Efficacy, safety and mechanism of HP-β-CD-PEI polymers as absorption enhancers on the intestinal absorption of poorly absorbable drugs in rats

References

• Aisner J. Overview of the changing paradigm in cancer treatment: oral chemotherapy. AM J Health Syst Pharm 2007;64:S4–7.
   PubMed Web of Science ®Google Scholar
• DeMario MD, Ratain MJ. Oral chemotherapy: rationale and future directions. J Clin Oncol 1998;16:2557–67.
   PubMed Web of Science ®Google Scholar
• Yamamoto A, Lee VHL. Penetration and enzymatic barriers to peptide and protein absorption. Adv Drug Deliv Rev 1990;4:171–207.
   Google Scholar
• Yamamoto A, Muranishi S. Rectal drug delivery system: improvement of rectal peptide absorption by absorption enhancers, protease inhibitors and chemical modification. Adv Drug Deliv Rev 1997;28:275–99.
   Web of Science ®Google Scholar
• Mukaizawa F, Taniguchi K, Miyake M, et al. Novel oral absorption system containing polyamines and bile salts enhances drug transport via both trancellular and paracellular pathways across Caco-2 cell monolayers. Int J Pharm 2009;367:103–8.
   PubMed Web of Science ®Google Scholar
• Lin YL, Fujimori TK, Kawaguchi NK, et al. Polyamidoamine dendrimers as novel potential absorption enhancers for improving the small intestinal absorption of poorly absorbable drugs in rats. J Control Release 2011;149:21–8.
   PubMed Web of Science ®Google Scholar
• Linn M, Collnot EM, Djuric D, et al. Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo. Eur J Pharm Sci 2012;45:336–43.
   PubMed Web of Science ®Google Scholar
• Fu QX, Wang HZ, Xia MX, et al. The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism. Eur J Pharm Sci 2015;80:1–8.
   PubMed Web of Science ®Google Scholar
• Kishimoto H, Miyazaki K, Takizawa Y, et al. Absorption-enhancing effect of nitric oxide on the absorption of hydrophobic drugs in rat duodenum. J Pharm Sci 2016;105:729–33.
   PubMed Web of Science ®Google Scholar
• Mosher GL, Thompson DO. Complexations and cyclodextrins. In: Swarbrick J, ed. Encyclopedia of pharmaceutical technology. 2nd edn. New York, NY: Marcel Dekker; 2002.
   Google Scholar
• Loftsson T, Brewster ME, Masson M. Role of cyclodextrins in improving oral drug delivery. Am J Drug Del 2004;2:175–261.
   Google Scholar
• Loftsson T, Brewster ME, Masson M. Cyclodextrins as functional excipients: methods to enhance complexation efficiency. J Pharm Sci 2012;101:3019–32.
   PubMed Web of Science ®Google Scholar
• Davis ME, Brewster ME. Cyclodextrin-based pharmaceutics: past, present and future. Nat Rev Drug Discov 2004;3:1023–35.
   PubMed Web of Science ®Google Scholar
• Tang GP, Guo HY, Alexis F, et al. Low molecular weight polyethylenimines linked by beta-cyclodextrin for gene transfer into the nervous system. J Gene Med 2006;8:736–44.
   PubMed Web of Science ®Google Scholar
• Huang H, Yu H, Li D, et al. A novel copolymer based on hydroxypropyl-α-cyclodextrin conjugated to low molecular weight polyethylenimine as an in vitro gene delivery vector. Int J Mol Sci 2008;9:2278–89.
   PubMed Web of Science ®Google Scholar
• Hu YP, Tang GP, Liu J, et al. FGF receptor-mediated gene delivery using ligands coupled to PEI-β-CyD. J Biomed Biotechnol 2012;2012:989235.
   PubMedGoogle Scholar
• Wang K, Yan Y, Zhao GL, et al. In vitro and in vivo application of hydroxypropyl-β-cyclodextrin-grafted polyethyleneimine used as a transdermal penetration enhancer. Polym Chem 2014;5:4658–69.
