Altered cardiovascular function is related to reduced BDNF in Parkinson’s disease

References

• Allen, J. D., Welsch, M., Aucoin, N., Wood, R., Lee, M., & LeBlanc, K. E. (2001). Forearm vasoreactivity in type I diabetic subjects. Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee, 26(1), 34–43. doi:10.1139/h01-003
   PubMedGoogle Scholar
• Alomari, M. A., Keewan, E. F., Shammaa, R. A., Alawneh, K., Khatib, S. Y., & Welsch, M. A. (2012). Vascular function and handgrip strength in rheumatoid arthritis patients. [Research Support, Non-U.S. Gov’t]. The Scientific World Journal, 2012, 1–6. doi:10.1100/2012/580863
   Web of Science ®Google Scholar
• Alomari, M. A., Khabour, O. F., Alzoubi, K. H., & Alzubi, M. A. (2013). Forced and voluntary exercises equally improve spatial learning and memory and hippocampal BDNF levels. Behavioural Brain Research, 247, 34–39. doi:10.1016/j.bbr.2013.03.007
   PubMed Web of Science ®Google Scholar
• Alomari, M. A., Khabour, O. F., Alzoubi, K. H., & Alzubi, M. A. (2016). Combining restricted diet with forced or voluntary exercises improves hippocampal BDNF and cognitive function in rats. International Journal of Neuroscience, 126(4), 366–373. doi:10.3109/00207454.2015.1012587
   PubMed Web of Science ®Google Scholar
• Alomari, M. A., Khabour, O. F., Alzoubi, K. H., Shqair, D. M., & Stoner, L. (2015). Acute vascular effects of waterpipe smoking: Importance of physical activity and fitness status. Atherosclerosis, 240(2), 472–476. doi:10.1016/j.atherosclerosis.2015.02.047
   PubMed Web of Science ®Google Scholar
• Alomari, M. A., Khabour, O. F., Maikano, A., & Alawneh, K. (2015). Vascular function and brain-derived neurotrophic factor: The functional capacity factor. Vascular Medicine, 20(6), 518–526. doi:10.1177/1358863X15598390
   PubMed Web of Science ®Google Scholar
• Alomari, M. A., Mekary, R. A., & Welsch, M. A. (2010). Rapid vascular modifications to localized rhythmic handgrip training and detraining: Vascular conditioning and deconditioning. European Journal of Applied Physiology, 109(5), 803–809. doi:10.1007/s00421-010-1367-0
   PubMed Web of Science ®Google Scholar
• Alomari, M. A., Shqair, D. M., Khabour, O. F., Alawneh, K., Nazzal, M. I., & Keewan, E. F. (2012). The clinical and nonclinical values of nonexercise estimation of cardiovascular endurance in young asymptomatic individuals. [Research Support, Non-U.S. Gov’t]. The Scientific World Journal, 2012, 1–9. doi:10.1100/2012/958752
   Web of Science ®Google Scholar
• Alomari, M. A., Solomito, A., Reyes, R., Khalil, S. M., Wood, R. H., & Welsch, M. A. (2004). Measurements of vascular function using strain-gauge plethysmography: Technical considerations, standardization, and physiological findings. American Journal of Physiology-Heart and Circulatory Physiology, 286(1), H99–H107. doi:10.1152/ajpheart.00529.2003
   PubMed Web of Science ®Google Scholar
• Alrefai, A., Habahbih, M., Alkhawajah, M., Darwish, M., Batayha, W., Khader, Y., & El-Salem, K. (2009). Prevalence of Parkinson’s disease in Northern Jordan. Clinical Neurology and Neurosurgery, 111(10), 812–815. doi:10.1016/j.clineuro.2009.08.010
   PubMed Web of Science ®Google Scholar
• Anastasia, A., Deinhardt, K., Wang, S., Martin, L., Nichol, D., Irmady, K., … Kermani, P. (2014). Trkb signaling in pericytes is required for cardiac microvessel stabilization. PLoS One, 9(1), e87406. doi:10.1371/journal.pone.0087406PONE-D-13-26116
   PubMed Web of Science ®Google Scholar
• Beard, D. A., & Feigl, E. O. (2011). Understanding Guyton’s venous return curves. [Research Support, N.I.H., Extramural]. American Journal of Physiology-Heart and Circulatory Physiology, 301(3), H629–633. doi:10.1152/ajpheart.00228.2011
   PubMed Web of Science ®Google Scholar
• Biaggioni, I. (2007). The sympathetic nervous system and blood volume regulation: Lessons from autonomic failure patients. [Review]. The American Journal of the Medical Sciences, 334(1), 61–64. doi:10.1097/MAJ.0b013e318065c03b
   PubMed Web of Science ®Google Scholar
• Caporali, A., & Emanueli, C. (2009). Cardiovascular actions of neurotrophins. Physiological Reviews, 89(1), 279–308. doi:10.1152/physrev.00007.2008
   PubMed Web of Science ®Google Scholar
• Cardwell, R. J., & Webb, R. C. (1984). Diabetes and reactivity of isolated human saphenous vein. Clinical Physiology, 4(6), 509–517. doi:10.1111/j.1475-097X.1984.tb00136.x
   PubMedGoogle Scholar
• Chaldakov, G. N., Fiore, M., Hristova, M. G., & Aloe, L. (2003). Metabotrophic potential of neurotrophins: Implicationin obesity and related diseases? Medical Science Monitor, 9(10), HY19–21.
