A novel vehicle for local protein delivery to the inner ear: injectable and biodegradable thermosensitive hydrogel loaded with PLGA nanoparticles

References

• Moser T. Gene therapy for deafness: How close are we? Sci Transl Med. 2015;7:295fs228.
   Web of Science ®Google Scholar
• Liu H, Hao J, Li KS. Current strategies for drug delivery to the inner ear. Acta Pharm Sin B. 2013;3:86–96.
   Web of Science ®Google Scholar
• McCall AA, Swan EE, Borenstein JT, et al. Drug delivery for treatment of inner ear disease: current state of knowledge. Ear Hear. 2010;31:56–65.
   Google Scholar
• Lustig LR. The history of intratympanic drug therapy in otology. Otolaryngol Clin North Am. 2004;37:1001–1017.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Su H, Wen L, et al. Mathematical modeling for local trans-round window membrane drug transport in the inner ear. Drug Deliv. 2016;23:3082–3087.
   PubMed Web of Science ®Google Scholar
• Lajud SA, Han Z, Chi FL, et al. A regulated delivery system for inner ear drug application. J Control Release. 2013;166:268–276.
   PubMed Web of Science ®Google Scholar
• Yu D, Sun C, Zheng Z, et al. Inner ear delivery of dexamethasone using injectable silk-polyethylene glycol (PEG) hydrogel. Int J Pharm. 2016;503:229–237.
   PubMed Web of Science ®Google Scholar
• Chen G, Zhang X, Yang F, et al. Disposition of nanoparticle-based delivery system via inner ear administration. Curr Drug Metab. 2010;11:886–897.
   PubMed Web of Science ®Google Scholar
• Li L, Chao T, Brant J, et al. Advances in nano-based inner ear delivery systems for the treatment of sensorineural hearing loss. Adv Drug Deliv Rev. 2016;108:2–12.
   PubMed Web of Science ®Google Scholar
• Pritz CO, Dudas J, Rask-Andersen H, et al. Nanomedicine strategies for drug delivery to the ear. Nanomedicine (Lond). 2013;8:1155–1172.
   PubMed Web of Science ®Google Scholar
• Danhier F, Ansorena E, Silva JM, et al. PLGA-based nanoparticles: an overview of biomedical applications. J Control Release. 2012;161:505–522.
   PubMed Web of Science ®Google Scholar
• Zhang K, Tang X, Zhang J, et al. PEG-PLGA copolymers: their structure and structure-influenced drug delivery applications. J Control Release. 2014;183:77–86.
   PubMed Web of Science ®Google Scholar
• Tamura T, Kita T, Nakagawa T, et al. Drug delivery to the cochlea using PLGA nanoparticles. Laryngoscope. 2005;115:2000–2005.
   PubMed Web of Science ®Google Scholar
• Ge X, Jackson RL, Liu J, et al. Distribution of PLGA nanoparticles in chinchilla cochleae. Otolaryngol Head Neck Surg. 2007;137:619–623.
   PubMed Web of Science ®Google Scholar
• Cai H, Wen X, Wen L, et al. Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration. Int J Nanomed. 2014;9:5591–5601.
   PubMed Web of Science ®Google Scholar
• Zhang X, Chen G, Wen L, et al. Novel multiple agents loaded PLGA nanoparticles for brain delivery via inner ear administration: in vitro and in vivo evaluation. Eur J Pharm Sci. 2013;48:595–603.
   PubMed Web of Science ®Google Scholar
• Salt AN, Hartsock J, Plontke S, et al. Distribution of dexamethasone and preservation of inner ear function following intratympanic delivery of a gel-based formulation. Audiol Neurotol. 2011;16:323–335.
   PubMed Web of Science ®Google Scholar
• Engleder E, Honeder C, Klobasa J, et al. Preclinical evaluation of thermoreversible triamcinolone acetonide hydrogels for drug delivery to the inner ear. Int J Pharm. 2014;471:297–302.
