju C. 2006. Role of neutrophils in a mouse model of halothane-induced liver injury. Hepatology. 44(6):1421–1431.
   PubMed Web of Science ®Google Scholar
• Yue D, Brintnell W, Mannik LA, Christie DA, Haeryfar SM, Madrenas J, Chakrabarti S, Bell DA, Cairns E. 2010. CTLA-4Ig blocks the development and progression of citrullinated fibrinogen-induced arthritis in DR4-transgenic mice. Arthritis Rheum. 62(10):2941–2952.
   PubMed Web of Science ®Google Scholar
• Yuksel M, Wang Y, Tai N, Peng J, Guo J, Beland K, Lapierre P, David C, Alvarez F, Colle I, et al. 2015. A novel "humanized mouse" model for autoimmune hepatitis and the association of gut microbiota with liver inflammation. Hepatology. 62(5):1536–1550.
   PubMed Web of Science ®Google Scholar
• Zhang M, Zhou Z, Wang J, Li S. 2016. ZnT8107-115/HLA-A2 dimers attenuate the severity of diabetes by inducing CD8+ T cell tolerance. Immunol Lett. 180:66–72.
   PubMed Web of Science ®Google Scholar