Ginsenoside Rg3 liposomes regulate tumor microenvironment for the treatment of triple negative breast cancer

References

• Cleere DW. Triple-negative breast cancer: a clinical update. Community Oncol. 2010;5:203–211.
   Google Scholar
• Freedman GM, Anderson PR, Li T, et al. Locoregional recurrence of triple‐negative breast cancer after breast‐conserving surgery and radiation. Cancer. 2009;115:946–951.
   PubMedGoogle Scholar
• Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer. 2006;6(5):392–401.
   PubMed Web of Science ®Google Scholar
• Yu Y, Xiao CH, Tan LD, et al. Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling. Br J Cancer. 2014;110:724–732.
   PubMed Web of Science ®Google Scholar
• Kreike B, Kouwenhove MV, Horlings H, et al. Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas. Breast Cancer Res. 2007;9:1–14.
   Google Scholar
• Chen YZ, Song WT, Shen LM, et al. Vasodilator hydralazine promotes nanoparticle penetration in advanced desmoplastic tumors. ACS Nano. 2019;13:1751–1763.
   PubMedGoogle Scholar
• Marsh T, Pietras K, McAllister SS. Fibroblasts as architects of cancer pathogenesis. Biochim Biophys Acta. 2013;1832(7):1070–1078.
   PubMed Web of Science ®Google Scholar
• Bierie B, Moses HL. TGFβ: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer. 2006;6(7):506–520.
   PubMed Web of Science ®Google Scholar
• Ivanović V, Todorović-Raković N, Demajo M, et al. Elevated plasma levels of transforming growth factor-beta 1 (TGF-beta 1) in patients with advanced breast cancer: association with disease progression. Eur J Cancer. 2003;39(4):454–461.
   PubMed Web of Science ®Google Scholar
• Cherng S, Young J, Ma H. Alpha-smooth muscle actin (α-SMA). J Am Sci. 2008;4:7–9.
   Google Scholar
• Wang M, Zhang J, Huang Y, et al. Cancer-associated fibroblasts autophagy enhances progression of triple-negative breast cancer cells. Med Sci Monit. 2017;23:3904–3912.
   PubMed Web of Science ®Google Scholar
• Xu H, Hu MN, Liu M, et al. Nano-puerarin regulates tumor microenvironment and facilitates chemo-and immunotherapy in murine triple negative breast cancer model. Biomaterials. 2020;235:119769.
   PubMed Web of Science ®Google Scholar
• Chen R, Huang L, Hu K. Natural products remodel cancer-associated fibroblasts in desmoplastic tumors. Acta Pharm Sin B. 2020;10(11):2140–2155.
   PubMedGoogle Scholar
• Liu JP, Lu D, Nicholson RC, et al. Toxicity of a novel anti-tumor agent 20(S)-ginsenoside Rg3: a 26-week intramuscular repeated administration study in rats. Food Chem Toxicol. 2012;50:3388–3396.
   PubMedGoogle Scholar
• Hien TT, Kim ND, Pokharel YR, et al. Ginsenoside Rg3 increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase: essential roles of estrogen receptor-dependent PI3-kinase and AMP-activated protein kinase. Toxicol Appl Pharm. 2010;246:171–183.
   PubMedGoogle Scholar
• Tang M, Bian W, Cheng L, et al. Ginsenoside Rg3 inhibits keloid fibroblast proliferation, angiogenesis and collagen synthesis in vitro via the TGF-β/smad and ERK signaling pathways. Int J Mol Med. 2018;41:1487–1499.
   PubMed Web of Science ®Google Scholar
• Wen L, Huang SZ, Du WA, et al. Effects of the molecular weight and molar ratio of poly(2-ethyl-2-oxazoline)-based lipid on the pH sensitivity, stability, and anti-tumor efficacy of liposomes. Drug Dev Ind Pharm. 2020;46:283–295.
   PubMedGoogle Scholar
• Moll R, Davis B. Iron, vitamin B12 and folate. Medicine. 2017;45:198–203.
   Google Scholar
• Ha D, Yang NN, Nadithe V. Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges. Acta Pharm Sin B. 2016;6:287–296.