   PubMed Web of Science ®Google Scholar
• Luo J, Xu L. Distribution of gentamicin in inner ear after local administration via a chitosan glycerophosphate hydrogel delivery system. Ann Otol Rhinol Laryngol. 2012;121:208–216.
   PubMed Web of Science ®Google Scholar
• van de Heyning P, Muehlmeier G, Cox T, et al. Efficacy and safety of AM-101 in the treatment of acute inner ear tinnitus-a double-blind, randomized, placebo-controlled phase II study. Otol Neurotol. 2014;35:589–597.
   PubMed Web of Science ®Google Scholar
• Chen G, Hou SX, Liu J, et al. In vivo distribution and pharmacokinetics of dexamethasone sodium phosphate thermosensitive in situ gel following intratympanic injection. Sichuan Da Xue Xue Bao Yi Xue Ban. 2006;37:456–459.
   PubMedGoogle Scholar
• Ruel-Gariepy E, Chenite A, Chaput C, et al. Characterization of thermosensitive chitosan gels for the sustained delivery of drugs. Int J Pharm. 2000;203:89–98.
   PubMed Web of Science ®Google Scholar
• Tahrir FG, Ganji F, Ahooyi TM. Injectable thermosensitive chitosan/glycerophosphate-based hydrogels for tissue engineering and drug delivery applications: a review. Ddf. 2015;9:107–120.
   Google Scholar
• Paulson DP, Abuzeid W, Jiang H, et al. A novel controlled local drug delivery system for inner ear disease. Laryngoscope. 2008;118:706–711.
   PubMed Web of Science ®Google Scholar
• Saber A, Strand SP, Ulfendahl M. Use of the biodegradable polymer chitosan as a vehicle for applying drugs to the inner ear. Eur J Pharm Sci. 2010;39:110–115.
   PubMed Web of Science ®Google Scholar
• Namburi BVN, Yadav HKS, Hemanth S, et al. Formulation and evaluation of polymeric nanoparticulate gel for topical delivery. Int J Polymeric Mater Polymeric Biomater. 2014;63:476–485.
   Web of Science ®Google Scholar
• Hu YF, Liu ZQ. Evaluation of brain protein hydrolysate for the treatment of sudden deafness. Gansu Zhong Yi Xue Yuan Xue Bao. 2000;17:28–30.
   Google Scholar
• Lee KY, Nakagawa T, Okano T, et al. Novel therapy for hearing loss: delivery of insulin-like growth factor 1 to the cochlea using gelatin hydrogel. Otol Neurotol. 2007;28:976–981.
   PubMed Web of Science ®Google Scholar
• Omotehara Y, Hakuba N, Hato N, et al. Protection against ischemic cochlear damage by intratympanic administration of AM-111. Otol Neurotl. 2011;32:1422–1427.
   PubMed Web of Science ®Google Scholar
• Jin CH. Recent advances in drug treatment of sudden deafness. Zhongguo Yi Yuan Yao Xue Za Zhi. 1997;17:85–86.
   Google Scholar
• Chen G, Mu L, Lu CY, et al. Preliminary study on brain-targeted delivery of human interferon α-2b following intratympanic administration. Zhongguo Yao Xue Za Zhi. 2010;22:1922–1925.
   Google Scholar
• Wang W. Advanced protein formulations. Protein Sci. 2015;24:1031–1039.
   PubMed Web of Science ®Google Scholar
• Teekamp N, Duque LF, Frijlink HW, et al. Production methods and stabilization strategies for polymer-based nanoparticles and microparticles for parenteral delivery of peptides and proteins. Expert Opin Drug Deliv. 2015;12:1311–1331.
   PubMed Web of Science ®Google Scholar
• Li Z, Cho S, Kwon IC, et al. Preparation and characterization of glycol chitin as a new thermogelling polymer for biomedical applications. Carbohydr Polym. 2013;92:2267–2275.
