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Research Article

Chiral Separation of Alkylamine Antihistamines in Pharmaceuticals by Capillary Isotachophoresis with Charged Cyclodextrin

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Pages 1199-1204 | Published online: 25 Sep 2008

REFERENCES

  • Chankvetadze B., Burjanadze N., Pintore G., Bergenthal D., Bergander K., Mühlenbrock C., Breitkreuz J., Blaschke G. Separation of brompheniramine enantiomers by capillary electrophoresis and study of chiral recognition mechanisms of cyclodextrins using NMR-spectroscopy, UV spectrometry, electrospray ionization mass spectrometry and X-ray crystallography. J. Chromatogr. A 2000b; 875: 471–484
  • Chankvetadze B., Endresz G., Blaschke G. About some aspects of the use of charged cyclodextrins for capillary electrophoresis enantioseparation. Electrophoresis 1994; 15: 804–807
  • Chankvetadze B., Pintore G., Burjanadze N., Bergenthal D., Bergander K., Breitkreuz J., Mühlenbrock C., Blaschke G. Mechanistic study of opposite migration order of dimethindene enantiomers in capillary electrophoresis in the presence of native β-cyclodextrin and heptakis (2,3,6-tri-O-methyl)-β-cyclodextrin. J. Chromatogr. A 2000a; 875: 455–469
  • Chankvetadze B., Schulte G., Bergenthal D., Blaschke G. Comparative capillary electrophoresis and NMR studies of enantioseparation of dimethindene with cyclodextrins. J. Chromatogr. A 1998; 798: 315–323
  • Danková M., Kaniansky D., Fanali S., Ivanyi F. Capillary zone electrophoresis separations of enantiomers present in complex ionic matrices with on-line isotachophoretic sample pretreatment. J. Chromatogr. A 1999; 838: 31–43
  • Fanali S. Controlling enantioselectivity in chiral capillary electrophoresis with inclusion–complexation. J. Chromatogr. A 1997; 792: 227–267
  • Fanali S. Enantioselective determination by capillary electrophoresis with cyclodextrins as chiral selectors. J. Chromatogr. A 2000; 875: 89–122
  • Hermansson J., Grahn A. Optimization of the separation of enantiomers of basic drugs retention mechanisms and dynamic modification of the chiral bonding properties on a α1-acid glycoprotein column. J. Chromatogr. A 1995; 694: 57–69
  • Heuermann M., Blaschke G. Application of cyclodextrin buffers in capillary electrophoresis to enantioselective determination of the H1-antihistamine dimethindene in human urine. Pharmazie 1993; 48: 74–75
  • Heuermann M., Blaschke G. Simultaneous enantioselective determination and quantification of dimethindene and its metabolite N-demethyl-dimethindene in human urine using cyclodextrins as chiral additives in capillary electrophoresis. J. Pharmaceut. Biomed. Anal. 1994; 12: 753–760
  • Jin L. J., Li S. F. Y. Comparison of chiral recognition capabilities of cyclodextrins for the separation of basic drugs in capillary zone electrophoresis. J. Chromatogr. B 1998; 708: 257–266
  • Jin Y. K., Stalcup A. M. Application of heparin to chiral separations of antihistamines by capillary electrophoresis. Electrophoresis 1998; 19: 2119–2123
  • Kemp G. Capillary electrophoresis: A versatile family of analytical techniques. Biotechnol. Appl. Biochem. 1998; 27: 9–17
  • Lai X. H., Ng S. C. Preparation and chiral recognition of a novel chiral stationary phase for high-performance liquid chromatography, based on mono (6A-N-allylamino-6A-deoxy)-perfunctionalized β-cyclodextrin and covalently bonded silica gel. J. Chromatogr. A 2004; 1031: 135–142
  • Matsunaga H., Tanimoto T., Haginaka J. Separation of basic drug enantiomers by capillary electrophoresis using methylated glucuronyl glucosyl beta-cyclodextrin as a chiral selector. J. Sep. Sci. 2002; 25: 1175–1182
  • Mikuš P., Kaniansky D., Šebesta R., Sališová M. Cyclodextrins and their complexes—Structure and interactions. Chem. Listy 2002; 96: 693–697
  • Rudolf J., Blaschke G. Stereoselectivity of the Phase-II-metabolism of the H-1 antihistaminic drug dimethindene investigated by capillary electrophoresis. Enantiomer 1999; 4: 317–323
  • Schneiderman E., Stalcup A. M. Cyclodextrins: A versatile tool in separation science. J. Chromatogr. B 2000; 745: 83–102
  • Schuster A., Gotte C., Bernhardt G., Buschauer A. Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods. Chirality 2001; 13: 285–293
  • Stephani R., Cesare V. Enantiomeric enrichment of non-racemic antihistamines by achiral high-performance liquid chromatography. J. Chromatogr. A 1998; 813: 79–84
  • Terabe S. Electrokinetic chromatography—An interface between electrophoresis and chromatography. Trends Anal. Chem. 1989; 8: 129–134
  • Van Eeckhaut A., Detaevernier M. R., Crommen J., Michotte Y. Differential effects of organic modifiers in the enantioseparation of dimetindene maleate with carboxymethly-beta-cyclodextrin in capillary electrophoresis. J. Sep. Sci. 2004a; 27: 21–27
  • Van Eeckhaut A., Detaevernier M. R., Crommen J., Michotte Y. Influence of methanol on the enantioresolution of antihistamines with carboxymethyl-beta-cyclodextrin in capillary electrophoresis. Electrophoresis 2004b; 25: 2838–2847
  • Van Eeckhaut A., Detaevernier M. R., Michotte Y. Development of a validated capillary electrophoresis method for enantiomeric purity testing of dexchlorpheniramine maleate. J. Chromatogr. A 2002; 958: 291–297
  • Wu H. L., Huang C. H., Chen S. H., Wu S. M. Chiral quantitation of pheniramine, chlorpheniramine, and brompheniramine maleates by capillary zone electrophoresis. J. Chromatogr. Sci. 1999; 37: 24–30

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