Multi-directionally evaluating the formation mechanism of 1,4-dihydropyridine drug nanosuspensions through experimental validation and computer-aided drug design

References

• Kuk DH, Ha ES, Ha DH, et al. Development of a resveratrol nanosuspension using the antisolvent precipitation method without solvent removal, based on a quality by design (QbD) approach. Pharmaceutics. 2019;11(12):688.
   PubMed Web of Science ®Google Scholar
• Shariare MH, Altamimi MA, Marzan AL, et al. In vitro dissolution and bioavailability study of furosemide nanosuspension prepared using design of experiment (DoE). Saudi Pharm J. 2019;27(1):96–105.
   PubMed Web of Science ®Google Scholar
• Lee S, Han D, Kang HG, et al. Intravenous sustained-release nifedipine ameliorates nonalcoholic fatty liver disease by restoring autophagic clearance. Biomaterials. 2019;197:1–11.
   PubMed Web of Science ®Google Scholar
• Knapik-Kowalczuk J, Tu W, Chmiel K, et al. Co-stabilization of amorphous pharmaceuticals-the case of nifedipine and nimodipine. Mol Pharm. 2018;15(6):2455–2465.
   PubMed Web of Science ®Google Scholar
• Zhou J, He F, Sun B, et al. Polytropic influence of TRIB3 rs2295490 genetic polymorphism on response to antihypertensive agents in patients with essential hypertension. Front Pharmacol. 2019;10:236.
   PubMed Web of Science ®Google Scholar
• Koli AR, Ranch KM, Patel HP, et al. Oral bioavailability improvement of felodipine using tailored microemulsion: surface science, ex vivo and in vivo studies. Int J Pharm. 2021;596:120202.
   PubMedGoogle Scholar
• Szafraniec-Szczęsny J, Antosik-Rogóż A, Kurek M, et al. How does the addition of kollidon®VA64 inhibit the recrystallization and improve ezetimibe dissolution from amorphous solid dispersions? Pharmaceutics. 2021;13(2):147.
   PubMed Web of Science ®Google Scholar
• Lorenzoni R, Contri RV, Lima C, et al. Dermatopharmacokinetic and pharmacodynamic evaluation of a novel nanostructured formulation containing capsaicinoids for treating neuropathic pain. Int J Pharm. 2021;596:120294.
   PubMedGoogle Scholar
• Alshweiat A, Csóka I, Tömösi F, et al. Nasal delivery of nanosuspension-based mucoadhesive formulation with improved bioavailability of loratadine: preparation, characterization, and in vivo evaluation. Int J Pharm. 2020;579:119166.
   PubMedGoogle Scholar
• Na YG, Pham T, Byeon JJ, et al. Development and evaluation of TPGS/PVA-based nanosuspension for enhancing dissolution and oral bioavailability of ticagrelor. Int J Pharm. 2020;581:119287.
   PubMed Web of Science ®Google Scholar
• Wang P, Cao X, Chu Y, et al. Ginkgolides-loaded soybean phospholipid-stabilized nanosuspension with improved storage stability and in vivo bioavailability. Colloids Surf B Biointerfaces. 2019;181:910–917.
   PubMed Web of Science ®Google Scholar
• Date AA, Halpert G, Babu T, et al. Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease. Biomaterials. 2018;185:97–105.
   PubMed Web of Science ®Google Scholar
• Huang S, Zhang Q, Li H, et al. Increased bioavailability of efonidipine hydrochloride nanosuspensions by the wet-milling method. Eur J Pharm Biopharm. 2018;130:108–114.
   PubMed Web of Science ®Google Scholar
• Czyz S, Wewers M, Finke JH, et al. Spray drying of API nanosuspensions: importance of drying temperature, type and content of matrix former and particle size for successful formulation and process development. Eur J Pharm Biopharm. 2020;152:63–71.
   PubMed Web of Science ®Google Scholar
• Ouranidis A, Gkampelis N, Vardaka E, et al. Overcoming the solubility barrier of ibuprofen by the rational process design of a nanocrystal formulation. Pharmaceutics. 2020;12(10):969.
   Web of Science ®Google Scholar
• Ibrahim AH, Rosqvist E, Smått JH, et al. Formulation and optimization of lyophilized nanosuspension tablets to improve the physicochemical properties and provide immediate release of silymarin. Int J Pharm. 2019;563:217–227.