   Web of Science ®Google Scholar
• Yan Y, Xing JF, Xu W, et al. Hydroxypropyl-β-cyclodextrin grafted polyethyleneimine used as transdermal penetration enhancer of diclofenac sodium. Int J Pharm 2014;474:182–92.
   PubMed Web of Science ®Google Scholar
• Yamamoto A, Taniguchi T, Rikyuu K, et al. Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm Res 1994;11:1496–500.
   PubMed Web of Science ®Google Scholar
• Gao Y, He L, katsumi H, et al. Improvement of intestinal absorption of water-soluble macromolecules by various polyamines: intestinal mucosal toxicity and absorption-enhancing mechanism of spermine. Int J Pharm 2008;354:126–34.
   PubMed Web of Science ®Google Scholar
• Grass GM, Sweetana SA. In vitro measurement of gastrointestinal tissue permeability using a new diffusion cell. Pharm Res 1988;5:372–6.
   PubMed Web of Science ®Google Scholar
• Khuriah AH, Lin YL, Gao Y, et al. The effect of wellsolve, a novel solubilizing agent, on the intestinal barrier function and intestinal absorption of griseofulvin in rats. Biol Pharm Bull 2009;32:1898–905.
   PubMed Web of Science ®Google Scholar
• Dong ZQ, Khuriah AH, Gao Y, et al. Polyamidoamine dendrimers can improve the pulmonary absorption of insulin and calcitonin in rats. J Pharm Sci 2011;100:1866–78.
   PubMed Web of Science ®Google Scholar
• Yamada K, Odomi M, Okada N, et al. Chitosan oligomers as potential and safe absorption enhancers for improving the pulmonary absorption of interferon-alpha in rats. J Pharm Sci 2005;94:2432–40.
   PubMed Web of Science ®Google Scholar
• Gao Y, He L, Katsumi H, et al. Improvement of intestinal absorption of insulin and water-soluble macromolecular compounds by chitosan oligomers in rats. Int J Pharm 2008;359:70–80.
   PubMed Web of Science ®Google Scholar
• He L, Gao Y, Lin YL, et al. Improvement of pulmonary absorption of insulin and other water-soluble compounds by polyamines in rats. J Control Release 2007;122:94–101.
   PubMed Web of Science ®Google Scholar
• Yamamoto A, Tatsumi H, Maruyama M, et al. Modulation of intestinal permeability of nitric oxide donors: implications in intestinal delivery of poorly absorbable drugs. J Pharmacol Exp Ther 2001;296:84–90.
   PubMed Web of Science ®Google Scholar
• Marttin E, Verhoef JC, Merkus FWHM. Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs. J Drug Target 1998;6:17–36.
   PubMed Web of Science ®Google Scholar
• Haeberlin B, Gengenbacher T, Meinzer A, Fricker G. Cyclodextrins-useful excipients for oral peptide administration? Int J Pharm 1996;137:103–10.
   Web of Science ®Google Scholar
• Zhang Y, Meng FC, Cui YL, Song YF. Enhancing effect of hydroxypropyl-β-cyclodextrin on the intestinal absorption process of genipin. J Agric Food Chem 2011;59:10919–26.
   PubMed Web of Science ®Google Scholar
• Yeagle PL. Cholesterol and the cell membrane. Biochim Biophys Acta 1985;822:267–87.
   PubMed Web of Science ®Google Scholar
• Shao Z, Krishnamoorthy R, Mitra AK. Cyclodextrins as nasal absorption promoters of insulin: mechanistic evaluations. Pharm Res 1992;9:1157–63.
   PubMed Web of Science ®Google Scholar
• Marttin E, Verhoef JC, Romeijn SG, Merkus FWHM. Effects of absorption enhancers on rat nasal epithelium in vivo: release of marker compounds in the nasal cavity. Pharm Res 1995;12:1151–7.
   PubMed Web of Science ®Google Scholar