Sustained release effects of berberine-loaded chitosan microspheres on in vitro chondrocyte culture

References

• Luyten FP, Tylzanowski P, Lories RJ. Wnt signaling and osteoarthritis. Bone. 2009;44:522–527.
   PubMed Web of Science ®Google Scholar
• Hunter DJ, Felson DT. Osteoarthritis. BMJ. 2006;332:639–642.
   PubMed Web of Science ®Google Scholar
• Haseeb A, Haqqi TM. Immunopathogenesis of osteoarthritis. Clin Immunol. 2013;146:185–196.
   PubMed Web of Science ®Google Scholar
• Wick MC, Kastlunger M, Weiss RJ. Clinical imaging assessments of knee osteoarthritis in the elderly: a mini-review. Gerontology. 2014;60:386–394.
   PubMed Web of Science ®Google Scholar
• Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med. 2004;10:1344–1351.
   PubMed Web of Science ®Google Scholar
• Lan T, Wu T, Chen C, et al. Berberine attenuates high glucose-induced proliferation and extracellular matrix accumulation in mesangial cells: involvement of suppression of cell cycle progression and NF-kappaB/AP-1 pathways. Mol Cell Endocrinol. 2014;384:109–116.
   PubMed Web of Science ®Google Scholar
• Wang LH, Li XL, Li Q, et al. Berberine alleviates ischemic arrhythmias via recovering depressed I(to) and I(Ca) currents in diabetic rats. Phytomedicine. 2012;19:206–210.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li X, Zhang Q, et al. Berberine hydrochloride prevents postsurgery intestinal adhesion and inflammation in rats. J Pharmacol Exp Ther. 2014;349:417–426.
   PubMed Web of Science ®Google Scholar
• Wu CM, Li TM, Tan TW, et al. Berberine Reduces the Metastasis of Chondrosarcoma by modulating the alpha v beta 3 Integrin and the PKC delta, c-Src, and AP-1 signaling pathways. Evid Based Complement Altern Med. 2013;2013:423164.
   PubMed Web of Science ®Google Scholar
• Hu PF, Chen WP, Tang JL, et al. Protective effects of berberine in an experimental rat osteoarthritis model. Phytother Res. 2011;25:878–885.
   PubMed Web of Science ®Google Scholar
• Zhao H, Zhang T, Xia C, et al. Berberine ameliorates cartilage degeneration in interleukin-1beta-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling. J Cell Mol Med. 2014;18:283–292.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Tao H, Li Y, et al. Berberine promotes proliferation of sodium nitroprusside-stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt/beta-catenin pathway. Eur J Pharmacol. 2016;789:109–118.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Liu SQ, Yu L, et al. Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling. Apoptosis. 2015;20:1187–1199.
   PubMed Web of Science ®Google Scholar
• Chen W, Fan D, Meng L, et al. Enhancing effects of chitosan and chitosan hydrochloride on intestinal absorption of berberine in rats. Drug Dev Ind Pharm. 2012;38:104–110.
   PubMed Web of Science ®Google Scholar
• Lam J, Lu S, Kasper FK, et al. Strategies for controlled delivery of biologics for cartilage repair. Adv Drug Deliv Rev. 2015;84:123–134.
   PubMed Web of Science ®Google Scholar
• Arya N, Chakraborty S, Dube N, et al. Electrospraying: a facile technique for synthesis of chitosan-based micro/nanospheres for drug delivery applications. J Biomed Mater Res. 2009;88:17–31.
   Web of Science ®Google Scholar
• Qin F, Zeng L, Zhu Y, et al. Preparation and evaluation of a timolol maleate drug-resin ophthalmic suspension as a sustained-release formulation in vitro and in vivo. Drug Dev Ind Pharm. 2016;42:535–545.
   PubMed Web of Science ®Google Scholar
• Laurienzo P. Marine polysaccharides in pharmaceutical applications: an overview. Mar Drugs. 2010;8:2435–2465.