   PubMedGoogle Scholar
• Gajera BY, Shah DA, Dave RH. Development of an amorphous nanosuspension by sonoprecipitation-formulation and process optimization using design of experiment methodology. Int J Pharm. 2019;559:348–359.
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang S, Xu Y, et al. Etoposide amorphous nanopowder for improved oral bioavailability: formulation development, optimization, in vitro and in vivo evaluation. Int J Nanomedicine. 2020;15:7601–7613.
   PubMed Web of Science ®Google Scholar
• Singhal M, Baumgartner A, Turunen E, et al. Nanosuspensions of a poorly soluble investigational molecule ODM-106: impact of milling bead diameter and stabilizer concentration. Int J Pharm. 2020;587:119636.
   PubMedGoogle Scholar
• Liu Q, Guan J, Sun Z, et al. Influence of stabilizer type and concentration on the lung deposition and retention of resveratrol nanosuspension-in-microparticles. Int J Pharm. 2019;569:118562.
   PubMed Web of Science ®Google Scholar
• Leung DH, Lamberto DJ, Liu L, et al. A new and improved method for the preparation of drug nanosuspension formulations using acoustic mixing technology. Int J Pharm. 2014;473(1–2):10–19.
   PubMedGoogle Scholar
• Liu D, Zhang H, Cito S, et al. Core/shell nanocomposites produced by superfast sequential microfluidic nanoprecipitation. Nano Lett. 2017;17(2):606–614.
   PubMed Web of Science ®Google Scholar
• Heshmati AN, Lara EJ, Patel P, et al. High throughput preparation of poly(lactic-co-glycolic acid) nanoparticles using fiber fluidic reactor. Materials. 2020;13(14):3075.
   Web of Science ®Google Scholar
• Medarević D, Djuriš J, Ibrić S, et al. Optimization of formulation and process parameters for the production of carvedilol nanosuspension by wet media milling. Int J Pharm. 2018;540(1–2):150–161.
   PubMed Web of Science ®Google Scholar
• Omolo CA, Kalhapure RS, Agrawal N, et al. Formulation and molecular dynamics simulations of a fusidic acid nanosuspension for simultaneously enhancing solubility and antibacterial activity. Mol Pharm. 2018;15(8):3512–3526.
   PubMed Web of Science ®Google Scholar
• Kuroiwa Y, Higashi K, Ueda K, et al. Nano-scale and molecular-level understanding of wet-milled indomethacin/poloxamer 407 nanosuspension with TEM, suspended-state NMR, and raman measurements. Int J Pharm. 2018;537(1–2):30–39.
   PubMedGoogle Scholar
• Tasca E, Andreozzi P, Del Giudice A, et al. Poloxamer/sodium cholate co-formulation for micellar encapsulation of doxorubicin with high efficiency for intracellular delivery: an in-vitro bioavailability study. J Colloid Interface Sci. 2020;579:551–561.
   PubMed Web of Science ®Google Scholar
• Tsagogiorgas C, Anger F, Beck G, et al. Impact of different emulsifiers on biocompatibility and inflammatory potential of perfluorohexyloctane (F6H8) emulsions for new intravenous drug delivery systems. Drug Des Devel Ther. 2019;13:2097–2110.
   PubMed Web of Science ®Google Scholar
• Choi JS, Park JW, Park JS. Design of coenzyme Q10 solid dispersion for improved solubilization and stability. Int J Pharm. 2019;572:118832.
   PubMedGoogle Scholar
• Li Z, Huang Y, Wu Y, et al. Absolute binding free energy calculation and design of a subnanomolar inhibitor of phosphodiesterase-10. J Med Chem. 2019;62(4):2099–2011.
   PubMed Web of Science ®Google Scholar
• Ndlovu ST, Ullah N, Khan S, et al. Domperidone nanocrystals with boosted oral bioavailability: fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction. Drug Deliv Transl Res. 2019;9(1):284–297.
   PubMed Web of Science ®Google Scholar
• Cione E, Caroleo MC, Kagechika H, et al. Pharmacophore-guided repurposing of fibrates and retinoids as GPR40 allosteric ligands with activity on insulin release. J Enzyme Inhib Med Chem. 2021;36(1):377–383.
   PubMed Web of Science ®Google Scholar
• Wang Z, Ren J, Jin N, et al. Is crocin a potential anti-tumor candidate targeting microtubules? Computational insights from molecular docking and dynamics simulations. Front Mol Biosci. 2020;7:586970.