   PubMed Web of Science ®Google Scholar
• Xu H, Hu MN, Yu X, et al. Design and evaluation of pH-sensitive liposomes constructed by poly(2-ethyl-2-oxazoline)-cholesterol hemisuccinate for doxorubicin delivery. Eur J Pharm Biopharm. 2015;91:66–74.
   PubMed Web of Science ®Google Scholar
• Han S, Sun RY, Su H, et al. Delivery of docetaxel using pH-sensitive liposomes based on D-α-tocopheryl poly(2-ethyl-2-oxazoline) succinate: comparison with PEGylated liposomes. Asian J Pharm Sci. 2019;14:391–404.
   PubMed Web of Science ®Google Scholar
• Yan L. Targeted micelles based on folate conjugated poly (2-ethyl-2-oxazoline)-b-poly (ε-caprolact one) polymer: preparation and application in tumor therapy. Hangzhou: Zhejiang University, 2014.
   Google Scholar
• Le HK, Graham L, Cha E, et al. Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice. Int Immunopharmcol. 2009;9:900–909.
   PubMed Web of Science ®Google Scholar
• Glassner M, D'hooge DR, Park JY, et al. Systematic investigation of alkyl sulfonate initiators for the cationic ring-opening polymerization of 2-oxazolines revealing optimal combinations of monomers and initiators. Eur Polym J. 2015;65:298–304.
   Google Scholar
• Yue HX, Wang XC, Xu H. Synthesis and application of 2-oxazoline polymer in drug delivery systems: a review. Chinese Pharma J. 2017;52:713–720.
   Google Scholar
• Hoogenboom R, Fijten MWM, Schubert US. Parallel kinetic investigation of 2‐oxazoline polymerizations with different initiators as basis for designed copolymer synthesis. J Polym Sci Pol Chem. 2004;42:1830–1840.
   Web of Science ®Google Scholar
• Yu X, Xu H, Hu MN, et al. Ginsenoside Rg3 bile salt-phosphatidylcholine-based mixed micelles: design, characterization, and evaluation. Chem Pharm Bull. 2015;63(5):361–368.
   PubMed Web of Science ®Google Scholar
• Ye FF, Dai Y, Xu H, et al. Preparation and characterization of ginsenosides Rg3 liposomes and their inhibitory effect on melanoma cells. Chin J New Drug. 2014;23:2542–2546.
   Google Scholar
• Huang SK, Lee D, Hong K, et al. Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice. Cancer Res. 1992;52(19):5135–5143.
   PubMedGoogle Scholar
• Liu H, Tang R, He XX, et al. Effects of liposomes formulation and preparation method on the stability of acyclovir palmitate liposomes. Acta Pharm Sinica. 2002;37:563–566.
   Google Scholar
• Fatouros DG, Antimisiaris SG. Effect of amphiphilic drugs on the stability and zeta-potential of their liposome formulations: a study with prednisolone, diazepam, and griseofulvin. J Colloid Interf Sci. 2002;251:271–277.
   PubMed Web of Science ®Google Scholar
• Liu Y, Chen J. miR-425 suppresses EMT and the development of TNBC (triple-negative breast cancer) by targeting the TGF-β 1/SMAD 3 signaling pathway. Rsc Adv. 2019;9:151–165.
   Google Scholar
• Kim S, Lee J, You D, et al. Berberine suppresses cell motility through downregulation of TGF-β1 in triple negative breast cancer cells. Cell Physiol Biochem. 2018;45:795–807.
   PubMedGoogle Scholar
• Ao Z, Shah SH, Machlin LM, et al. Identification of cancer-associated fibroblasts in circulating blood from patients with metastatic breast cancer. Cancer Res. 2015;75:4681–4687.
   PubMedGoogle Scholar
• Hawinkels LJAC, Paauwe M, Verspaget HW, et al. Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts. Oncogene. 2014;33:97–107.
   PubMed Web of Science ®Google Scholar
• Xi C, Yin GB, Li X, et al. Effect of ulinastatin combined with doxifluridine on immune microenvironment of breast cancer. Chin J New Drug. 2017;26:1696–1705.
   Google Scholar