107
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Evaluation of the mechanical properties of extrusion-spheronized beads and multiparticulate systems

, &
Pages 683-693 | Received 27 Jun 2008, Accepted 02 Oct 2008, Published online: 19 May 2009

References

  • Dashevsky A, Kolter K, Bodmeier R. (2004). Compression of pellets coated with various aqueous polymer dispersions. Int J Pharm, 279:19–26.
  • Debunne A, Vervaet C, Mangelings D, Remon JP. (2004). Compaction of enteric-coated pellets: Influence of formulation and process parameters on tablet properties and in vivo evaluation. Eur J Pharm Sci, 22:305–14.
  • El-Mahdi IM, Deasy PB. (2000). Tabletting of coated ketoprofen pellets. J Microencapsul, 17:133–44.
  • Haslam JL, Forbes AE, Rork GS, Pipkin TL, Slade DA, Khossravi D. (1998). Tableting of controlled release multiparticulates, the effect of millisphere size and protective overcoating. Int J Pharm, 173:233–42.
  • Lundqvist AEK, Podczeck F, Newton JM. (1998). Compaction of, and drug release from, coated drug pellets mixed with other pellets. Eur J Pharm Biopharm, 46:369–79.
  • Torrado JJ, Augsburger LL. (1994). Effect of different excipients on the tableting of coated particles. Int J Pharm, 106:149–55.
  • Vergote GJ, Kiekens F, Vervaet C, Remon JP. (2002). Wax beads as cushioning agents during the compression of coated diltiazem pellets. Eur J Pharm Sci, 17:145–51.
  • Celik M, Maganti L. (1994). Formulation and compaction of microspheres. Drug Dev Ind Pharm, 20(20):3151–73.
  • Bodmeier R. (1997). Tableting of coated pellets. Eur J Pharm Biopharm, 43:1–8.
  • Clarke GM, Newton JM, Short MD. (1995). Comparative gastrointestinal transit of pellet systems of varying density. Int J Pharm, 114:1–11.
  • Aulton ME, Dyer AM, Khan KA. (1994). The strength and compaction of millispheres. Drug Dev Ind Pharm, 20(20):3069–104.
  • Beckert TE, Lehmann K, Schmidt PC. (1996). Compression of enteric-coated pellets to disintegrating tablets. Int J Pharm, 143:13–23.
  • Mount DL, Schwartz JB. (1996). Formulation and compaction of nonfracturing deformable coated beads. Drug Dev Ind Pharm, 22:609–21.
  • Wagner KG, Krumme M, Beckert TE, Schmidt PC. (2000). Development of disintegrating multiple-unit tablets on a high-speed rotary tablet press. Eur J Pharm Biopharm, 50:285–91.
  • Schwartz JB, Nguyen NH, Schnaare RL. (1994). Compaction studies on beads: Compression and consolidation parameters. Drug Dev Ind Pharm, 20(20):3105–29.
  • Heckel RW. (1961). An analysis of powder compaction phenomena. Trans Metall Soc AIME, 221:1001–8.
  • Heckel RW. (1961a). Density-pressure relationships in powder compaction. Trans Metall Soc AIME, 221:671–5.
  • Maganti L, Celik M. (1993). Compaction studies on pellets I. Uncoated pellets. Int J Pharm, 95:29–42.
  • Matz C, Bauer-Brandl A, Rigassi T, Schubert R, Becker D. (1999). On the accuracy of a new displacement instrumentation for rotary tablet presses. Drug Dev Ind Pharm, 25:117–30.
  • Schmidt PC, Tenter U. (1987). Force and displacement characteristics of rotary tableting machines. Pharm Ind, 49:637–42.
  • Levin M, Tsygan L, Dukler S. (1998). Press simulation apparatus. US Patent 6,106, 262. December 23, 1998.
  • Roberts RJ, Rowe RC. (1986). The effect of the relationship between punch velocity and particle size on the compaction behaviour of materials with varying deformation mechanisms. J Pharm Pharmacol, 38:567–71.
  • Garr JSM, Rubinstein MH. (1991). An investigation into the capping of paracetamol at increasing speeds of compression. Int J Pharm, 72:117–22.
  • Bashaiwoldu AB, Podczeck F, Newton JM. (2004). A study of the effect of drying techniques on the mechanical properties of pellets and compacted pellets. Eur J Pharm Sci, 21:119–29.
  • Maganti L, Celik M. (1994). Compaction studies on pellets. II: Coated pellets. Int J Pharm, 103:55–67.
  • Salako M, Podczeck F, Newton JM. (1998). Investigations into the deformability and tensile strength of pellets. Int J Pharm,168:49–57.
  • Cantor SL, Hoag SW, Augsburger LL. (2008). Formulation and characterization of a compacted multiparticulate system for modified release of water-soluble drugs—Part II theophylline and cimetidine. Drug Dev Ind Pharm, 31:1–15.
  • Ilkka JP. (1993). Prediction of the compression behaviour of powder mixtures by the Heckel equation. Int J Pharm, 94:181–7.
  • Iloanusi NO, Schwartz JB. (1998). The effect of wax on compaction of microcrystalline cellulose beads made by extrusion and spheronization. Drug Dev Ind Pharm, 24(1):37–44.
  • Fell JT, Newton JM. (1971). Effect of particle size and speed of compaction on density changes in tablets of crystalline and spray-dried lactose. J Pharm Sci, 60:1866–9.
  • Paronen P, Juslin M. (1983). Compressional characteristics of four starches. J Pharm Pharmacol, 35:627–35.
  • Sun C, Grant DJW. (2001). Influence of elastic deformation of particles on Heckel analysis. Pharm Dev Tech, 6(2):193–200.
  • Sonnergaard JM. (1999). A critical evaluation of the Heckel equation. Int J Pharm, 193:63–71.
  • Konkel P, Mielck JB. (1997). Associations of parameters characterizing the time course of the tabletting process on a reciprocating and on a rotary tabletting machine for high-speed production. Eur J Pharm Biopharm, 44:289–301.
  • Carstensen JT, Ertell C, Danjo K. (1989). Effect of compaction speed and die diameter on Athy–Heckel and crushing strength parameters of compressed tablets. Drug Dev Ind Pharm, 15:1–10.
  • Kiekens F, Debunne A, Vevaet C, Baert L, Vanhoutte F, Assche IV, . (2004). Influence of the punch diameter and curvature on the yield pressure of MCC-compacts during Heckel analysis. Eur J Pharm Sci, 22:117–26.
  • Armstrong NA, Palfrey LP. (1989). The effect of machine speed on the consolidation of four directly compressible tablet diluents. J Pharm Pharmacol, 41:149–51.
  • Celik M, Aulton ME. (1996). Viscoelastic deformation of some tableting materials as assessed by indentation rheology. Drug Dev Ind Pharm, 22(1):67–75.
  • van der voort Maarschalk K, Vromans H, Groenendijk W, Bolhuis GK, Lerk CF. (1997). Effect of water on deformation and bonding of pregelatinized starch compacts. Eur J Pharm Biopharm, 44(3):253–60.
  • Chowhan ZT, Chow YP. (1981). Compression properties of granulations made with binders containing different moisture contents. J Pharm Sci, 70:1134–9.
  • Muller FX, Augsburger LL. (1994). The role of the displacement-time waveform in the determination of Heckel behavior under dynamic conditions in a compaction simulator and a fully-instrumented rotary tablet machine. J Pharm Pharmacol, 46:468–75.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.