   PubMed Web of Science ®Google Scholar
• Gray JJ, Moughon S, Wang C, et al. Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations. J Mol Biol. 2003;331(1):281–299.
   PubMed Web of Science ®Google Scholar
• Mishra SS, Ranjan S, Sharma CS, et al. Computational investigation of potential inhibitors of novel coronavirus 2019 through structure-based virtual screening, molecular dynamics and density functional theory studies. J Biomol Struct Dyn. 2020;39(12):4449–4461.
   PubMed Web of Science ®Google Scholar
• Picco AS, Ferreira LF, Liberato MS, et al. Freeze-drying of silica nanoparticles: redispersibility toward nanomedicine applications. Nanomedicine. 2018;13(2):179–190.
   PubMed Web of Science ®Google Scholar
• Rabiei M, Palevicius A, Monshi A, et al. Comparing methods for calculating nano crystal size of natural hydroxyapatite using X-ray diffraction. Nanomaterials. 2020;10(9):1627.
   Web of Science ®Google Scholar
• Kaur A, Parmar PK, Bansal AK. Evaluation of different techniques for size determination of drug nanocrystals: a case study of celecoxib nanocrystalline solid dispersion. Pharmaceutics. 2019;11:516.
   Web of Science ®Google Scholar
• Shekhawat P, Pokharkar V. Risk assessment and QbD based optimization of an eprosartan mesylate nanosuspension: in-vitro characterization, PAMPA and in-vivo assessment. Int J Pharm. 2019;567:118415.
   PubMed Web of Science ®Google Scholar
• Chi C, Zhang C, Liu Y, et al. Phytosome-nanosuspensions for silybin-phospholipid complex with increased bioavailability and hepatoprotection efficacy. Eur J Pharm Sci. 2020;144:105212.
   PubMed Web of Science ®Google Scholar
• Zuo W, Qu W, Li N, et al. Fabrication of multicomponent amorphous bufadienolides nanosuspension with wet milling improves dissolution and stability. Artif Cells Nanomed Biotechnol. 2018;46(7):1513–1522.
   PubMed Web of Science ®Google Scholar
• Wang H, Xiao Y, Wang H, et al. Development of daidzein nanosuspensions: preparation, characterization, in vitro evaluation, and pharmacokinetic analysis. Int J Pharm. 2019;566:67–76.
   PubMed Web of Science ®Google Scholar
• Van Ngo H, Park C, Tran T, et al. Mechanistic understanding of salt-induced drug encapsulation in nanosuspension via acid-base neutralization as a nanonization platform technology to enhance dissolution rate of pH-dependent poorly water-soluble drugs. Eur J Pharm Biopharm. 2020;154:8–17.
   PubMed Web of Science ®Google Scholar
• Ferrar JA, Sellers BD, Chan C, et al. Towards an improved understanding of drug excipient interactions to enable rapid optimization of nanosuspension formulations. Int J Pharm. 2020;578:119094.
   PubMed Web of Science ®Google Scholar
• Hafiz SS, Labadini D, Riddell R, et al. Surfaces and interfaces of liquid metal core-shell nanoparticles under the microscope. Part Part Syst Charact. 2020;37(5):1900469.
   PubMed Web of Science ®Google Scholar
• Raagulan K, Ghim JS, Braveenth R, et al. EMI shielding of the hydrophobic, flexible, lightweight carbonless nano-plate composites. Nanomaterials. 2020;10(10):2086.
   Web of Science ®Google Scholar
• Daood U, Sauro S, Pichika MR, et al. Novel riboflavin/VE-TPGS modified universal dentine adhesive with superior dentine bond strength and self-crosslinking potential. Dent Mater. 2020;36(1):145–156.
   PubMed Web of Science ®Google Scholar
• Fadaka AO, Sibuyi NRS, Madiehe AM, et al. Computational insight of dexamethasone against potential targets of SARS-CoV-2. J Biomol Struct Dyn. 2020:1–11.doi:https://doi.org/10.1080/07391102.2020.1819880.
   Google Scholar
• Hasegawa Y, Higashi K, Yamamoto K, et al. Direct evaluation of molecular states of piroxicam/poloxamer nanosuspension by suspended-state NMR and Raman spectroscopies. Mol Pharm. 2015;12(5):1564–1572.
   PubMedGoogle Scholar