91
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Equilibria, kinetics and mechanism for the degradation of the cytotoxic compound L-NG-nitroarginine

, , , , &
Pages 624-631 | Received 03 Jun 2017, Accepted 08 Nov 2017, Published online: 04 Dec 2017

References

  • Chaplin DJ, Hill SA, Bell KM, et al. Modification of tumor blood flow: current status and future directions. Semin Radiat Oncol. 1998;8:151–163.
  • Pfeiffer S, Leopold E, Schmidt K, et al. Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol. 1996;118:1433–1440.
  • Andrade SP, Hart IR, Piper PJ. Inhibitors of nitric oxide synthase selectively reduce flow in tumor-associated neovasculature. Br J Pharmacol. 1992;107:1092–1095.
  • Wood PJ, Sansom JM, Butler SA, et al. Induction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-Nitro-L-arginine. Cancer Res. 1994;54:6458–6463.
  • Strickley RG. Solubilizing excipients in oral and injectable formulations. Pharm Res. 2004;21:201–230.
  • Hughes JP, Rees S, Kalindjian SB, et al. Principles of early drug discovery. Br J Pharmacol. 2011;162:1239–1249.
  • Boquet MP, Wagner DR. Injectable formulations of poorly water-soluble drugs. In: Williams RO, Watts AB, Miller DA, editors. Formulating poorly water soluble drugs. New York (NY): Springer; 2012. p. 209–242.
  • Simamora P, Pinsuwan S, Alvarez JM, et al. Effect of pH on injection phlebitis. J Pharm Sci. 1995;84:520–522.
  • Gerry S. Preformulation as an aid to product design in early drug development. In: Gibson M, editor. Pharmaceutical preformulation and formulation. United Kingdom: CRC Press; 2009. p. 188–246.
  • Loudon GM. Mechanistic interpretation of pH-rate profiles. J Chem Educ. 1991;68:973.
  • Qandil AM, Jamhawi NM, Tashtoush BM, et al. The hydrolysis kinetics of monobasic and dibasic aminoalkyl esters of ketorolac. Drug Dev Ind Pharm. 2013;39:1346–1356.
  • Yeh MK. Degradation kinetics of neostigmine in solution. Drug Dev Ind Pharm. 2000;26:1221–1226.
  • Gu L, Dunn J, Dvorak C. Preformulation prodrug research–chemical and enzymatic hydrolysis kinetics of the glycerol, glycolic acid and morpholino ethyl ester derivatives of a developmental analgesic agent (RS-82917). Drug Dev Ind Pharm. 1989;15:209–221.
  • Angelov T, Vlasenko A, Tashkov W. HPLC determination of pKa of parabens and investigation on their lipophilicity parameters. J Liq Chromatogr Relat Technol. 2007;31:188–197.
  • Chapter 27: amino acids, peptides and proteins [Internet]. USA: F. A. Carey; [cited 2017 Oct 12]. Available from: http://www.mhhe.com/physsci/chemistry/carey5e/Ch27/ch27-1-4-2.html
  • Košturiak A, Zacharová-Kálavska D. Study of the hydrolysis of the C = N bond in 3-phenyliminoxindol. Chem Pap. 1975;29:34–38.
  • Canneaux S, Hammaecher C, Louis F, et al. Rate constant calculation of benzylperoxy radical isomerization. In: Han K, Chu T, editors. Reaction rate constant computations: theories and applications. United Kingdom: The Royal Society of Chemistry; 2013. p. 34–54.
  • Hao AJ, Deng YJ, Li TF, et al. Degradation kinetics of fluorouracil-acetic-acid-dextran conjugate in aqueous solution. Drug Dev Ind Pharm. 2006;32:757–763.
  • Herrmann J, Bodmeier R. Degradation kinetics of somatostatin in aqueous solution. Drug Dev Ind Pharm. 2003;29:1027–1033.
  • Suleiman MS, Abdulhameed ME, Najib NM, et al. Degradation kinetics of diltiazem. Drug Dev Ind Pharm. 1990;16:685–694.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.