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Research Article

Therapeutic Effects Of Combined and Chronic Treatment of Tat-GluA23y and D-Serine on Cognitive Dysfunction in Postmenopausal Rats

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Received 01 Jun 2023, Accepted 30 Aug 2023, Published online: 03 Sep 2023

References

  • Agrawal, R., Nath, R., Shukla, C., & Nath, C. (2011). Insulin receptor signaling in rat hippocampus: A study in STZ (ICV) induced memory deficit model. European Neuropsychopharmacology, 21(3), 261–273. doi:10.1016/j.euroneuro.2010.11.009
  • Babaei, P. (2021). NMDA and AMPA receptors dysregulation in Alzheimer’s disease. European Journal of Pharmacology, 908, 174310. doi:10.1016/j.ejphar.2021.174310
  • Babaei, P., Damirchi, A., Hoseini, Z., & Hoseini, R. (2020, Jun). Co-treatment of vitamin D supplementation and aerobic training improves memory deficit in ovariectomized rat. The International Journal of Neuroscience, 130(6), 595–600. Epub 2020 Jan 27. PMID: 31775548. doi:10.1080/00207454.2019.1699082
  • Babaei, P., Shirkouhi, S. G., Hosseini, R., & Soltani Tehrani, B. (2017 Nov 15). Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats. Diabetology & Metabolic Syndrome, 9, 91. 10.1186/s13098-017-0288-z. PMID: 29177013; PMCID: PMC5688735.
  • Bakr, M. (2020). Role of vSnares in post-synaptic AMPAR trafficking, glutamatergic transmisson and plasticity. Neurons Cogn, 2020BORD0323.
  • Balu, D. T., & Coyle, J. T. (2014). Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction. Neurochemistry International, 75, 76–78. doi:10.1016/j.neuint.2014.05.015
  • Balu, D. T., & Coyle, J. T. (2015). The NMDA receptor ‘glycine modulatory site’ in schizophrenia: D-serine, glycine, and beyond. Current Opinion in Pharmacology, 20, 109–115. doi:10.1016/j.coph.2014.12.004 Epub 2014 Dec 23. PMID: 25540902; PMCID: PMC4805108.
  • Barnes, L. L., Lamar, M., & Schneider, J. A. (2019 Sep 15). Sex differences in mixed neuropathologies in community-dwelling older adults. Brain Research171911–16. 10.1016/j.brainres.2019.05.028. Epub 2019 May 22. PMID: 31128096; PMCID: PMC6636678.
  • Barrientos, R. M., Kitt, M. M., Watkins, L. R., & Maier, S. F. (2015). Neuroinflammation in the normal aging hippocampus. Neuroscience, 309, 84–99. doi:10.1016/j.neuroscience.2015.03.007
  • Barth, C., Villringer, A., & Sacher, J. (2015 Feb 20). Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods. Frontiers in Neuroscience937. 10.3389/fnins.2015.00037. PMID: 25750611; PMCID: PMC4335177.
  • Bassani, S., Folci, A., Zapata, J., & Passafaro, M. (2013). AMPAR trafficking in synapse maturation and plasticity. Cellular and Molecular Life Sciences: CMLS. 70(23):4411–4430. doi:10.1007/s00018-013-1309-1.
  • Bean, L. A., Ianov, L., & Foster, T. C. (2014, Oct). Estrogen receptors, the hippocampus, and memory. The Neuroscientist, 20(5), 534–545. Epub 2014 Feb 7. PMID: 24510074; PMCID: PMC4317255. doi:10.1177/1073858413519865
  • Ben-Yakov, A., Dudai, Y., & Mayford, M. R. 2015 Oct 5. Memory retrieval in mice and men. Cold Spring Harbor Perspectives in Biology712, a021790.doi:10.1101/cshperspecta021790. PMID: 26438596; PMCID: PMC4665077.
