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Research Articles

Eye drops and eye gels of levofloxacin: comparison of ocular absorption characterizations and therapeutic effects in the treatment of bacterial keratitis in rabbits

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Pages 673-681 | Received 01 Feb 2020, Accepted 22 Mar 2020, Published online: 20 Apr 2020

References

  • Austin A, Lietman T, Rose-Nussbaumer J. Update on the management of infectious keratitis. Ophthalmology. 2017;124(11):1678–1689.
  • Lakhundi S, Siddiqui R, Khan NA. Pathogenesis of microbial keratitis. Microb Pathog. 2017;104:97–109.
  • Mun Y, Kim MK, Oh JY. Ten-year analysis of microbiological profile and antibiotic sensitivity for bacterial keratitis in Korea. PLoS One. 2019;14(3):e0213103.
  • Nguyen V, Lee GA. Management of microbial keratitis in general practice. Aust J Gen Pract. 2019;48(8):516–519.
  • Oldenburg CE, Lietman TM. The challenge of controlling infectious keratitis. Am J Ophthalmol. 2017;176:xv–xvi.
  • Jian HJ, Wu RS, Lin TY, et al. Super-cationic carbon quantum dots synthesized from spermidine as an eye drop formulation for topical treatment of bacterial keratitis. ACS Nano. 2017;11(7):6703–6716.
  • Luo LJ, Lin TY, Yao CH, et al. Dual-functional gelatin-capped silver nanoparticles for antibacterial and antiangiogenic treatment of bacterial keratitis. J Colloid Interface Sci. 2019;536:112–126.
  • Ameeduzzafar Imam SS, Abbas Bukhari SN, et al. Formulation and optimization of levofloxacin loaded chitosan nanoparticle for ocular delivery: In-vitro characterization, ocular tolerance and antibacterial activity. Int J Biol Macromol. 2018;108:650–659.
  • Bhalerao H, Koteshwara KB, Chandran S. Levofloxacin hemihydrate in situ gelling ophthalmic solution: formulation optimization and in vitro and in vivo evaluation. AAPS PharmSciTech. 2019;20(7):272.
  • Palioura S, Gibbons A, Miller D, et al. Clinical features, antibiotic susceptibility profile, and outcomes of infectious keratitis caused by Stenotrophomonas maltophilia. Cornea. 2018;37(3):326–330.
  • Sharma A, Taniguchi J. Review: emerging strategies for antimicrobial drug delivery to the ocular surface: implications for infectious keratitis. Ocul Surf. 2017;15(4):670–679.
  • Oum BS, Kim NM, Lee JS, et al. Effects of fluoroquinolone eye solutions without preservatives on human corneal epithelial cells in vitro. Ophthalmic Res. 2014;51(4):216–223.
  • Bezwada P, Clark LA, Schneider S. Intrinsic cytotoxic effects of fluoroquinolones on human corneal keratocytes and endothelial cells. Curr Med Res Opin. 2008;24(2):419–424.
  • Fukuda M, Sasaki H. Effects of fluoroquinolone-based antibacterial ophthalmic solutions on corneal wound healing. J Ocul Pharmacol Ther. 2015;31(9):536–540.
  • Silva CND, Silva FRD, Dourado LFN, et al. A new topical eye drop containing LyeTxI-b, a synthetic peptide designed from a Lycosa erithrognata venom toxin, was effective to treat resistant bacterial keratitis. Toxins (Basel). 2019;11(4):203.
  • Zhang H, Liu S, Yue J, et al. In vitro antimicrobial activity of diacerein on 76 isolates of Gram-positive Cocci from bacterial keratitis patients and in vivo study of diacerein eye drops on Staphylococcus aureus keratitis in mice. Antimicrob Agents Chemother. 2019;63(4): e01874–18.
  • Aveyard J, Deller RC, Lace R, et al. Antimicrobial nitric oxide releasing contact lens gels for the treatment of microbial keratitis. ACS Appl Mater Interfaces. 2019;11(41):37491–37501.
  • Ubani-Ukoma U, Gibson D, Schultz G, et al. Evaluating the potential of drug eluting contact lenses for treatment of bacterial keratitis using an ex vivo corneal model. Int J Pharm. 2019;565:499–508.
  • Jiang H, Han S, Guo C, et al. In vitro and in vivo effectiveness evaluation of balofloxacin in experimental Staphylococcus aureus keratitis. J Ocul Pharmacol Ther. 2014;30(6):482–488.
  • Wu X, Jiang H, Xu Y, et al. Efficacy of gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis. J Ocul Pharmacol Ther. 2012;28(4):420–427.
  • Wu X, Yang X, Jiang H, et al. Safety evaluation of intracameral and subconjunctival injection of a novel mucoadhesive polysaccharide isolated from Bletilla striata in rabbit eye. J Ocul Pharmacol Ther. 2012;28(4):369–380.
  • Guo C, Zhang Y, Yang Z, et al. Nanomicelle formulation for topical delivery of cyclosporine A into the cornea: in vitro mechanism and in vivo permeation evaluation. Sci Rep. 2015;5(1):12968.
  • Dajcs JJ, Thibodeaux BA, Marquart ME, et al. Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis. Antimicrob Agents Chemother. 2004;48(6):1948–1952.
  • Miller D. Update on the epidemiology and antibiotic resistance of ocular infections. Middle East Afr J Ophthalmol. 2017;24(1):30–42.
  • Balzli CL, McCormick CC, Caballero AR, et al. Fluoroquinolone therapy in a rabbit model of post-LASIK methicillin-resistant Staphylococcus aureus keratitis. J Cataract Refract Surg. 2008;34(2):295–301.
  • Fukaya Y, Kurita A, Tsuruga H, et al. Antibiotic effects of WP-0405, a thermo-setting ofloxacin gel, on methicillin-resistant Staphylococcus aureus keratitis in rabbits. J Ocul Pharmacol Ther. 2006;22(4):258–266.
  • Johansen S, Rask-Pedersen E, Prause JU. An ocular bioavailability comparison in rabbits of prednisolone acetate after repeated topical applications formulated as a high-viscosity gel and as an aqueous suspension. Acta Ophthalmol Scand. 2009;74(3):259–264.
  • Smolle M, Keller C, Pinggera G, et al. Clear hydro-gel, compared to ointment, provides improved eye comfort after brief surgery. Can J Anesth/J Can Anesth. 2004;51(2):126–129.
  • Luo LJ, Nguyen DD, Lai JY. Benzoic acid derivative-modified chitosan-g-poly(N-isopropylacrylamide): methoxylation effects and pharmacological treatments of glaucoma-related neurodegeneration. J Control Release. 2020;317:246–258.
  • Nguyen DD, Luo LJ, Lai JY. Dendritic effects of injectable biodegradable thermogels on pharmacotherapy of inflammatory glaucoma-associated degradation of extracellular matrix. Adv Healthcare Mater. 2019;8(24):e1900702.
  • Nguyen DD, Luo LJ, Lue SJ, et al. The role of aromatic ring number in phenolic compound-conjugated chitosan injectables for sustained therapeutic antiglaucoma efficacy. Carbohydr Polym. 2020;231:115770.

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