Determination of mechanical properties of polymeric microspheres used in controlled drug delivery systems by nanoindentation

References

• El-Say, K. M.; El-Sawy, H. S. Polymeric Nanoparticles: Promising Platform for Drug Delivery. Int. J. Pharm. 2017, 528(1–2), 675–691. DOI: 10.1016/j.ijpharm.2017.06.052.
   PubMed Web of Science ®Google Scholar
• Steward, P. A.; Hearn, J.; Wilkinson, M. C. An Overview of Polymer Latex Film Formation and Properties. Adv. Colloid Interface Sci. 2000, 86(3), 195–267.
   PubMed Web of Science ®Google Scholar
• Tan, S.; Sherman, R. L.; Ford, W. T. Nanoscale Compression of Polymer Microspheres by Atomic Force Microscopy. Langmuir. 2004, 20(17), 7015–7020. DOI: 10.1021/la049597c.
   PubMed Web of Science ®Google Scholar
• Zalfen, A. M.; Nizet, D.; Jérôme, C.; Jérôme, R.; Frankenne, F.; Foidart, J. M.; Maquet, V.; Lecomte, F.; Hubert, P.; Evrard, B. Controlled Release of Drugs from Multi-Component Biomaterials. Acta Biomater. 2008, 4(6), 1788–1796. DOI: 10.1016/j.actbio.2008.05.021.
   PubMed Web of Science ®Google Scholar
• Heilmann, K. L.;. Therapeutic Systems- Rate Controlled Drug Delivery, Concept and Development; 2nd ed. New York: Thieme-Stratton Publishing Group, 1984; p. 159.
   Google Scholar
• Singh, R.; Vyas, S. P. Topical Liposomal System for Localized and Controlled Drug Delivery. J. Dermatol. Sci. 1996, 13(2), 107–111.
   PubMed Web of Science ®Google Scholar
• Nujoma, Y. N.; Kim, C. J. A Designer’s Polymer as an Oral Drug Carrier (Tablet) with Pseudo-Zero-Order Release Kinetics. J. Pharm Sci. 1996, 85(10), 1091–1095. DOI: 10.1021/js960030t.
   PubMed Web of Science ®Google Scholar
• Saranya, S.; Radha, K. V. Review of Nanobiopolymers for Controlled Drug Delivery. Polym. Plast Technol. Eng. 2014, 53(15), 1636–1646. DOI: 10.1080/03602559.2014.915035.
   Web of Science ®Google Scholar
• Shunyu Chen, Zhi Luo, Linzhao Wu, Chunling Xie & Xiufeng Xiao. Amino-Modified Polylactic Acid Nanofibre Microspheres as Drug Sustained Release Carriers for Alendronate. Polym. Plast Technol. Eng. 2018, 1–9.
   Web of Science ®Google Scholar
• Dave, A. M.; Mehta, M. H.; Aminabhavi, T. M.; Kulkarni, A. R.; Soppimath, K. S. A Review on Controlled Release of Nitrogen Fertilizers through Polymeric Membrane Devices. Polym. Plast Technol. Eng. 1999, 38(4), 675–711. DOI: 10.1080/03602559909351607.
   Web of Science ®Google Scholar
• Basak, P.; Adhikari, B.; Sen, A. K. Surface Cross-Linked Poly (Vinyl Alcohol) Hydrogel for Colon Targeted Drug Release. Polym. Plast Technol. Eng. 2011, 50(13), 1357–1361. DOI: 10.1080/03602559.2011.584238.
   Web of Science ®Google Scholar
• Varaprasad, K.; Vimala, K.; Ravindra, S.; Reddy, N. N.; Raju, K. M. Development of Sodium Carboxymethyl Cellulose-Based Poly(Acrylamide-Co-2acrylamido-2-Methyl-1-Propane Sulfonic Acid) Hydrogels for in Vitro Drug Release Studies of Ranitidine Hydrochloride an Anti-Ulcer Drug. Polym. Plast Technol. Eng. 2011, 50(12), 1199–1207. DOI: 10.1080/03602559.2011.553872.
   Web of Science ®Google Scholar
• Ketan Mehta, Y.-H. T.;. Modified Release Formulations Containing Drug-Ion Exchange Resin Complex. U.S. Patent, Editor. Tris Pharma Inc: US, 2011; p. 13.