  • Bermejo-Pareja, F., Llamas-Velasco, S., & Villarejo-Galende, A. (2016). Prevención de la enfermedad de Alzheimer: un camino a seguir. Revista Clínica Española, 216(9), 495–503. doi:10.1016/j.rce.2016.05.010
  • Budni, J., Feijó, D. P., Batista-Silva, H., Garcez, M. L., Mina, F. … Quevedo, J. (2017). Lithium and memantine improve spatial memory impairment and neuroinflammation induced by β-amyloid 1-42 oligomers in rats. Neurobiology of Learning and Memory, 141, 84–92. doi:10.1016/j.nlm.2017.03.017
  • Canu, E., Sarasso, E., Filippi, M., & Agosta, F. (2018 Feb 20). Effects of pharmacological and nonpharmacological treatments on brain functional magnetic resonance imaging in Alzheimer’s disease and mild cognitive impairment: A critical review. Alzheimer’s Research & Therapy101, 21. 10.1186/s13195-018-0347-1. PMID: 29458420; PMCID: PMC5819240
  • Dalli, T., Terzioglu-Usak, S., Akbas, F., Akbas, F., & Elibol, B. (2018). Thymoquinone activates MAPK pathway in hippocampus of streptozotocin-treated rat model. Biomedicine & Pharmacotherapy, 99, 391–401. doi:10.1016/j.biopha.2018.01.047
  • Dalmau, J., Rosenfeld, E., Martinez-Hernandez, M. R., Balice-Gordon, R., & Balice-Gordon, R. (2011). Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurology, 10(1), 63–74. doi:10.1016/S1474-4422(10)70253-2
  • De Strooper, DS, & Eric, K. (2016). The cellular phase of alzheimer’s disease. Cell, 164(4), 603–615. doi:10.1016/j.cell.2015.12.056
  • Deuker, L., Bellmund, J. L., Navarro Schröder, T., & Doeller, C. F. (2016). An event 560 map of memory space in the hippocampus. Elife.
  • Djiogue, S., Djiyou Djeuda, A. B., Seke Etet, P. F., Ketcha Wanda, G. J. M., Djikem Tadah, R. N., & Njamen, D. 2018 Jul 16. Memory and exploratory behavior impairment in ovariectomized Wistar rats. Behavioral and Brain Functions: BBF141, 14. 10.1186/s12993-018-0146-7. PMID: 30012162; PMCID: PMC6047120
  • Dong, Z., Li, H., Bai, Y., Tu, W., Wang, M., Tu, M., & Song, W. (2015). Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis. Journal of Clinical Investigation, 125(1), 234–247. doi:10.1172/JCI77888
  • Fischer, B., Gleason, C., & Asthana, S. (2014, Apr). Effects of hormone therapy on cognition and mood. Fertility and Sterility, 101(4), 898–904. PMID: 24680649; PMCID: PMC4330961. doi:10.1016/j.fertnstert.2014.02.025
  • Garcez, M. L., Mina, F., Bellettini-Santos, T., da Luz, A. P., Schiavo, G. L., Macieski, J. M. C., & Magnus, N. Q. (2019). The involvement of nlrp3 on the effects of minocycline in an ad-like pathology induced by β-amyloid oligomers administered to mice. Molecular Neurobiology, 56(4), 2606–2617. doi:10.1007/s12035-018-1211-9
  • Girard, R., Météreau, E., Thomas, J., Pugeat, M., Qu, C., & Dreher, J. C. (2017). Hormone therapy at early post-menopause increases cognitive control-related prefrontal activity. Scientific Reports, 7(1), 44917. doi:10.1038/srep44917
  • Gottesman, R. F., Schneider, A. L., Zhou, Y., Coresh, J., Green, E. … Mosley, T. H. (2017 Apr 11). Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition. Journal of the American Medical Association, 31714, 1443–1450. 10.1001/jama.2017.3090. PMID: 28399252; PMCID: PMC5921896.
  • Graham, W. V., & ST, B.-O. A., Sakmar, T P. Update on Alzheimer’s disease therapy and prevention strategies. Annual Review of Medicine. 2017;14(1):413–430. doi:10.1146/annurev-med-042915-103753.
  • Grieb, P. Intracerebroventricular streptozotocin injections as a model of Alzheimer’s disease: In search of a relevant mechanism. Molecular Neurobiology. 2016;53(3):1741–1752. doi:10.1007/s12035-015-9132-3.