   PubMedGoogle Scholar
• Chaldakov, G. N., Tonchev, A. B., & Aloe, L. (2009). NGF and BDNF: From nerves to adipose tissue, from neurokines to metabokines. Rivista Di Psichiatria, 44(2), 79–87.
   PubMed Web of Science ®Google Scholar
• Donovan, M. J., Lin, M. I., Wiegn, P., Ringstedt, T., Kraemer, R., Hahn, R., … Hempstead, B. L. (2000). Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development, 127(21), 4531–4540.
   PubMed Web of Science ®Google Scholar
• Ejiri, J., Inoue, N., Kobayashi, S., Shiraki, R., Otsui, K., Honjo, T., … Yokoyama, M. (2005). Possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease. Circulation, 112(14), 2114–2120. doi:10.1161/CIRCULATIONAHA.104.476903
   PubMed Web of Science ®Google Scholar
• Fujimura, H., Altar, C. A., Chen, R., Nakamura, T., Nakahashi, T., Kambayashi, J., … Tandon, N. N. (2002). Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost, 87(4), 728–734.
   PubMed Web of Science ®Google Scholar
• Fukui, Y., Hishikawa, N., Shang, J., Sato, K., Nakano, Y., Morihara, R., … Abe, K. (2016). Peripheral arterial endothelial dysfunction of neurodegenerative diseases. Journal of the Neurological Sciences, 366, 94–99. doi:10.1016/j.jns.2016.04.042
   PubMed Web of Science ®Google Scholar
• Gascho, J. A., Fanelli, C., & Zelis, R. (1989). Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects. The American Journal of Cardiology, 63(17), 1267–1270. doi:10.1016/0002-9149(89)90188-4
   PubMed Web of Science ®Google Scholar
• Golden, E., Emiliano, A., Maudsley, S., Windham, B. G., Carlson, O. D., Egan, J. M., … Mattson, M. P. (2010). Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: Data from the baltimore longitudinal study of aging. PLoS One, 5(4), e10099. doi:10.1371/journal.pone.0010099
   PubMed Web of Science ®Google Scholar
• Hassin-Baer, S., Cohen, O., Vakil, E., Sela, B. A., Nitsan, Z., Schwartz, R., … Tanne, D. (2006). Plasma homocysteine levels and Parkinson disease: Disease progression, carotid intima-media thickness and neuropsychiatric complications. Clinical Neuropharmacology, 29(6), 305–311. doi:10.1097/01.WNF.0000236763.16032.6000002826-200611000-00002
   PubMed Web of Science ®Google Scholar
• Helan, M., Aravamudan, B., Hartman, W. R., Thompson, M. A., Johnson, B. D., Pabelick, C. M., & Prakash, Y. S. (2014). BDNF secretion by human pulmonary artery endothelial cells in response to hypoxia. Journal of Molecular and Cellular Cardiology, 68, 89–97. doi:10.1016/j.yjmcc.2014.01.006
   PubMed Web of Science ®Google Scholar
• Heller, J., Dogan, I., Schulz, J. B., & Reetz, K. (2014). Evidence for gender differences in cognition, emotion and quality of life in Parkinson’s disease? Aging and Diseases, 5(1), 63–75. doi:10.14366/AD.2014.050063ad-5-1-63
   PubMed Web of Science ®Google Scholar
• Hokanson, D. E., Sumner, D. S., & Strandness, D. E., Jr. (1975). An electrically calibrated plethysmograph for direct measurement of limb blood flow. IEEE Transactions on Bio-Medical Engineering, 22(1), 21–25.