   Google Scholar
• García-Encina, G.; Torres, D.; Seijo, B.; Vila Jato, J. L. In Vivo Evaluation of Nylon-Coated Diclofenac-Resin Complexes. J. Controlled Release. 1993, 23(3), 201–207. DOI: 10.1016/0168-3659(93)90001-L.
   Web of Science ®Google Scholar
• Dorkoosh, F. A.; Coos Verhoef, J.; Ambagts, M. H. C.; Rafiee-Tehrani, M.; Borchard, G.; Junginger, H. E. Peroral Delivery Systems Based on Superporous Hydrogel Polymers: Release Characteristics for the Peptide Drugs Buserelin, Octreotide and Insulin. Eur. J. Pharm. Sci. 2002, 15(5), 433–439.
   PubMed Web of Science ®Google Scholar
• Huang, J.; Turner, S. R. Hypercrosslinked Polymers: A Review. Polymer Rev. 2018, 58(1), 1–41. DOI: 10.1080/15583724.2017.1344703.
   Web of Science ®Google Scholar
• Reis, C. P.; Neufeld, R. J.; Ribeiro, A. J.; Veiga, F. Nanoencapsulation I. Methods for Preparation of Drug-Loaded Polymeric Nanoparticles. Nanomedicine. 2006, 2(1), 8–21. DOI: 10.1016/j.nano.2005.12.003.
   PubMed Web of Science ®Google Scholar
• Sao Pedro, A.; Fernandes, R.; Villarreal, C. F.; Fialho, R.; Albuquerque, E. C. Opioid-Based Micro and Nanoparticulate Formulations: Alternative Approach on Pain Management. J. Microencapsul. 2016, 33(1), 18–29. DOI: 10.3109/02652048.2015.1134687.
   PubMed Web of Science ®Google Scholar
• Qiu, X.; Leporatti, S.; Donath, E.; Möhwald, H. Studies on the Drug Release Properties of Polysaccharide Multilayers Encapsulated Ibuprofen Microparticles. Langmuir. 2001, 17(17), 5375–5380. DOI: 10.1021/la010201w.
   Web of Science ®Google Scholar
• Wang, Y.; Bansal, V.; Zelikin, A. N.; Caruso, F. Templated Synthesis of Single-Component Polymer Capsules and Their Application in Drug Delivery. Nano Lett. 2008, 8(6), 1741–1745. DOI: 10.1021/nl080877c.
   PubMed Web of Science ®Google Scholar
• Budd, P. M.; McKeown, N. B.; Fritsch, D. Free Volume and Intrinsic Microporosity in Polymers. J. Mater Chem. 2005, 15(20), 1977–1986. DOI: 10.1039/b417402j.
   Web of Science ®Google Scholar
• Bera, K.; Khanam, J.; Mohanraj, K. P.; Mazumder, B. Design and Evaluation of Mucoadhesive Beads of Glipizide as a Controlled Release Drug Delivery System. J. Microencapsul. 2014, 31(3), 220–229. DOI: 10.3109/02652048.2013.834989.
   PubMed Web of Science ®Google Scholar
• Jambhekar, S. S.; Breen, P. J.; Rojanasakul, Y. Influence of Formulation and Other Factors on the Release of Chlorpheniramine Mateate from Polymer Coated Beads. Drug Dev. Ind. Pharm. 1987, 13(15), 2789–2810. DOI: 10.3109/03639048709022090.
   Web of Science ®Google Scholar
• Yerriswamy, B.; Reddy, C. L.; Prasad, C. V.; Subha, M. C. S.; Rao, K. C. Synthesis and Characterization of Sodium Alginate-g-2-Hydroxyethyl Methacrylate Interpenetrating Beads for Controlled Release of Acebutolol Hydrochloride. Des. Monomers. Polym. 2011, 14(1), 25–37. DOI: 10.1163/138577210X541178.
   Web of Science ®Google Scholar
• Razzaque, S.; Cai, C.; Lu, Q.-W.; Huang, F.-Z.; Li, Y.-S.; Tang, H.-B.; Hussain, I.; Tan, B. Development of Functionalized Hollow Microporous Organic Capsules Encapsulating Morphine – An in Vitro and in Vivo Study. J. Mater. Chem. B. 2017, 5(4), 742–749. DOI: 10.1039/C6TB02497A.
