Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 43, 2019 - Issue 2
214
Views
14
CrossRef citations to date
0
Altmetric
Original Articles

The Sub-Phenotypes of Sickle Cell Disease in Kuwait

, , , &
Pages 83-87 | Received 10 Jan 2019, Accepted 01 Apr 2019, Published online: 30 May 2019

References

  • Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. Blood Rev. 2007;21(1):37–47.
  • Rother RP, Bell L, Hillmen P, et al. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA 2005;293(13):1653–1662.
  • Kato GJ, McGowan V, Machado RF. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood 2006;107(6):2279–2285.
  • Wagener FA, Abraham NG, van Kooyk Y, et al. Heme-induced cell adhesion in the pathogenesis of sickle-cell disease and inflammation. Trends Pharmacol Sci. 2001;22(2):52–54.
  • Steinberg MH. Genetic etiologies for phenotypic diversity in sickle cell anemia. ScientificWorldJournal 2009;9:46–67.
  • Powars DR. Sickle cell anemia and major organ failure. Hemoglobin 1990;14(6):573–598.
  • Adekile AD, Haider MZ. Morbidity, βS haplotype and α-globin gene patterns among sickle cell anemia patients in Kuwait. Acta Haematol. 1996;96(3):150–154.
  • Galarneau G, Palmer CD, Sankaran VG, et al. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. Nat Genet. 2010;42(12):1049–1051.
  • Menzel S, Garner C, Gut I, et al. A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat Genet. 2007;39(10):1197–1199.
  • Thein SL, Menzel S, Lathrop M, et al. Control of fetal hemoglobin: new insights emerging from genomics and clinical implications. Hum Mol Genet. 2009;18(R2):R216–R223.
  • Embury SH. α Thalassemia. A modifier of sickle cell disease. Ann NY Acad Sci 1989;565:213–221.
  • Milner PF, Kraus AP, Sebes JI, et al. Sickle cell disease as a cause of osteonecrosis of the femoral head. N Engl J Med. 1991;325(21):1476–1481.
  • Adekile AD, Tuli M, Haider MZ, et al. Influence of α-thalassemia trait on spleen function in sickle cell anemia patients with high Hb F. Am J Hematol. 1996;53(1):1–5.
  • Adekile AD, Gu LH, Baysal E, et al. Molecular characterization of α-thalassemia determinants, β-thalassemia alleles, and βS haplotypes among Kuwaiti Arabs. Acta Haematol. 1994;92(4):176–181.
  • Kuwait Population [http://worldpopulationreview.com/countries/kuwait/].
  • White JM, Byrne M, Richards R, et al. Red cell genetic abnormalities in Peninsular Arabs: sickle haemoglobin, G6PD deficiency, and α and β thalassaemia. J Med Genet. 1986;23(3):245–251.
  • Baysal E, Huisman THJ. Detection of common deletional α-thalassemia-2 determinants by PCR. Am J Hematol. 1994;46(3):208–213.
  • Thein S, Wallace R, Pressley L, et al. The polyadenylation site mutation in the α-globin gene cluster. Blood 1988;71(2):313–319.
  • Bookchin RM, Nagel RL, Balazs T. Role of hybrid tetramer formation in gelation of Haemoglobin S. Nature. 1975;256(5519):667–668.
  • Old J. Hemoglobinopathies In: Elles R, Editor. Methods in Molecular Medicine: Molecular Diagnosis of Genetic Disease. Totowa (NJ, USA): Humana Press Inc. 1996:169–183.
  • Adekile AD, Akbulut N, Azab AF, et al. The sickle β-Thalassemia Phenotype. J Pediatr Hematol Oncol. 2017;39(5):327–331.
  • Adekile A, Menzel S, Gupta R, et al. Response to hydroxyurea among Kuwaiti patients with sickle cell disease and elevated baseline Hb F levels. Am J Hematol. 2015;90(7):E138–E139.
  • Adekile AD. Sickle cell disease in Kuwait. Hemoglobin. 2001;25(2):219–225.
  • Adekile A, Al-Kandari M, Haider M, et al. Hemoglobin F concentration as a function of age in Kuwaiti sickle cell disease patients. Med Princ Pract. 2007;16(4):286–290.
  • Andemariam B, Owarish-Gross J, Grady J, et al. Identification of risk factors for an unsuccessful transition from pediatric to adult sickle cell disease care. Pediatr Blood Cancer. 2014;61(4):697–701.
  • McLaughlin JF, Ballas SK. High mortality among children with sickle cell anemia and overt stroke who discontinue blood transfusion after transition to an adult program. Transfusion. 2016;56(5):1014–1021.
  • Quinn CT, Rogers ZR, McCavit TL, et al. Improved survival of children and adolescents with sickle cell disease. Blood. 2010;115(17):3447–3452.
  • Powars DR. Natural history of sickle cell disease-the first ten years. Semin Hematol. 1975;12(3):267–285.
  • Adegoke SA, Adeodu OO, Adekile AD. Sickle cell disease clinical phenotypes in children from South-Western, Nigeria. Niger J Clin Pract. 2015;18(1):95–101.
  • Adekile AD, Owunwanne A, Al-Za’abi K, et al. Temporal sequence of splenic dysfunction in sickle cell disease. Am J Hematol. 2002;69(1):23–27.
  • Adekile AD, Gupta R, Yacoub F, et al. Avascular necrosis of the hip in children with sickle cell disease and high Hb F: magnetic resonance imaging findings and influence of α-thalassemia trait. Acta Haematol. 2001;105(1):27–31.
  • Marouf R, Gupta R, Haider MZ, et al. Avascular necrosis of the femoral head in adult Kuwaiti sickle cell disease patients. Acta Haematol. 2003;110(1):11–15.
  • Gill F, Sleeper L, Weiner S, et al. Clinical events in the first decade in a cohort of infants with sickle cell disease. Cooperative Study of Sickle Cell Disease. Blood. 1995;86(2):776–783.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.