   PubMed Web of Science ®Google Scholar
• Chen X, Li X, Zhou Y, et al. Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization, and in vivo evaluation. J Biomater Appl. 2012;27:391–402.
   PubMed Web of Science ®Google Scholar
• Cho J, Heuzey MC, Begin A, et al. Effect of urea on solution behavior and heat-induced gelation of chitosan-β-glycerophosphate. Carbohydr Polym. 2006;63:507–518.
   Web of Science ®Google Scholar
• Chenite A, Buschmann M, Wang D, et al. Rheological characterization of thermogelling chitosan/glycerol-phosphate solutions. Carbohydr Polym. 2001;46:39–47.
   Web of Science ®Google Scholar
• Zhou HY, Chen XG, Kong M, et al. Effect of molecular weight and degree of chitosan deacetylation on the preparation and characteristics of chitosan thermosensitive hydrogel as a delivery system. Carbohydr Polym. 2008;73:265–273.
   Web of Science ®Google Scholar
• Raftery R, O’Brien FJ, Cryan SA. Chitosan for gene delivery and orthopedic tissue engineering applications. Molecules. 2013;18:5611–5647.
   PubMed Web of Science ®Google Scholar
• Lü S, Liu M, Ni B. An injectable oxidized carboxymethylcellulose/N-succinyl-chitosan hydrogel system for protein delivery. Chem Eng J. 2010;160:779–787.
   Web of Science ®Google Scholar
• Zarzycki R, Rogacki G, Modrzejewska Z, et al. Modeling of drug (Albumin) release from thermosensitive chitosan hydrogels. Ind Eng Chem Res. 2011;50:5866–5872.
   Web of Science ®Google Scholar
• Peng Q, Sun X, Gong T, et al. Injectable and biodegradable thermosensitive hydrogels loaded with PHBHHx nanoparticles for the sustained and controlled release of insulin. Acta Biomater. 2013;9:5063–5069.
   PubMed Web of Science ®Google Scholar
• Senyigit ZA, Karavana SY, Ilem-Ozdemir D, et al. Design and evaluation of an intravesical delivery system for superficial bladder cancer: preparation of gemcitabine HCl-loaded chitosan-thioglycolic acid nanoparticles and comparison of chitosan/poloxamer gels as carriers. Int J Nanomed. 2015;10:6493–6507.
   PubMed Web of Science ®Google Scholar
• Salt AN, Kellner C, Hale S. Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid. Hear Res. 2003;182:24–33.
   PubMed Web of Science ®Google Scholar
• Salt AN. Pharmacokinetics of drug entry into cochlear fluids. Volta Rev. 2005;105:277–298.
   PubMed Web of Science ®Google Scholar
• Vaishya R, Khurana V, Patel S, et al. Long-term delivery of protein therapeutics. Expert Opin Drug Deliv. 2015;12:415–440.
   PubMed Web of Science ®Google Scholar
• Chelikh L, Teixeira M, Martin C, et al. High variability of perilymphatic entry of neutral molecules through the round window. Acta Otolaryngol. 2003;123:199–202.
   PubMed Web of Science ®Google Scholar
• Yoshioka M, Naganawa S, Sone M, et al. Individual differences in the permeability of the round window: evaluating the movement of intratympanic gadolinium into the inner ear. Otol Neurotol. 2009;30:645–648.
   PubMed Web of Science ®Google Scholar
• Horie RT, Sakamoto T, Nakagawa T, et al. Sustained delivery of lidocaine into the cochlea using poly lactic/glycolic acid microparticles. Laryngoscope. 2010;120:377–383.
   PubMed Web of Science ®Google Scholar
• Rivera T, Sanz L, Camarero G, et al. Drug delivery to the inner ear: strategies and their therapeutic implications for sensorineural hearing loss. Curr Drug Deliv. 2012;9:231–242.
   PubMed Web of Science ®Google Scholar