   Web of Science ®Google Scholar
• Tambe, A., Vyasarayani, R., Datla, A., Ponrathnam, S., & Demnerova, K. Macroporous Poly(Vinyl Acetate-Co-Divinyl Benzene) Copolymer Beads as Adsorptive Support for the Direct Immobilization of Candida Antarctica Lipase B. Enzym. Eng 4:130. 2015, 04(02).
   Google Scholar
• Jamekhorshid, A.; Sadrameli, S. M.; Farid, M. A Review of Microencapsulation Methods of Phase Change Materials (Pcms) as A Thermal Energy Storage (TES) Medium. Renewable. Sustainable. Energy. Rev. 2014, 31, 531–542. DOI: 10.1016/j.rser.2013.12.033.
   Web of Science ®Google Scholar
• Prajapati, V. D.; Jani, G. K.; Kapadia, J. R. Current Knowledge on Biodegradable Microspheres in Drug Delivery. Expert Opin. Drug Deliv. 2015, 12(8), 1283–1299. DOI: 10.1517/17425247.2015.1015985.
   PubMed Web of Science ®Google Scholar
• Tonnesen, H. H.; Karlsen, J. Alginate in Drug Delivery Systems. Drug Dev. Ind. Pharm. 2002, 28(6), 621–630. DOI: 10.1081/DDC-120003853.
   PubMed Web of Science ®Google Scholar
• Yang, J.; Han, S.; Zheng, H.; Dong, H.; Liu, J. Preparation and Application of Micro/Nanoparticles Based on Natural Polysaccharides. Carbohydr Polym. 2015, 123, 53–66. DOI: 10.1016/j.carbpol.2015.01.029.
   PubMed Web of Science ®Google Scholar
• Huang, H.-J.; Yuan, W.-K.; Chen, X. D. Microencapsulation Based on Emulsification for Producing Pharmaceutical Products: A Literature Review. Dev. Chem. Eng. Mineral Process. 2006, 14(3–4), 515–544. DOI: 10.1002/apj.5500140318.
   Google Scholar
• Jyothi, N. V.; Prasanna, P. M.; Sakarkar, S. N.; Prabha, K. S.; Ramaiah, P. S.; Srawan, G. Y. Microencapsulation Techniques, Factors Influencing Encapsulation Efficiency. J. Microencapsul. 2010, 27(3), 187–197. DOI: 10.3109/02652040903131301.
   PubMed Web of Science ®Google Scholar
• Iconomopoulou, S. M.; Andreopoulou, A. K.; Soto, A.; Kallitsis, J. K.; Voyiatzis, G. A. Incorporation of Low Molecular Weight Biocides into Polystyrene-Divinyl Benzene Beads with Controlled Release Characteristics. J. Control Release. 2005, 102(1), 223–233. DOI: 10.1016/j.jconrel.2004.10.006.
   PubMed Web of Science ®Google Scholar
• Prajapat, A.; Midda, A.; Jhanjharia, M. Formulation, Evaluation and Optimization of Ranitidine Hydrochloride Floating Tablets with Improved Gi Absorption. J. Drug Deliv. Ther. 2017, 7(5), 114-119. https://doi.org/10.22270/jddt.v7i5.1496.
   Google Scholar
• Thulluru, A.; Varma, M. M.; Setty, C. M.; Chintamaneni, P. K.; Samayamanthula, S. Effect of Sodium Alginate in Combination with HPMC K 100 M in Extending the Release of Metoprolol Succinate from Its Gastro-Retentive Floating Tablets. Indian J. Pharm. Educ. Res. 2015, 49(4), 293–303. DOI: 10.5530/ijper.
   Web of Science ®Google Scholar
• Asane, G. S.; Nirmal, S. A.; Rasal, K. B.; Naik, A. A.; Mahadik, M. S.; Rao, Y. M. Polymers for Mucoadhesive Drug Delivery System: A Current Status. Drug Dev. Ind. Pharm. 2008, 34(11), 1246–1266. DOI: 10.1080/03639040802026012.