   PubMed Web of Science ®Google Scholar
• Liu SQ, Qiu B, Chen LY, et al. The effects of carboxymethylated chitosan on metalloproteinase-1, -3 and tissue inhibitor of metalloproteinase-1 gene expression in cartilage of experimental osteoarthritis. Rheumatol Int. 2005;26:52–57.
   PubMed Web of Science ®Google Scholar
• Chen Q, Liu SQ, Du YM, et al. Carboxymethyl-chitosan protects rabbit chondrocytes from interleukin-1beta-induced apoptosis. Eur J Pharmacol. 2006;541:1–8.
   PubMed Web of Science ®Google Scholar
• Wu H, Xu Y, Liu G, et al. Emulsion cross-linked chitosan/nanohydroxyapatite microspheres for controlled release of alendronate. J Mater Sci Mater Med. 2014;25:2649–2658.
   PubMed Web of Science ®Google Scholar
• Hou J, Wang J, Cao L, et al. Segmental bone regeneration using rhBMP-2-loaded collagen/chitosan microspheres composite scaffold in a rabbit model. Biomed Mater. 2012;7:035002.
   PubMed Web of Science ®Google Scholar
• Piccirilli GN, Garcia A, Leonardi D, et al. Chitosan microparticles: influence of the gelation process on the release profile and oral bioavailability of albendazole, a class II compound. Drug Dev Ind Pharm. 2014;40:1476–1482.
   PubMed Web of Science ®Google Scholar
• Islam MA, Firdous J, Choi YJ, et al. Design and application of chitosan microspheres as oral and nasal vaccine carriers: an updated review. Int J Nanomed. 2012;7:6077–6093.
   PubMed Web of Science ®Google Scholar
• Bresolin JR, Largura MC, Dalri CC, et al. Spray-dried O-carboxymethyl chitosan as potential hydrophilic matrix tablet for sustained release of drug. Drug Dev Ind Pharm. 2014;40:503–510.
   PubMed Web of Science ®Google Scholar
• Lin YH, Lin JH, Chou SC, et al. Berberine-loaded targeted nanoparticles as specific Helicobacter pylori eradication therapy: in vitro and in vivo study. Nanomedicine (London, England). 2015;10:57–71.
   PubMed Web of Science ®Google Scholar
• Yu F, Li Y, Chen Q, et al. Monodisperse microparticles loaded with the self-assembled berberine-phospholipid complex-based phytosomes for improving oral bioavailability and enhancing hypoglycemic efficiency. Eur J Pharm Biopharm. 2016;103:136–148.
   PubMed Web of Science ®Google Scholar
• Yedurkar P, Dhiman MK, Petkar K, et al. Mucoadhesive bilayer buccal tablet of carvedilol-loaded chitosan microspheres: in vitro, pharmacokinetic and pharmacodynamic investigations. J Microencapsulation. 2012;29:126–137.
   PubMed Web of Science ®Google Scholar
• Zhang J, Tang Q, Xu X, et al. Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery. Int J Pharm. 2013;448:168–174.
   PubMed Web of Science ®Google Scholar
• Abulaihaiti M, Wu XW, Qiao L, et al. Efficacy of albendazole-chitosan microsphere-based treatment for alveolar echinococcosis in mice. Plos Negl Trop Dis. 2015;9:e0003950.
   PubMed Web of Science ®Google Scholar
• Guo K, Cang J. A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation. Drug Design Dev Therapy 2016;10:1291–1298.
   PubMed Web of Science ®Google Scholar
• Tsai CJ, Hsu LR, Fang JY, et al. Chitosan hydrogel as a base for transdermal delivery of berberine and its evaluation in rat skin. Biol Pharm Bull. 1999;22:397–401.
   PubMed Web of Science ®Google Scholar
• Zou Q, Li Y, Zhang L, et al. Antibiotic delivery system using nano-hydroxyapatite/chitosan bone cement consisting of berberine. J Biomed Mater Res. 2009;89:1108–1117.
   Web of Science ®Google Scholar
• Khan AB, Thakur RS. Formulation and evaluation of mucoadhesive microspheres of tenofovir disoproxil fumarate for intravaginal use. Curr Drug Deliv. 2014;11:112–122.
