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Drug Development and Industrial Pharmacy Volume 45, 2019 - Issue 1
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Research Article

SCC4 cell monolayers as an alternative sublingual barrier model: influence of nanoencapsulation on carvedilol transport

Paula dos Santos ChavesPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; View further author information
,
Fernanda VisioliPrograma de Pós-Graduação em Odontologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; ORCID Iconhttp://orcid.org/0000-0002-4033-8431View further author information
ORCID Icon,
Andréia BuffonPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; View further author information
,
Adriana Raffin PohlmannPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; ;Departamento de Química Orgânica, Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, BrazilORCID Iconhttp://orcid.org/0000-0001-5222-1807View further author information
ORCID Icon,
Sílvia Stanisçuaski GuterresPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; View further author information
&
Ruy Carlos Ruver BeckPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-6262-1097View further author information
ORCID Icon
Pages 63-66 | Received 29 Jan 2018, Accepted 22 Aug 2018, Published online: 19 Sep 2018

References

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  • Wang Y, Zuo Z, Lee KK, et al. Evaluation of HO-1-u-1 cell line as an in vitro model for sublingual drug delivery involving passive diffusion—Initial validation studies. Int J Pharm. 2007;334:27–34.
  • Murdoch C, Reeves KJ, Hearnden V, et al. Internalization and biodistribution of polymersomes into oral squamous cell carcinoma cells in vitro and in vivo. Nanomedicine (Lond). 2010;5:1025–1036.
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  • Teubl BJ, Absenger M, Fröhlich E, et al. The oral cavity as a biological barrier system: design of an advanced buccal in vitro permeability model. Eur J Pharm Biopharm. 2013;84:386–393.
  • Vichai V, Kirtikara K. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc. 2006;1:1112–1116.

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