Anemia Severity in β-Thalassemia Correlates with Elevated Levels of microRNA-125b in Activated Phagocytic Monocytes

References

• Advani R, Sorenson S, Shinar E, et al. Characterization and comparison of the red blood cell membrane damage in severe human α- and β-thalassemia. Blood. 1992;79(4):1058–1063.
   PubMed Web of Science ®Google Scholar
• Taher AT, Weatherall DJ, Cappellini MD. Thalassaemia. Lancet. 2018;391(10116):155–167.
   PubMed Web of Science ®Google Scholar
• Higgs DR, Engel JD, Stamatoyannopoulos G. Thalassaemia. Lancet. 2012;379(9813):373–383.
   PubMed Web of Science ®Google Scholar
• Srinoun K, Svasti S, Chumworathayee W, et al. Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice. Haematologica. 2009;94(9):1211–1219.
   PubMed Web of Science ®Google Scholar
• Rund D, Rachmilewitz E. β-Thalassemia. N Engl J Med. 2005;353(11):1135–1146.
   PubMed Web of Science ®Google Scholar
• Wanachiwanawin W, Siripanyaphinyo U, Fucharoen S, et al. Activation of monocytes for the immune clearance of red cells in β0-thalassaemia/Hb E. Br J Haematol. 1993;85(4):773–777.
   PubMed Web of Science ®Google Scholar
• Wiener E, Allen D, Porter RJ, et al. Role of FcgammaRI (CD64) in erythrocyte elimination and its up-regulation in thalassaemia. Br J Haematol. 1999;106(4):923–930.
   PubMed Web of Science ®Google Scholar
• Chinprasertsuk S, Wanachiwanawin W, Pattanapanyasat K, et al. Relation of haemolytic anaemia and erythrocyte-bound IgG in α- and β-thalassaemic syndromes. Eur J Haematol. 1997;58(2):86–91.
   PubMed Web of Science ®Google Scholar
• Wiener E, Wanachiwanawin W, Chinprasertsuk S, et al. Increased serum levels of macrophage colony-stimulating factor (M-CSF) in α- and β-thalassaemia syndromes: correlation with anaemia and monocyte activation. Eur J Haematol. 1996;57(5):364–369.
   PubMed Web of Science ®Google Scholar
• ] Banyatsuppasin W, Butthep P, Atichartakarn V, et al. Activation of mononuclear phagocytes and its relationship to asplenia and phosphatidylserine exposing red blood cells in Hemoglobin E/β-thalassemia patients. Am J Hematol. 2011;86(1):89–92.
   PubMed Web of Science ®Google Scholar
• Srinoun K, Nopparatana C, Wongchanchailert M, et al. MiR-155 enhances phagocytic activity of β-thalassemia/Hb E monocytes via targeting of BACH1. Int J Hematol. 2017;106(5):638–647.
   PubMed Web of Science ®Google Scholar
• O’Connell RM, Rao DS, Baltimore D. MicroRNA regulation of inflammatory responses. Annu Rev Immunol. 2012;30:295–312.
   PubMed Web of Science ®Google Scholar
• O’Connell RM, Zhao JL, Rao DS. MicroRNA function in myeloid biology. Blood. 2011;118(11):2960–2969.
   PubMed Web of Science ®Google Scholar
• Chaudhuri AA, So AY, Sinha N, et al. MicroRNA-125b potentiates macrophage activation. J Immunol. 2011;187(10):5062–5068.
   PubMed Web of Science ®Google Scholar
• Oldenborg PA, Zheleznyak A, Fang YF, et al. Role of CD47 as a marker of self on red blood cells. Science. 2000;288(5473):2051–2054.
   PubMed Web of Science ®Google Scholar
• Ishikawa-Sekigami T, Kaneko Y, Okazawa H, et al. SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages. Blood. 2006;107(1):341–348.
   PubMed Web of Science ®Google Scholar
• So AY, Sookram R, Chaudhuri AA, et al. Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias. Blood. 2014;124(9):1502–1512.
   PubMed Web of Science ®Google Scholar
• Chapiro E, Russell LJ, Struski S, et al. A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia. Leukemia. 2010;24(7):1362–1364.
   PubMed Web of Science ®Google Scholar
• Rajasekhar M, Schmitz U, Flamant S, et al. Identifying microRNA determinants of human myelopoiesis. Sci Rep. 2018;8(1):7264–7278.
   PubMed Web of Science ®Google Scholar
• Zhang B, Wang LS, Zhou YH. Elevated microRNA-125b promotes inflammation in rheumatoid arthritis by activation of NF-κB pathway. Biomed Pharmacother. 2017;93:1151–1157.
   PubMed Web of Science ®Google Scholar
• Bala S, Marcos M, Kodys K, et al. Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem. 2011;286(2):1436–1444.
   PubMed Web of Science ®Google Scholar
• Kim JK, Jang SW, Suk K, et al. Fascin regulates TLR4/PKC-mediated translational activation through miR-155 and miR-125b, which targets the 3′ untranslated region of TNF-α RNA. Immunol Invest. 2015;44(3):309–320.
   PubMed Web of Science ®Google Scholar
• Tili E, Michaille JJ, Cimino A, et al. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-α stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol. 2007;179(8):5082–5089.
   PubMed Web of Science ®Google Scholar
• Chaichompoo P, Qillah A, Sirankapracha P, et al. Abnormal red blood cell morphological changes in thalassaemia associated with iron overload and oxidative stress. J Clin Pathol. 2019;72:520–524.
   PubMed Web of Science ®Google Scholar
• Lang KS, Lang PA, Bauer C, et al. Mechanisms of suicidal erythrocyte death. Cell Physiol Biochem. 2005;15(5):195–202.
   PubMedGoogle Scholar
• Lang E, Lang F. Mechanisms and pathophysiological significance of eryptosis, the suicidal erythrocyte death. Semin Cell Dev Biol. 2015;39:35–42.
   PubMed Web of Science ®Google Scholar
• Ibrahim HA, Fouda MI, Yahya RS, et al. Erythrocyte phosphatidylserine exposure in β-thalassemia. Lab Hematol. 2014;20(2):9–14.
   PubMedGoogle Scholar
• Zahedpanah M, Azarkeivan A, Aghaieepour M, et al. Erythrocytic phosphatidylserine exposure and hemostatic alterations in β-thalassemia intermediate patients. Hematology. 2014;19(8):472–476.
   PubMed Web of Science ®Google Scholar
• Basu S, Banerjee D, Chandra S, et al. Loss of phospholipid membrane asymmetry and sialylated glycoconjugates from erythrocyte surface in Haemoglobin E β-thalassaemia. Br J Haematol. 2008;141(1):92–99.
   PubMed Web of Science ®Google Scholar
• Fernandez-Boyanapalli RF, Frasch SC, McPhillips K, et al. Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood. 2009;113(9):2047–2055.
   PubMed Web of Science ®Google Scholar