References
- Abramoff B, Caldera FE. Osteoarthritis: pathology, diagnosis, and treatment options. Med Clin North Am. 2020;104(2):293–311.
- Boehme KA, Rolauffs B. Onset and progression of human Osteoarthritis-Can growth factors, inflammatory cytokines, or differential miRNA expression concomitantly induce proliferation, ECM degradation, and inflammation in articular cartilage? IJMS. 2018;19(8):2282.
- Sanchez-Adams J, Leddy HA, McNulty AL, et al. The mechanobiology of articular cartilage: bearing the burden of osteoarthritis. Curr Rheumatol Rep. 2014;16(10):451
- Loeser RF, Collins JA, Diekman BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12(7):412–420.
- Murphy C, Withrow J, Hunter M, et al. Emerging role of extracellular vesicles in musculoskeletal diseases. Mol Aspects Med. 2018;60:123–128.
- Yang J, Li Y, Liu Q, et al. Brief introduction of medical database and data mining technology in big data era. J Evid Based Med. 2020;13(1):57–69.
- Hu Y, Yu Z, Cheng X, et al. A bibliometric analysis and visualization of medical data mining research. Medicine (Baltimore)). 2020;99(22):e20338),
- Boezio B, Audouze K, Ducrot P, et al. Network-based approaches. Pharmacol Mol Inform. 2017;36(10):170048.
- Luo TT, Lu Y, Yan SK, et al. Network pharmacology in research of chinese medicine formula: Methodology, application and Prospective. Chin J Integr Med. 2020;26(1):72–80.
- Huo MQ, Peng S, Ren Y, et al. [Discovery and application of traditional Chinese medicine efficacy markers based on systematic traditional chinese medicine]. Zhongguo Zhong Yao Za Zhi. 2020;45(14):3245–3250.
- Kaur T, Madgulkar A, Bhalekar M, et al. Molecular docking in formulation and development. Curr Drug Discov Technol. 2019;16(1):30–39.
- Dong D, Xu Z, Zhong W, et al. Parallelization of molecular docking: a review. Curr Top Med Chem. 2018;18(12):1015–1028.
- Wang J, Ran Q, Zeng HR, et al. Cellular stress response mechanisms of rhizoma coptidis: a systematic review. Chin Med. 2018;13:27
- Dong L, Vecchio AJ, Sharma NP, et al. Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer. J Biol Chem. 2011;286(21):19035–19046.
- Yoshikawa K, Takei S, Hasegawa-Ishii S, et al. Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the Central nervous system. Brain Res. 2011;1367:22–32.
- Chevalier D, Lo-Guidice JM, Sergent E, et al. Identification of genetic variants in the human thromboxane synthase gene (CYP5A1). Mutat Res. 2001;432(3-4):61–67.
- Miyata A, Yokoyama C, Ihara H, et al. Characterization of the human gene (TBXAS1) encoding thromboxane synthase. Eur J Biochem. 1994;224(2):273–279.
- Peng CZ, Cao JM, Xiao T, et al. [Concentration of IL-18 and PGE2 in synovial fluid in patients with osteoarthritis and its significance]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006;31(6):862–865.
- Maghsoudi H, Hallajzadeh J, Rezaeipour M. Evaluation of the effect of polyphenol of escin compared with ibuprofen and dexamethasone in synoviocyte model for osteoarthritis: an in vitro study. Clin Rheumatol. 2018;37(9):2471–2478.
- Aikawa J, Uchida K, Takano S, et al. Regulation of calcitonin gene-related peptide expression through the COX-2/mPGES-1/PGE2 pathway in the infrapatellar fat pad in knee osteoarthritis. Lipids Health Dis. 2018;17(1):215
- Liu M, Xie W, Zheng W, et al. [Targeted binding of estradiol with ESR1 promotes proliferation of human chondrocytes in vitro by inhibiting activation of ERK signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2019;39(2):134–143.
