Water-soluble porphyrin-PAMAM-conjugates of melphalan and their anticancer activity

References

• Sarosy G, Leyland-Jones B, Soochan P, Cheson BD. The systemic administration of intravenous melphalan. J Clin Oncol. 1988;6:1768–1782.
   PubMed Web of Science ®Google Scholar
• Sanchorawala V, Wright DG, Seldin DC, et al. High-dose intravenous melphalan and autologous stem cell transplantation as initial therapy or following two cycles of oral chemotherapy for the treatment of AL amyloidosis: results of a prospective randomized trial. Bone Marrow Transplant. 2004;33:381–388.
   PubMed Web of Science ®Google Scholar
• Lu B, Huang D, Zheng H, et al. Preparation, characterization, and in vitro efficacy of O-carboxymethyl chitosan conjugate of melphalan. Carbohydr Polym. 2013;98:36–42.
   PubMed Web of Science ®Google Scholar
• Maeda H, Wu J, Sawa T, et al. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release. 2000;65:271–284.
   PubMed Web of Science ®Google Scholar
• Langer R. New methods of drug delivery. Science. 1990;249:1527–1533.
   PubMed Web of Science ®Google Scholar
• Challener CA. New drug-delivery methods: from concept to patient. BioPharm Int. 2016;2:14–18.
   Google Scholar
• Agostinis P, Berg K, Cengel KA, et al. Photodynamic therapy of cancer: An update. CA-Cancer J Clin. 2011;61:250–281.
   PubMed Web of Science ®Google Scholar
• Ideta R, Tasaka F, Jang WD, et al. Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano Lett. 2005;5:2426–2431.
   PubMed Web of Science ®Google Scholar
• Patri AK, Majoros I, Baker JRJ. Dendritic polymer macromolecular carriers for drug delivery. Curr Opin Chem Biol. 2002;6:466–471.
   PubMed Web of Science ®Google Scholar
• Shao N, Dai T, Liu Y, et al. Evidence of guest encapsulation within G8 and G10 dendrimers using NMR techniques. Soft Matter. 2014;10:9153–9158.
   PubMed Web of Science ®Google Scholar
• Madaan K, Kumar S, Poonia N, et al. Dendrimers in drug delivery and targeting: drug-dendrimer interactions and toxicity issues. J Pharm Bioallied Sci. 2014;6:139–150.
   PubMedGoogle Scholar
• Mudshinge SR, Deore AB, Patil S, et al. Nanoparticles: emerging carriers for drug delivery. Saudi Pharm J. 2011;19:129–141.
   PubMed Web of Science ®Google Scholar
• Lin Q, Jiang G, Tong K. Dendrimers in drug-delivery, applications. Des Monomers Polym. 2010;13:301–324.
   Web of Science ®Google Scholar
• Svenson S, Tomalia DA. Dendrimers in biomedical applications reflections on the field. Adv Drug Delivery Rev. 2012;64:102–115.
   Web of Science ®Google Scholar
• Laurenţia GN, Rodica AM. Boron neutron capture therapy: delivery agents used in boron administration therapeutics. J Pharmacol Clin Toxicol. 2016;1:25–32.
   Google Scholar
• Nwe K, Bryant LH, Jr, Brechbiel MW. Poly(amidoamine) dendrimer based MRI contrast agents exhibiting enhanced relaxivities derived via metal preligation techniques. Bioconjugate Chem 2010;21:1014–1017.
   PubMed Web of Science ®Google Scholar
• Konda SD, Aref M, Wang S, et al. Specific targeting of folate-dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts. MAGMA. 2001;12:104–113.
   PubMedGoogle Scholar
• Talanov V, Regino C, Kobayashi H, et al. Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging. Nano Lett. 2006;6:1459–1463.
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Kawamoto S, Jo SK, et al. Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores. Bioconjugate Chem. 2003;14:388–394.
   PubMed Web of Science ®Google Scholar
• Wu G, Barth RF, Yang W, et al. Site-specific conjugation of boron-containing dendrimers to anti-EGF receptor monoclonal antibody cetuximab (IMC-C225) and its evaluation as a potential delivery agent for neutron capture therapy. Bioconjug Chem. 2004;15:185–194.
   PubMed Web of Science ®Google Scholar
• Esfand R, Tomalia DA. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discov Today. 2001;6:427–436.
   PubMed Web of Science ®Google Scholar
• Lee CC, MacKay JA, Fréchet JJ, et al. Designing dendrimers for biological applications. Nat Biotechnol. 2005;23:1517–1526.
   PubMed Web of Science ®Google Scholar
• Beezer AE, King ASH, Martin IK, et al. Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives. Tetrahedron. 2003;59:3873–3880.
   Web of Science ®Google Scholar
• Twyman LJ, Beezer AE, Esfand R, et al. The synthesis of water soluble dendrimers, and their application as possible drug delivery systems. Tetrahedron Lett. 1999;40:1743–1746.
   Web of Science ®Google Scholar
• Cortez-Maya S, Hernández-Ortega S, Ramírez-Apan T, et al. Synthesis of 5-aryl-1,4-benzodiazepine derivatives attached in resorcinaren-PAMAM dendrimers and their anti-cancer activity. Bioorg Med Chem. 2012;20:415–421.
   PubMed Web of Science ®Google Scholar
• Pedro-Hernández LD, Martínez-Klimova E, Cortez-Maya S, et al. Synthesis, characterization and nanomedical applications of conjugates between resorcinarene-dendrimers and ibuprofen. Nanomaterials. 2017;7:163–173.
   Web of Science ®Google Scholar
• Oar MA, Dichtel WR, Serin JM, et al. Light-harvesting chromophores with metalated porphyrin cores for tuned photosensitization of singlet oxygen via two-photon excited FRET. Chem Mater. 2006;18:3682–3692.
   Web of Science ®Google Scholar
• Gonsalves AMAR, Varejão JMTB, Pereira MM. Some new aspects related to the synthesis of mesosubstituted porphyrins. J Heterocycl Chem. 1991;28:635–640.
   Web of Science ®Google Scholar
• Monks A, Scudiero D, Skehan P, et al. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst. 1991;83:757–766.
   PubMed Web of Science ®Google Scholar
• Cortes-Benítez F, Cabeza M, Ramírez-Apan MT, et al. Synthesis of 17b-N-arylcarbamoylandrost-4-en-3-one derivatives and their anti-proliferative effect on human androgen-sensitive LNCaP cell line. Eur J Medicinal Chem. 2016;121:737–746.
   PubMed Web of Science ®Google Scholar
• Kim JB, Adler AD, Longo FR. In: Dolphin, D., editor. The porphyrins, vol. 1: Part A. New York, NY: Academic, 1978; p 85.
   Google Scholar