  • Guntupalli, S., Widagdo, J., & Anggono, V. (2016). Amyloid-β-induced dysregulation of ampa receptor trafficking. Neural Plasticity, 2016, 3204519. Epub 2016 Mar 17. PMID: 27073700; PMCID: PMC4814684. 10.1155/2016/3204519
  • Hamdan, A. C., & Ramos, A. A. (2016). Avaliação Neuropsicológica na Doença Alzheimer e Demência Frontotemporal: critérios nosológicos. Interação em 605 Psicol, 18(3), 605. doi:10.5380/psi.v18i3.47039
  • Hardingham, G. E., & Bading, H. (2010, Oct). Synaptic versus extrasynaptic NMDA receptor signalling: Implications for neurodegenerative disorders. Nature Reviews Neuroscience, 11(10), 682–696. Epub 2010 Sep 15. PMID: 20842175; PMCID: PMC2948541. doi:10.1038/nrn2911
  • Harrison, T. M., Burggren, A. C., Small, G. W., & Bookheimer, S. Y. (2016). Altered memory-related functional connectivity of the anterior and posterior 611 hippocampus in older adults at increased genetic risk for Alzheimer’s 612 disease. Human Brain Mapping, 37(1), 366–380. doi:10.1002/hbm.23036
  • Hering, B. E., & Nicoll, R. A. (2016). Long-Term potentiation: From CaMKII to AMPA receptor trafficking. Annual Review of Physiology, 78(1), 351–365. doi:10.1146/annurev-physiol-021014-071753
  • Hernando-Requejo, V. (2018). [Neurological pathology associated with vitamin B group deficiency: Thiamine, folate and cobalamin]. Nutricion hospitalaria : organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral, 35(Spec No6), 54–59. doi:10.20960/nh.2289
  • Huang, Y., Shen, W., Su, J., Cheng, B., Li, D., Liu, G., Zhou, W. X., & Zhang, Y. X. (2017). Modulating the balance of synaptic and extrasynaptic nmda receptors shows positive effects against amyloid-β-induced neurotoxicity’. Journal of Alzheimer's Disease, 57(3), 885–897. doi:10.3233/JAD-161186
  • Igaz, L. M., Cammarota, M., Izquierdo, L. A., Alonso, M., Medina, I., Izquierdo, J. H., & Medina, J. H. (2006). Early activation of extracellular signal-regulated kinase signaling pathway in the hippocampus is required for short-term memory formation of a fear-motivated learning. Cellular and Molecular Neurobiology, 26(4), 987–1000. doi:10.1007/s10571-006-9116-y
  • Kamat, P. K., Tota, S., Rai, S., Swarnkar, S., Tyagi, C., Nath, N., & Tyagi, N. (2016). Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer’s disease: Understanding the therapeutics strategies. Molecular Neurobiology, 53(1), 648–661. doi:10.1007/s12035-014-9053-6
  • Kellar, D., & Craft, S. (2020, Sep). Brain insulin resistance in Alzheimer’s disease and related disorders: Mechanisms and therapeutic approaches. Lancet Neurology, 19(9), 758–766. Epub 2020 Jul 27. PMID: 32730766. doi:10.1016/S1474-4422(20)30231-3
  • Kida, S., & Serita, T. (2014). Functional roles of CREB as a positive regulator in the formation and enhancement of memory. brain res bul. Brain Research Bulletin, 105, 17–24. doi:10.1016/j.brainresbull.2014.04.011
  • Kim, S. H., Kandiah, N., Hsu, J. L., Suthisisang, C., Udommongkol, C., & Dash, A. (2017). Beyond symptomatic effects: Potential of donepezil as a 629 neuroprotective agent and disease modifier in Alzheimer’s disease. British 630 Journal of Clinical Pharmacology, 174(23), 4224–4232. doi:10.1111/bph.14030
  • Kouhestani, S., Jafari, A., & Babaei, P. (2018). Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia. Neural Regeneration Research, 13(10), 1827–1832. doi:10.4103/1673-5374.238714
  • Kumar, M., Kaur, D., & Bansal, N. (2017, Jan). Caffeic Acid Phenethyl Ester (CAPE) prevents development of STZ-ICV induced dementia in rats. Pharmacognosy Magazine, 13(Suppl 1), S10–S15. Epub 2017 Apr 7. PMID: 28479719; PMCID: PMC5407100 doi: 10.4103/0973-1296.203974
  • Labrie, V., Wong, A. H., & Roder, J. C. (2012, Mar). Contributions of the D-serine pathway to schizophrenia. Neuropharmacology, 62(3), 1484–1503. Epub 2011 Feb 2. PMID: 21295046 doi: 10.1016/j.neuropharm.2011.01.030
  • Licznerski, P., & Jonas, E. A. (2018). BDNF signaling: Harnessing stress to battle mood disorder. Proceedings of the National Academy of Sciences of the United States of America, 115(15), 3742–3744. doi:10.1073/pnas.1803645115
  • Lin, H., Jocobi, A. A., Anderson, S. A., & Lynch, D. R. (2016). D-Serine and serine racemase are associated with PSD-95 and glutamatergic synapse stability. Frontiers in Cellular Neuroscience, 10(34). doi:10.3389/fncel.2016.00034
  • Lobo, R. A., Davis, S. R., De Villiers, T. J., Gompel, A., Henderson, V. W., Hodis, H. N., & Baber, R. J. (2014). Prevention of diseases after menopause. Climacteric, 17, 240–56.