   Google Scholar
• Jain, S., & Goldstein, D. S. (2012). Cardiovascular dysautonomia in Parkinson disease: From pathophysiology to pathogenesis. [Review]. Neurobiology of Disease, 46(3), 572–580. doi:10.1016/j.nbd.2011.10.025
   PubMed Web of Science ®Google Scholar
• Kermani, P., & Hempstead, B. (2007). Brain-derived neurotrophic factor: A newly described mediator of angiogenesis. Trends in Cardiovascular Medicine, 17(4), 140–143. doi:10.1016/j.tcm.2007.03.002
   PubMed Web of Science ®Google Scholar
• Khalil, H., Alomari, M. A., Khabour, O. F., Al-Hieshan, A., & Bajwa, J. A. (2016). Relationship of circulatory BDNF with cognitive deficits in people with Parkinson’s disease. [Research Support, Non-U.S. Gov’t]. Journal of the Neurological Sciences, 362, 217–220. doi:10.1016/j.jns.2016.01.032
   PubMed Web of Science ®Google Scholar
• Lam, C.-T., Yang, Z.-F., Lau, C.-K., Tam, K.-H., Fan, S.-T., & Poon, R. T. (2011). Brain-derived neurotrophic factor promotes tumorigenesis via induction of neovascularization: Implication in hepatocellular carcinoma. Clinical Cancer Research, 17(10), 3123–3133. doi:10.1158/1078-0432.CCR-10-2802
   PubMed Web of Science ®Google Scholar
• Lin, C.-Y., Hung, S.-Y., Chen, H.-T., Tsou, H.-K., Fong, Y.-C., Wang, S.-W., & Tang, C.-H. (2014). Brain-derived neurotrophic factor increases vascular endothelial growth factor expression and enhances angiogenesis in human chondrosarcoma cells. Biochemical Pharmacology, 91(4), 522–533. doi:10.1016/j.bcp.2014.08.008
   PubMed Web of Science ®Google Scholar
• Liu, Y., Sun, L., Huan, Y., Zhao, H., & Deng, J. (2006). Application of bFGF and BDNF to improve angiogenesis and cardiac function. Journal of Surgical Research, 136(1), 85–91. doi:10.1016/j.jss.2006.04.034
   PubMed Web of Science ®Google Scholar
• Lommatzsch, M., Zingler, D., Schuhbaeck, K., Schloetcke, K., Zingler, C., Schuff-Werner, P., & Virchow, J. C. (2005). The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiology of Aging, 26(1), 115–123. doi:10.1016/j.neurobiolaging.2004.03.002
   PubMed Web of Science ®Google Scholar
• Lu, Y., Fang, J.-Q., Tian, L., & Jin, H. (2015). Advanced medical statistics (2nd ed.). World Scientific Publishing.
   Google Scholar
• Magder, S. (2016). Volume and its relationship to cardiac output and venous return. [Review]. Journal of Critical Care, 20, 271. doi:10.1186/s13054-016-1438-7
   Web of Science ®Google Scholar
• Manni, L., Nikolova, V., Vyagova, D., Chaldakov, G. N., & Aloe, L. (2005). Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes. International Journal of Cardiology, 102(1), 169–171. doi:10.1016/j.ijcard.2004.10.041
   PubMed Web of Science ®Google Scholar
• Matthews, V. B., Astrom, M. B., Chan, M. H., Bruce, C. R., Krabbe, K. S., Prelovsek, O., … Febbraio, M. A. (2015). Erratum to: Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. [Published Erratum]. Diabetologia, 58(4), 854–855. doi:10.1007/s00125-015-3502-2
   PubMed Web of Science ®Google Scholar
• Meuchel, L. W., Thompson, M. A., Cassivi, S. D., Pabelick, C. M., & Prakash, Y. S. (2011). Neurotrophins induce nitric oxide generation in human pulmonary artery endothelial cells. Cardiovasc Res, 91(4), 668–676. doi:10.1093/cvr/cvr107.
