References
- Piel FB, Hay SI, Gupta S, et al. Global burden of sickle cell anaemia in children under five, 2010 2050: modeling based on demographics, excess mortality, and interventions. PLoS Med. 2013;10(7):e1001484.
- Steinberg MH, Sebastiani P. Genetic modifiers of sickle cell disease. Am J Hematol. 2012;87(8):795–803.
- Akinsheye I, Alsultan A, Solovieff N, et al. Fetal hemoglobin in sickle cell anemia. Blood. 2011;118(1):19–27.
- Galarneau G, Palmer CD, Sankaran VG, et al. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. Nat Genet. 2010;42(12):1049–1051.
- Dover GJ, Boyer SH, Charache S, Heintzelman K. Individual variation in the production and survival of F cells in sickle-cell disease. N Engl J Med. 1978;299(26):1428–1435..
- Ngo D, Bae H, Steinberg MH, et al. Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype. Blood Cells Mol Dis. 2013;51(1):22–26.
- Perrine RP, Brown MJ, Clegg JB, et al. Benign sickle-cell anaemia. Lancet. 1972;300(7788):1163–1167.
- Nagel RL, Fabry ME, Pagnier J, et al. Hematologically and genetically distinct forms of sickle cell anemia in Africa. The Senegal type and the Benin type. N Engl J Med. 1985;312(14):880–884.
- Alsultan A, Alabdulaali MK, Griffin PJ, et al. Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab-Indian haplotype is not benign. Br J Haematol. 2014;164(4):597–604.
- Sutton M, Bouhassira EE, Nagel RL. Polymerase chain reaction amplification applied to the determination of β-like globin gene cluster haplotypes. Am J Hematol. 1989;32(1):66–69.
- Joly P, Lacan P, Garcia C, et al. Rapid and reliable β-globin gene cluster haplotyping of sickle cell disease patients by FRET light cycler and HRM assays. Clin Chim Acta. 2011;412(13–14):1257–1261.
- Shaikho EM, Farrell JJ, Alsultan A, et al. A phased SNP-based classification of sickle cell anemia HBB haplotypes. BMC Genomics. 2017;18(1):608–614.
- Falchi A, Giovannoni L, Vacca L, et al. β-Globin gene cluster haplotypes associated with β-thalassemia on Corsica Island. Am J Hematol. 2005;78(1):27–32.
- Shriner D, Rotimi CN. Whole-genome-sequence-based haplotypes reveal single origin of the sickle allele during the holocene wet phase. Am J Hum Genet. 2018;102(4):547–556.
- Laval G, Peyrégne S, Zidane N, et al. Recent adaptive acquisition by African rain forest hunter-gatherers of the late Pleistocene sickle-cell mutation suggests past differences in malaria exposure. Am J Hum Genet. 2019;104(3):553–561.
- Vathipadiekal V, Alsultan A, Baltrusaitis K, et al. Homozygosity for a haplotype in the HBG2-OR51B4 region is exclusive to Arab-Indian haplotype sickle cell anemia. Am J Hematol. 2016;91(6):E308–E311.
- Vathipadiekal V, Farrell JJ, Wang S, et al. A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia. Am J Hematol. 2016;91(11):1118–1122.
- Alsultan A, Solovieff N, Aleem A, et al. Fetal hemoglobin in sickle cell anemia: Saudi patients from the Southwestern province have similar HBB haplotypes but higher Hb F levels than African Americans. Am J Hematol. 2011;86(7):612–614.
- Shaikho EM, Farrell JJ, Alsultan A, et al. Genetic determinants of Hb F in Saudi Arabian and African Benin haplotype sickle cell anemia. Am J Hematol. 2017;92(9):E555–E557.
- El-Hazmi MA, Warsy AS, Al-Swailem AR, et al. Genetic compounds – Hb S, thalassaemias and enzymopathies: spectrum of interactions. J Trop Pediatr. 1994;40(3):149–156.
- Adekile AD, Al-Sherida S, Marouf R, et al. The sub-phenotypes of sickle cell disease in Kuwait. Hemoglobin. 2019;43(2):83–87.
- Kazazian HH Jr, Antonarakis SE, Cheng T, et al. Use of haplotype analysis in the β-globin gene cluster to discover β-thalassemia mutations . Prog Clin Biol Res. 1983;134:91–98.
- Oberoi S, Das R, Panigrahi I, et al. Xmn1 Gγ polymorphism and clinical predictors of severity of disease in β-thalassemia intermedia. Pediatr Blood Cancer. 2011;57(6):1025–1028.
- Miri-Moghaddam E, Bahrami S, Naderi M, et al. Xmn1-158 γGvariant in B-thalassemia intermediate patients in South-East of Iran. Int J Hematol Oncol Stem Cell Res. 2017;11(2):165–171.
- Agouti I, Badens C, Abouyoub A, et al. Genotypic correlation between six common β-thalassemia mutations and the XmnI polymorphism in the Moroccan population. Hemoglobin. 2007;31(2):141–149.
- Alsultan A, Ngo D, Bae H, et al. Genetic studies of fetal hemoglobin in the Arab-Indian haplotype sickle cell-β0 thalassemia. Am J Hematol. 2013;88(6):531–532.
- Steinberg MH, Chui DH, Dover GJ, et al. Fetal hemoglobin in sickle cell anemia: a glass half full? Blood. 2014;123(4):481–485.
- Steinberg MH, Lu ZH, Nagel RL, et al. Hematological effects of atypical and Cameroon β-globin gene haplotypes in adult sickle cell anemia. Am J Hematol. 1998;59(2):121–126.
- Okumura JV, Silva DGH, Torres LS, et al. Atypical β-S haplotypes: classification and genetic modulation in patients with sickle cell anemia. J Hum Genet. 2019;64(3):239–248.