  • Luscher, C., & Malenka, R. C. (2012). NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). Cold Spring Harbor Perspectives in Biology, 4(6), a005710. doi:10.1101/cshperspect.a005710
  • Ma, T. M., Paul, B. C., Fu, C., Hu, S., Zhu, H., Blackshaw, S., & Wolosker, H. (2014). Serine racemase regulated by binding to stargazin and PSD-95: Potential N-methyl-D-aspartate-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (NMDA-AMPA) glutamate neurotransmission cross-talk. The Journal of Biological Chemistry, 289(43), 29631–29641. doi:10.1074/jbc.M114.571604
  • Matsui, T., Sekiguchi, M., Hashimoto, A., Tomita, U., Nishikawa, T., & Wada, K. (1995). Functional comparison of D-serine and glycine in rodents: The effect on cloned NMDA receptors and the extracellular concentration. Journal of Neurochemistry, 65(1), 454–458. doi:10.1046/j.1471-4159.1995.65010454.x
  • Mishra, S. K., Singh, S., Shukla, S., & Shukla, R. (2018). Intracerebroventricular streptozotocin impairs adult neurogenesis and cognitive functions via regulating neuroinflammation and insulin signaling in adult rats. Neurochemistry International, 113, 56–68. doi:10.1016/j.neuint.2017.11.012
  • Mosconi, L., Rahman, A., Diaz, I., Wu, X., Scheyer, O. … Brinton, R. D. 2018 Dec 12. Increased Alzheimer’s risk during the menopause transition: A 3-year longitudinal brain imaging study. PLoS ONE1312, e0207885. 10.1371/journal.pone.0207885. PMID: 30540774; PMCID: PMC6291073.
  • Mozdzanowski, J., Hembach, P., & Speicher, D. W. (1992). High yield electroblotting onto polyvinylidene difluoride membranes from polyacrylamide gels. Electrophoresis, 13, 59–64.
  • Nebel, R. A., Aggarwal, N. T., Barnes, L. L., Gallagher, A., Goldstein, J. M., Kantarci, K., & Mielke, MM. (2018). Understanding the impact of sex and gender 669 in Alzheimer’s disease: A call to action. Alzheimer’s Dement, 14(9), 1171–1183. doi:10.1016/j.jalz.2018.04.008
  • Nikseresht, Z., Babaei, M., & Badrikoohi, P., Babaei, P. (2021). Synergistic enhancing-memory effect of D-serine and RU360, a mitochondrial calcium uniporter blocker in rat model of Alzheimer’s disease. Behavioural Brain Research, 409, 113307. doi:10.1016/j.bbr.2021.113307
  • Pal, M. M. (2021). Glutamate: The master neurotransmitter and its implications in chronic stress and mood disorders. Frontiers in Human Neuroscience, 15, 722323. doi:10.3389/fnhum.2021.722323
  • Papouin, T., Ladépêche, L., Ruel, J., Sacchi, S., Labasque, M., Hanini, M., & Mothet, J.-P. (2012). Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. Cell, 150, 633–646. doi:10.1016/j.cell.2012.06.029
  • Pourmir, M., Babaei, P., Soltani Tehrani, B. Kisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system. physiol pharmacol [Internet]. 2016;38–47. Available from: http://ppj.phypha.ir/article-1-1157-en.html
  • Priyal, B., Sanjeev, A., Acharya, S., & Acharya, N. (2018). Bergenia ciliata ameliorates streptozotocin-induced spatial memory deficits through dual cholinesterase inhibition and attenuation of oxidative stress in rats. Biomed & Pharmacother, 102, 966–980. doi:10.1016/j.biopha.2018.03.115
  • Rajasekar, N., Nath, C., Hanif, K., & Shukla, R. (2017). Intranasal insulin improves cerebral blood flow, Nrf-2 expression and BDNF in STZ (ICV)-induced memory impaired rats. Life Sciences, 173, 1–10. doi:10.1016/j.lfs.2016.09.020
  • Rush, T., & Buisson, A. (2014, May). Reciprocal disruption of neuronal signaling and Aβ production mediated by extrasynaptic NMDA receptors: A downward spiral. Cell and Tissue Research, 356(2), 279–286. doi:10.1007/s00441-013-1789-1 Epub 2014 Feb 5. PMID: 24496511
  • Sachser, R. M., Lunardi, P. S., Lunardi, P. S., & de Oliveira Alvares, L. (2017). Forgetting of what was once learned: Exploring the role of postsynaptic ionotropic glutamate receptors on memory formation, maintenance, and decay. Neuropharmacology, 112, 94–103. doi:10.1016/j.neuropharm.2016.07.015