   Google Scholar
• Oncel, C., Ince, B., Apaydin, H., Ozekmekci, S., & Uluduz, D. (2008). Hypertrophy of intima media of the carotid artery due to L-dopa therapy in Parkinson’s disease. Advances in Therapy, 25(3), 201–207. doi:10.1007/s12325-008-0035-9
   PubMed Web of Science ®Google Scholar
• Parain, K., Murer, M. G., Yan, Q., Faucheux, B., Agid, Y., Hirsch, E., & Raisman-Vozari, R. (1999). Reduced expression of brain-derived neurotrophic factor protein in Parkinsonʼs disease substantia nigra. Neuroreport, 10(3), 557–561. doi:10.1097/00001756-199902250-00021
   PubMed Web of Science ®Google Scholar
• Pathak, A., & Senard, J.-M. (2006). Blood pressure disorders during Parkinson’s disease: Epidemiology, pathophysiology and management. [Review]. Expert Review of Neurotherapeutics, 6(8), 1173–1180. doi:10.1586/14737175.6.8.1173
   PubMedGoogle Scholar
• Pedersen, B. K., Pedersen, M., Krabbe, K. S., Bruunsgaard, H., Matthews, V. B., & Febbraio, M. A. (2009). Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals. Experimental Physiology, 94(12), 1153–1160. doi:10.1113/expphysiol.2009.048561
   PubMed Web of Science ®Google Scholar
• Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., & Timmusk, T. (2007). Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters. Genomics, 90(3), 397–406. doi:10.1016/j.ygeno.2007.05.004
   PubMed Web of Science ®Google Scholar
• Radka, S. F., Hoist, P. A., Fritsche, M., & Altar, C. A. (1996). Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Research, 709(1), 122–130. doi:10.1016/0006-8993(95)01321-0
   PubMed Web of Science ®Google Scholar
• Rezaee, F., Rellick, S. L., Piedimonte, G., Akers, S. M., O’Leary, H. A., Martin, K., … Gibson, L. F. (2010). Neurotrophins regulate bone marrow stromal cell IL-6 expression through the MAPK pathway. [Research Support, N.I.H., Extramural]. PLoS One, 5(3), e9690. doi:10.1371/journal.pone.0009690
   PubMed Web of Science ®Google Scholar
• Santhanam, A. V., Smith, L. A., & Katusic, Z. S. (2010). Brain-Derived Neurotrophic Factor Stimulates Production of Prostacyclin in Cerebral Arteries * Supplemental Data. Stroke, 41(2), 350–356. doi:10.1161/STROKEAHA.109.564492
   PubMed Web of Science ®Google Scholar
• Scalzo, P., Kümmer, A., Bretas, T. L., Cardoso, F., & Teixeira, A. L. (2010). Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson’s disease. Journal of Neurology, 257(4), 540–545. doi:10.1007/s00415-009-5357-2
   PubMed Web of Science ®Google Scholar
• Tolosa, E., & Pont-Sunyer, C. (2011). Progress in defining the premotor phase of Parkinson’s disease. [Research Support, Non-U.S. Gov’t Review]. Journal of the Neurological Sciences, 310(1–2), 4–8. doi:10.1016/j.jns.2011.05.027
   PubMed Web of Science ®Google Scholar
• Ventriglia, M., Zanardini, R., Bonomini, C., Zanetti, O., Volpe, D., Pasqualetti, P., … Bocchio-Chiavetto, L. (2013). Serum brain-derived neurotrophic factor levels in different neurological diseases. BioMed Research International, 2013, 1–7. doi:10.1155/2013/901082
   Web of Science ®Google Scholar
• Welsch, M. A., Alomari, M., Parish, T. R., Wood, R. H., & Kalb, D. (2002). Influence of venous function on exercise tolerance in chronic heart failure. [Research Support, U.S. Gov’t, P.H.S.]. Journal of Cardiopulmonary Rehabilitation & Prevention, 22(5), 321–326. doi:10.1097/00008483-200209000-00002
   Google Scholar
• Welsch, M. A., Dobrosielski, D. A., Arce-Esquivel, A. A., Wood, R. H., Ravussin, E., Rowley, C., & Jazwinski, S. M. (2008). The association between flow-mediated dilation and physical function in older men. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Medicine & Science in Sports & Exercise, 40(7), 1237–1243. doi:10.1249/MSS.0b013e31816c5552
   PubMed Web of Science ®Google Scholar
• Yoon, J. H., Lee, J. S., Yong, S. W., Hong, J. M., & Lee, P. H. (2014). Endothelial dysfunction and hyperhomocysteinemia in Parkinson’s disease: Flow-mediated dilation study. Movement Disorders, 29(12), 1551–1555. doi:10.1002/mds.26005
   PubMed Web of Science ®Google Scholar
• Yoon, J. H., Park, D. K., Yong, S. W., & Hong, J. M. (2015). Vitamin D deficiency and its relationship with endothelial dysfunction in patients with early Parkinson’s disease. Journal of Neural Transmission (Vienna), 122(12), 1685–1691. doi:10.1007/s00702-015-1452-y
   PubMed Web of Science ®Google Scholar
• Young, D. B. (2010). Control of Cardiac Output. San Rafael, CA: Morgan & Claypool Life Sciences.
   Google Scholar
• Ziebell, M., Andersen, B. B., Thomsen, G., Pinborg, L. H., Karlsborg, M., Hasselbalch, S. G., & Knudsen, G. M. (2012). Predictive value of dopamine transporter SPECT imaging with [123I]PE2I in patients with subtle parkinsonian symptoms. European Journal of Nuclear Medicine and Molecular Imaging, 39(2), 242–250. doi:10.1007/s00259-011-1976-9
   PubMed Web of Science ®Google Scholar