   PubMed Web of Science ®Google Scholar
• Gomathi T, Govindarajan C, Rose HRM, et al. Studies on drug-polymer interaction, in vitro release and cytotoxicity from chitosan particles excipient. Int J Pharm. 2014;468:214–222.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Liu SQ, Peng H, et al. In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis. Int Immunopharmacol. 2015;28:34–43.
   PubMed Web of Science ®Google Scholar
• Cho AR, Chun YG, Kim BK, et al. Preparation of chitosan-TPP microspheres as resveratrol carriers. J Food Sci. 2014;79:E568–E576.
   PubMed Web of Science ®Google Scholar
• Diaz MS, Freile ML, Gutierrez MI. Solvent effect on the UV/Vis absorption and fluorescence spectroscopic properties of berberine. Photochem Photobiol Sci. 2009;8:970–974.
   PubMed Web of Science ®Google Scholar
• Wang H, Xu Y, Zhou X. Docetaxel-loaded chitosan microspheres as a lung targeted drug delivery system: in vitro and in vivo evaluation. IJMS. 2014;15:3519–3532.
   Web of Science ®Google Scholar
• Varma S, Sadasivan C. A long acting biodegradable controlled delivery of chitosan microspheres loaded with tetanus toxoide as model antigen. Biomed Pharmacother. 2014;68:225–230.
   PubMed Web of Science ®Google Scholar
• Jiang H, Tian R, Hu W, et al. Formulation and evaluation of gastroretentive floating drug delivery system of dipyridamole. Drug Dev Ind Pharm. 2015;41:674–680.
   PubMed Web of Science ®Google Scholar
• Mitra A, Dey B. Chitosan microspheres in novel drug delivery systems. Indian J Pharm Sci 2011;73:355–366.
   PubMed Web of Science ®Google Scholar
• He P, Davis SS, Illum L. Sustained release chitosan microspheres prepared by novel spray drying methods. J Microencapsulation 1999;16:343–355.
   PubMed Web of Science ®Google Scholar
• Patel MP, Patel RR, Patel JK. Chitosan mediated targeted drug delivery system: a review. JPPS. 2010;13:536–557.
   Google Scholar
• Wu H, Wang S, Fang H, et al. Chitosan-polycaprolactone copolymer microspheres for transforming growth factor-beta1 delivery. Colloids Surfaces B Biointerf. 2011;82:602–608.
   PubMed Web of Science ®Google Scholar
• Lee JY, Kim JS, Cho HJ, et al. Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery. Int J Nanomed. 2014;9:2803–2813.
   PubMed Web of Science ®Google Scholar
• Han Y, Li S, Cao X, et al. Different inhibitory effect and mechanism of hydroxyapatite nanoparticles on normal cells and cancer cells in vitro and in vivo. Sci Rep. 2014;4:7134.
   PubMed Web of Science ®Google Scholar
• Zeng W, Huang J, Hu X, et al. Ionically cross-linked chitosan microspheres for controlled release of bioactive nerve growth factor. Int J Pharm. 2011;421:283–290.
   PubMed Web of Science ®Google Scholar
• Takada K, Hirose J, Yamabe S, et al. Endoplasmic reticulum stress mediates nitric oxide-induced chondrocyte apoptosis. Biomed Rep. 2013;1:315–319.
   PubMedGoogle Scholar
• Liang Q, Wang XP, Chen TS. Resveratrol protects rabbit articular chondrocyte against sodium nitroprusside-induced apoptosis via scavenging ROS. Apoptosis. 2014;19:1354–1363.
   PubMed Web of Science ®Google Scholar
• Haudenschild DR, Chen J, Pang N, et al. Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis. J Orthop Res. 2011;29:20–25.
   PubMed Web of Science ®Google Scholar
• Gomez R, Conde J, Scotece M, et al. Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes. J Orthop Res. 2014;32:1137–1146.
   PubMed Web of Science ®Google Scholar
• Chen K, Li G, Geng F, et al. Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K-Akt signaling in diabetic rats. Apoptosis 2014;19:946–957.
   PubMed Web of Science ®Google Scholar