- Hah N, Kraus WL. Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells. Mol Cell Endocrinol. 2014;382(1):652–664.
- Smith DF, Toft DO. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Mol Endocrinol. 2008;22(10):2229–2240.
- Mo C, Ke J, Zhao D, et al. Role of the renin-angiotensin-aldosterone system in bone metabolism. J Bone Miner Metab. 2020;38(6):772–779. ).
- Wu Y, Zeng Y, Li M, et al. [Expressions of renin, angiotensin converting enzyme, angiotensin receptor 1, and angiotensin receptor 2 in synovial tissue of osteoarthritis at different stages]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2020;34(3):362–366.
- Wu Y, Li M, Zeng J, et al. Differential expression of Renin-Angiotensin system-related components in patients with rheumatoid arthritis and Osteoarthritis. Am J Med Sci. 2020;359(1):17–26.
- Wu Y, Lu X, Li M, et al. Renin-angiotensin system in osteoarthritis: a new potential therapy. Int Immunopharmacol. 2019;75:105796
- Wang W, Han X, Zhao T, et al. AGT, targeted by miR-149-5p, promotes IL-6-induced inflammatory responses of chondrocytes in osteoarthritis via activating JAK2/STAT3 pathway. Clin Exp Rheumatol. 2020;6(38):1088–1095.
- Miossec P, Kolls JK. Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov. 2012;11(10):763–776.
- Rossini M, Viapiana O, Adami S, et al. Focal bone involvement in inflammatory arthritis: the role of IL17. Rheumatol Int. 2016;36(4):469–482.
- Kobayashi M, Squires GR, Mousa A, et al. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum. 2005;52(1):128–135.
- Kim HJ, Seo SJ, Kim JY, et al. IL-17 promotes osteoblast differentiation, bone regeneration, and remodeling in mice. Biochem Biophys Res Commun. 2020;524(4):1044–1050.
- Huang Z, Pei X, Graves DT. The interrelationship between diabetes, IL-17 and bone Loss. Curr Osteoporos Rep. 2020;18(1):23–31.
- Sung MS, Lee EG, Jeon HS, et al. Quercetin inhibits IL-1β-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast . INFLAMMATION. 2012;35(4):1585–1594.
- Shen SC, Lee WR, Lin HY, et al. In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. Eur J Pharmacol. 2002;446(1-3):187–194.
- Yoon HY, Lee EG, Lee H, et al. Kaempferol inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs . Int J Mol Med. 2013;32(4):971–977.
- Genin O, Hasdai A, Shinder D, et al. The effect of inhibition of heat-shock proteins on thiram-induced tibial dyschondroplasia. Poult Sci. 2012;91(7):1619–1626.
- Chen YC, Shen SC, Chen LG, et al. Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem Pharmacol. 2001;61(11):1417–1427.
- Suh MG, Choi HS, Cho K, et al. Anti-inflammatory action of herbal medicine comprised of scutellaria baicalensis and chrysanthemum morifolium. Biosci Biotechnol Biochem. 2020;84(9):1799–1809.
- Khan NM, Haseeb A, Ansari MY, et al. Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human osteoarthritis chondrocytes. Free Radic Biol Med. 2017;106:288–301.
- Bai SK, Lee SJ, Na HJ, et al. beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation. Exp Mol Med. 2005;37(4):323–334.
- Wu J, Li J, Li W, et al. Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in sanmiao wan using an acute gouty arthritis rat model. J Ethnopharmacol. 2018;221:100–108.
- Ahn HY, Cho JH, Nam D, et al. Efficacy and safety of cortex eucommiae (eucommia ulmoides oliver) extract in subjects with mild osteoarthritis: Study protocol for a 12-week, multicenter, randomized, double-blind, placebo-controlled trial. Medicine (Baltimore)). 2019;98(50):e18318
- Gao Z, Lu Y, Halmurat U, et al. Study of osteoporosis treatment principles used historically by ancient physicians in chinese medicine. Chin J Integr Med. 2013;19(11):862–868.