   PubMed Web of Science ®Google Scholar
• Pawar, V. K.; Kansal, S.; Garg, G.; Awasthi, R.; Singodia, D.; Kulkarni, G. T. Gastroretentive Dosage Forms: A Review with Special Emphasis on Floating Drug Delivery Systems. Drug Deliv. 2011, 18(2), 97–110. DOI: 10.3109/10717544.2010.520354.
   PubMed Web of Science ®Google Scholar
• Awasthi, R.; Kulkarni, G. T. Decades of Research in Drug Targeting to the Upper Gastrointestinal Tract Using Gastroretention Technologies: Where Do We Stand? Drug Deliv. 2016, 23(2), 378–394. DOI: 10.3109/10717544.2014.936535.
   PubMed Web of Science ®Google Scholar
• Athawale, V. D.; Kolekar, S. L.; Raut, S. S. Recent Developments in Polyurethanes and Poly(Acrylates) Interpenetrating Polymer Networks. J. Macromol. Sci. Part. C. 2003, 43(1), 1–26. DOI: 10.1081/MC-120018018.
   Google Scholar
• Varde, N. K.; Pack, D. W. Microspheres for Controlled Release Drug Delivery. Expert Opin. Biol.Ther. 2004, 4(1), 35–51. DOI: 10.1517/14712598.4.1.35.
   PubMed Web of Science ®Google Scholar
• Wattendorf, U.; Coullerez, G.; Vörös, J.; Textor, M.; Merkle, H. P. Mannose-Based Molecular Patterns on Stealth Microspheres for Receptor-Specific Targeting of Human Antigen-Presenting Cells. Langmuir. 2008, 24(20), 11790–11802. DOI: 10.1021/la801085d.
   PubMed Web of Science ®Google Scholar
• Florence, A. T.; Siepmann, J. Modern Pharmaceutics, Volume 2 Applications and Advances, 5 ed. CRC Press: Boca Raton, 2009.
   Google Scholar
• Tarn, D.; Ashley, C. E.; Xue, M.; Carnes, E. C.; Zink, J. I.; Brinker, C. J. Mesoporous Silica Nanoparticle Nanocarriers: Biofunctionality and Biocompatibility. Acc. Chem. Res. 2013, 46(3), 792–801. DOI: 10.1021/ar3000986.
   PubMed Web of Science ®Google Scholar
• Siepmann, J.; Faisant, N.; Akiki, J.; Richard, J.; Benoit, J. P. Effect of the Size of Biodegradable Microparticles on Drug Release: Experiment and Theory. J. Control Release. 2004, 96(1), 123–134. DOI: 10.1016/j.jconrel.2004.01.011.
   PubMed Web of Science ®Google Scholar
• Sun, Y.; Chen, R.; Zhao, G.; Yang, F. Nanoindentation of Carbon Microspheres. Int. J. Mater. Res. 2016, 107(8), 687–691. DOI: 10.3139/146.111366.
   Web of Science ®Google Scholar
• Hao, P.; Liu, Y.; Du, Y.; Zhang, Y. Young’s Modulus of Polycrystalline Titania Microspheres Determined by in Situ Nanoindentation and Finite Element Modeling. J. Nanomater. 2014, 2014, 1–5. DOI: 10.1155/2014/309827.
   Google Scholar
• Unsal, E.; Elmas, B.; Camli, S. T.; Senel, S.; Tuncel, A. Uniform Particles for the Reversed-Phase Separation of Proteins with High-Resolution and High-Column Efficiency. Sep. Sci. Technol. 2005, 40, 1425–1438. DOI: 10.1081/SS-200053011.
   Web of Science ®Google Scholar
• Çaglayan, B.; Unsal, E.; Camli, S. T.; Tuncel, M.; Tuncel, A. Monodisperse Porous Poly(Vinyl Acetate-Co-Divinylbenzene) Particles by Single-Stage Seeded Polymerization: A Packing Material for Reversed Phase HPLC. J. Sep. Sci. 2006, 29(7), 936–944.
   PubMed Web of Science ®Google Scholar
• Johnson, K. L.;. One Hundred Years of Hertz Contact. Proc. Inst. Mech. Eng. 1982, 196(1), 363–378. DOI: 10.1243/PIME_PROC_1982_196_039_02.
   Google Scholar