  • Saleh, R. A., Eissa, T. F., Abdallah, D. M., Saad, M. A., & El-Abhar, H. S. 2021 Jun 8. Peganum harmala enhanced GLP-1 and restored insulin signaling to alleviate AlCl3-induced Alzheimer-like pathology model. Scientific Reports11112040. 10.1038/s41598-021-90545-4. PMID: 34103557; PMCID: PMC8187628
  • Savolainen-Peltonen, H., Hoti, F., Vattulainen, P., Gissler, M., Mikkola, O., Ylikorkala, T. S., & Mikkola, T. S. (2019). Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: Nationwide case-control study. BMJ, 6(364), 1665. doi:10.1136/bmj.l665
  • Schell, M. J., Brady, R. O., Molliver, M. E., & Snyder, S. H. (1997). D-Serine as a neuromodulator: Regional and developmental localizations in rat brain glia resemble NMDA receptors. Journal of Neuroscience, 17(5), 1604–1615. doi:10.1523/JNEUROSCI.17-05-01604.1997
  • Sharma, Y., & Garabadu, D. (2020). Ruthenium red, mitochondrial calcium uniporter inhibitor, attenuates cognitive deficits in STZ-ICV challenged experimental animals. brain res bull. 164, 121–135. doi:10.1016/j.brainresbull.2020.08.020
  • Shen, J., Shen, L., & Ji, H. F. (2015). Vitamin D deficiency is associated with increased risk of Alzheimer’s disease and dementia: Evidence from meta-analysis. Nutrition, 707(1). doi:10.1186/s12937-015-0063-7
  • Shleper, M., Kartvelishvily, E., & Wolosker, H. (2005). D-Serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices. Journal of Neuroscience, 25(41), 9413–9417. doi:10.1523/JNEUROSCI.3190-05.2005
  • Shumaker, S. (2004). Conjugated Equine Estrogens and Incidence of Probable Dementia and Mild Cognitive Impairment in Postmenopausal Women: Women’s Health Initiative Memory Study. Journal of the American Medical Association, 291(24), 2947–2958. doi:10.1001/jama.291.24.2947
  • Shumakher, S., Legault, C., Rapp, S. R., Thal, L., Wallace, R. B., Ockene, J. K., & Wactawski-Wende, J. (2003). Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: The women’s health initiative memory study: A randomized controlled trial. JAMA, 289(20), 2651–2662. doi:10.1001/jama.289.20.2651
  • Siebert, C., Pierozan, P., Kolling, J., dos Santos, T. M., Sebotaio, M. C., Marques, E. P., & Netto, C. A. (2017). Vitamin D3 reverses the hippocampal 710 cytoskeleton imbalance but not memory deficits caused by ovariectomy 711 inadult wistar rats. Neuromolecular Medicine, 19(2–3), 345–356. doi:10.1007/s12017-017-8449-7
  • Sutton, M. A., Masters, S. E., & Carew, T. J. (2002). Interaction between amount and pattern of training in the induction of intermediate- and long-term memory for sensitization in aplysia. Learning & Memory (Cold Spring Harbor, N.Y.), 9(1), 29–40. doi:10.1101/lm.44802
  • Takahashi, T. A., & Johnson, K. M. (2015). Medical clinics of North America. Menopause, 99(3), 521–34.
  • Tomé, D. F., Sadeh, S., & Clopath, C. (2022). Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation. nat com. InternetAvailable from. 13(1),840. doi:10.1038/s41467-022-28339-z
  • Yuan, G., Lidong, L., Tak Pan, W., & Bo, G. (2019). p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression. Nature, 10, 408.
  • Zhang, Q. G., Hu, S. Q., Li, C., Yu, C. Z., Wang, R., Wang, R., & Zhang, G.-Y. (2010). Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn‐ERK1/2‐CREB signaling in rat brain ischemia. Hippocampus, 20(10), NA–NA. doi:10.1002/hipo.20593
  • Zhao, L., Woody, S. K., & Chhibber, A. (2015). Estrogen receptor β in Alzheimer’s disease: From mechanisms to therapeutics. Ageing Research Reviews, 24(Pt B), 178–90. doi:10.1016/j.arr.2015.08.001
  • Zhao, X., Zeng, Z., Liu, L., & Wang, H. (2020). Glutamate attenuates the survival property of IGFR through NR2B containing N-Methyl-D-aspartate receptors in cortical neurons, 5173184. Available from. doi:10.1155/2020/5173184

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