189
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Meta-analysis: association of homocysteine with recurrent spontaneous abortion

, MS, , MS, , MD, MPH, , MD, , MS & , MD, PhD
Pages 713-720 | Received 03 Nov 2020, Accepted 15 Jul 2021, Published online: 01 Aug 2021

References

  • Boas, W. V., R. O. Gonçalves, O. L. Costa, and M. S. Goncalves. 2015. Metabolism and gene polymorphisms of the folate pathway in Brazilian women with history of recurrent abortion. Rev Bras Ginecol Obstet.37 37 (2):71–76. doi:10.1590/SO100-720320140005223.
  • Bricker, L. 2002. Types of pregnancy loss in recurrent miscarriage: Implications for research and clinical practice. Human Reproduction 17 (5):1345–50. doi:10.1093/humrep/17.5.1345.
  • Chakraborty, P., S. K. Goswami, S. Rajani, S. Sharma, S. N. Kabir, B. Chakravarty, K. Jana, and S. Franks. 2013. Recurrent pregnancy loss in polycystic ovary syndrome: Role of hyperhomocysteinemia and insulin resistance. PLoS One 8 (5):e64446. doi:10.1371/journal.pone.0064446.
  • Creus, M., R. Deulofeu, J. Penarrubia, F. Carmona, and J. Balasch. 2013. Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: A case-control study in Spain. Clinical Chemistry and Laboratory Medicine 51 (3):693–99. doi:10.1515/cclm-2012-0452.
  • D’Uva, M., P. Di Micco, I. Strina, C. Alviggi, M. Iannuzzo, A. Ranieri, A. Mollo, and G. De Placido. 2007. Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: A preliminary report. Thrombosis Journal 5 (1):10. doi:10.1186/1477-9560-5-10.
  • Del Bianco, A., G. Maruotti, A. M. Fulgieri, T. Celeste, L. Lombardi, N. A. Amato, and F. Pietropaolo. 2004. Recurrent spontaneous miscarriages and hyperhomocysteinemia. Minerva ginecologica 56 (5):379–83.
  • Duval, S., and R. Tweedie. 2000. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56 (2):455–63. doi:10.1111/j.0006-341X.2000.00455.x.
  • Li, T. C. 2002. Recurrent miscarriage: Aetiology, management and prognosis. Human Reproduction Update 8 (5):463–81. doi:10.1093/humupd/8.5.463.
  • Li, X. M., Y. Z. Zhang, Y. X. Xu, and S. Jiang. 2004. Study on the relationship of MTHFR polymorphisms with unexplained recurrent spontaneous abortion. Chinese Journal of Medical Genetics 21 (1):39–42.
  • Luyin, S., Q. Qianhui, Y. Daxian, Z. Hongying, C. Shengqiang, L. Jinyu. 2005. Relationship between genetic polymorphism of homocysteine metabolism enzyme and unexplained repeated spontaneous abortion. Chinese Journal of Perinatal Medicine 8:3
  • Makino, A., T. Nakanishi, M. Sugiura-Ogasawara, Y. Ozaki, N. Suzumori, and K. Suzumori. 2004. No association of C677T methylenetetrahydrofolate reductase and an endothelial nitric oxide synthase polymorphism with recurrent pregnancy loss. American Journal of Reproductive Immunology 52 (1):60–66. doi:10.1111/j.1600-0897.2004.00187.x.
  • Medicine, P. C. O. T. A. S. F. R. 2012. Evaluation and treatment of recurrent pregnancy loss: A committee opinion. Fertility and Sterility . 98: 1103–1111
  • Nelen, W. L., H. J. Blom, E. A. Steegers, M. den Heijer, C. M. Thomas, and T. K. Eskes. 2000b. Homocysteine and folate levels as risk factors for recurrent early pregnancy loss. Obstetrics and Gynecology 95 (4):519–24.
  • Nelen, W. L. D. M., H. J. Blom, E. A. P. Steegers, M. den Heijer, and T. K. A. B. Eskes. 2000a. Hyperhomocysteinemia and recurrent early pregnancy loss: A meta-analysis. Fertility and Sterility 74 (6):1196–99. doi:10.1016/S0015-0282(00)01595-8.
  • Obstetrics Subgroup, C. S. O. O., and C. M. A. Gynecology. 2016. Chinese expert consensus on the diagnosis and tretment of recurrent spontaneous abortion. Chinese Journal of Practical Gynecology and Obstetrics 36 (11):1082–90.
  • Park, C. W., H. J. Lee, J. Kwak-Kim, S. Y. Park, J. Y. Han, M. K. Koong, I. O. Song, and K. M. Yang. 2009. The role of methylenetetrahydrofolate reductase (MTHFR) C677T mutations in women with unexplained recurrent miscarriages; does it have any effect on modulating immune response? American Journal of Reproductive Immunology 61 (6):407.
  • Ping, P. 2020. Endocrine factors and recurrent miscarriage. Chinese Medical Journal 55 (3):244–48.
  • Rpl, T. E. G. G. O., B. A. Ruth, C. O. Bjarne, E. Janine, K. A. Marie, L. Sheena, M. Saskia, N. Willianne, P. Braulio, and Q. Siobhan. 2018. ESHRE guideline: Recurrent pregnancy loss. Human Reproduction Open(2) 2. hoy004
  • Songdi, Y. 2010. Homocysteine and recurrent spontaneous abortion. Chinese Medical Innovation 07 (22):6–7.
  • Steegers-Theunissen, R. P., G. J. Boers, H. J. Blom, F. M. Trijbels, and T. A. B. Eskes. 1992. Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. The Lancet 339 (8801):1122–23. doi:10.1016/0140-6736(92)90725-I.
  • Wouters, M. G. A. J., G. H. J. Boers, H. J. Blom, F. J. M. Trijbels, C. M. G. Thomas, G. F. Borm, R. P. M. Steegers-Theunissen, T. K. A. B. Eskes et al.. 1993. Hyperhomocysteinemia: A risk factor in women with unexplained recurrent early pregnancy loss *†*Supported by grant number 28.1006.1 from Praeventiefonds, The Hague, The Netherlands.†Presented at the 40th Annual Meeting of Society for Gynecologic Investigation, Toronto, Canada, March 31 to April 3, 1993. Fertility and Sterility. 60(5):820–25. doi:10.1016/S0015-0282(16)56282-7.
  • Zammiti, W., N. Mtiraoui, and T. Mahjoub. 2008. Lack of consistent association between endothelial nitric oxide synthase gene polymorphisms Homocysteine Levels and Recurrent Pregnancy Loss in Tunisian Women. America Journal Reproductive Immunology 59 (2):139–45.
  • Zarfeshan Fard, Y., O. Kooshkaki, D. Kordi Tammandani, and G. Anani Sarab. 2019. Investigation of the association between C677T polymorphism of the MTHFR gene and plasma homocysteine level in recurrent fetal miscarriage. The Journal of Obstetrics and Gynaecology Research 45 (8):8. doi:10.1111/jog.13989.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.